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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:altered insulin secretion pathway
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Accession:PW:0000677 term browser browse the term
Definition:An insulin secretion pathway that deviates from what its normal course should be. Altered insulin secretion has been associated with type 2 diabetes mellitus. Multiple defects are thought to underle malfunctions of insulin secretion; the exact molecular mechanisms are only partially understood.
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altered insulin secretion pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 ISO DNA:missense mutation::A1369S (human) RGD PMID:17259403 RGD:2313628 NCBI chr 1:105,734,992...105,816,272
Ensembl chr 1:105,734,992...105,815,982 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 ISO polymorphisms in the human gene are linked to altered insulin secretion; E23K polymorphism appears to confer susceptibility to diabetes type-2 in Caucasian population
DNA:missense mutation::p.E23K (human) 		RGD PMID:15565284 PMID:17259403 RGD:2313610, RGD:2313628 NCBI chr 1:105,727,473...105,731,167
Ensembl chr 1:105,727,570...105,731,169 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3864
      altered regulatory pathway 79
        altered homeostasis pathway 30
          altered glucose homeostasis pathway 6
            altered insulin secretion pathway 2
Path 2
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3864
      homeostasis pathway 1772
        organic chemical homeostasis pathway 767
          glucose homeostasis pathway 344
            altered glucose homeostasis pathway 6
              altered insulin secretion pathway 2
paths to the root