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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:Notch signaling pathway
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Accession:PW:0000204 term browser browse the term
Definition:The Notch signaling pathway regulates processes involved in early embryonic development. It plays an important role in cell fate determination. Target genes of Notch have been implicated in angiogenesis, somitogenesis and gliogenesis. Deregulation of the Notch signaling pathway underlies a broad spectrum of diseases and clinical conditions.
Synonyms:related_synonym: Signaling by NOTCH
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Notch signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 ADAM metallopeptidase domain 10 ISS
ISO 		PID
RGD		 PMID:12354787 PMID:17761886 PID:200015, RGD:1300252, RGD:2302204 NCBI chr 8:80,226,862...80,358,728
Ensembl chr 8:80,226,674...80,361,600 		JBrowse link
G Adam12 ADAM metallopeptidase domain 12 ISO PID PID:200015 NCBI chr 1:198,116,968...198,443,680
Ensembl chr 1:198,116,975...198,447,552 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 ISO
IEA 		KEGG
RGD		 PMID:17761886 rno:04330, RGD:2302204 NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344 		JBrowse link
G Aph1a aph-1A gamma-secretase subunit ISO
IEA 		KEGG
PID
RGD		 PMID:17761886 PID:200015 rno:04330, RGD:2302204 NCBI chr 2:186,123,023...186,130,886
Ensembl chr 2:186,127,323...186,132,045 		JBrowse link
G Aph1b aph-1B gamma-secretase subunit ISO
IEA 		KEGG
PID
RGD		 PMID:17761886 PID:200015 rno:04330, RGD:2302204 NCBI chr 8:76,310,380...76,334,146
Ensembl chr 8:76,310,380...76,331,428 		JBrowse link
G Cbl Cbl proto-oncogene ISO PID PID:200015 NCBI chr 8:53,384,656...53,468,067
Ensembl chr 8:53,384,656...53,468,067 		JBrowse link
G Ccnd1 cyclin D1 ISO PID PID:200015 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO PID PID:200015 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cirsr corepressor of RBPJ and splicing regulator IEA KEGG rno:04330 NCBI chr 3:78,566,438...78,596,309
Ensembl chr 3:78,566,438...78,596,309 		JBrowse link
G Cntn1 contactin 1 ISO PID PID:200015 NCBI chr 7:125,142,638...125,440,397
Ensembl chr 7:125,142,696...125,440,391 		JBrowse link
G Cntn6 contactin 6 ISO PID PID:200015 NCBI chr 4:138,911,090...139,307,339
Ensembl chr 4:138,911,380...139,311,816 		JBrowse link
G Crebbp CREB binding lysine acetyltransferase IEA KEGG rno:04330 NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266 		JBrowse link
G Ctbp1 C-terminal binding protein 1 ISO
IEA 		PID
KEGG		 PID:200015 rno:04330 NCBI chr14:81,679,956...81,707,331
Ensembl chr14:81,679,765...81,707,554 		JBrowse link
G Ctbp2 C-terminal binding protein 2 IEA KEGG rno:04330 NCBI chr 1:197,208,536...197,348,802
Ensembl chr 1:197,212,133...197,254,261 		JBrowse link
G Cul1 cullin 1 ISO PID PID:200015 NCBI chr 4:77,551,781...77,634,210
Ensembl chr 4:77,551,787...77,621,760 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 ISO PID PID:200015 NCBI chr 6:134,192,491...134,199,779
Ensembl chr 6:134,192,518...134,200,529 		JBrowse link
G Dll1 delta like canonical Notch ligand 1 TAS
IEA
ISO 		KEGG
PID
RGD		 PMID:14743446 PMID:17761886 PID:200015 rno:04330, RGD:1304491, RGD:2302204 NCBI chr 1:64,985,161...64,993,274
Ensembl chr 1:64,985,161...64,993,276 		JBrowse link
G Dll3 delta like canonical Notch ligand 3 TAS
IEA
ISO 		KEGG
PID
RGD		 PMID:14743446 PMID:17761886 PID:200015 rno:04330, RGD:1304491, RGD:2302204 NCBI chr 1:92,689,577...92,698,125
Ensembl chr 1:92,689,577...92,697,406 		JBrowse link
G Dll4 delta like canonical Notch ligand 4 ISO
IEA 		KEGG
PID
RGD		 PMID:17761886 PID:200015 rno:04330, RGD:2302204 NCBI chr 3:126,770,945...126,780,769
Ensembl chr 3:126,770,794...126,780,763 		JBrowse link
G Dner delta/notch-like EGF repeat containing ISO PID PID:200015 NCBI chr 9:93,035,108...93,350,568
Ensembl chr 9:93,035,108...93,350,568 		JBrowse link
G Dnm1 dynamin 1 ISO PID PID:200015 NCBI chr 3:36,002,535...36,055,220
Ensembl chr 3:36,002,064...36,046,289 		JBrowse link
G Dtx1 deltex E3 ubiquitin ligase 1 ISO PID PID:200015 NCBI chr12:41,510,252...41,541,433
Ensembl chr12:41,510,264...41,541,430 		JBrowse link
G Dtx2 deltex E3 ubiquitin ligase 2 IEA KEGG rno:04330 NCBI chr12:26,279,899...26,319,541
Ensembl chr12:26,279,899...26,319,507 		JBrowse link
G Dtx3 deltex E3 ubiquitin ligase 3 IEA KEGG rno:04330 NCBI chr 7:64,898,693...64,904,636
Ensembl chr 7:64,898,866...64,903,752 		JBrowse link
G Dtx3l deltex E3 ubiquitin ligase 3L IEA KEGG rno:04330 NCBI chr11:78,320,225...78,329,837
Ensembl chr11:78,317,650...78,329,837 		JBrowse link
G Dtx4 deltex E3 ubiquitin ligase 4 IEA KEGG rno:04330 NCBI chr 1:218,882,391...218,969,837
Ensembl chr 1:218,832,284...218,917,130 		JBrowse link
G Dvl1 dishevelled segment polarity protein 1 IEA KEGG rno:04330 NCBI chr 5:171,738,911...171,750,967
Ensembl chr 5:171,739,133...171,750,966 		JBrowse link
G Dvl3 dishevelled segment polarity protein 3 IEA KEGG rno:04330 NCBI chr11:93,869,834...93,887,013
Ensembl chr11:93,869,834...93,886,903 		JBrowse link
G Eno1 enolase 1 ISO PID PID:200015 NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003 		JBrowse link
G Ep300 EP300 lysine acetyltransferase ISO
IEA 		PID
KEGG		 PID:200015 rno:04330 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574 		JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 ISO PID PID:200015 NCBI chr 5:129,274,487...129,374,856
Ensembl chr 5:129,274,502...129,374,856 		JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 ISO PID PID:200015 NCBI chr 2:172,447,738...172,609,591
Ensembl chr 2:172,447,738...172,609,591 		JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) ISO PID PID:200015 NCBI chr 1:143,757,389...143,770,430
Ensembl chr 1:143,757,391...143,773,497 		JBrowse link
G Gata3 GATA binding protein 3 ISO PID PID:200015 NCBI chr17:73,544,234...73,575,670
Ensembl chr17:73,553,548...73,575,670 		JBrowse link
G Hdac1 histone deacetylase 1 ISO
IEA 		PID
KEGG		 PID:200015 rno:04330 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387 		JBrowse link
G Hdac1l histone deacetylase 1-like IEA KEGG rno:04330 NCBI chr 9:87,901,045...87,903,045
Ensembl chr 9:87,896,472...87,903,613 		JBrowse link
G Hdac2 histone deacetylase 2 IEA KEGG rno:04330 NCBI chr20:42,101,815...42,126,486
Ensembl chr20:42,102,861...42,126,311 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 ISO
IEA 		KEGG
RGD		 PMID:17586813 rno:04330, RGD:5135539 NCBI chr11:84,210,632...84,213,045
Ensembl chr11:84,210,633...84,213,061 		JBrowse link
G Hes5 hes family bHLH transcription factor 5 ISO
IEA 		KEGG
RGD		 PMID:17586813 rno:04330, RGD:5135539 NCBI chr 5:170,804,511...170,807,988
Ensembl chr 5:170,803,940...170,806,021 		JBrowse link
G Hes7 hes family bHLH transcription factor 7 ISO RGD PMID:17586813 RGD:5135539 NCBI chr10:54,322,971...54,327,776
Ensembl chr10:54,322,971...54,327,776 		JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 IDA
ISO 		RGD PMID:11741889 PMID:17586813 RGD:70528, RGD:5135539 NCBI chr 2:95,003,935...95,006,457
Ensembl chr 2:95,002,943...95,007,624 		JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 ISO
IDA 		RGD PMID:17586813 PMID:11741889 RGD:5135539, RGD:70528 NCBI chr 1:28,641,100...28,651,187
Ensembl chr 1:28,641,057...28,651,187 		JBrowse link
G Heyl hes-related family bHLH transcription factor with YRPW motif-like ISO RGD PMID:17586813 RGD:5135539 NCBI chr 5:140,793,271...140,810,262
Ensembl chr 5:140,793,271...140,810,262 		JBrowse link
G Il4 interleukin 4 ISO PID PID:200015 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Itch itchy E3 ubiquitin protein ligase ISO PID PID:200015 NCBI chr 3:164,102,490...164,193,932
Ensembl chr 3:164,105,812...164,193,932 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 IDA
IEA
ISO
IMP 		KEGG
PID
RGD		 PMID:7697721 PMID:15057910 PMID:17761886 PID:200015 rno:04330, RGD:69863, RGD:1334443, RGD:2302204 NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:144,859,453...144,894,872 		JBrowse link
G Jag2 jagged canonical Notch ligand 2 ISO
IEA 		KEGG
PID
RGD		 PMID:17761886 PID:200015 rno:04330, RGD:2302204 NCBI chr 6:137,804,133...137,826,738
Ensembl chr 6:137,804,133...137,826,738 		JBrowse link
G Kat2a lysine acetyltransferase 2A IEA KEGG rno:04330 NCBI chr10:86,132,535...86,140,877
Ensembl chr10:86,132,535...86,140,485 		JBrowse link
G Kat2b lysine acetyltransferase 2B IEA KEGG rno:04330 NCBI chr 9:6,799,101...6,903,616
Ensembl chr 9:6,799,145...6,903,616 		JBrowse link
G Kdm1a lysine demethylase 1A ISO PID PID:200015 NCBI chr 5:154,066,436...154,121,913
Ensembl chr 5:154,065,543...154,121,775 		JBrowse link
G Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase IDA
IEA
ISO 		KEGG
RGD		 PMID:12167404 PMID:17761886 rno:04330, RGD:727405, RGD:2302204 NCBI chr12:19,144,474...19,152,951
Ensembl chr12:19,124,662...19,152,918 		JBrowse link
G Lnx1 ligand of numb-protein X 1 ISO PID PID:200015 NCBI chr14:33,868,517...33,971,217
Ensembl chr14:33,868,571...33,971,217 		JBrowse link
G Maml1 mastermind-like transcriptional coactivator 1 ISO
IEA 		KEGG
PID
RGD		 PMID:17761886 PID:200015 rno:04330, RGD:2302204 NCBI chr10:35,089,715...35,124,100
Ensembl chr10:35,089,715...35,124,100 		JBrowse link
G Maml2 mastermind-like transcriptional coactivator 2 ISO
IEA 		KEGG
PID
RGD		 PMID:17761886 PID:200015 rno:04330, RGD:2302204 NCBI chr 8:18,552,480...18,869,923
Ensembl chr 8:18,552,281...18,869,900 		JBrowse link
G Maml3 mastermind-like transcriptional coactivator 3 ISO RGD PMID:17761886 RGD:2302204 NCBI chr 2:137,871,267...138,288,615
Ensembl chr 2:137,871,267...138,287,960 		JBrowse link
G Mark2 microtubule affinity regulating kinase 2 ISO PID PID:200015 NCBI chr 1:213,890,213...213,955,417
Ensembl chr 1:213,890,213...213,955,149 		JBrowse link
G Mfap2 microfibril associated protein 2 ISO PID PID:200015 NCBI chr 5:158,595,121...158,603,283
Ensembl chr 5:158,597,512...158,610,656 		JBrowse link
G Mfap5 microfibril associated protein 5 ISO PID PID:200015 NCBI chr 4:157,399,919...157,422,448
Ensembl chr 4:157,395,597...157,422,448 		JBrowse link
G Mfng MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase ISS
IEA
ISO 		KEGG
RGD		 PMID:9187150 PMID:17761886 rno:04330, RGD:1302739, RGD:2302204 NCBI chr 7:112,191,288...112,209,129
Ensembl chr 7:112,161,071...112,209,129 		JBrowse link
G Mib1 MIB E3 ubiquitin protein ligase 1 ISO PID
RGD		 PMID:12530964 PID:200015, RGD:1334454 NCBI chr18:2,075,309...2,199,774
Ensembl chr18:2,075,309...2,193,475 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO PID PID:200015 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Mycbp Myc binding protein ISO PID PID:200015 NCBI chr 5:141,420,727...141,427,938
Ensembl chr 5:141,420,707...141,430,681 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 ISO PID PID:200015 NCBI chr10:47,498,852...47,641,612
Ensembl chr10:47,498,852...47,640,350 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 ISO
IEA 		PID
KEGG		 PID:200015 rno:04330 NCBI chr12:37,127,736...37,289,612
Ensembl chr12:37,127,686...37,289,612 		JBrowse link
G Ncstn nicastrin TAS
IEA
ISO 		KEGG
PID
RGD		 PMID:12736250 PMID:17761886 PID:200015 rno:04330, RGD:724403, RGD:2302204 NCBI chr13:87,062,827...87,078,839
Ensembl chr13:87,062,831...87,078,839 		JBrowse link
G Neurl1 neuralized E3 ubiquitin protein ligase 1 ISO RGD PMID:14986688 RGD:1334462 NCBI chr 1:256,008,012...256,094,219
Ensembl chr 1:256,008,160...256,094,224 		JBrowse link
G Neurl2 neuralized E3 ubiquitin protein ligase 2 ISO RGD PMID:14986688 RGD:1334462 NCBI chr 3:173,985,996...173,988,717
Ensembl chr 3:173,986,857...173,989,043 		JBrowse link
G Notch1 notch receptor 1 IDA
IEA
ISO
IMP 		KEGG
PID
RGD		 PMID:11900468 PMID:15247148 PMID:15057910 PMID:17761886 PMID:12853432 PID:200015 rno:04330, RGD:724389, RGD:2306423, RGD:1334443, RGD:2302204, RGD:1358543 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613 		JBrowse link
G Notch2 notch receptor 2 ISO
IEA 		KEGG
PID
RGD		 PMID:17761886 PID:200015 rno:04330, RGD:2302204 NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:188,299,336...188,432,823 		JBrowse link
G Notch3 notch receptor 3 ISO
IEA
IDA 		KEGG
PID
RGD		 PMID:11971902 PMID:15247148 PMID:17761886 PID:200015 rno:04330, RGD:625426, RGD:2306423, RGD:2302204 NCBI chr 7:11,783,550...11,834,585
Ensembl chr 7:11,784,272...11,834,778 		JBrowse link
G Notch4 notch receptor 4 IDA
IEA
ISO 		KEGG
PID
RGD		 PMID:10964583 PMID:17761886 PID:200015 rno:04330, RGD:1304484, RGD:2302204 NCBI chr20:4,164,969...4,189,072
Ensembl chr20:4,161,730...4,189,072 		JBrowse link
G Numb NUMB, endocytic adaptor protein TAS
IEA
ISO 		KEGG
PID
RGD		 PMID:12500307 PID:200015 rno:04330, RGD:724390 NCBI chr 6:109,162,499...109,284,527
Ensembl chr 6:109,162,499...109,284,463 		JBrowse link
G Numbl NUMB-like, endocytic adaptor protein ISO
IEA 		KEGG
RGD		 PMID:15492044 rno:04330, RGD:1334451 NCBI chr 1:91,677,437...91,701,415
Ensembl chr 1:91,677,242...91,701,424 		JBrowse link
G Pofut1 protein O-fucosyltransferase 1 ISS
ISO 		RGD PMID:14570055 PMID:17761886 RGD:1334453, RGD:2302204 NCBI chr 3:162,168,855...162,195,798
Ensembl chr 3:162,168,606...162,195,018 		JBrowse link
G Psen1 presenilin 1 TAS
IEA
ISO 		KEGG
PID
RGD		 PMID:12736250 PMID:17761886 PID:200015 rno:04330, RGD:724403, RGD:2302204 NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:109,060,352...109,106,189 		JBrowse link
G Psen2 presenilin 2 ISO
IEA 		KEGG
RGD		 PMID:17761886 rno:04330, RGD:2302204 NCBI chr13:94,499,451...94,528,419
Ensembl chr13:94,499,928...94,525,116 		JBrowse link
G Psenen presenilin enhancer gamma secretase subunit ISO
IEA 		KEGG
PID
RGD		 PMID:17761886 PID:200015 rno:04330, RGD:2302204 NCBI chr 1:94,942,348...94,943,545
Ensembl chr 1:94,942,225...94,943,752 		JBrowse link
G Ptcra pre T-cell antigen receptor alpha IEA KEGG rno:04330 NCBI chr 9:21,716,522...21,726,751
Ensembl chr 9:21,716,522...21,726,751 		JBrowse link
G Rab11a RAB11a, member RAS oncogene family ISO PID PID:200015 NCBI chr 8:74,118,922...74,141,760
Ensembl chr 8:74,118,922...74,141,837 		JBrowse link
G Rbbp8 RB binding protein 8, endonuclease ISO PID PID:200015 NCBI chr18:3,198,188...3,263,643
Ensembl chr18:3,197,310...3,263,985 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region IDA
IEA
ISO 		KEGG
PID
RGD		 PMID:15247148 PID:200015 rno:04330, RGD:2306423 NCBI chr14:61,551,366...61,736,220
Ensembl chr14:61,551,366...61,736,307 		JBrowse link
G Rbpjl recombination signal binding protein for immunoglobulin kappa J region-like IEA KEGG rno:04330 NCBI chr 3:173,553,389...173,565,869
Ensembl chr 3:173,553,498...173,565,869 		JBrowse link
G Rbpjl2 recombination signal binding protein for immunoglobulin kappa J region-like 2 IEA KEGG rno:04330 NCBI chr 5:10,248,069...10,249,467 JBrowse link
G Rfng RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase IMP
IEA
ISO 		KEGG
RGD		 PMID:11165380 PMID:17761886 rno:04330, RGD:633801, RGD:2302204 NCBI chr10:106,545,543...106,548,644
Ensembl chr10:106,545,543...106,548,644 		JBrowse link
G Skp1 S-phase kinase-associated protein 1 ISO PID PID:200015 NCBI chr10:36,898,670...36,917,828
Ensembl chr10:36,903,078...36,918,308 		JBrowse link
G Skp2 S-phase kinase associated protein 2 ISO PID PID:200015 NCBI chr 2:59,888,406...59,916,471
Ensembl chr 2:59,888,413...59,916,438 		JBrowse link
G Snw1 SNW domain containing 1 IEA KEGG rno:04330 NCBI chr 6:112,826,374...112,850,459
Ensembl chr 6:112,826,381...112,858,180 		JBrowse link
G Spen spen family transcriptional repressor ISO PID PID:200015 NCBI chr 5:159,058,258...159,131,789
Ensembl chr 5:159,058,258...159,165,934 		JBrowse link
G Sspo SCO-spondin ISO PID PID:200015 NCBI chr 4:78,725,829...78,781,330
Ensembl chr 4:78,727,275...78,781,315 		JBrowse link
G Yy1 YY1 transcription factor ISO PID PID:200015 NCBI chr 6:133,471,615...133,500,875
Ensembl chr 6:133,471,562...133,497,257 		JBrowse link
altered Notch signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 ISS paper on the human protein which may be involved in disease RGD PMID:10079256 RGD:1304492 NCBI chr 1:64,985,161...64,993,274
Ensembl chr 1:64,985,161...64,993,276 		JBrowse link
G Dll3 delta like canonical Notch ligand 3 ISS paper mentions mutations and diseases, deletion in mice RGD PMID:12141422 RGD:1304493 NCBI chr 1:92,689,577...92,698,125
Ensembl chr 1:92,689,577...92,697,406 		JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 ISS RGD PMID:12548545 RGD:1334460 NCBI chr 2:95,003,935...95,006,457
Ensembl chr 2:95,002,943...95,007,624 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 ISS RGD PMID:10964583 RGD:1304484 NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:144,859,453...144,894,872 		JBrowse link
G Jag2 jagged canonical Notch ligand 2 ISS RGD PMID:10079256 RGD:1304492 NCBI chr 6:137,804,133...137,826,738
Ensembl chr 6:137,804,133...137,826,738 		JBrowse link
G Notch1 notch receptor 1 ISS RGD PMID:11900468 RGD:724389 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613 		JBrowse link
G Notch4 notch receptor 4 ISS RGD PMID:10964583 RGD:1304484 NCBI chr20:4,164,969...4,189,072
Ensembl chr20:4,161,730...4,189,072 		JBrowse link
G Numb NUMB, endocytic adaptor protein ISS RGD PMID:15492044 RGD:1334451 NCBI chr 6:109,162,499...109,284,527
Ensembl chr 6:109,162,499...109,284,463 		JBrowse link
G Pofut1 protein O-fucosyltransferase 1 ISS RGD PMID:14570055 RGD:1334453 NCBI chr 3:162,168,855...162,195,798
Ensembl chr 3:162,168,606...162,195,018 		JBrowse link
altered Notch signaling pathway involving promoters term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 ISS RGD PMID:12548545 RGD:1334460 NCBI chr 2:95,003,935...95,006,457
Ensembl chr 2:95,002,943...95,007,624 		JBrowse link
altered Notch signaling pathway involving the macromolecules modifying the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Numb NUMB, endocytic adaptor protein ISS In humans, loss of Numb regulation over Notch is involved in breast cancer. RGD PMID:15492044 RGD:1334451 NCBI chr 6:109,162,499...109,284,527
Ensembl chr 6:109,162,499...109,284,463 		JBrowse link
G Pofut1 protein O-fucosyltransferase 1 ISS RGD PMID:14570055 RGD:1334453 NCBI chr 3:162,168,855...162,195,798
Ensembl chr 3:162,168,606...162,195,018 		JBrowse link
G Psen2 presenilin 2 ISO C. elegans transgenics expressing human wild-type and mutant PSEN2 RGD PMID:16474849 RGD:2302525 NCBI chr13:94,499,451...94,528,419
Ensembl chr13:94,499,928...94,525,116 		JBrowse link
altered Notch signaling pathway involving the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll3 delta like canonical Notch ligand 3 ISS RGD PMID:12141422 RGD:1304493 NCBI chr 1:92,689,577...92,698,125
Ensembl chr 1:92,689,577...92,697,406 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 ISS RGD PMID:15057910 RGD:1334443 NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:144,859,453...144,894,872 		JBrowse link
G Notch1 notch receptor 1 ISS RGD PMID:15472075 RGD:1334450 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613 		JBrowse link
G Notch3 notch receptor 3 ISS RGD PMID:14667809 RGD:1334442 NCBI chr 7:11,783,550...11,834,585
Ensembl chr 7:11,784,272...11,834,778 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      signaling pathway pertinent to development 536
        Notch signaling pathway 90
          altered Notch signaling pathway + 11
Path 2
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      cell adhesion signaling pathway 413
        cell-cell signaling pathway 253
          Notch signaling pathway 90
            altered Notch signaling pathway + 11
paths to the root