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ONTOLOGY REPORT - ANNOTATIONS

Term:interleukin-1-mediated signaling pathway
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Accession:GO:0070498 term browser browse the term
Definition:The series of molecular signals initiated by interleukin-1 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: IL-1-mediated signaling pathway;   interleukin-1-mediated signalling pathway
 narrow_synonym: IL-1 alpha-mediated signaling pathway;   IL-1 beta-mediated signaling pathway;   interleukin-1 alpha-mediated signaling pathway;   interleukin-1 beta-mediated signaling pathway
 xref: Reactome:R-HSA-9020702 "Interleukin-1 signaling"


show annotations for term's descendants           Sort by:
interleukin-1-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egr1 early growth response 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:20018936) 		Ensembl
RGD		 PMID:20018936 GO_REF:0000107 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta involved_in ISO (PMID:25816133) RGD PMID:25816133 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Il1b interleukin 1 beta involved_in IEA
ISO 		GO_REF:0000107
(PMID:10383454), (PMID:12958148), (PMID:1919436), (PMID:19727662), (PMID:25327529), (PMID:28331908), (PMID:2950091), (PMID:32719155), (PMID:33377178)
(PMID:16865359)
(PMID:30893590) 		Ensembl
RGD		 PMID:1919436 PMID:2950091 PMID:10383454 PMID:12958148 PMID:16865359 More... GO_REF:0000107 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 involved_in IMP
ISO
IBA
IEA 		(PMID:30893590)
(PMID:10854325)
(PMID:10383454), (PMID:2950091)
GO_REF:0000033
GO_REF:0000108
GO_REF:0000107
GO_REF:0000117 		RGD
GO_Central
GOC
Ensembl
UniProt		 PMID:2950091 PMID:10383454 PMID:10854325 PMID:30893590 PMID:20967881 GO_REF:0000033 GO_REF:0000107 GO_REF:0000108 GO_REF:0000117, RGD:5130945 NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579 		JBrowse link
G Il1rap interleukin 1 receptor accessory protein involved_in IEA
ISO 		GO_REF:0000107
(PMID:30893590), (PMID:9065432) 		Ensembl
RGD		 PMID:9065432 PMID:30893590 GO_REF:0000107 NCBI chr11:87,567,813...87,704,346
Ensembl chr11:87,575,116...87,704,342 		JBrowse link
G Il1rl2 interleukin 1 receptor-like 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 9:50,087,271...50,134,225
Ensembl chr 9:50,083,903...50,204,607 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 NOT|involved_in
acts_upstream_of_or_within 		ISO
IEA
IBA 		(PMID:11397809)
(PMID:12054681)
(PMID:10854325)
GO_REF:0000117
GO_REF:0000033
(PMID:10383454), (PMID:14625308) 		RGD
UniProt
GO_Central		 PMID:10383454 PMID:10854325 PMID:11397809 PMID:12054681 PMID:14625308 GO_REF:0000033 GO_REF:0000117 NCBI chr  X:156,919,927...156,929,825
Ensembl chr  X:156,920,081...156,929,825 		JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 involved_in ISO
IEA
IBA 		(PMID:10383454)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:10383454 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:148,341,704...148,398,211
Ensembl chr 4:148,341,719...148,398,210 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 involved_in
acts_upstream_of_or_within 		ISO
IEA
IBA 		(PMID:10383454)
(PMID:12054681)
GO_REF:0000117
GO_REF:0000107
GO_REF:0000033 		RGD
UniProt
Ensembl
GO_Central		 PMID:10383454 PMID:12054681 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 7:57,538,522...57,600,166
Ensembl chr 7:57,539,557...57,598,706 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 involved_in ISO
IEA 		(PMID:20485341)
GO_REF:0000107 		RGD
Ensembl		 PMID:20485341 GO_REF:0000107 NCBI chr 7:127,561,777...127,588,762
Ensembl chr 7:127,561,717...127,597,109 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 involved_in ISO
IEA 		(PMID:10094049)
GO_REF:0000107 		RGD
Ensembl		 PMID:10094049 GO_REF:0000107 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:51,154,352...51,212,012 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 involved_in ISO (PMID:20018936) RGD PMID:20018936 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mir146a microRNA 146a involved_in ISO (PMID:20937840) RGD PMID:20937840 NCBI chr10:28,349,996...28,350,090 JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor involved_in ISO
IEA 		(PMID:9430229)
GO_REF:0000107
(PMID:10854325) 		RGD
Ensembl		 PMID:9430229 PMID:10854325 GO_REF:0000107 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230 		JBrowse link
G Nfkbia NFKB inhibitor alpha involved_in ISO (PMID:26020802) RGD PMID:26020802 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Plcb1 phospholipase C beta 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:8872139) 		Ensembl
RGD		 PMID:8872139 GO_REF:0000107 NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:142,513,033...143,225,646 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit involved_in ISO
IEA 		UniProtKB:P01584 (PMID:25327529)
GO_REF:0000107 		RGD
Ensembl		 PMID:25327529 GO_REF:0000107 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rps6ka4 ribosomal protein S6 kinase A4 involved_in ISO
IEA 		(PMID:20018936)
GO_REF:0000107 		RGD
Ensembl		 PMID:20018936 GO_REF:0000107 NCBI chr 1:213,451,026...213,461,982
Ensembl chr 1:213,451,027...213,461,982 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 involved_in ISO
IEA 		(PMID:20018936)
GO_REF:0000107 		RGD
Ensembl		 PMID:20018936 GO_REF:0000107 NCBI chr 6:125,558,434...125,736,576
Ensembl chr 6:125,558,434...125,735,856 		JBrowse link
G St18 ST18 C2H2C-type zinc finger transcription factor involved_in ISO
IEA 		(PMID:18676404)
GO_REF:0000107 		RGD
Ensembl		 PMID:18676404 GO_REF:0000107 NCBI chr 5:17,369,383...17,701,094
Ensembl chr 5:17,371,000...17,458,676 		JBrowse link
G Tirap TIR domain containing adaptor protein NOT|involved_in ISO (PMID:11544529) RGD PMID:11544529 NCBI chr 8:41,789,557...41,805,903
Ensembl chr 8:41,791,878...41,796,312 		JBrowse link
G Tnip2 TNFAIP3 interacting protein 2 involved_in IEA
ISO 		GO_REF:0000107
(PMID:16633345) 		Ensembl
RGD		 PMID:16633345 GO_REF:0000107 NCBI chr14:80,452,936...80,470,141
Ensembl chr14:80,452,845...80,470,992 		JBrowse link
G Tollip toll interacting protein involved_in ISO
IEA 		(PMID:10854325)
GO_REF:0000107 		RGD
Ensembl		 PMID:10854325 GO_REF:0000107 NCBI chr 1:206,391,120...206,413,809
Ensembl chr 1:206,380,308...206,411,988 		JBrowse link
G Traf6 TNF receptor associated factor 6 involved_in IMP
ISO
IEA 		(PMID:10421844)
GO_REF:0000117 		RGD
UniProt		 PMID:10421844 PMID:20967881 GO_REF:0000117, RGD:5130945 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328 		JBrowse link
negative regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano9 anoctamin 9 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 1:205,638,571...205,659,780
Ensembl chr 1:205,638,572...205,659,489 		JBrowse link
G Il1r2 interleukin 1 receptor type 2 acts_upstream_of_or_within ISO PR:000045525 (PMID:23395675) RGD PMID:23395675 NCBI chr 9:49,879,928...49,920,374
Ensembl chr 9:49,877,266...49,920,374 		JBrowse link
G Il1rn interleukin 1 receptor antagonist involved_in ISO
IBA
IEA 		(PMID:2137200), (PMID:2139180)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:2137200 PMID:2139180 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Il6 interleukin 6 involved_in ISO (PMID:11159963) RGD PMID:11159963 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Mir21 microRNA 21 acts_upstream_of_or_within ISO UniProtKB:P01584 (PMID:25327529) RGD PMID:25327529 NCBI chr10:71,902,600...71,902,691 JBrowse link
G Mir27a microRNA 27a involved_in ISO UniProtKB:P01584 (PMID:25327529) RGD PMID:25327529 NCBI chr19:40,859,603...40,859,689 JBrowse link
G Otud4 OTU deubiquitinase 4 involved_in ISO
IBA 		(PMID:29395066)
GO_REF:0000033 		RGD
GO_Central		 PMID:29395066 GO_REF:0000033 NCBI chr19:45,141,043...45,184,136
Ensembl chr19:45,141,043...45,184,136 		JBrowse link
G Sigirr single Ig and TIR domain containing involved_in ISO (PMID:12925853) RGD PMID:12925853 NCBI chr 1:205,625,742...205,637,883
Ensembl chr 1:205,627,708...205,637,802 		JBrowse link
G Tax1bp1 Tax1 binding protein 1 involved_in ISO
IEA 		(PMID:18239685)
GO_REF:0000107 		RGD
Ensembl		 PMID:18239685 GO_REF:0000107 NCBI chr 4:83,152,549...83,208,463
Ensembl chr 4:83,110,062...83,209,657 		JBrowse link
positive regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1r1 interleukin 1 receptor type 1 acts_upstream_of_or_within ISO PR:000045524 (PMID:23395675) RGD PMID:23395675 NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579 		JBrowse link
regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vrk2 VRK serine/threonine kinase 2 involved_in ISO (PMID:18286207) RGD PMID:18286207 NCBI chr14:104,514,815...104,635,549
Ensembl chr14:104,514,100...104,720,933 		JBrowse link
G Zbp1 Z-DNA binding protein 1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:31630209) 		UniProt
RGD		 PMID:31630209 GO_REF:0000024 NCBI chr 3:182,411,665...182,427,604
Ensembl chr 3:182,411,665...182,422,839 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19688
    cellular process 18845
      signal transduction 7248
        cell surface receptor signaling pathway 2949
          cytokine-mediated signaling pathway 518
            interleukin-1-mediated signaling pathway 35
              negative regulation of interleukin-1-mediated signaling pathway 9
              positive regulation of interleukin-1-mediated signaling pathway 1
              regulation of interleukin-1-mediated signaling pathway + 12
Path 2
Term Annotations click to browse term
  biological_process 19688
    response to stimulus 10793
      response to chemical 5904
        response to peptide 1295
          response to cytokine 1270
            cellular response to cytokine stimulus 1123
              cytokine-mediated signaling pathway 518
                interleukin-1-mediated signaling pathway 35
                  negative regulation of interleukin-1-mediated signaling pathway 9
                  positive regulation of interleukin-1-mediated signaling pathway 1
                  regulation of interleukin-1-mediated signaling pathway + 12
paths to the root