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ONTOLOGY REPORT - ANNOTATIONS

Term:cholesterol biosynthetic process
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Accession:GO:0006695 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
Synonyms:exact_synonym: cholesterol anabolism;   cholesterol biosynthesis;   cholesterol formation;   cholesterol synthesis
 xref: Reactome:R-HSA-191273 "Cholesterol biosynthesis"


show annotations for term's descendants           Sort by:
cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07021955.1 involved_in IEA GO_REF:0000041
GO_REF:0000043
GO_REF:0000104 		UniProt GO_REF:0000041 GO_REF:0000043 GO_REF:0000104
G Apoa1 apolipoprotein A1 acts_upstream_of_or_within ISO MGI:2180783 (PMID:8647961) RGD PMID:8647961 NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729 		JBrowse link
G Ces1d carboxylesterase 1D involved_in ISO (PMID:11015575) RGD PMID:11015575 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449 		JBrowse link
G Cftr CF transmembrane conductance regulator acts_upstream_of_or_within ISO MGI:1856709 (PMID:17085523) RGD PMID:17085523 NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643 		JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 7:116,186,729...116,204,290
Ensembl chr 7:116,186,729...116,204,306 		JBrowse link
G Cyp51 cytochrome P450, family 51 involved_in IEA GO_REF:0000043
GO_REF:0000117 		UniProt GO_REF:0000043 GO_REF:0000117 NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase involved_in
acts_upstream_of_or_within 		ISS
ISO
IEA 		GO_REF:0000024
(PMID:14684813)
MGI:3027024 (PMID:14684813), (PMID:16321981), (PMID:16513830)
(PMID:11519011)
GO_REF:0000043
GO_REF:0000041
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:11519011 PMID:14684813 PMID:16321981 PMID:16513830 GO_REF:0000024 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107 NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase involved_in TAS
IBA
IEA
ISO
IMP
IC
IDA 		GO_REF:0000033
GO_REF:0000107
GO_REF:0000043
GO_REF:0000041
GO_REF:0000104
(PMID:9465114) 		GO_Central
Ensembl
UniProt
RGD		 PMID:9465114 PMID:12031495 PMID:9831636 PMID:10666310 PMID:10329655 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107, RGD:625561, RGD:2316918, RGD:2316916, RGD:632010 NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382 		JBrowse link
G Ebp EBP, cholestenol delta-isomerase involved_in IDA
IBA
IEA
ISO
TAS 		GO_REF:0000033
GO_REF:0000107
GO_REF:0000043
(PMID:9894009)
GO_REF:0000041 		GO_Central
Ensembl
UniProt
RGD		 PMID:9894009 PMID:11171067 PMID:11171067 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107, RGD:628445, RGD:628445 NCBI chr  X:16,971,372...16,977,782
Ensembl chr  X:16,971,405...16,977,781 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 involved_in IMP
IBA
IEA 		GO_REF:0000033
GO_REF:0000043 		GO_Central
UniProt
RGD		 PMID:16440058 GO_REF:0000033 GO_REF:0000043, RGD:1626611 NCBI chr15:41,588,114...41,616,168
Ensembl chr15:41,588,117...41,616,168 		JBrowse link
G Fdps farnesyl diphosphate synthase involved_in TAS
IEA 		GO_REF:0000117
GO_REF:0000043 		UniProt
RGD		 PMID:1321149 GO_REF:0000043 GO_REF:0000117, RGD:728501 NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase involved_in ISO
IEA 		(PMID:12027950)
GO_REF:0000107 		RGD
Ensembl		 PMID:12027950 GO_REF:0000107 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:157,352,373...157,372,144 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase involved_in
acts_upstream_of_or_within 		ISO
IEA 		(PMID:23063590)
(PMID:15845870), (PMID:7798939), (PMID:8647961)
GO_REF:0000107
GO_REF:0000043 		RGD
Ensembl
UniProt		 PMID:7798939 PMID:8647961 PMID:15845870 PMID:23063590 GO_REF:0000043 GO_REF:0000107 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:188,547,767...188,592,242 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 involved_in
acts_upstream_of_or_within 		ISO
IBA
ISS
IEA 		(PMID:12829805)
GO_REF:0000033
GO_REF:0000024
GO_REF:0000107 		RGD
GO_Central
UniProt
Ensembl		 PMID:12829805 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr13:84,702,875...84,722,810
Ensembl chr13:84,705,631...84,722,754 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 involved_in TAS
IEA 		GO_REF:0000043 UniProt
RGD		 PMID:9228075 GO_REF:0000043, RGD:729078 NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524 		JBrowse link
G Idi2l2 isopentenyl-diphosphate delta isomerase 2 like 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:66,064,199...66,077,329 JBrowse link
G Idi2l3 isopentenyl-diphosphate delta isomerase 2 like 3 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:66,243,932...66,258,028 JBrowse link
G Insig1 insulin induced gene 1 involved_in
acts_upstream_of_or_within 		ISO
IBA 		(PMID:32322062)
MGI:1920249 (PMID:16955138)
GO_REF:0000033 		RGD
GO_Central		 PMID:16955138 PMID:32322062 GO_REF:0000033 NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:8,049,556...8,057,778 		JBrowse link
G Insig2 insulin induced gene 2 involved_in
acts_upstream_of_or_within 		ISS
ISO
IBA
IEA 		GO_REF:0000024
MGI:1916289 (PMID:16955138)
GO_REF:0000033
GO_REF:0000107
(PMID:32322062) 		UniProt
RGD
GO_Central
Ensembl		 PMID:16955138 PMID:32322062 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr13:35,025,160...35,052,937
Ensembl chr13:35,025,164...35,047,658 		JBrowse link
G Lbr lamin B receptor involved_in ISO
IEA
IBA
ISS 		(PMID:16784888), (PMID:27336722)
(PMID:18785926), (PMID:22140257)
GO_REF:0000043
GO_REF:0000104
GO_REF:0000107
GO_REF:0000033
GO_REF:0000041
GO_REF:0000024 		RGD
UniProt
Ensembl
GO_Central		 PMID:16784888 PMID:18785926 PMID:22140257 PMID:27336722 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107 NCBI chr13:96,071,058...96,095,709
Ensembl chr13:96,071,081...96,095,709 		JBrowse link
G Lipa lipase A, lysosomal acid type acts_upstream_of_or_within ISO MGI:2451080 (PMID:25147230), (PMID:29599133) RGD PMID:25147230 PMID:29599133 NCBI chr 1:241,437,524...241,470,936
Ensembl chr 1:241,437,524...241,470,740 		JBrowse link
G LOC102550988 isopentenyl-diphosphate delta-isomerase 2-like involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:66,177,924...66,183,831 JBrowse link
G LOC102551575 isopentenyl-diphosphate delta-isomerase 2-like involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:66,231,196...66,233,878 JBrowse link
G LOC120097764 isopentenyl-diphosphate delta-isomerase 2-like involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:66,029,966...66,041,139 JBrowse link
G LOC120102490 insulin-induced gene 1 protein-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:68,295,478...68,300,681
Ensembl chr 4:68,297,489...68,298,247 		JBrowse link
G LOC134482779 isopentenyl-diphosphate delta-isomerase 2-like involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:66,362,131...66,368,964 JBrowse link
G LOC134482866 isopentenyl-diphosphate delta-isomerase 2-like involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:66,414,607...66,417,195 JBrowse link
G Lss lanosterol synthase involved_in IMP
IBA
IEA
IDA
ISO 		GO_REF:0000033
GO_REF:0000117
GO_REF:0000107
PMID:7568116
(PMID:17186944) 		GO_Central
UniProt
Ensembl
RGD		 PMID:17186944 PMID:16440058 PMID:7568116 PMID:1429550 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117, RGD:1626611, RGD:728996, RGD:2316919 NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 involved_in IEA GO_REF:0000041
GO_REF:0000043 		UniProt GO_REF:0000041 GO_REF:0000043 NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase involved_in NAS
IEA 		GO_REF:0000043
GO_REF:0000041 		UniProt
RGD		 PMID:11767099 GO_REF:0000041 GO_REF:0000043, RGD:729305 NCBI chr19:67,404,911...67,414,974
Ensembl chr19:67,404,911...67,422,366 		JBrowse link
G Mvk mevalonate kinase involved_in TAS
IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
GO_REF:0000043
(PMID:1377680) 		GO_Central
Ensembl
UniProt
RGD		 PMID:1377680 PMID:2158094 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107, RGD:728935 NCBI chr12:47,802,002...47,819,503
Ensembl chr12:47,802,002...47,819,503 		JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 involved_in ISO (PMID:17140581) RGD PMID:17140581 NCBI chr14:85,285,387...85,305,050
Ensembl chr14:85,285,390...85,305,050 		JBrowse link
G Nsdhl NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr  X:155,817,301...155,848,224
Ensembl chr  X:155,817,340...155,848,220 		JBrowse link
G Pmvk phosphomevalonate kinase involved_in ISO
IBA
IEA
NAS 		(PMID:8663599)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000043
GO_REF:0000104
GO_REF:0000002
PMID:10191291 		RGD
GO_Central
Ensembl
UniProt
InterPro		 PMID:8663599 PMID:10191291 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107, RGD:8553625 NCBI chr 2:177,174,344...177,184,076
Ensembl chr 2:177,174,335...177,184,080 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324 		JBrowse link
G Sc5d sterol-C5-desaturase involved_in ISO
IEA 		(PMID:10786622)
GO_REF:0000107 		RGD
Ensembl		 PMID:10786622 GO_REF:0000107 NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:51,529,346...51,538,277 		JBrowse link
G Spatc1l spermatogenesis and centriole associated 1-like involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr20:12,073,542...12,082,866
Ensembl chr20:12,073,543...12,118,253 		JBrowse link
G Sqle squalene epoxidase involved_in ISO
IEA 		(PMID:33791309)
GO_REF:0000107 		RGD
Ensembl		 PMID:33791309 GO_REF:0000107 NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:92,757,409...92,773,050 		JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 involved_in IEA
ISO 		GO_REF:0000041
(PMID:18785926)
GO_REF:0000107
GO_REF:0000043
GO_REF:0000104
(PMID:16784888) 		UniProt
RGD
Ensembl		 PMID:16784888 PMID:18785926 GO_REF:0000041 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107 NCBI chr 1:212,785,217...212,789,572
Ensembl chr 1:212,785,217...212,789,557 		JBrowse link
cholesterol biosynthetic process via 24,25-dihydrolanosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp51 cytochrome P450, family 51 involved_in IDA
IBA 		GO_REF:0000033 GO_Central
RGD		 PMID:7581240 GO_REF:0000033, RGD:2316902 NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450 		JBrowse link
cholesterol biosynthetic process via desmosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat2 acetyl-CoA acetyltransferase 2 involved_in ISO MGI:3811923 (PMID:18669642) RGD PMID:18669642 NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:50,100,817...50,135,095 		JBrowse link
G Arv1 ARV1 fatty acid homeostasis modulator involved_in ISO MGI:6149716 (PMID:20663892), (PMID:26479315) RGD PMID:20663892 PMID:26479315 NCBI chr19:69,589,728...69,601,547
Ensembl chr19:69,589,328...69,601,537 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase involved_in ISO
IEA 		(PMID:11519011)
GO_REF:0000107
(PMID:30891795) 		RGD
Ensembl		 PMID:11519011 PMID:30891795 GO_REF:0000107 NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase involved_in ISO (PMID:12812989) RGD PMID:12812989 NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382 		JBrowse link
G Ebp EBP, cholestenol delta-isomerase involved_in ISO
IEA 		(PMID:32286791)
GO_REF:0000107 		RGD
Ensembl		 PMID:32286791 GO_REF:0000107 NCBI chr  X:16,971,372...16,977,782
Ensembl chr  X:16,971,405...16,977,781 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 involved_in ISO MGI:3811923 (PMID:18669642) RGD PMID:18669642 NCBI chr15:41,588,114...41,616,168
Ensembl chr15:41,588,117...41,616,168 		JBrowse link
G Fdps farnesyl diphosphate synthase involved_in ISO MGI:3811923 (PMID:18669642) RGD PMID:18669642 NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase involved_in ISO
IEA 		MGI:3811923 (PMID:18669642)
GO_REF:0000107 		RGD
Ensembl		 PMID:18669642 GO_REF:0000107 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 involved_in ISO
IEA 		MGI:3811923 (PMID:18669642)
GO_REF:0000107 		RGD
Ensembl		 PMID:18669642 GO_REF:0000107 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 involved_in ISO
IEA 		MGI:3811923 (PMID:18669642)
GO_REF:0000107 		RGD
Ensembl		 PMID:18669642 GO_REF:0000107 NCBI chr13:84,702,875...84,722,810
Ensembl chr13:84,705,631...84,722,754 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 involved_in ISO MGI:3811923 (PMID:18669642) RGD PMID:18669642 NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524 		JBrowse link
G Lbr lamin B receptor involved_in ISO
IEA 		MGI:3811923 (PMID:18669642)
GO_REF:0000107 		RGD
Ensembl		 PMID:18669642 GO_REF:0000107 NCBI chr13:96,071,058...96,095,709
Ensembl chr13:96,071,081...96,095,709 		JBrowse link
G Lss lanosterol synthase involved_in ISO
IEA 		MGI:3811923 (PMID:18669642)
GO_REF:0000107 		RGD
Ensembl		 PMID:18669642 GO_REF:0000107 NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 involved_in ISO
IEA 		MGI:3811923 (PMID:18669642)
GO_REF:0000107 		RGD
Ensembl		 PMID:18669642 GO_REF:0000107 NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase involved_in ISO
IEA 		MGI:3811923 (PMID:18669642)
GO_REF:0000107 		RGD
Ensembl		 PMID:18669642 GO_REF:0000107 NCBI chr19:67,404,911...67,414,974
Ensembl chr19:67,404,911...67,422,366 		JBrowse link
G Mvk mevalonate kinase involved_in ISO
IEA 		MGI:3811923 (PMID:18669642)
GO_REF:0000107 		RGD
Ensembl		 PMID:18669642 GO_REF:0000107 NCBI chr12:47,802,002...47,819,503
Ensembl chr12:47,802,002...47,819,503 		JBrowse link
G Nsdhl NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL involved_in ISO
IEA 		MGI:3811923 (PMID:18669642)
GO_REF:0000107 		RGD
Ensembl		 PMID:18669642 GO_REF:0000107 NCBI chr  X:155,817,301...155,848,224
Ensembl chr  X:155,817,340...155,848,220 		JBrowse link
G Pmvk phosphomevalonate kinase involved_in ISO
IEA 		MGI:3811923 (PMID:18669642)
GO_REF:0000107 		RGD
Ensembl		 PMID:18669642 GO_REF:0000107 NCBI chr 2:177,174,344...177,184,076
Ensembl chr 2:177,174,335...177,184,080 		JBrowse link
G Sc5d sterol-C5-desaturase involved_in ISO
IEA 		(PMID:12812989)
GO_REF:0000107 		RGD
Ensembl		 PMID:12812989 GO_REF:0000107 NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:51,529,346...51,538,277 		JBrowse link
G Sqle squalene epoxidase involved_in ISO
IEA 		MGI:3811923 (PMID:18669642)
GO_REF:0000107 		RGD
Ensembl		 PMID:18669642 GO_REF:0000107 NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:92,757,409...92,773,050 		JBrowse link
cholesterol biosynthetic process via lathosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat2 acetyl-CoA acetyltransferase 2 involved_in ISO (PMID:23180723), (PMID:3189812) RGD PMID:3189812 PMID:23180723 NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:50,100,817...50,135,095 		JBrowse link
G Arv1 ARV1 fatty acid homeostasis modulator involved_in ISO MGI:6149716 (PMID:26479315) RGD PMID:26479315 NCBI chr19:69,589,728...69,601,547
Ensembl chr19:69,589,328...69,601,537 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase involved_in ISO
IEA 		(PMID:34782454)
GO_REF:0000107 		RGD
Ensembl		 PMID:34782454 GO_REF:0000107 NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase involved_in ISO
IEA 		(PMID:38297129), (PMID:38297130)
MGI:2181641 (PMID:16636072)
GO_REF:0000107 		RGD
Ensembl		 PMID:16636072 PMID:38297129 PMID:38297130 GO_REF:0000107 NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382 		JBrowse link
G Ebp EBP, cholestenol delta-isomerase involved_in ISO
IEA 		(PMID:32286791)
GO_REF:0000107 		RGD
Ensembl		 PMID:32286791 GO_REF:0000107 NCBI chr  X:16,971,372...16,977,782
Ensembl chr  X:16,971,405...16,977,781 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 involved_in ISO MGI:2383989 (PMID:10521476), (PMID:15793579) RGD PMID:10521476 PMID:15793579 NCBI chr15:41,588,114...41,616,168
Ensembl chr15:41,588,117...41,616,168 		JBrowse link
G Fdps farnesyl diphosphate synthase involved_in ISO (PMID:23180723), (PMID:3189812) RGD PMID:3189812 PMID:23180723 NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase involved_in ISO
IEA 		(PMID:23180723), (PMID:3189812)
GO_REF:0000107 		RGD
Ensembl		 PMID:3189812 PMID:23180723 GO_REF:0000107 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 involved_in ISO
IEA 		(PMID:23180723), (PMID:3189812)
GO_REF:0000107 		RGD
Ensembl		 PMID:3189812 PMID:23180723 GO_REF:0000107 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 involved_in ISO
IEA 		(PMID:26921468)
GO_REF:0000107 		RGD
Ensembl		 PMID:26921468 GO_REF:0000107 NCBI chr13:84,702,875...84,722,810
Ensembl chr13:84,705,631...84,722,754 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 involved_in ISO (PMID:23180723), (PMID:3189812) RGD PMID:3189812 PMID:23180723 NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524 		JBrowse link
G Lss lanosterol synthase involved_in ISO
IEA 		MGI:6423088 (PMID:32101538)
GO_REF:0000107 		RGD
Ensembl		 PMID:32101538 GO_REF:0000107 NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase involved_in ISO
IEA 		(PMID:23180723), (PMID:3189812)
GO_REF:0000107 		RGD
Ensembl		 PMID:3189812 PMID:23180723 GO_REF:0000107 NCBI chr19:67,404,911...67,414,974
Ensembl chr19:67,404,911...67,422,366 		JBrowse link
G Mvk mevalonate kinase involved_in ISO
IEA 		(PMID:23180723), (PMID:3189812)
GO_REF:0000107 		RGD
Ensembl		 PMID:3189812 PMID:23180723 GO_REF:0000107 NCBI chr12:47,802,002...47,819,503
Ensembl chr12:47,802,002...47,819,503 		JBrowse link
G Nsdhl NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL involved_in ISO
IEA 		(PMID:10369263)
GO_REF:0000107 		RGD
Ensembl		 PMID:10369263 GO_REF:0000107 NCBI chr  X:155,817,301...155,848,224
Ensembl chr  X:155,817,340...155,848,220 		JBrowse link
G Pmvk phosphomevalonate kinase involved_in ISO
IEA 		(PMID:23180723), (PMID:3189812)
GO_REF:0000107 		RGD
Ensembl		 PMID:3189812 PMID:23180723 GO_REF:0000107 NCBI chr 2:177,174,344...177,184,076
Ensembl chr 2:177,174,335...177,184,080 		JBrowse link
G Sc5d sterol-C5-desaturase involved_in IDA
IEA
IBA
ISO 		GO_REF:0000107
GO_REF:0000033
MGI:2668464 (PMID:12812989), (PMID:16636072)
PMID:4019441
(PMID:10786622) 		Ensembl
GO_Central
RGD		 PMID:10786622 PMID:12812989 PMID:16636072 PMID:7961720 PMID:4019441 GO_REF:0000033 GO_REF:0000107, RGD:2316911, RGD:405866208 NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:51,529,346...51,538,277 		JBrowse link
G Sqle squalene epoxidase involved_in ISO
IEA 		(PMID:38613784)
GO_REF:0000107 		RGD
Ensembl		 PMID:38613784 GO_REF:0000107 NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:92,757,409...92,773,050 		JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 involved_in ISO
IEA 		MGI:2138281 (PMID:17403717)
GO_REF:0000107 		RGD
Ensembl		 PMID:17403717 GO_REF:0000107 NCBI chr 1:212,785,217...212,789,572
Ensembl chr 1:212,785,217...212,789,557 		JBrowse link
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in IDA
IEA
ISO 		GO_REF:0000107
(PMID:1917954) 		Ensembl
RGD		 PMID:1917954 PMID:9225228 GO_REF:0000107, RGD:10059686 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855 		JBrowse link
G Chlsn cholesin involved_in ISO (PMID:38503280) RGD PMID:38503280 NCBI chr12:20,298,968...20,402,890
Ensembl chr12:20,388,520...20,402,922 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO
IEA 		(PMID:24217618)
GO_REF:0000107 		RGD
Ensembl		 PMID:24217618 GO_REF:0000107 NCBI chr 1:252,870,356...252,905,681
Ensembl chr 1:252,870,356...252,905,947 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in ISO
IEA 		(PMID:24217618)
GO_REF:0000117 		RGD
UniProt		 PMID:24217618 GO_REF:0000117 NCBI chr16:71,720,486...71,736,999
Ensembl chr16:71,721,364...71,736,503 		JBrowse link
G Idi2 isopentenyl-diphosphate delta isomerase 2 involved_in
acts_upstream_of_or_within 		ISO (PMID:17202134) RGD PMID:17202134 NCBI chr17:66,022,731...66,026,333 JBrowse link
G Insig1 insulin induced gene 1 involved_in ISO (PMID:26311497) RGD PMID:26311497 NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:8,049,556...8,057,778 		JBrowse link
G Marchf6 membrane associated ring-CH-type finger 6 involved_in ISO
IEA 		(PMID:32755570)
GO_REF:0000107 		RGD
Ensembl		 PMID:32755570 GO_REF:0000107 NCBI chr 2:84,166,570...84,243,817
Ensembl chr 2:84,166,570...84,243,792 		JBrowse link
G Mir185 microRNA 185 acts_upstream_of ISO RNAcentral:URS00002367FA_9606|RNAcentral:URS00004176D4_9606 (PMID:23951060), (PMID:24296663) RGD PMID:23951060 PMID:24296663 NCBI chr11:96,169,028...96,169,107
Ensembl chr11:96,169,028...96,169,107 		JBrowse link
G Mir342 microRNA 342 acts_upstream_of ISO (PMID:23951060) RGD PMID:23951060 NCBI chr 6:133,329,655...133,329,753
Ensembl chr 6:133,329,655...133,329,753 		JBrowse link
G Mir98 microRNA 98 involved_in ISO (PMID:30195495) RGD PMID:30195495 NCBI chr  X:24,460,648...24,460,755
Ensembl chr  X:24,460,648...24,460,755 		JBrowse link
positive regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg1 ATP binding cassette subfamily G member 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:17916878) 		Ensembl
RGD		 PMID:17916878 GO_REF:0000107 NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563 		JBrowse link
G Abcg4 ATP binding cassette subfamily G member 4 involved_in IEA
ISO 		GO_REF:0000107
GO_REF:0000117
(PMID:17916878) 		Ensembl
UniProt
RGD		 PMID:17916878 GO_REF:0000107 GO_REF:0000117 NCBI chr 8:53,508,005...53,525,314
Ensembl chr 8:53,508,005...53,523,571 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 involved_in IDA PMID:23536474 BHF-UCL PMID:23536474 RGD:13792517 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202 		JBrowse link
G Fdps farnesyl diphosphate synthase IMP RGD PMID:18637708 RGD:2316295 NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136 		JBrowse link
G Fgf1 fibroblast growth factor 1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:19229075) 		UniProt
RGD		 PMID:19229075 GO_REF:0000024 NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,939,870...30,961,393 		JBrowse link
G Gnai1 G protein subunit alpha i1 involved_in ISO (PMID:38503280) RGD PMID:38503280 NCBI chr 4:17,706,061...17,790,176
Ensembl chr 4:17,706,025...17,789,198 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 involved_in ISO
IEA 		(PMID:38503280)
GO_REF:0000107 		RGD
Ensembl		 PMID:38503280 GO_REF:0000107 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mbtps2 membrane-bound transcription factor peptidase, site 2 involved_in ISO
IEA 		(PMID:11163209)
GO_REF:0000107 		RGD
Ensembl		 PMID:11163209 GO_REF:0000107 NCBI chr  X:41,225,956...41,290,030
Ensembl chr  X:41,254,335...41,277,701 		JBrowse link
G Mir182 microRNA 182 involved_in ISO RNAcentral:URS000016FF9C_9606 (PMID:23823476) RGD PMID:23823476 NCBI chr 4:59,752,246...59,752,307 JBrowse link
G Mir96 microRNA 96 involved_in
acts_upstream_of 		ISO RNAcentral:URS00001CC379_9606 (PMID:23823476)
(PMID:30460077) 		RGD PMID:23823476 PMID:30460077 NCBI chr 4:59,755,841...59,755,946 JBrowse link
G Npy1r neuropeptide Y receptor Y1 IMP RGD PMID:32976883 RGD:405096663 NCBI chr16:27,804,416...27,814,070
Ensembl chr16:27,804,416...27,813,387 		JBrowse link
G Paqr3 progestin and adipoQ receptor family member 3 involved_in ISO
IEA 		(PMID:26311497)
GO_REF:0000107 		RGD
Ensembl		 PMID:26311497 GO_REF:0000107 NCBI chr14:12,766,539...12,796,461
Ensembl chr14:12,766,570...12,790,001 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha involved_in ISO
IEA 		(PMID:38503280)
GO_REF:0000107 		RGD
Ensembl		 PMID:38503280 GO_REF:0000107 NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494 		JBrowse link
G Qki QKI, KH domain containing RNA binding involved_in ISO (PMID:33942715) RGD PMID:33942715 NCBI chr 1:52,935,357...53,047,338
Ensembl chr 1:52,935,382...53,047,337 		JBrowse link
G Scap SREBF chaperone involved_in ISO
IEA 		(PMID:32322062)
GO_REF:0000107 		RGD
Ensembl		 PMID:32322062 GO_REF:0000107 NCBI chr 8:119,184,366...119,239,086
Ensembl chr 8:119,184,438...119,239,075 		JBrowse link
G Scp2 sterol carrier protein 2 IDA RGD PMID:2554812 RGD:9850260 NCBI chr 5:128,035,714...128,110,015
Ensembl chr 5:128,008,125...128,110,043 		JBrowse link
G Sec14l2 SEC14-like lipid binding 2 IDA RGD PMID:11226224 RGD:727312 NCBI chr14:83,197,384...83,222,059
Ensembl chr14:83,197,387...83,217,317 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 involved_in
acts_upstream_of_or_within 		ISO
ISS
IEA 		(PMID:12177166)
(PMID:32322062)
GO_REF:0000024
GO_REF:0000107
MGI:2177958|MGI:2177959 (PMID:16046411), (PMID:9329978)
(PMID:8833906), (PMID:9062341) 		RGD
UniProt
Ensembl		 PMID:8833906 PMID:9062341 PMID:9329978 PMID:12177166 PMID:16046411 More... GO_REF:0000024 GO_REF:0000107 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 involved_in IEA
ISO
ISS 		GO_REF:0000107
(PMID:32322062)
GO_REF:0000024
(PMID:12177166), (PMID:38503280) 		Ensembl
RGD
UniProt		 PMID:12177166 PMID:32322062 PMID:38503280 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:115,543,290...115,600,943 		JBrowse link
G Yy2 YY2 transcription factor involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr  X:41,253,481...41,257,103
Ensembl chr  X:41,254,335...41,277,701 		JBrowse link
regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 NOT|involved_in ISO (PMID:21810484) RGD PMID:21810484 NCBI chr 3:28,642,660...28,662,689
Ensembl chr 3:28,642,758...28,662,681 		JBrowse link
G Apob apolipoprotein B acts_upstream_of_or_within ISO MGI:2183298 (PMID:16455790) RGD PMID:16455790 NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814 		JBrowse link
G Aqp8 aquaporin 8 involved_in IEA
ISO
ISS 		GO_REF:0000107
(PMID:30579780)
GO_REF:0000024 		Ensembl
RGD
UniProt		 PMID:30579780 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:187,424,314...187,430,243
Ensembl chr 1:187,424,417...187,430,242 		JBrowse link
G Cyp51 cytochrome P450, family 51 TAS RGD PMID:7665087 RGD:1298863 NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase IDA RGD PMID:10329655 RGD:632010 NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO
IEA 		(PMID:24217618)
GO_REF:0000107 		RGD
Ensembl		 PMID:24217618 GO_REF:0000107 NCBI chr 1:252,870,356...252,905,681
Ensembl chr 1:252,870,356...252,905,947 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in ISO (PMID:24217618) RGD PMID:24217618 NCBI chr16:71,720,486...71,736,999
Ensembl chr16:71,721,364...71,736,503 		JBrowse link
G Gpr146 G protein-coupled receptor 146 involved_in ISO
IEA 		(PMID:38503280)
GO_REF:0000107 		RGD
Ensembl		 PMID:38503280 GO_REF:0000107 NCBI chr12:20,365,790...20,381,122
Ensembl chr12:20,364,269...20,381,345 		JBrowse link
G Lpcat3 lysophosphatidylcholine acyltransferase 3 involved_in ISS
ISO 		GO_REF:0000024
(PMID:29395055) 		UniProt
RGD		 PMID:29395055 GO_REF:0000024 NCBI chr 4:159,154,690...159,196,176
Ensembl chr 4:159,154,158...159,196,358 		JBrowse link
G Mvk mevalonate kinase NAS RGD PMID:2158094 RGD:728935 NCBI chr12:47,802,002...47,819,503
Ensembl chr12:47,802,002...47,819,503 		JBrowse link
G Pex2 peroxisomal biogenesis factor 2 acts_upstream_of_or_within ISO MGI:2180128 (PMID:14673138) RGD PMID:14673138 NCBI chr 2:97,957,479...97,973,767
Ensembl chr 2:97,948,443...97,981,092 		JBrowse link
G Scap SREBF chaperone involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
MGI:2148743|MGI:2180899 (PMID:16054043) 		GO_Central
RGD		 PMID:16054043 GO_REF:0000033 NCBI chr 8:119,184,366...119,239,086
Ensembl chr 8:119,184,438...119,239,075 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19688
    cellular process 18845
      metabolic process 11694
        biosynthetic process 8313
          lipid biosynthetic process 743
            steroid biosynthetic process 196
              sterol biosynthetic process 83
                cholesterol biosynthetic process 78
                  cholesterol biosynthetic process via 24,25-dihydrolanosterol 1
                  cholesterol biosynthetic process via desmosterol 20
                  cholesterol biosynthetic process via lathosterol 19
                  negative regulation of cholesterol biosynthetic process 10
                  positive regulation of cholesterol biosynthetic process 20
                  regulation of cholesterol biosynthetic process + 39
Path 2
Term Annotations click to browse term
  biological_process 19688
    cellular process 18845
      metabolic process 11694
        primary metabolic process 10271
          lipid metabolic process 1494
            steroid metabolic process 377
              sterol metabolic process 183
                cholesterol metabolic process 168
                  cholesterol biosynthetic process 78
                    cholesterol biosynthetic process via 24,25-dihydrolanosterol 1
                    cholesterol biosynthetic process via desmosterol 20
                    cholesterol biosynthetic process via lathosterol 19
                    negative regulation of cholesterol biosynthetic process 10
                    positive regulation of cholesterol biosynthetic process 20
                    regulation of cholesterol biosynthetic process + 39
paths to the root