Pik3ca (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha) - Rat Genome Database

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Gene: Pik3ca (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha) Rattus norvegicus
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Symbol: Pik3ca
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
RGD ID: 620916
Description: Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including positive regulation of smooth muscle cell proliferation; response to dexamethasone; and response to leucine. Part of phosphatidylinositol 3-kinase complex. Biomarker of autosomal recessive polycystic kidney disease and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome 5; breast cancer (multiple); cutaneous Paget's disease; and gastrointestinal system cancer (multiple). Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha); PARTICIPATES IN adenosine signaling pathway; altered phosphatidylinositol 3-kinase signaling pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH (+)-taxifolin; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC116320; p110alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphoinositide-3-kinase catalytic alpha polypeptide; phosphoinositide-3-kinase, catalytic, alpha polypeptide; PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; ptdIns-3-kinase subunit alpha; ptdIns-3-kinase subunit p110-alpha; serine/threonine protein kinase PIK3CA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82117,103,643 - 117,177,411 (+)NCBIGRCr8
mRatBN7.22115,175,275 - 115,249,034 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2115,174,984 - 115,249,032 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2121,832,703 - 121,862,791 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02119,945,342 - 119,975,430 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02114,646,275 - 114,676,345 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02118,831,350 - 118,861,456 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2118,831,350 - 118,861,454 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02138,491,967 - 138,521,934 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42118,640,277 - 118,672,440 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12118,603,330 - 118,613,969 (+)NCBI
Celera2110,329,861 - 110,360,075 (+)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
adrenocortical carcinoma  (ISO)
Agenesis of Corpus Callosum  (ISO)
autosomal recessive polycystic kidney disease  (IEP)
Bannayan-Riley-Ruvalcaba syndrome  (ISO)
basal cell carcinoma  (ISO)
Brain Neoplasms  (ISO)
breast adenocarcinoma  (ISO)
breast angiosarcoma  (ISO)
breast cancer  (ISO,ISS)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
Cardiovascular Abnormalities  (ISO)
Cerebral Cavernous Malformation 4  (ISO)
CLAPO Syndrome  (ISO)
CLOVES syndrome  (ISO)
colon adenocarcinoma  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
Colorectal Neoplasms  (ISO)
complex cortical dysplasia with other brain malformations  (ISO)
Cowden syndrome  (ISO)
Cowden syndrome 5  (ISO)
Currarino syndrome  (ISO)
cutaneous Paget's disease  (ISO)
Developmental Disabilities  (ISO)
Diabetic Cardiomyopathies  (ISO)
diaphragmatic eventration  (ISO)
diffuse large B-cell lymphoma  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Down syndrome  (ISO)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
epidermal nevus  (ISO)
esophageal cancer  (ISO)
esophageal carcinoma  (ISO)
esophagus adenocarcinoma  (ISO)
estrogen-receptor positive breast cancer  (ISO)
Facial Asymmetry  (ISO)
familial multiple nevi flammei  (ISO)
gallbladder cancer  (ISO)
gallbladder carcinoma  (ISO)
gastric adenocarcinoma  (ISO)
Gastrointestinal Neoplasms  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
glycogen storage disease II  (ISO)
Growth Disorders  (ISO)
head and neck cancer  (ISO)
Head and Neck Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hemimegalencephaly  (ISO)
hepatocellular carcinoma  (IEP,ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
Hyperplasia  (ISO)
Hypertelorism  (ISO)
keratoacanthoma  (ISO)
Klippel-Trenaunay syndrome  (ISO)
Leber congenital amaurosis  (ISO)
liver cancer  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung oat cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
Macrocephaly  (ISO)
medulloblastoma  (ISO)
Megalencephaly - Cutis Marmorata Telangiectatica Congenita  (ISO)
Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome  (ISO)
Megalodactyly  (ISO)
melanoma  (ISO)
Mouth Neoplasms  (ISO)
multiple myeloma  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Neoplasm Metastasis  (ISO)
neuroblastoma  (ISO)
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES  (ISO)
non-Hodgkin lymphoma  (ISO)
Noonan syndrome 8  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
ovarian serous cystadenocarcinoma  (ISO)
pancreatic adenocarcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
Paraproteinemias  (ISO)
Penile Neoplasms  (ISO)
plasma cell neoplasm  (ISO)
polycystic kidney disease  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
PTEN hamartoma tumor syndrome  (ISO)
rectal benign neoplasm  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
rosette-forming glioneuronal tumor  (ISO)
sarcoma  (ISO)
seborrheic keratosis  (ISO)
skin melanoma  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
uterine cancer  (ISO)
uterine carcinosarcoma  (ISO)
Uterine Cervical Neoplasms  (ISO)
Vascular Malformations  (ISO)
Ventricular Dysfunction, Left  (ISO)
Weight Gain  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-hexanedione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
baicalein  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carvacrol  (ISO)
CGP 52608  (ISO)
chitosan  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corn oil  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dactolisib  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ergothioneine  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (EXP)
fenvalerate  (EXP)
geldanamycin  (ISO)
ginsenoside Rg1  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
idelalisib  (ISO)
iron atom  (EXP)
iron dextran  (EXP)
iron(0)  (EXP)
ivermectin  (ISO)
lead diacetate  (ISO)
lithium chloride  (ISO)
LY294002  (ISO)
metformin  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
microcystin-LR  (ISO)
monosodium L-glutamate  (EXP)
morusin  (ISO)
N-nitrosodiethylamine  (EXP)
naringin  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
ochratoxin A  (ISO)
oleanolic acid  (ISO)
omacetaxine mepesuccinate  (ISO)
orotic acid  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctanoic acid  (EXP)
pioglitazone  (ISO)
pyrethrins  (EXP)
pyrvinium  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
SB 431542  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sucrose  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tetracycline  (ISO)
thalidomide  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
wogonin  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
adipose tissue development  (ISO)
angiogenesis  (IEA)
autosome genomic imprinting  (ISO)
cardiac muscle cell contraction  (ISO)
cell migration  (IEA)
cellular response to glucose stimulus  (ISO)
cellular response to hydrostatic pressure  (ISO)
cellular response to insulin stimulus  (ISO)
energy homeostasis  (ISO)
glucose metabolic process  (ISO)
insulin receptor signaling pathway  (ISO)
insulin-like growth factor receptor signaling pathway  (ISO)
liver development  (ISO)
negative regulation of actin filament depolymerization  (ISO)
negative regulation of anoikis  (ISO)
negative regulation of fibroblast apoptotic process  (ISO)
negative regulation of gene expression  (IGI)
negative regulation of neuron apoptotic process  (ISO)
phagocytosis  (IEA)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
phosphatidylinositol phosphate biosynthetic process  (IDA)
phosphatidylinositol-3-phosphate biosynthetic process  (IBA)
phosphatidylinositol-mediated signaling  (IBA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein localization to membrane  (ISO)
positive regulation of smooth muscle cell proliferation  (IMP)
regulation of actin filament organization  (ISO)
regulation of cellular respiration  (ISO)
regulation of gene expression  (ISO)
regulation of multicellular organism growth  (ISO)
regulation of protein phosphorylation  (ISO)
relaxation of cardiac muscle  (ISO)
response to activity  (IEP)
response to butyrate  (IEP)
response to dexamethasone  (IEP)
response to L-leucine  (IEP)
response to muscle inactivity  (IEP)
response to muscle stretch  (ISO)
vascular endothelial growth factor signaling pathway  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway  (IEA)
adenosine signaling pathway   (ISO)
aldosterone signaling pathway  (IEA)
altered phosphatidylinositol 3-kinase signaling pathway  (ISO)
altered phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
apoptotic cell death pathway  (IEA)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (IEA)
Chagas disease pathway  (IEA)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway   (IEA)
colorectal cancer pathway  (IEA)
E-cadherin signaling pathway   (ISO)
endometrial cancer pathway  (IEA,ISO)
Entamoebiasis pathway  (IEA)
ephrin - ephrin receptor bidirectional signaling axis   (ISO)
epidermal growth factor/neuregulin signaling pathway   (IEA,ISO)
FasL mediated signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (IEA,ISO)
Fc gamma receptor mediated signaling pathway  (IEA)
fibroblast growth factor signaling pathway  (ISO)
glioma pathway  (IEA)
granulocyte-macrophage colony-stimulating factor signaling pathway   (ISO)
Hedgehog signaling pathway  (ISO)
hepatitis C pathway  (IEA)
influenza A pathway  (IEA)
inositol metabolic pathway  (ISO)
inositol phosphate metabolic pathway   (IEA)
insulin signaling pathway  (IEA,ISO)
insulin-like growth factor signaling pathway   (ISO)
interleukin-1 signaling pathway  (ISO)
interleukin-2 signaling pathway  (ISO)
interleukin-23 signaling pathway  (ISO)
interleukin-3 signaling pathway  (ISO)
interleukin-4 signaling pathway  (ISO)
interleukin-5 signaling pathway   (ISO)
interleukin-6 signaling pathway   (ISO)
Jak-Stat signaling pathway  (IEA)
measles pathway  (IEA)
melanoma pathway   (IEA)
mTOR signaling pathway  (IEA)
N-cadherin signaling pathway  (ISO)
neurotrophic factor signaling pathway   (IEA)
non-small cell lung carcinoma pathway   (IEA,ISO)
nuclear factor kappa B signaling pathway   (ISO)
pancreatic cancer pathway  (IEA)
phosphatidylinositol 3-kinase class I signaling pathway  (ISO)
phosphatidylinositol 3-kinase signaling pathway   (IEA)
phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
phosphoinositide metabolic pathway  (ISO)
platelet-derived growth factor signaling pathway   (ISO)
prostate cancer pathway   (IEA,ISO)
Reelin signaling pathway   (ISO)
renal cell carcinoma pathway  (IEA)
small cell lung carcinoma pathway  (IEA)
T cell receptor signaling pathway   (IEA)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway   (IEA)
Trail mediated signaling pathway   (ISO)
type 2 diabetes mellitus pathway  (IEA)
type II interferon signaling pathway   (ISO)
vascular endothelial growth factor signaling pathway  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies. Bansal N, etal., Cancer Control. 2009 Jan;16(1):8-13.
2. Leucine and HMB differentially modulate proteasome system in skeletal muscle under different sarcopenic conditions. Baptista IL, etal., PLoS One. 2013 Oct 4;8(10):e76752. doi: 10.1371/journal.pone.0076752. eCollection 2013.
3. The mutational landscape of prostate cancer. Barbieri CE, etal., Eur Urol. 2013 Oct;64(4):567-76. doi: 10.1016/j.eururo.2013.05.029. Epub 2013 May 18.
4. Primary mammary angiosarcomas harbor frequent mutations in KDR and PIK3CA and show evidence of distinct pathogenesis. Beca F, etal., Mod Pathol. 2020 Aug;33(8):1518-1526. doi: 10.1038/s41379-020-0511-6. Epub 2020 Mar 2.
5. MiR-339 inhibits proliferation of pulmonary artery smooth muscle cell by targeting FGF signaling. Chen J, etal., Physiol Rep. 2017 Sep;5(18). pii: 5/18/e13441. doi: 10.14814/phy2.13441.
6. Expression and prognostic roles of PIK3CA, JAK2, PD-L1, and PD-L2 in Epstein-Barr virus-associated gastric carcinoma. Dong M, etal., Hum Pathol. 2016 Jul;53:25-34. doi: 10.1016/j.humpath.2016.02.007. Epub 2016 Mar 4.
7. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Engelman JA, etal., Nat Rev Genet. 2006 Aug;7(8):606-19.
8. PI3K/Akt: getting it right matters. Franke TF Oncogene. 2008 Oct 27;27(50):6473-88.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Mutant PIK3CA-bearing colon cancer cells display increased metastasis in an orthotopic model. Guo XN, etal., Cancer Res. 2007 Jun 15;67(12):5851-8.
12. Heterozygous expression of the oncogenic Pik3ca(H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects. Hare LM, etal., Dev Biol. 2015 Aug 1;404(1):14-26. doi: 10.1016/j.ydbio.2015.04.022. Epub 2015 May 7.
13. Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes. Hers I, etal., Biochem J 2002 Dec 15;368(Pt 3):875-84.
14. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
15. Correlation of DLC1 gene methylation with oncogenic PIK3CA mutations in extramammary Paget's disease. Kang Z, etal., Mod Pathol. 2012 Aug;25(8):1160-8. doi: 10.1038/modpathol.2012.65. Epub 2012 Apr 20.
16. Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor. Kaplan-Albuquerque N, etal., J Biol Chem. 2003 Oct 10;278(41):39830-8. Epub 2003 Jul 25.
17. Clinicopathological characteristics of PIK3CA and HBx mutations in Korean patients with hepatocellular carcinomas. Kim DC, etal., APMIS. 2014 Oct;122(10):1001-6. doi: 10.1111/apm.12245. Epub 2014 Mar 28.
18. An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice. Kinross KM, etal., J Clin Invest. 2012 Feb;122(2):553-7. doi: 10.1172/JCI59309. Epub 2012 Jan 3.
19. PIK3CA polymorphisms associated with susceptibility to hepatocellular carcinoma. Li HG, etal., Int J Clin Exp Pathol. 2015 Nov 1;8(11):15255-9. eCollection 2015.
20. [A study of the relationship between the mutation of PIK3CA, PTEN and the occurrence of liver metastasis of colorectal cancer: survival analysis]. Liang L, etal., Zhonghua Wai Ke Za Zhi. 2012 Nov;50(11):1007-10.
21. Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA. Lindhurst MJ, etal., Nat Genet. 2012 Jun 24;44(8):928-33. doi: 10.1038/ng.2332.
22. Swimming exercise training-induced left ventricular hypertrophy involves microRNAs and synergistic regulation of the PI3K/AKT/mTOR signaling pathway. Ma Z, etal., Eur J Appl Physiol. 2013 Oct;113(10):2473-86. doi: 10.1007/s00421-013-2685-9. Epub 2013 Jun 28.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Mutations of the PIK3CA gene in hereditary colorectal cancers. Miyaki M, etal., Int J Cancer. 2007 Oct 1;121(7):1627-30. doi: 10.1002/ijc.22829.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. New driver mutations in non-small-cell lung cancer. Pao W and Girard N, Lancet Oncol. 2011 Feb;12(2):175-80.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
31. Activation of the PI3K/mTOR pathway is involved in cystic proliferation of cholangiocytes of the PCK rat. Ren XS, etal., PLoS One. 2014 Jan 30;9(1):e87660. doi: 10.1371/journal.pone.0087660. eCollection 2014.
32. GOA pipeline RGD automated data pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Somatic mutations of signaling genes in non-small-cell lung cancer. Sanders HR and Albitar M, Cancer Genet Cytogenet. 2010 Nov;203(1):7-15.
36. Exon 9 Mutation of PIK3CA Associated With Poor Survival in Patients With Epstein-Barr Virus-associated Gastric Cancer. Seo AN, etal., Anticancer Res. 2019 Apr;39(4):2145-2154. doi: 10.21873/anticanres.13328.
37. Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1. Slattery ML, etal., Carcinogenesis. 2010 Sep;31(9):1604-11. Epub 2010 Jul 9.
38. Analysis of ESR1 and PIK3CA mutations in plasma cell-free DNA from ER-positive breast cancer patients. Takeshita T, etal., Oncotarget. 2017 Jun 14;8(32):52142-52155. doi: 10.18632/oncotarget.18479. eCollection 2017 Aug 8.
39. Absence of PIK3CA hotspot mutations in hepatocellular carcinoma in Japanese patients. Tanaka Y, etal., Oncogene. 2006 May 11;25(20):2950-2. doi: 10.1038/sj.onc.1209311.
40. Class IA Phosphatidylinositol 3-Kinase Isoform p110a Mediates Vascular Remodeling. Vantler M, etal., Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1434-44. doi: 10.1161/ATVBAHA.114.304887. Epub 2015 Apr 23.
41. The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors. Vargiu P, etal., Oncogene 2004 Jan 15;23(2):559-68.
42. LncRNA H19 inhibits ER stress induced apoptosis and improves diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis. Wang S, etal., Aging (Albany NY). 2022 Aug 30;14(16):6809-6828. doi: 10.18632/aging.204256. Epub 2022 Aug 30.
43. PIK3CA and PIK3CB expression and relationship with multidrug resistance in colorectal carcinoma. Wen F, etal., Int J Clin Exp Pathol. 2014 Oct 15;7(11):8295-303. eCollection 2014.
44. MicroRNA-21 promotes cell proliferation, migration, and resistance to apoptosis through PTEN/PI3K/AKT signaling pathway in esophageal cancer. Wu YR, etal., Tumour Biol. 2016 Sep;37(9):12061-12070. doi: 10.1007/s13277-016-5074-2. Epub 2016 May 17.
45. Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway. Zhang CL, etal., Int J Biol Sci. 2015 Apr 25;11(6):643-51. doi: 10.7150/ijbs.10785. eCollection 2015.
46. The oncogene phosphatidylinositol 3'-kinase catalytic subunit alpha promotes angiogenesis via vascular endothelial growth factor in ovarian carcinoma. Zhang L, etal., Cancer Res 2003 Jul 15;63(14):4225-31.
47. Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling. Zhang XF, etal., Hepatology. 2010 Sep;52(3):954-65. doi: 10.1002/hep.23747.
48. Expression and significance of EBV, ARID1A and PIK3CA in gastric carcinoma. Zhou H, etal., Mol Med Rep. 2019 Mar;19(3):2125-2136. doi: 10.3892/mmr.2019.9886. Epub 2019 Jan 22.
Additional References at PubMed
PMID:2174051   PMID:7542745   PMID:8628286   PMID:8889548   PMID:10860857   PMID:11596118   PMID:12477932   PMID:12486171   PMID:12904469   PMID:14657280   PMID:15192701   PMID:16625210  
PMID:17475835   PMID:19202327   PMID:20514400   PMID:21047779   PMID:21127054   PMID:21736902   PMID:22402981   PMID:24006492   PMID:24577313   PMID:24691033   PMID:25327288   PMID:27322831  
PMID:27372651   PMID:27991911   PMID:34129205  


Genomics

Comparative Map Data
Pik3ca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82117,103,643 - 117,177,411 (+)NCBIGRCr8
mRatBN7.22115,175,275 - 115,249,034 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2115,174,984 - 115,249,032 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2121,832,703 - 121,862,791 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02119,945,342 - 119,975,430 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02114,646,275 - 114,676,345 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02118,831,350 - 118,861,456 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2118,831,350 - 118,861,454 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02138,491,967 - 138,521,934 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42118,640,277 - 118,672,440 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12118,603,330 - 118,613,969 (+)NCBI
Celera2110,329,861 - 110,360,075 (+)NCBICelera
Cytogenetic Map2q24NCBI
PIK3CA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383179,148,126 - 179,240,093 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3179,148,114 - 179,240,093 (+)EnsemblGRCh38hg38GRCh38
GRCh373178,866,145 - 178,957,881 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363180,349,005 - 180,435,194 (+)NCBINCBI36Build 36hg18NCBI36
Build 343180,349,012 - 180,435,197NCBI
Celera3177,295,797 - 177,383,366 (+)NCBICelera
Cytogenetic Map3q26.32NCBI
HuRef3176,269,843 - 176,355,772 (+)NCBIHuRef
CHM1_13178,829,221 - 178,915,414 (+)NCBICHM1_1
T2T-CHM13v2.03181,951,917 - 182,043,930 (+)NCBIT2T-CHM13v2.0
Pik3ca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39332,451,203 - 32,520,256 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl332,451,820 - 32,522,635 (+)EnsemblGRCm39 Ensembl
GRCm38332,397,065 - 32,466,112 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl332,397,671 - 32,468,486 (+)EnsemblGRCm38mm10GRCm38
MGSCv37332,335,073 - 32,367,408 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36332,627,755 - 32,654,380 (+)NCBIMGSCv36mm8
Celera332,346,082 - 32,378,426 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map315.7NCBI
Pik3ca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554208,356,353 - 8,427,024 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554208,355,415 - 8,427,024 (+)NCBIChiLan1.0ChiLan1.0
PIK3CA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22177,018,967 - 177,103,829 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13177,023,686 - 177,108,546 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03176,182,765 - 176,272,024 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13184,355,789 - 184,441,997 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3184,355,785 - 184,441,977 (+)Ensemblpanpan1.1panPan2
PIK3CA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13412,600,140 - 12,681,905 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3412,600,233 - 12,675,910 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3416,743,641 - 16,822,678 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03412,496,918 - 12,576,076 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3412,497,011 - 12,573,751 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13412,551,928 - 12,630,858 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03412,531,843 - 12,610,836 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03412,771,120 - 12,850,124 (+)NCBIUU_Cfam_GSD_1.0
Pik3ca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602109,269,676 - 109,296,792 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365663,923,934 - 3,951,073 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365663,924,013 - 3,951,052 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3CA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13117,180,544 - 117,274,587 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113117,193,935 - 117,282,151 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213126,401,142 - 126,461,414 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3CA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11510,218,034 - 10,304,874 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1510,218,805 - 10,294,316 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606319,096,074 - 19,187,036 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3ca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473056,938,215 - 56,966,137 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473056,895,065 - 56,970,563 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pik3ca
299 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:612
Count of miRNA genes:302
Interacting mature miRNAs:373
Transcripts:ENSRNOT00000014527
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527143657569Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527143657569Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat

Markers in Region
BF399071  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22115,249,365 - 115,249,506 (+)MAPPERmRatBN7.2
Rnor_6.02118,861,788 - 118,861,928NCBIRnor6.0
Rnor_5.02138,522,266 - 138,522,406UniSTSRnor5.0
RGSC_v3.42118,672,772 - 118,672,912UniSTSRGSC3.4
Celera2110,360,407 - 110,360,547UniSTS
RH 3.4 Map2692.6UniSTS
Cytogenetic Map2q25UniSTS
AA963575  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22115,248,821 - 115,248,918 (+)MAPPERmRatBN7.2
Rnor_6.02118,861,244 - 118,861,340NCBIRnor6.0
Rnor_5.02138,521,722 - 138,521,818UniSTSRnor5.0
RGSC_v3.42118,672,228 - 118,672,324UniSTSRGSC3.4
Celera2110,359,863 - 110,359,959UniSTS
RH 3.4 Map2690.6UniSTS
Cytogenetic Map2q25UniSTS
RH138898  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22115,247,075 - 115,247,279 (+)MAPPERmRatBN7.2
Rnor_6.02118,859,523 - 118,859,726NCBIRnor6.0
Rnor_5.02138,520,001 - 138,520,204UniSTSRnor5.0
RGSC_v3.42118,670,483 - 118,670,686UniSTSRGSC3.4
Celera2110,358,118 - 110,358,321UniSTS
RH 3.4 Map2692.6UniSTS
Cytogenetic Map2q25UniSTS
RH141610  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22115,246,391 - 115,246,594 (-)MAPPERmRatBN7.2
mRatBN7.22115,246,391 - 115,246,594 (+)MAPPERmRatBN7.2
Rnor_6.02118,858,839 - 118,859,041NCBIRnor6.0
Rnor_6.0X23,242,695 - 23,242,897NCBIRnor6.0
Rnor_5.02138,519,317 - 138,519,519UniSTSRnor5.0
Rnor_5.0X23,654,956 - 23,655,158UniSTSRnor5.0
RGSC_v3.4X41,988,145 - 41,988,347UniSTSRGSC3.4
RGSC_v3.42118,669,799 - 118,670,001UniSTSRGSC3.4
Celera2110,357,434 - 110,357,636UniSTS
CeleraX21,844,948 - 21,845,150UniSTS
Cytogenetic MapXq21UniSTS
Cytogenetic Map2q25UniSTS
UniSTS:257082  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X23,245,316 - 23,245,841NCBIRnor6.0
Rnor_5.0X23,657,577 - 23,658,102UniSTSRnor5.0
RGSC_v3.4X41,990,766 - 41,991,291UniSTSRGSC3.4
CeleraX21,847,568 - 21,848,093UniSTS
Cytogenetic MapXq21UniSTS
Cytogenetic Map2q25UniSTS
UniSTS:257083  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X23,244,005 - 23,244,413NCBIRnor6.0
Rnor_5.0X23,656,266 - 23,656,674UniSTSRnor5.0
RGSC_v3.4X41,989,455 - 41,989,863UniSTSRGSC3.4
CeleraX21,846,257 - 21,846,665UniSTS
Cytogenetic MapXq21UniSTS
Cytogenetic Map2q25UniSTS
UniSTS:257081  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22115,218,994 - 115,219,253 (-)MAPPERmRatBN7.2
mRatBN7.22115,218,994 - 115,219,253 (+)MAPPERmRatBN7.2
Rnor_6.0X23,246,386 - 23,246,644NCBIRnor6.0
Rnor_6.02118,831,425 - 118,831,683NCBIRnor6.0
Rnor_5.0X23,658,647 - 23,658,905UniSTSRnor5.0
Rnor_5.02138,492,042 - 138,492,300UniSTSRnor5.0
Celera2110,329,936 - 110,330,194UniSTS
CeleraX21,848,638 - 21,848,896UniSTS
Cytogenetic Map2q25UniSTS
Cytogenetic MapXq21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 39 23 19 23 8 10 74 35 36 11 8
Low 7 18 18 18 1 5
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_133399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF395897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP500486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ203660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB793501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK366194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK366305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR754046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV722574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV728106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DY314099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM035395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM096453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000083720   ⟹   ENSRNOP00000072496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2115,174,984 - 115,249,032 (+)Ensembl
Rnor_6.0 Ensembl2118,831,350 - 118,861,454 (+)Ensembl
RefSeq Acc Id: NM_133399   ⟹   NP_596890
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82117,147,299 - 117,177,411 (+)NCBI
mRatBN7.22115,218,920 - 115,249,034 (+)NCBI
Rnor_6.02118,831,350 - 118,861,456 (+)NCBI
Rnor_5.02138,491,967 - 138,521,934 (+)NCBI
Celera2110,329,861 - 110,360,075 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101610   ⟹   XP_038957538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82117,103,643 - 117,177,391 (+)NCBI
mRatBN7.22115,175,275 - 115,249,003 (+)NCBI
Protein Sequences
Protein RefSeqs NP_596890 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957538 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A0A0G2K344 (Get FASTA)   NCBI Sequence Viewer  
  AAK83379 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072496
  ENSRNOP00000072496.1
  ENSRNOP00055014022
  ENSRNOP00060002555
  ENSRNOP00065010305
Reference Protein Sequences
RefSeq Acc Id: NP_596890   ⟸   NM_133399
- UniProtKB: A0A0G2K344 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072496   ⟸   ENSRNOT00000083720
RefSeq Acc Id: XP_038957538   ⟸   XM_039101610
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K344 (UniProtKB/Swiss-Prot)
Protein Domains
C2 PI3K-type   PI3K-ABD   PI3K-RBD   PI3K/PI4K catalytic   PIK helical

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K344-F1-model_v2 AlphaFold A0A0G2K344 1-1068 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620916 AgrOrtholog
BioCyc Gene G2FUF-53432 BioCyc
BioCyc Pathway PWY-6352 [3-phosphoinositide biosynthesis] BioCyc
BioCyc Pathway Image PWY-6352 BioCyc
Ensembl Genes ENSRNOG00000056371 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055010309 UniProtKB/Swiss-Prot
  ENSRNOG00060002338 UniProtKB/Swiss-Prot
  ENSRNOG00065008709 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000083720.2 UniProtKB/Swiss-Prot
  ENSRNOT00055017425 UniProtKB/Swiss-Prot
  ENSRNOT00060003682 UniProtKB/Swiss-Prot
  ENSRNOT00065013857 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1070.11 UniProtKB/Swiss-Prot
  1.25.40.70 UniProtKB/Swiss-Prot
  2.60.40.150 UniProtKB/Swiss-Prot
InterPro ARM-type_fold UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  Kinase-like_dom UniProtKB/Swiss-Prot
  PI3/4_kinase_cat_dom UniProtKB/Swiss-Prot
  PI3/4_kinase_cat_sf UniProtKB/Swiss-Prot
  PI3/4_kinase_CS UniProtKB/Swiss-Prot
  PI3K_accessory_sf UniProtKB/Swiss-Prot
  PI3K_adapt-bd_dom UniProtKB/Swiss-Prot
  PI3K_C2_dom UniProtKB/Swiss-Prot
  PI3K_Ras-bd_dom UniProtKB/Swiss-Prot
  PI3Kalpha_dom UniProtKB/Swiss-Prot
  PI_Kinase UniProtKB/Swiss-Prot
  PInositide-3_kin_accessory_dom UniProtKB/Swiss-Prot
  Ubiquitin-rel_dom UniProtKB/Swiss-Prot
KEGG Report rno:170911 UniProtKB/Swiss-Prot
NCBI Gene 170911 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM UniProtKB/Swiss-Prot
  PTHR10048 UniProtKB/Swiss-Prot
Pfam PI3_PI4_kinase UniProtKB/Swiss-Prot
  PI3K_C2 UniProtKB/Swiss-Prot
  PI3K_p85B UniProtKB/Swiss-Prot
  PI3K_rbd UniProtKB/Swiss-Prot
  PI3Ka UniProtKB/Swiss-Prot
PharmGKB PIK3CA RGD
PhenoGen Pik3ca PhenoGen
PROSITE PI3_4_KINASE_1 UniProtKB/Swiss-Prot
  PI3_4_KINASE_2 UniProtKB/Swiss-Prot
  PI3_4_KINASE_3 UniProtKB/Swiss-Prot
  PI3K_ABD UniProtKB/Swiss-Prot
  PI3K_C2 UniProtKB/Swiss-Prot
  PI3K_RBD UniProtKB/Swiss-Prot
  PIK_HELICAL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000056371 RatGTEx
  ENSRNOG00055010309 RatGTEx
  ENSRNOG00060002338 RatGTEx
  ENSRNOG00065008709 RatGTEx
SMART PI3K_C2 UniProtKB/Swiss-Prot
  PI3K_p85B UniProtKB/Swiss-Prot
  PI3K_rbd UniProtKB/Swiss-Prot
  PI3Ka UniProtKB/Swiss-Prot
  PI3Kc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot
  SSF49562 UniProtKB/Swiss-Prot
  SSF54236 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A0G2K344 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-10 Pik3ca  phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha  Pik3ca  phosphoinositide-3-kinase, catalytic, alpha polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Pik3ca  phosphoinositide-3-kinase, catalytic, alpha polypeptide  Pik3ca  phosphatidylinositol 3-kinase, catalytic, alpha polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Pik3ca  phosphatidylinositol 3-kinase, catalytic, alpha polypeptide      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Pik3ca  phosphatidylinositol 3-kinase, catalytic, alpha polypeptide      Symbol and Name status set to provisional 70820 PROVISIONAL