Tubb2a (tubulin, beta 2A class IIa)

Gene: Tubb2a (tubulin, beta 2A class IIa) Rattus norvegicus

Analyze

Symbol:

Tubb2a

Name:

tubulin, beta 2A class IIa

RGD ID:

1588452

Description:

Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in cerebral cortex development; microtubule cytoskeleton organization; and mitotic cell cycle. Predicted to be located in intercellular bridge and mitotic spindle. Predicted to be active in cytoplasm and microtubule. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 5. Orthologous to human TUBB2A (tubulin beta 2A class IIa); PARTICIPATES IN phagocytosis pathway; INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC108348176; LOC498736; similar to tubulin, beta 2; T beta-15; Tubb2b; tubulin beta-2A chain; tubulin beta-2A chain pseudogene; Tubulin beta-2B chain; tubulin, beta 2A

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TUBB2A (tubulin beta 2A class IIa)	HGNC	Ensembl, HomoloGene, Inparanoid, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Tubb2a (tubulin, beta 2A class IIA)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TUBB2A (tubulin beta 2A class IIa)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TUBB2A (tubulin beta 2A class IIa)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TUBB2B (tubulin beta 2B class IIb)	HGNC	EggNOG, OrthoDB, PhylomeDB, Treefam
Homo sapiens (human):	TUBB6 (tubulin beta 6 class V)	HGNC	OrthoDB
Homo sapiens (human):	TUBB3 (tubulin beta 3 class III)	HGNC	OrthoDB
Homo sapiens (human):	TUBB4A (tubulin beta 4A class IVa)	HGNC	OrthoDB
Homo sapiens (human):	TUBB4B (tubulin beta 4B class IVb)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	TUBB2A (tubulin beta 2A class IIa)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tubb2a (tubulin, beta 2A class IIA)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tubb2 (tubulin, beta 2A class IIa)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	TUB2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	betaTub85D	Alliance	DIOPT (Ensembl Compara\|OMA)
Caenorhabditis elegans (roundworm):	tbb-4	Alliance	DIOPT (InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tubb2b	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	31,002,186 - 31,006,057 (+)	NCBI		GRCr8
mRatBN7.2	17	30,796,842 - 30,800,713 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	30,747,503 - 30,800,714 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	30,610,793 - 30,614,662 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	32,214,539 - 32,218,408 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	30,606,536 - 30,610,405 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	31,493,145 - 31,496,827 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	31,493,107 - 31,498,651 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	33,390,589 - 33,391,837 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	37,139,177 - 37,143,049 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	17	30,361,117 - 30,364,988 (+)	NCBI		Celera
Cytogenetic Map	17	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

cerebellar hypoplasia (ISO)

complex cortical dysplasia with other brain malformations 5 (ISO)

Creutzfeldt-Jakob disease (ISO)

Developmental Disease (ISO)

epilepsy (ISO)

genetic disease (ISO)

juvenile rheumatoid arthritis (ISO)

NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES (ISO)

Neurodevelopmental Disorders (ISO)

tubulinopathy (ISO)

vascular dementia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

1,3-dinitrobenzene (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (EXP)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

5-bromo-2'-deoxyuridine (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (ISO)

aldehydo-D-glucose (ISO)

amitrole (EXP)

antimycin A (ISO)

aripiprazole (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

azoxystrobin (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

Benzo[k]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (EXP,ISO)

bleomycin A2 (EXP,ISO)

bortezomib (ISO)

bromobenzene (EXP)

buspirone (EXP)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP)

captan (ISO)

carbon nanotube (ISO)

choline (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

clobetasol (ISO)

clofibrate (ISO)

clotrimazole (EXP)

cobalt dichloride (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

D-glucose (ISO)

decabromodiphenyl ether (EXP,ISO)

deguelin (ISO)

dexamethasone (ISO)

diallyl trisulfide (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (EXP)

dioxygen (ISO)

diquat (ISO)

disulfiram (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

entinostat (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

folpet (ISO)

formaldehyde (ISO)

fumonisin B1 (ISO)

furan (EXP,ISO)

glucose (ISO)

graphene oxide (ISO)

HC toxin (ISO)

hexadecanoic acid (ISO)

indometacin (EXP,ISO)

inulin (ISO)

isobutanol (ISO)

isoprenaline (ISO)

ivermectin (ISO)

L-methionine (ISO)

lead(0) (ISO)

Licochalcone B (ISO)

lipopolysaccharide (ISO)

methamphetamine (EXP)

methapyrilene (EXP)

methimazole (EXP)

methotrexate (ISO)

methylisothiazolinone (ISO)

methylmercury chloride (ISO)

N-nitrosodiethylamine (ISO)

N-nitrosomorpholine (EXP)

nefazodone (EXP)

nimesulide (EXP)

oleic acid (ISO)

oxaliplatin (EXP)

p-toluidine (EXP)

panobinostat (ISO)

paracetamol (EXP,ISO)

parathion (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenethyl isothiocyanate (ISO)

phenformin (EXP)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

progesterone (ISO)

propiconazole (ISO)

rotenone (EXP,ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP,ISO)

sodium fluoride (ISO)

Soman (EXP)

sunitinib (ISO)

tamoxifen (ISO)

tebufenpyrad (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

testosterone undecanoate (ISO)

tetrachloroethene (ISO)

tetrachloromethane (EXP,ISO)

tetraphene (ISO)

thifluzamide (ISO)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

triadimefon (EXP)

tributylstannane (ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (EXP)

triptonide (ISO)

trovafloxacin (EXP)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cerebral cortex development (IEA,ISO)

microtubule cytoskeleton organization (IBA,IEA)

mitotic cell cycle (IBA,IEA)

Cellular Component

cytoplasm (IBA,IEA)

intercellular bridge (IEA,ISO)

microtubule (IBA,IEA,ISO)

microtubule cytoskeleton (ISO)

mitotic spindle (IEA,ISO)

Molecular Function

GTP binding (IBA,IEA)

GTPase activity (IEA)

metal ion binding (IEA)

protein binding (ISO)

structural constituent of cytoskeleton (IBA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

phagocytosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:2868892	PMID:15057822	PMID:15865439	PMID:19056867	PMID:21525035	PMID:21630459	PMID:22871113	PMID:24625528	PMID:24769233	PMID:25931508	PMID:29476059	PMID:31505169
PMID:31904090

Genomics

Comparative Map Data

Tubb2a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	31,002,186 - 31,006,057 (+)	NCBI		GRCr8
mRatBN7.2	17	30,796,842 - 30,800,713 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	30,747,503 - 30,800,714 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	30,610,793 - 30,614,662 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	32,214,539 - 32,218,408 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	30,606,536 - 30,610,405 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	31,493,145 - 31,496,827 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	31,493,107 - 31,498,651 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	33,390,589 - 33,391,837 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	37,139,177 - 37,143,049 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	17	30,361,117 - 30,364,988 (+)	NCBI		Celera
Cytogenetic Map	17	p12	NCBI

TUBB2A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	3,153,666 - 3,157,544 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	3,153,497 - 3,157,544 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	3,153,900 - 3,157,778 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	3,098,899 - 3,102,782 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	3,098,902 - 3,102,759	NCBI
Celera	6	4,382,770 - 4,386,674 (-)	NCBI		Celera
Cytogenetic Map	6	p25.2	NCBI
HuRef	6	3,024,011 - 3,027,895 (-)	NCBI		HuRef
CHM1_1	6	3,153,792 - 3,157,676 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	3,020,886 - 3,024,765 (-)	NCBI		T2T-CHM13v2.0

Tubb2a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	34,258,261 - 34,261,991 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	34,258,257 - 34,261,990 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	34,074,278 - 34,078,008 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	34,074,274 - 34,078,007 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	34,166,147 - 34,169,877 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	34,081,743 - 34,085,453 (-)	NCBI		MGSCv36	mm8
Celera	13	35,203,665 - 35,207,395 (-)	NCBI		Celera
Cytogenetic Map	13	A3.3	NCBI
cM Map	13	14.03	NCBI

TUBB2A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	17,787,003 - 17,790,900 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	13,786,855 - 13,790,770 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	2,993,653 - 2,997,570 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	3,083,230 - 3,085,242 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	3,080,751 - 3,255,882 (-)	Ensembl	panpan1.1		panPan2

TUBB2A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	35	3,448,402 - 3,450,783 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	35	3,448,435 - 3,452,091 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	35	3,456,142 - 3,460,841 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	35	3,505,153 - 3,509,899 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	35	3,505,153 - 3,558,836 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	35	3,380,360 - 3,384,881 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	35	3,402,361 - 3,407,093 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	35	4,734,869 - 4,739,525 (-)	NCBI		UU_Cfam_GSD_1.0

Variants

Variants in Tubb2a
15 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	15
Count of miRNA genes:	14
Interacting mature miRNAs:	15
Transcripts:	ENSRNOT00000023611
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	31701463	Rat
70184	BpQTLcluster14	Blood pressure QTL cluster 14	3.38		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	1	31990913	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	37830672	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	60781592	Rat
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2115149	34551001	Rat
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	4299130	35837242	Rat
1354596	Bw32	Body weight QTL 32	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	17	4299130	60781592	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4528038	49528038	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4528038	49528038	Rat
2303561	Bw91	Body weight QTL 91	2		body mass (VT:0001259)	body weight (CMO:0000012)	17	8868462	53868462	Rat
2300002	Iddm36	Insulin dependent diabetes mellitus QTL 36	1.98		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	9991286	40540197	Rat
1331765	Hrtrt15	Heart rate QTL 15	4.094		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	17	15330613	55836425	Rat
1354640	Scl32	Serum cholesterol level QTL 32	5.4		blood HDL cholesterol amount (VT:0000184)	blood high density lipoprotein cholesterol level (CMO:0000052)	17	15781592	60781592	Rat
1354659	Scl68	Serum cholesterol level QTL 68	3.9		blood VLDL cholesterol amount (VT:0005144)	blood very low density lipoprotein cholesterol level (CMO:0000648)	17	15781592	60781592	Rat
7394837	Memor18	Memory QTL 18			exploratory behavior trait (VT:0010471)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	17	18640182	63640182	Rat
1354628	Stl13	Serum triglyceride level QTL 13	3.8		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	21293039	60781592	Rat
70157	Niddm32	Non-insulin dependent diabetes mellitus QTL 32	4.34		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	22454924	50909196	Rat
61394	Bp8	Blood pressure QTL 8	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	23080567	59555013	Rat
7488966	Bp370	Blood pressure QTL 370		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	57246843	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23653184	68653184	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23653184	68653184	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23653184	68653184	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23653184	68653184	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	68653184	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23653184	70974005	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	24599340	69599340	Rat
4889891	Eae32	Experimental allergic encephalomyelitis QTL 32	4.8	0.0002	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	27027949	36146731	Rat
1581512	Cm55	Cardiac mass QTL 55	2.8	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	27027949	56836890	Rat
4889955	Bss93	Bone structure and strength QTL 93	4.4		tibia size trait (VT:0100001)	tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)	17	27027949	60463643	Rat
2302377	Scl61	Serum cholesterol level QTL 61	4.36		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	17	27389946	53481766	Rat
8552928	Pigfal9	Plasma insulin-like growth factor 1 level QTL 9	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	28409147	73409147	Rat
9590107	Sffal7	Serum free fatty acids level QTL 7	4.81	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	17	28409147	73409147	Rat

Markers in Region

RH141796

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	30,797,428 - 30,797,622 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	31,493,732 - 31,493,925	NCBI	Rnor6.0
Rnor_5.0	17	33,386,918 - 33,387,111	UniSTS	Rnor5.0
RGSC_v3.4	17	37,139,765 - 37,139,958	UniSTS	RGSC3.4
Celera	17	30,361,704 - 30,361,897	UniSTS
RH 3.4 Map	17	326.32	UniSTS
Cytogenetic Map	17	p12	UniSTS

Tubb2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	30,800,424 - 30,800,619 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	31,498,363 - 31,498,557	NCBI	Rnor6.0
Rnor_5.0	17	33,391,549 - 33,391,743	UniSTS	Rnor5.0
RGSC_v3.4	17	37,142,761 - 37,142,955	UniSTS	RGSC3.4
Celera	17	30,364,700 - 30,364,894	UniSTS
Cytogenetic Map	17	p12	UniSTS

MARC_26445-26446:1030655521:1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	30,749,123 - 30,749,576 (+)	MAPPER	mRatBN7.2
mRatBN7.2	17	30,798,685 - 30,799,569 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	31,494,989 - 31,495,872	NCBI	Rnor6.0
Rnor_6.0	17	31,443,030 - 31,443,482	NCBI	Rnor6.0
Rnor_5.0	17	33,388,175 - 33,389,058	UniSTS	Rnor5.0
Rnor_5.0	17	33,337,455 - 33,337,907	UniSTS	Rnor5.0
RGSC_v3.4	17	37,089,312 - 37,089,764	UniSTS	RGSC3.4
RGSC_v3.4	17	37,141,022 - 37,141,905	UniSTS	RGSC3.4
Celera	17	30,362,961 - 30,363,844	UniSTS
Celera	17	30,313,507 - 30,313,959	UniSTS
Cytogenetic Map	17	p12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2		22	20	3	20			70	22	16	11
Low	1	43	35	21	16	21	8	11	4	13	25		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212912	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X03369	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000023582 ⟹ ENSRNOP00000023582

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	30,747,503 - 30,800,703 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000023611 ⟹ ENSRNOP00000023611

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	30,798,942 - 30,800,668 (+)	Ensembl
Rnor_6.0 Ensembl	17	31,493,107 - 31,496,825 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000086264 ⟹ ENSRNOP00000071729

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	30,796,841 - 30,800,714 (+)	Ensembl
Rnor_6.0 Ensembl	17	31,493,145 - 31,498,651 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000099483 ⟹ ENSRNOP00000093166

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	30,796,841 - 30,800,708 (+)	Ensembl

RefSeq Acc Id:

NM_001109119 ⟹ NP_001102589

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	31,002,186 - 31,006,057 (+)	NCBI
mRatBN7.2	17	30,796,842 - 30,800,713 (+)	NCBI
Rnor_6.0	17	31,493,145 - 31,496,827 (+)	NCBI
Rnor_5.0	17	33,390,589 - 33,391,837 (+)	NCBI
RGSC_v3.4	17	37,139,177 - 37,143,049 (+)	RGD
Celera	17	30,361,117 - 30,364,988 (+)	RGD

Sequence:

show sequence

GTCTTTTGCTCTCCTTAGCCCTCGGTCCACGCACTGCTCCTAGGGCAAGAGCCTTCACCTCTTC
TACAGCCAACACCATGCGCGAGATCGTGCACATCCAGGCGGGCCAATGCGGCAACCAGATCGGC
GCTAAGTTTTGGGAGGTGATAAGCGATGAGCATGGCATCGACCCCACTGGCAGTTACCATGGCG
ACAGTGACTTGCAGCTGGAGAGAATCAATGTGTACTACAATGAAGCTGCTGGCAACAAATATGT
ACCTCGGGCCATCCTAGTGGACCTGGAGCCAGGCACCATGGACTCAGTGAGGTCGGGACCATTC
GGCCAGATCTTCAGGCCAGACAACTTTGTGTTCGGTCAGAGTGGTGCAGGAAATAACTGGGCAA
AGGGCCACTACACAGAGGGTGCCGAGCTGGTGGACTCTGTCCTGGATGTGGTGAGGAAGGAGTC
AGAAAGCTGTGACTGTCTCCAGGGCTTCCAGCTGACCCACTCACTGGGGGGAGGCACTGGCTCA
GGCATGGGGACCCTGCTCATCAGCAAGATCAGAGAAGAGTACCCAGACCGCATCATGAACACCT
TCAGCGTCATGCCCTCACCCAAGGTCTCTGACACTGTGGTGGAGCCCTATAATGCCACCCTCTC
CGTGCACCAGCTGGTAGAGAACACAGATGAAACCTATTCCATTGACAATGAGGCTCTGTATGAC
ATCTGCTTCCGCACCCTGAAGCTGACCACGCCCACCTATGGCGATCTCAACCACCTGGTGTCAG
CCACCATGAGTGGAGTGACCACCTGCCTGCGCTTCCCTGGCCAGCTGAACGCAGACCTGCGCAA
GCTGGCTGTGAACATGGTGCCCTTCCCGCGCCTGCACTTCTTCATGCCAGGCTTCGCACCTCTG
ACCAGCAGGGGCAGCCAGCAGTACCGAGCCCTGACAGTGCCCGAGCTCACCCAGCAGATGTTCG
ACTCCAAGAACATGATGGCTGCCTGCGACCCACGCCATGGCCGCTACCTGACCGTAGCCGCCAT
TTTCCGGGGCCGCATGTCCATGAAGGAGGTGGATGAGCAGATGCTCAACGTGCAGAACAAGAAC
AGCAGCTACTTCGTGGAGTGGATCCCCAACAATGTGAAGACGGCCGTGTGTGACATCCCTCCTC
GTGGCCTCAAGATGTCAGCCACCTTCATTGGCAACAGCACCGCCATCCAGGAGCTGTTCAAGCG
CATCTCGGAGCAGTTCACTGCCATGTTCAGGCGCAAGGCTTTCCTGCACTGGTACACGGGCGAG
GGCATGGACGAGATGGAGTTCACCGAGGCAGAGAGCAACATGAATGACCTGGTGTCTGAGTACC
AGCAGTACCAGGATGCCACGGCTGATGAGCAGGGCGAGTTCGAGGAGGAGGAGGGCGAGGATGA
GGCTTAAGAACTTCTCGGATACATTGTGCACCCTTAGTGAACTTCTGTTGTCCTCCAGCATGGT
CTTTCTATTTGTAAATTATGGTGCTCAGTTTGCCTCTGTCTGAAATTCACTGTTGATGTAATAG
TGTGAACCTCCTTTCAAGATTACAGTATTGTCTCAGAAATCTATATGAATAAAAAAGCATGTGT
ATA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102589	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAA27067	(Get FASTA)	NCBI Sequence Viewer
	EDL98318	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000023582.4
	ENSRNOP00000023611.4
	ENSRNOP00000071729
	ENSRNOP00000071729.2
	ENSRNOP00000093166.1
	ENSRNOP00055019908
	ENSRNOP00060028702
GenBank Protein	P85108	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001102589 ⟸ NM_001109119

- UniProtKB:

P85108 (UniProtKB/Swiss-Prot), A6J7G7 (UniProtKB/TrEMBL), A0A8L2R4U4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAI
LVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCD
CLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQL
VENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVN
MVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGR
MSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQ
FTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA

hide sequence

RefSeq Acc Id:

ENSRNOP00000023611 ⟸ ENSRNOT00000023611

RefSeq Acc Id:

ENSRNOP00000071729 ⟸ ENSRNOT00000086264

RefSeq Acc Id:

ENSRNOP00000093166 ⟸ ENSRNOT00000099483

RefSeq Acc Id:

ENSRNOP00000023582 ⟸ ENSRNOT00000023582

Protein Domains

Tubulin/FtsZ 2-layer sandwich Tubulin/FtsZ GTPase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P85108-F1-model_v2	AlphaFold	P85108	1-445	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700420

Promoter ID:

EPDNEW_R10936

Type:

single initiation site

Name:

Tubb2a_1

Description:

tubulin, beta 2A class IIa

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	31,493,144 - 31,493,204	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1588452	AgrOrtholog
BioCyc Gene	G2FUF-9600	BioCyc
Ensembl Genes	ENSRNOG00000017558	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00055014170	UniProtKB/Swiss-Prot
	ENSRNOG00060020190	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000023582.5	UniProtKB/TrEMBL
	ENSRNOT00000023611.7	UniProtKB/TrEMBL
	ENSRNOT00000086264	ENTREZGENE
	ENSRNOT00000086264.2	UniProtKB/TrEMBL
	ENSRNOT00000099483.1	UniProtKB/TrEMBL
	ENSRNOT00055024356	UniProtKB/Swiss-Prot
	ENSRNOT00060034947	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.287.600	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.1330.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.1440	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Beta-tubulin_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Beta_tubulin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tub_FtsZ_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin/FtsZ-like_C	UniProtKB/TrEMBL
	Tubulin/FtsZ_2-layer-sand-dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin/FtsZ_C_sf	UniProtKB/Swiss-Prot
	Tubulin/FtsZ_GTPase_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin_FtsZ_GTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:498736	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	498736	ENTREZGENE
PANTHER	PTHR11588	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TUBULIN BETA-1 CHAIN	UniProtKB/TrEMBL
	TUBULIN BETA-2A CHAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Tubulin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Tubb2a	PhenoGen
PRINTS	BETATUBULIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TUBULIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	TUBULIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TUBULIN_B_AUTOREG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000017558	RatGTEx
	ENSRNOG00055014170	RatGTEx
	ENSRNOG00060020190	RatGTEx
SMART	Tubulin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52490	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55307	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6AFA2_RAT	UniProtKB/TrEMBL
	A0A8L2QD97_RAT	UniProtKB/TrEMBL
	A0A8L2R4U4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2UJU7_RAT	UniProtKB/TrEMBL
	A6J7G7	ENTREZGENE, UniProtKB/TrEMBL
	P85108	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Tubb2a	tubulin, beta 2A class IIa	LOC108348176	tubulin beta-2A chain pseudogene	Data merged from RGD:11388883	737654	PROVISIONAL
2016-08-02	LOC108348176	tubulin beta-2A chain pseudogene			Symbol and Name status set to provisional	70820	PROVISIONAL
2011-10-19	Tubb2a	tubulin, beta 2A class IIa	Tubb2a	tubulin, beta 2A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-10-12	Tubb2a	tubulin, beta 2A	Tubb2a	tubulin, beta 2A class IIa	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-10-10	Tubb2a	tubulin, beta 2A class IIa	Tubb2a	tubulin, beta 2a	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-05	Tubb2a	tubulin, beta 2a	LOC498736	similar to tubulin, beta 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-19	LOC498736	similar to tubulin, beta 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)