Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | ISO | Hmgxb4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of HMGXB4 mRNA | CTD | PMID:36331819 | 1,2-dichloroethane | increases expression | ISO | Hmgxb4 (Mus musculus) | 6480464 | ethylene dichloride results in increased expression of HMGXB4 mRNA | CTD | PMID:28189721 and PMID:28960355 | 1,2-dimethylhydrazine | increases expression | ISO | Hmgxb4 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of HMGXB4 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | multiple interactions | ISO | Hmgxb4 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HMGXB4 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Hmgxb4 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HMGXB4 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Hmgxb4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of HMGXB4 mRNA | CTD | PMID:21570461 | acrolein | multiple interactions | ISO | HMGXB4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of HMGXB4 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of HMGXB4 mRNA | CTD | PMID:32699268 | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of HMGXB4 mRNA | CTD | PMID:28959563 | acrylamide | decreases expression | ISO | HMGXB4 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of HMGXB4 mRNA | CTD | PMID:32763439 | all-trans-retinoic acid | decreases expression | ISO | HMGXB4 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of HMGXB4 mRNA | CTD | PMID:33167477 | alpha-pinene | multiple interactions | ISO | HMGXB4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of HMGXB4 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of HMGXB4 mRNA | CTD | PMID:32699268 | amiodarone | increases expression | ISO | HMGXB4 (Homo sapiens) | 6480464 | Amiodarone results in increased expression of HMGXB4 mRNA | CTD | PMID:19774075 | aristolochic acid A | decreases expression | ISO | HMGXB4 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of HMGXB4 mRNA | CTD | PMID:33212167 | benzo[a]pyrene | increases expression | ISO | Hmgxb4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of HMGXB4 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | affects methylation | ISO | HMGXB4 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of HMGXB4 promoter | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | HMGXB4 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20382639 | benzo[a]pyrene diol epoxide I | increases expression | ISO | HMGXB4 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:26238291 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of HMGXB4 mRNA | CTD | PMID:25181051 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of HMGXB4 gene | CTD | PMID:28505145 | cadmium dichloride | increases expression | ISO | HMGXB4 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of HMGXB4 mRNA | CTD | PMID:26472689 | caffeine | affects phosphorylation | ISO | HMGXB4 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of HMGXB4 protein | CTD | PMID:35688186 | CGP 52608 | multiple interactions | ISO | HMGXB4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to HMGXB4 gene] | CTD | PMID:28238834 | chlorpyrifos | decreases expression | ISO | Hmgxb4 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of HMGXB4 mRNA | CTD | PMID:37019170 | coumarin | decreases phosphorylation | ISO | HMGXB4 (Homo sapiens) | 6480464 | coumarin results in decreased phosphorylation of HMGXB4 protein | CTD | PMID:35688186 | cyclosporin A | increases expression | ISO | HMGXB4 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of HMGXB4 mRNA | CTD | PMID:25562108 | decabromodiphenyl ether | decreases expression | EXP | | 6480464 | decabromobiphenyl ether results in decreased expression of HMGXB4 mRNA | CTD | PMID:23640034 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of HMGXB4 mRNA | CTD | PMID:25152437 | doxorubicin | decreases expression | ISO | HMGXB4 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of HMGXB4 mRNA | CTD | PMID:29803840 | elemental selenium | multiple interactions | ISO | HMGXB4 (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of HMGXB4 mRNA | CTD | PMID:19244175 | elemental selenium | decreases expression | ISO | HMGXB4 (Homo sapiens) | 6480464 | Selenium results in decreased expression of HMGXB4 mRNA | CTD | PMID:19244175 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of HMGXB4 mRNA | CTD | PMID:30307764 | formaldehyde | decreases expression | ISO | HMGXB4 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of HMGXB4 mRNA | CTD | PMID:20655997 | FR900359 | affects phosphorylation | ISO | HMGXB4 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of HMGXB4 protein | CTD | PMID:37730182 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of HMGXB4 mRNA | CTD | PMID:33387578 | geraniol | decreases expression | ISO | HMGXB4 (Homo sapiens) | 6480464 | geraniol results in decreased expression of HMGXB4 mRNA | CTD | PMID:27683099 | hydralazine | multiple interactions | ISO | HMGXB4 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of HMGXB4 mRNA | CTD | PMID:17183730 | leflunomide | increases expression | ISO | HMGXB4 (Homo sapiens) | 6480464 | leflunomide results in increased expression of HMGXB4 mRNA | CTD | PMID:28988120 | ozone | multiple interactions | ISO | HMGXB4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of HMGXB4 mRNA more ... | CTD | PMID:32699268 | paracetamol | affects expression | ISO | Hmgxb4 (Mus musculus) | 6480464 | Acetaminophen affects the expression of HMGXB4 mRNA | CTD | PMID:17562736 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Hmgxb4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of HMGXB4 mRNA | CTD | PMID:36331819 | phenobarbital | affects expression | ISO | Hmgxb4 (Mus musculus) | 6480464 | Phenobarbital affects the expression of HMGXB4 mRNA | CTD | PMID:23091169 | pirinixic acid | multiple interactions | ISO | Hmgxb4 (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HMGXB4 mRNA | CTD | PMID:19710929 | selenium atom | multiple interactions | ISO | HMGXB4 (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of HMGXB4 mRNA | CTD | PMID:19244175 | selenium atom | decreases expression | ISO | HMGXB4 (Homo sapiens) | 6480464 | Selenium results in decreased expression of HMGXB4 mRNA | CTD | PMID:19244175 | sodium arsenite | increases expression | ISO | Hmgxb4 (Mus musculus) | 6480464 | sodium arsenite results in increased expression of HMGXB4 mRNA | CTD | PMID:32068019 | Soman | decreases expression | EXP | | 6480464 | Soman results in decreased expression of HMGXB4 mRNA | CTD | PMID:19281266 | tungsten | decreases expression | ISO | Hmgxb4 (Mus musculus) | 6480464 | Tungsten results in decreased expression of HMGXB4 mRNA | CTD | PMID:30912803 | valproic acid | decreases expression | ISO | Hmgxb4 (Mus musculus) | 6480464 | Valproic Acid results in decreased expression of HMGXB4 mRNA | CTD | PMID:21427059 | valproic acid | multiple interactions | ISO | HMGXB4 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of HMGXB4 mRNA | CTD | PMID:17183730 | valproic acid | decreases methylation | ISO | HMGXB4 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of HMGXB4 gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | HMGXB4 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of HMGXB4 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | HMGXB4 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of HMGXB4 mRNA | CTD | PMID:23179753 and PMID:25192806 | vitamin E | multiple interactions | ISO | HMGXB4 (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of HMGXB4 mRNA | CTD | PMID:19244175 | vitamin E | decreases expression | ISO | HMGXB4 (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of HMGXB4 mRNA | CTD | PMID:19244175 | |