Adcy3 (adenylate cyclase 3) - Rat Genome Database

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Gene: Adcy3 (adenylate cyclase 3) Rattus norvegicus
Analyze
Symbol: Adcy3
Name: adenylate cyclase 3
RGD ID: 71009
Description: Enables calcium- and calmodulin-responsive adenylate cyclase activity. Involved in cAMP biosynthetic process and cellular response to forskolin. Located in several cellular components, including apical cytoplasm; dendritic knob; and sperm midpiece. Part of ciliary necklace. Biomarker of cardiomyopathy and diabetes mellitus. Orthologous to human ADCY3 (adenylate cyclase 3); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AC-III; AC3; adenylate cyclase type 3; adenylate cyclase type III; adenylate cyclase, olfactive type; adenylyl cyclase 3; ATP pyrophosphate-lyase 3; type III adenylyl cyclase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Adcy3em2Mcwi
Genetic Models: WKY-Adcy3em2Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8632,819,602 - 32,923,174 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl632,843,961 - 32,923,173 (+)EnsemblGRCr8
mRatBN7.2627,100,089 - 27,203,686 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl627,124,828 - 27,203,686 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx627,417,094 - 27,495,948 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0627,732,977 - 27,811,837 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0627,210,479 - 27,289,371 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0628,570,941 - 28,648,848 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl628,571,351 - 28,650,148 (+)Ensemblrn6Rnor6.0
Rnor_5.0638,378,060 - 38,454,926 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4627,118,325 - 27,202,275 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera626,598,414 - 26,676,272 (+)NCBICelera
RGSC_v3.1627,121,352 - 27,205,228 (+)NCBI
Cytogenetic Map6q14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
disulfiram  (ISO)
divanadium pentaoxide  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
FR900359  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
Licarin A  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
N-nitrosodiethylamine  (EXP)
nitrogen dioxide  (ISO)
Octicizer  (ISO)
ozone  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
rotenone  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (EXP)
thiram  (ISO)
toluene  (EXP)
triclosan  (EXP)
triphenyl phosphate  (ISO)
undecane  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
acrosomal vesicle  (IDA)
apical cytoplasm  (IDA)
ciliary membrane  (IEA,ISO)
ciliary necklace  (IDA)
cilium  (IDA,IEA,ISO,ISS)
cytoplasm  (IEA,ISO)
dendritic knob  (IDA)
Golgi apparatus  (IDA,IEA)
membrane  (IEA,ISO,ISS)
neuronal cell body  (IDA)
nucleus  (IDA)
perinuclear region of cytoplasm  (IDA)
plasma membrane  (IBA,IDA,IEA,ISO,TAS)
sperm midpiece  (IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Identification of a specialized adenylyl cyclase that may mediate odorant detection. Bakalyar HA and Reed RR, Science 1990 Dec 7;250(4986):1403-6.
2. Non-raft adenylyl cyclase 2 defines a cAMP signaling compartment that selectively regulates IL-6 expression in airway smooth muscle cells: differential regulation of gene expression by AC isoforms. Bogard AS, etal., Naunyn Schmiedebergs Arch Pharmacol. 2014 Apr;387(4):329-39. doi: 10.1007/s00210-013-0950-4. Epub 2013 Dec 22.
3. An abnormal gene expression of the beta-adrenergic system contributes to the pathogenesis of cardiomyopathy in cirrhotic rats. Ceolotto G, etal., Hepatology. 2008 Dec;48(6):1913-23. doi: 10.1002/hep.22533.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. 'Smelling' the cerebrospinal fluid: olfactory signaling molecules are expressed in and mediate chemosensory signaling from the choroid plexus. Gonçalves I, etal., FEBS J. 2016 May;283(9):1748-66. doi: 10.1111/febs.13700. Epub 2016 Mar 30.
7. Rodent oocytes express an active adenylyl cyclase required for meiotic arrest. Horner K, etal., Dev Biol 2003 Jun 15;258(2):385-96.
8. Expression pattern of type 3 adenylyl cyclase in rodent dorsal root ganglion and its primary afferent terminals. Hu ML, etal., Neurosci Lett. 2019 Jan 23;692:16-22. doi: 10.1016/j.neulet.2018.10.049. Epub 2018 Oct 23.
9. Characterization of adenylyl cyclase isoforms in rat peripheral pulmonary arteries. Jourdan KB, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1359-69.
10. Genetic Fine-Mapping and Identification of Candidate Genes and Variants for Adiposity Traits in Outbred Rats. Keele GR, etal., Obesity (Silver Spring). 2018 Jan;26(1):213-222. doi: 10.1002/oby.22075. Epub 2017 Nov 28.
11. Meglumine cyclic adenylate improves neurological function following acute spinal cord injury in rats. Liao J, etal., Mol Med Rep. 2014 Sep;10(3):1225-30. doi: 10.3892/mmr.2014.2352. Epub 2014 Jun 25.
12. Inactivation of the mouse adenylyl cyclase 3 gene disrupts male fertility and spermatozoon function. Livera G, etal., Mol Endocrinol. 2005 May;19(5):1277-90. Epub 2005 Feb 10.
13. Immunocytochemical Localization of Olfactory-signaling Molecules in Human and Rat Spermatozoa. Makeyeva Y, etal., J Histochem Cytochem. 2020 Jul;68(7):491-513. doi: 10.1369/0022155420939833. Epub 2020 Jun 30.
14. Developmental expression of G-proteins and adenylyl cyclase in peripheral olfactory systems. Light microscopic and freeze-substitution electron microscopic immunocytochemistry. Menco BP, etal., J Neurocytol. 1994 Nov;23(11):708-27. doi: 10.1007/BF01181645.
15. Gene Data Set MGD Curation, June 12, 2002
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Nicotinic acetylcholine receptor alpha 7 regulates cAMP signal within lipid rafts. Oshikawa J, etal., Am J Physiol Cell Physiol. 2003 Sep;285(3):C567-74. Epub 2003 May 14.
19. Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. Ostrom RS, etal., J Biol Chem. 2003 Jul 4;278(27):24461-8. Epub 2003 Apr 23.
20. A nuclear location for Ca2+-activated adenylyl cyclases I and III in neurones. Parkinson NA and Bolsover SR, Brain Res Mol Brain Res. 2001 Jul 13;91(1-2):43-9.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies. Sadana R and Dessauer CW, Neurosignals. 2009;17(1):5-22. Epub 2008 Oct 24.
26. Increased expression of adenylyl cyclase 3 in pancreatic islets and central nervous system of diabetic Goto-Kakizaki rats: a possible regulatory role in glucose homeostasis. Seed Ahmed M, etal., Islets. 2012 Sep-Oct;4(5):343-8. doi: 10.4161/isl.22283. Epub 2012 Sep 1.
27. α-Cedrene protects rodents from high-fat diet-induced adiposity via adenylyl cyclase 3. Tong T, etal., Int J Obes (Lond). 2019 Jan;43(1):202-216. doi: 10.1038/s41366-018-0176-0. Epub 2018 Dec 19.
Additional References at PubMed
PMID:8889548   PMID:11055432   PMID:11549699   PMID:15499025   PMID:18596612   PMID:19946888   PMID:22179047   PMID:22531884   PMID:22871113   PMID:23077041   PMID:26393535   PMID:28154160  
PMID:35625651  


Genomics

Comparative Map Data
Adcy3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8632,819,602 - 32,923,174 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl632,843,961 - 32,923,173 (+)EnsemblGRCr8
mRatBN7.2627,100,089 - 27,203,686 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl627,124,828 - 27,203,686 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx627,417,094 - 27,495,948 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0627,732,977 - 27,811,837 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0627,210,479 - 27,289,371 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0628,570,941 - 28,648,848 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl628,571,351 - 28,650,148 (+)Ensemblrn6Rnor6.0
Rnor_5.0638,378,060 - 38,454,926 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4627,118,325 - 27,202,275 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera626,598,414 - 26,676,272 (+)NCBICelera
RGSC_v3.1627,121,352 - 27,205,228 (+)NCBI
Cytogenetic Map6q14NCBI
ADCY3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38224,819,169 - 24,920,237 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl224,819,169 - 24,920,299 (-)Ensemblhg38GRCh38
GRCh37225,042,038 - 25,143,106 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36224,895,542 - 24,995,559 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34224,953,691 - 25,053,654NCBI
Celera224,882,356 - 24,982,363 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef224,779,864 - 24,880,170 (-)NCBIHuRef
CHM1_1224,971,569 - 25,071,569 (-)NCBICHM1_1
T2T-CHM13v2.0224,853,918 - 24,954,979 (-)NCBIT2T-CHM13v2.0
Adcy3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39124,183,397 - 4,263,525 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl124,183,103 - 4,263,525 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38124,133,116 - 4,213,525 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl124,133,103 - 4,213,525 (+)Ensemblmm10GRCm38
MGSCv37124,133,397 - 4,213,524 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36124,134,076 - 4,214,096 (+)NCBIMGSCv36mm8
Celera124,061,963 - 4,140,655 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map121.99NCBI
Adcy3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554696,929,092 - 7,026,758 (-)Ensembl
ChiLan1.0NW_0049554696,933,208 - 7,026,179 (-)NCBIChiLan1.0ChiLan1.0
ADCY3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212101,605,337 - 101,706,428 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A101,609,330 - 101,710,392 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A24,812,729 - 24,913,539 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A24,908,108 - 25,009,163 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A24,908,108 - 25,009,163 (-)EnsemblpanPan2panpan1.1
ADCY3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11719,153,732 - 19,231,943 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1719,154,571 - 19,232,411 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1719,050,504 - 19,129,367 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01719,426,953 - 19,505,567 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1719,426,958 - 19,505,153 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11719,163,469 - 19,242,122 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01719,172,925 - 19,251,551 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01719,212,943 - 19,298,018 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Adcy3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629263,506,132 - 63,589,371 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364937,250,194 - 7,335,691 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364937,250,194 - 7,333,433 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3113,876,339 - 113,982,369 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13113,875,005 - 113,969,053 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23121,107,146 - 121,199,908 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADCY3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11482,752,786 - 82,858,727 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1482,753,177 - 82,859,415 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604529,309,587 - 29,414,423 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adcy3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247387,163,354 - 7,249,190 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247387,163,189 - 7,249,249 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Adcy3
852 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:72
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000005389
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63118500276185002Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)62228825732981219Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat

Markers in Region
RH134597  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,203,769 - 27,203,964 (+)MAPPERmRatBN7.2
Rnor_6.0628,648,932 - 28,649,126NCBIRnor6.0
Rnor_5.0638,455,009 - 38,455,203UniSTSRnor5.0
Celera626,676,356 - 26,676,550UniSTS
RH 3.4 Map6116.9UniSTS
Cytogenetic Map6q14UniSTS
UniSTS:496038  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,186,204 - 27,186,925 (+)MAPPERmRatBN7.2
Rnor_6.0628,631,368 - 28,632,088NCBIRnor6.0
Rnor_5.0638,437,445 - 38,438,165UniSTSRnor5.0
RGSC_v3.4627,184,795 - 27,185,515UniSTSRGSC3.4
Celera626,658,792 - 26,659,512UniSTS
Cytogenetic Map6q14UniSTS
ADCY3_1034  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,202,796 - 27,203,615 (+)MAPPERmRatBN7.2
Rnor_6.0628,647,959 - 28,648,777NCBIRnor6.0
Rnor_5.0638,454,036 - 38,454,854UniSTSRnor5.0
RGSC_v3.4627,201,386 - 27,202,204UniSTSRGSC3.4
Celera626,675,383 - 26,676,201UniSTS
Cytogenetic Map6q14UniSTS


Genetic Models
This gene Adcy3 is modified in the following models/strains:
WKY-Adcy3em2Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 352 192 11 141 77 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000005389   ⟹   ENSRNOP00000005389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl632,843,961 - 32,923,173 (+)Ensembl
mRatBN7.2 Ensembl627,124,828 - 27,203,686 (+)Ensembl
Rnor_6.0 Ensembl628,571,351 - 28,650,148 (+)Ensembl
RefSeq Acc Id: NM_130779   ⟹   NP_570135
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,844,320 - 32,923,173 (+)NCBI
mRatBN7.2627,124,828 - 27,203,686 (+)NCBI
Rnor_6.0628,571,133 - 28,648,848 (+)NCBI
Rnor_5.0638,378,060 - 38,454,926 (+)NCBI
RGSC_v3.4627,118,325 - 27,202,275 (+)RGD
Celera626,598,414 - 26,676,272 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239847   ⟹   XP_006239909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,844,441 - 32,923,174 (+)NCBI
mRatBN7.2627,124,951 - 27,202,951 (+)NCBI
Rnor_6.0628,571,305 - 28,648,237 (+)NCBI
Rnor_5.0638,378,060 - 38,454,926 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239848   ⟹   XP_006239910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,844,500 - 32,923,174 (+)NCBI
mRatBN7.2627,125,005 - 27,202,951 (+)NCBI
Rnor_6.0628,571,380 - 28,648,237 (+)NCBI
Rnor_5.0638,378,060 - 38,454,926 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239849   ⟹   XP_006239911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,844,510 - 32,923,174 (+)NCBI
mRatBN7.2627,125,002 - 27,202,951 (+)NCBI
Rnor_6.0628,570,941 - 28,648,237 (+)NCBI
Rnor_5.0638,378,060 - 38,454,926 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239850   ⟹   XP_006239912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,844,510 - 32,923,174 (+)NCBI
mRatBN7.2627,125,697 - 27,202,951 (+)NCBI
Rnor_6.0628,571,305 - 28,648,237 (+)NCBI
Rnor_5.0638,378,060 - 38,454,926 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112876   ⟹   XP_038968804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,819,602 - 32,923,174 (+)NCBI
mRatBN7.2627,100,089 - 27,202,951 (+)NCBI
RefSeq Acc Id: XM_063262445   ⟹   XP_063118515
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,844,443 - 32,923,174 (+)NCBI
RefSeq Acc Id: NP_570135   ⟸   NM_130779
- UniProtKB: P21932 (UniProtKB/Swiss-Prot),   G3V6I2 (UniProtKB/TrEMBL),   A6HAH1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239911   ⟸   XM_006239849
- Peptide Label: isoform X1
- UniProtKB: P21932 (UniProtKB/Swiss-Prot),   G3V6I2 (UniProtKB/TrEMBL),   A6HAH1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239910   ⟸   XM_006239848
- Peptide Label: isoform X1
- UniProtKB: P21932 (UniProtKB/Swiss-Prot),   G3V6I2 (UniProtKB/TrEMBL),   A6HAH1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239912   ⟸   XM_006239850
- Peptide Label: isoform X2
- UniProtKB: P21932 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006239909   ⟸   XM_006239847
- Peptide Label: isoform X1
- UniProtKB: P21932 (UniProtKB/Swiss-Prot),   G3V6I2 (UniProtKB/TrEMBL),   A6HAH1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005389   ⟸   ENSRNOT00000005389
RefSeq Acc Id: XP_038968804   ⟸   XM_039112876
- Peptide Label: isoform X1
- UniProtKB: P21932 (UniProtKB/Swiss-Prot),   G3V6I2 (UniProtKB/TrEMBL),   A6HAH1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118515   ⟸   XM_063262445
- Peptide Label: isoform X2
- UniProtKB: P21932 (UniProtKB/Swiss-Prot)
Protein Domains
Guanylate cyclase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21932-F1-model_v2 AlphaFold P21932 1-1144 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71009 AgrOrtholog
BioCyc Gene G2FUF-38279 BioCyc
Ensembl Genes ENSRNOG00000003999 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000005389 ENTREZGENE
Gene3D-CATH 3.30.70.1230 UniProtKB/Swiss-Prot
InterPro A/G_cyclase UniProtKB/Swiss-Prot
  A/G_cyclase_CS UniProtKB/Swiss-Prot
  AC_N UniProtKB/Swiss-Prot
  Adcy UniProtKB/Swiss-Prot
  Nucleotide_cyclase UniProtKB/Swiss-Prot
KEGG Report rno:64508 UniProtKB/Swiss-Prot
NCBI Gene 64508 ENTREZGENE
PANTHER ADENYLATE CYCLASE TYPE 1 UniProtKB/Swiss-Prot
  ADENYLATE CYCLASE TYPE 3 UniProtKB/Swiss-Prot
Pfam AC_N UniProtKB/Swiss-Prot
  Guanylate_cyc UniProtKB/Swiss-Prot
PhenoGen Adcy3 PhenoGen
PIRSF Ade_cyc UniProtKB/Swiss-Prot
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003999 RatGTEx
SMART CYCc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55073 UniProtKB/Swiss-Prot
UniProt A6HAH1 ENTREZGENE, UniProtKB/TrEMBL
  ADCY3_RAT UniProtKB/Swiss-Prot
  G3V6I2 ENTREZGENE, UniProtKB/TrEMBL
  P21932 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Adcy3  adenylate cyclase 3      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process mediates odorant detection (possibly) via modulation of intracellular cAMP concentration 724707