Fkbp4 (FKBP prolyl isomerase 4) - Rat Genome Database

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Gene: Fkbp4 (FKBP prolyl isomerase 4) Rattus norvegicus
Analyze
Symbol: Fkbp4
Name: FKBP prolyl isomerase 4
RGD ID: 628729
Description: Enables copper-dependent protein binding activity and tau protein binding activity. Involved in copper ion transport and negative regulation of microtubule polymerization. Located in several cellular components, including axonal growth cone; neuronal cell body; and perinuclear region of cytoplasm. Part of protein-containing complex. Orthologous to human FKBP4 (FKBP prolyl isomerase 4); PARTICIPATES IN aldosterone signaling pathway; cortisol signaling pathway; estrogen signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; FK506 binding protein 4; FK506 binding protein 4 (59 kDa); FK506 binding protein 52; FK506-binding protein 4; FKBP-4; FKBP-52; FKBP52 protein; FKBP59; HBI; HSP-binding immunophilin; immunophilin FKBP52; p59; peptidyl-prolyl cis-trans isomerase; peptidyl-prolyl cis-trans isomerase FKBP4; PPIase; PPIase FKBP4; rotamase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84163,389,464 - 163,397,918 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4163,389,464 - 163,397,918 (-)EnsemblGRCr8
mRatBN7.24161,703,379 - 161,711,833 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4161,703,379 - 161,711,833 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4167,932,996 - 167,941,451 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04163,715,934 - 163,724,389 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04162,349,970 - 162,358,425 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04161,748,993 - 161,757,447 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4161,748,993 - 161,757,447 (-)Ensemblrn6Rnor6.0
Rnor_5.04226,954,534 - 226,962,988 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44165,448,027 - 165,456,481 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4150,404,805 - 150,413,259 (-)NCBICelera
RGSC_v3.14165,694,232 - 165,699,379 (-)NCBI
Cytogenetic Map4q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2-methylcholine  (ISO)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
azoxystrobin  (EXP)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP,ISO)
GSK-J4  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
imidacloprid  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
levofloxacin  (EXP)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylseleninic acid  (ISO)
miconazole  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodimethylamine  (EXP)
nitrates  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phytoestrogen  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
pyrogallol  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
triptonide  (ISO)
trovafloxacin  (EXP)
valproic acid  (EXP,ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The immunophilin FKBP52 specifically binds to tubulin and prevents microtubule formation. Chambraud B, etal., FASEB J. 2007 Sep;21(11):2787-97. Epub 2007 Apr 13.
2. A role for FKBP52 in Tau protein function. Chambraud B, etal., Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2658-63. doi: 10.1073/pnas.0914957107. Epub 2010 Jan 25.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Chaperoning of glucocorticoid receptors. Pratt WB, etal., Handb Exp Pharmacol. 2006;(172):111-38.
7. Subcellular rearrangement of hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth. Quinta HR, etal., J Neurochem. 2010 Nov;115(3):716-34. doi: 10.1111/j.1471-4159.2010.06970.x. Epub 2010 Sep 28.
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. A novel role for the immunophilin FKBP52 in copper transport. Sanokawa-Akakura R, etal., J Biol Chem 2004 Jul 2;279(27):27845-8. Epub 2004 May 7.
11. Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions. Smith DF and Toft DO, Mol Endocrinol. 2008 Oct;22(10):2229-40. Epub 2008 May 1.
12. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
Additional References at PubMed
PMID:1376003   PMID:2592022   PMID:7693550   PMID:8341706   PMID:9660753   PMID:11350175   PMID:11751894   PMID:15199065   PMID:15831525   PMID:16176985   PMID:17142810   PMID:19056867  
PMID:20458337   PMID:22658674   PMID:29476059   PMID:30483787   PMID:31505169   PMID:31540954  


Genomics

Comparative Map Data
Fkbp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84163,389,464 - 163,397,918 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4163,389,464 - 163,397,918 (-)EnsemblGRCr8
mRatBN7.24161,703,379 - 161,711,833 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4161,703,379 - 161,711,833 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4167,932,996 - 167,941,451 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04163,715,934 - 163,724,389 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04162,349,970 - 162,358,425 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04161,748,993 - 161,757,447 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4161,748,993 - 161,757,447 (-)Ensemblrn6Rnor6.0
Rnor_5.04226,954,534 - 226,962,988 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44165,448,027 - 165,456,481 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4150,404,805 - 150,413,259 (-)NCBICelera
RGSC_v3.14165,694,232 - 165,699,379 (-)NCBI
Cytogenetic Map4q42NCBI
FKBP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38122,794,970 - 2,805,423 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl122,794,290 - 2,805,423 (+)Ensemblhg38GRCh38
GRCh37122,904,136 - 2,914,589 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,774,414 - 2,783,385 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34122,774,413 - 2,783,383NCBI
Celera124,518,032 - 4,528,525 (+)NCBICelera
Cytogenetic Map12p13.33NCBI
HuRef122,762,075 - 2,772,155 (+)NCBIHuRef
CHM1_1122,903,346 - 2,913,827 (+)NCBICHM1_1
T2T-CHM13v2.0122,800,969 - 2,811,423 (+)NCBIT2T-CHM13v2.0
Fkbp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396128,407,066 - 128,415,619 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6128,406,698 - 128,415,640 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386128,430,103 - 128,438,656 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6128,429,735 - 128,438,677 (-)Ensemblmm10GRCm38
MGSCv376128,380,125 - 128,388,649 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366128,395,726 - 128,404,250 (-)NCBIMGSCv36mm8
Celera6130,106,929 - 130,115,449 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map663.0NCBI
Fkbp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542918,334,939 - 18,344,530 (+)Ensembl
ChiLan1.0NW_00495542918,334,939 - 18,344,530 (+)NCBIChiLan1.0ChiLan1.0
FKBP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2108,341,673 - 8,353,904 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1128,338,572 - 8,350,663 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0122,915,017 - 2,924,423 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1122,847,333 - 2,856,118 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl122,847,496 - 2,856,107 (+)EnsemblpanPan2panpan1.1
FKBP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12741,950,087 - 41,959,136 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2741,950,509 - 41,959,034 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha274,725,111 - 4,734,083 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02742,308,268 - 42,317,245 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2742,308,301 - 42,317,761 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12742,249,772 - 42,258,704 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02742,219,464 - 42,228,431 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0274,084,855 - 4,093,764 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fkbp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945106,052,813 - 106,061,344 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366063,122,736 - 3,134,823 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366063,122,798 - 3,131,352 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FKBP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl567,313,480 - 67,322,028 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1567,314,010 - 67,321,628 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2569,600,337 - 69,607,970 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FKBP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1112,860,932 - 2,869,885 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl112,860,935 - 2,870,383 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660635,446,823 - 5,455,813 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fkbp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624860122,208 - 134,415 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624860122,728 - 135,258 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fkbp4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1619,265,028 - 19,273,062 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fkbp4
72 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:213
Count of miRNA genes:142
Interacting mature miRNAs:167
Transcripts:ENSRNOT00000008737
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4149763204169799698Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4160623982184426481Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat

Markers in Region
BI279823  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24161,704,185 - 161,704,351 (+)MAPPERmRatBN7.2
Rnor_6.04161,749,800 - 161,749,965NCBIRnor6.0
Rnor_5.04226,955,341 - 226,955,506UniSTSRnor5.0
RGSC_v3.44165,448,834 - 165,448,999UniSTSRGSC3.4
Celera4150,405,612 - 150,405,777UniSTS
RH 3.4 Map41011.2UniSTS
Cytogenetic Map4q42UniSTS
RH125352  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84163,392,098 - 163,392,729 (+)Marker Load Pipeline
mRatBN7.24161,706,013 - 161,706,644 (+)MAPPERmRatBN7.2
Rnor_6.04161,751,628 - 161,752,258NCBIRnor6.0
Rnor_5.04226,957,169 - 226,957,799UniSTSRnor5.0
RGSC_v3.44165,450,662 - 165,451,292UniSTSRGSC3.4
Celera4150,407,440 - 150,408,070UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008737   ⟹   ENSRNOP00000008737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4163,389,464 - 163,397,918 (-)Ensembl
mRatBN7.2 Ensembl4161,703,379 - 161,711,833 (-)Ensembl
Rnor_6.0 Ensembl4161,748,993 - 161,757,447 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109259   ⟹   ENSRNOP00000078521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4163,389,464 - 163,397,918 (-)Ensembl
mRatBN7.2 Ensembl4161,704,001 - 161,711,811 (-)Ensembl
RefSeq Acc Id: NM_001191863   ⟹   NP_001178792
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84163,389,464 - 163,397,918 (-)NCBI
mRatBN7.24161,703,379 - 161,711,833 (-)NCBI
Rnor_6.04161,748,993 - 161,757,447 (-)NCBI
Rnor_5.04226,954,534 - 226,962,988 (-)NCBI
Celera4150,404,805 - 150,413,259 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178792 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAM95632 (Get FASTA)   NCBI Sequence Viewer  
  EDM01775 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008737
  ENSRNOP00000008737.6
GenBank Protein Q9QVC8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001178792   ⟸   NM_001191863
- UniProtKB: A6IM14 (UniProtKB/Swiss-Prot),   Q8K3U8 (UniProtKB/Swiss-Prot),   Q9QVC8 (UniProtKB/Swiss-Prot),   A0A8I5ZLF1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008737   ⟸   ENSRNOT00000008737
Ensembl Acc Id: ENSRNOP00000078521   ⟸   ENSRNOT00000109259
Protein Domains
PPIase FKBP-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QVC8-F1-model_v2 AlphaFold Q9QVC8 1-458 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693426
Promoter ID:EPDNEW_R3951
Type:initiation region
Name:Fkbp4_1
Description:FK506 binding protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04161,757,432 - 161,757,492EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628729 AgrOrtholog
BioCyc Gene G2FUF-42855 BioCyc
Ensembl Genes ENSRNOG00000006444 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008737 ENTREZGENE
  ENSRNOT00000008737.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot
  3.10.50.40 UniProtKB/Swiss-Prot
InterPro Immunophilin_FKBP-type UniProtKB/Swiss-Prot
  PPIase_dom_sf UniProtKB/Swiss-Prot
  PPIase_FKBP_dom UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
  TPR_2 UniProtKB/Swiss-Prot
  TPR_repeat UniProtKB/Swiss-Prot
KEGG Report rno:260321 UniProtKB/Swiss-Prot
NCBI Gene 260321 ENTREZGENE
PANTHER PEPTIDYLPROLYL ISOMERASE UniProtKB/Swiss-Prot
  TETRATRICOPEPTIDE REPEAT DOMAIN 9 UniProtKB/Swiss-Prot
Pfam FKBP_C UniProtKB/Swiss-Prot
  TPR_1 UniProtKB/Swiss-Prot
  TPR_2 UniProtKB/Swiss-Prot
PhenoGen Fkbp4 PhenoGen
PROSITE FKBP_PPIASE UniProtKB/Swiss-Prot
  TPR UniProtKB/Swiss-Prot
  TPR_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006444 RatGTEx
SMART TPR UniProtKB/Swiss-Prot
Superfamily-SCOP FKBP-like UniProtKB/Swiss-Prot
  SSF48452 UniProtKB/Swiss-Prot
UniProt A0A8I5ZLF1 ENTREZGENE, UniProtKB/TrEMBL
  A6IM14 ENTREZGENE
  FKBP4_RAT UniProtKB/Swiss-Prot
  Q8K3U8 ENTREZGENE
  Q9QVC8 ENTREZGENE
UniProt Secondary A6IM14 UniProtKB/Swiss-Prot
  Q8K3U8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-11-09 Fkbp4  FKBP prolyl isomerase 4  Fkbp4  FK506 binding protein 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Fkbp4  FK506 binding protein 4    FK506 binding protein 4 (59 kDa)  Name updated 1299863 APPROVED
2003-02-27 Fkbp4  FK506 binding protein 4 (59 kDa)      Symbol and Name status set to provisional 70820 PROVISIONAL