Cyp3a23-3a1 (cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cyp3a23-3a1 (cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp3a23-3a1
Name: cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
RGD ID: 628626
Description: Enables demethylase activity and testosterone 6-beta-hydroxylase activity. Involved in several processes, including oxidative demethylation; response to dexamethasone; and response to genistein. Located in endoplasmic reticulum membrane. Used to study alcohol dependence. Biomarker of cholestasis and depressive disorder. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; and essential hypertension. Orthologous to several human genes including CYP3A5 (cytochrome P450 family 3 subfamily A member 5); PARTICIPATES IN tamoxifen pharmacokinetics pathway; linoleic acid metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene; 1,2,4-trichlorobenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AABR07035343.1; cDEX; CYP; Cyp3a1; CYP3A23; Cyp3a23/3a1; Cyp3a3; CYPIIIA1; cytochrome P-450; cytochrome P-450PCN (PNCN inducible); cytochrome P450 3A1; cytochrome P450 3A1-like; cytochrome P450, family 3, subfamily a, polypeptide 1; cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1; cytochrome P450, subfamily 3A, polypeptide 3; Cytochrome P450, subfamily IIIA, polypeptide 3; cytochrome P450-PCN1; cytochrome P450/6 beta B; LOC100910877; MGC108757; P450 IIIA; P450-PCN1; RL33
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Allele / Splice: Cyp3a23-3a1em1Myliu
Genetic Models: SD-Cyp3a23/3a1em1Myliu,Cyp3a2em1Myliu
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81214,369,950 - 14,398,803 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1214,368,266 - 14,398,813 (-)EnsemblGRCr8
mRatBN7.2129,256,159 - 9,285,020 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,254,475 - 9,285,030 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl129,015,383 - 9,285,008 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1210,058,901 - 10,087,682 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01210,682,086 - 10,710,867 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,705,516 - 9,734,297 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01211,053,888 - 11,082,742 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,655,402 - 11,733,136 (-)Ensemblrn6Rnor6.0
Rnor_5.01213,145,742 - 13,174,596 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4129,567,120 - 9,595,974 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1211,063,015 - 11,090,937 (-)NCBICelera
RGSC_v3.1129,596,712 - 9,625,890 (-)NCBI
RH 3.4 Map12117.0RGD
Cytogenetic Map12p11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (EXP)
1,2,4-trichlorobenzene  (EXP)
1,2-dichloroethene  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,4'-trichlorobiphenyl  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-acetamidofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-methylcholanthrene  (EXP)
3-oxo-5beta-cholanic acid  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone  (EXP)
4-nitrophenol  (EXP)
4-nonylphenol  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetonitrile  (EXP)
Acetyl tributyl citrate  (EXP)
acrylamide  (EXP)
actinomycin D  (EXP)
alachlor  (EXP)
alkaloid  (EXP)
alpha-hexachlorocyclohexane  (EXP)
alpha-Hydroxyalprazolam  (EXP)
alprazolam  (EXP)
amiodarone  (EXP)
amitraz  (EXP)
amitriptyline  (EXP)
andrographolide  (EXP)
anthocyanin  (EXP)
Aroclor 1254  (EXP)
arsenite(3-)  (EXP)
atorvastatin calcium  (EXP)
benzbromarone  (EXP)
benzene  (EXP)
benzophenone  (EXP)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bilirubin IXalpha  (EXP)
bilobalide  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
bitertanol  (EXP)
Bromadiolone  (EXP)
bromuconazole  (EXP)
cadmium acetate  (EXP)
calcitriol  (EXP)
capsaicin  (EXP)
carbamazepine  (EXP)
carvedilol  (EXP)
chalcone  (EXP)
chenodeoxycholic acid  (EXP)
chloroform  (EXP)
chlorohydrocarbon  (EXP)
chlorpyrifos  (EXP)
chlorzoxazone  (EXP)
cholesterol  (EXP)
cholic acid  (EXP)
choline  (EXP)
ciprofibrate  (EXP)
ciprofloxacin  (EXP)
cisplatin  (EXP)
clofibrate  (EXP)
clofibric acid  (EXP)
clomipramine  (EXP)
clothianidin  (EXP)
clotrimazole  (EXP)
cocaine  (EXP)
cordycepin  (EXP)
corticosterone  (EXP)
cortisol  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproconazole  (EXP)
DDD  (EXP)
DDE  (EXP)
decabromodiphenyl ether  (EXP)
dehydroepiandrosterone  (EXP)
deoxycholic acid  (EXP)
dexamethasone  (EXP)
dextromethorphan  (EXP)
Diallyl sulfide  (EXP)
dibenziodolium  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
dicofol  (EXP)
diflubenzuron  (EXP)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (EXP)
diuron  (EXP)
enilconazole  (EXP)
epoxiconazole  (EXP)
erythromycin estolate  (EXP)
ethanol  (EXP)
ethoxyquin  (EXP)
farnesol  (EXP)
felbamate  (EXP)
fenofibrate  (EXP)
fenvalerate  (EXP)
fipronil  (EXP)
fipronil-sulfone  (EXP)
fluconazole  (EXP)
Furafylline  (EXP)
furan  (EXP)
gabapentin  (EXP)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP)
genistein(1-)  (EXP)
gentamycin  (EXP)
Ginkgolide A  (EXP)
glafenine  (EXP)
glutathione  (EXP)
glycyrrhizinic acid  (EXP)
hexachlorobenzene  (EXP)
huperzine A  (EXP)
ifosfamide  (EXP)
imipramine  (EXP)
indole-3-methanol  (EXP)
indometacin  (EXP)
isoniazide  (EXP)
ketamine  (EXP)
ketoconazole  (EXP)
L-ethionine  (EXP)
L-methionine  (EXP)
lactacystin  (EXP)
lamotrigine  (EXP)
Lasiocarpine  (EXP)
leflunomide  (EXP)
lithocholic acid  (EXP)
mangiferin  (EXP)
metazachlor  (EXP)
methapyrilene  (EXP)
methotrexate  (EXP)
methoxsalen  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (EXP)
miconazole  (EXP)
midazolam  (EXP)
mifepristone  (EXP)
monocrotaline  (EXP)
Muraglitazar  (EXP)
musk xylene  (EXP)
N'-(2,4-dimethylphenyl)-N-methylformamidine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Vinyl-2-pyrrolidone  (EXP)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
nelfinavir  (EXP)
nemorubicin  (EXP)
nevirapine  (EXP)
nicardipine  (EXP)
nifedipine  (EXP)
Nonylphenol  (EXP)
obeticholic acid  (EXP)
octamethylcyclotetrasiloxane  (EXP)
okadaic acid  (EXP)
oltipraz  (EXP)
omeprazole  (EXP)
oxycodone  (EXP)
Panaxytriol  (EXP)
paracetamol  (EXP)
Paraoxon-methyl  (EXP)
parathion-methyl  (EXP)
PCB138  (EXP)
pentachlorobenzene  (EXP)
pentachlorophenol  (EXP)
perfluorobutyric acid  (EXP)
perfluorodecanoic acid  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenacetin  (EXP)
phenobarbital  (EXP)
phenytoin  (EXP)
phthalic acid  (EXP)
pioglitazone  (EXP)
pirinixic acid  (EXP)
poly(I:C)  (EXP)
pravastatin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
progesterone  (EXP)
propiconazole  (EXP)
pyrazinecarboxamide  (EXP)
pyrene  (EXP)
pyridine  (EXP)
rifampicin  (EXP)
ritonavir  (EXP)
rotenone  (EXP)
sanguinarine  (EXP)
sodium arsenite  (EXP)
spironolactone  (EXP)
stilbene oxide  (EXP)
strychnine  (EXP)
Sudan III  (EXP)
sulfoxaflor  (EXP)
tamoxifen  (EXP)
taurocholic acid  (EXP)
Territrem B  (EXP)
tert-butyl ethyl ether  (EXP)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP)
thiacloprid  (EXP)
thioacetamide  (EXP)
toremifene  (EXP)
trabectedin  (EXP)
trans-1,2-dichloroethene  (EXP)
trans-chalcone  (EXP)
triadimefon  (EXP)
trichloroethene  (EXP)
triclosan  (EXP)
trifluralin  (EXP)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
troglitazone  (EXP)
troleandomycin  (EXP)
uranium atom  (EXP)
ursodeoxycholic acid  (EXP)
valdecoxib  (EXP)
valproic acid  (EXP)
vinclozolin  (EXP)
zaragozic acid A  (EXP)
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The influence of soybean extract on the expression level of selected drug transporters, transcription factors and cytochrome P450 genes encoding phase I drug-metabolizing enzymes. Bogacz A, etal., Ginekol Pol. 2014 May;85(5):348-53. doi: 10.17772/gp/1741.
2. Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis. Gabbia D, etal., World J Gastroenterol. 2017 Nov 14;23(42):7519-7530. doi: 10.3748/wjg.v23.i42.7519.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Complete cDNA and protein sequence of a pregnenolone 16 alpha-carbonitrile-induced cytochrome P-450. A representative of a new gene family. Gonzalez FJ, etal., J Biol Chem 1985 Jun 25;260(12):7435-41.
5. Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase. Hunter SR, etal., Drug Metab Dispos. 2017 Feb;45(2):118-129. doi: 10.1124/dmd.116.073833. Epub 2016 Nov 16.
6. Alpha-hydroxylation of tamoxifen and toremifene by human and rat cytochrome P450 3A subfamily enzymes. Kim SY, etal., Chem Res Toxicol. 2003 Sep;16(9):1138-44.
7. Comparative study on nobiletin metabolism with liver microsomes from rats, Guinea pigs and hamsters and rat cytochrome p450. Koga N, etal., Biol Pharm Bull. 2007 Dec;30(12):2317-23.
8. Hepatic drug metabolizing profile of Flinders Sensitive Line rat model of depression. Kotsovolou O, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1075-84. Epub 2010 Jun 4.
9. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
10. Autoantibodies against cytochromes P-4502E1 and P-4503A in alcoholics. Lytton SD, etal., Mol Pharmacol. 1999 Feb;55(2):223-33. doi: 10.1124/mol.55.2.223.
11. Using real-time quantitative TaqMan RT-PCR to evaluate the role of dexamethasone in gene regulation of rat P-glycoproteins mdr1a/1b and cytochrome P450 3A1/2. Mei Q, etal., J Pharm Sci. 2004 Oct;93(10):2488-96.
12. Structure and expression of the rat CYP3A1 gene: isolation of the gene (P450/6betaB) and characterization of the recombinant protein. Nagata K, etal., Arch Biochem Biophys. 1999 Feb 15;362(2):242-53.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Profile of territrem metabolism and cytochrome P-450 3A expression in liver microsomes from Wistar rats of both genders as a function of age. Peng FC, etal., J Toxicol Environ Health A. 2005 Nov 12;68(21):1871-88.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. Effects of chronic exposure to cadmium on renal cytochrome P450-dependent monooxygenase system in rats. Plewka A, etal., Arch Toxicol. 2004 Apr;78(4):194-200. Epub 2003 Nov 1.
17. Selective downregulation of hepatic cytochrome P450 expression and activity in a rat model of inflammatory pain. Projean D, etal., Pharm Res. 2005 Jan;22(1):62-70.
18. Role of temperature on protein and mRNA cytochrome P450 3A (CYP3A) isozymes expression and midazolam oxidation by cultured rat precision-cut liver slices. Rekka E, etal., Biochem Pharmacol 2002 Aug 15;64(4):633-43.
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Soy protein isolate induces CYP3A1 and CYP3A2 in prepubertal rats. Ronis MJ, etal., Exp Biol Med (Maywood). 2006 Jan;231(1):60-9.
22. In vivo effects of chronic contamination with depleted uranium on CYP3A and associated nuclear receptors PXR and CAR in the rat. Souidi M, etal., Toxicology. 2005 Oct 15;214(1-2):113-22.
23. Induction of cytochrome P450 enzymes in rat liver by two conazoles, myclobutanil and triadimefon. Sun G, etal., Xenobiotica. 2007 Feb;37(2):180-93.
24. Critical amino-terminal segments in insertion of rat liver cytochrome P450 3A1 into the endoplasmic reticulum membrane. Van den Broek PJ, etal., Experientia 1996 Sep 15;52(9):851-5.
Additional References at PubMed
PMID:1298226   PMID:1372436   PMID:1417000   PMID:1731631   PMID:2398038   PMID:3875783   PMID:7528203   PMID:7681660   PMID:8274011   PMID:11901229   PMID:12477932   PMID:15979568  
PMID:16461430   PMID:19435144   PMID:19504095   PMID:19848203   PMID:20599767   PMID:22159698   PMID:22822673   PMID:23235327   PMID:23762486   PMID:24212381   PMID:25302309   PMID:25989892  
PMID:26900149   PMID:27899252   PMID:28532222   PMID:29381299   PMID:30811654   PMID:34461081  


Genomics

Variants

.
Variants in Cyp3a23-3a1
164 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:181
Count of miRNA genes:139
Interacting mature miRNAs:156
Transcripts:ENSRNOT00000075671
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12592191825247790Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1357337Gluco3Glucose level QTL 30.0004adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)12116966671Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)121186960016966542Rat
61334Gluco17Glucose level QTL 176.3adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)12116966671Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12115486827Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat

Markers in Region
RH94398  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,255,993 - 9,256,161 (+)MAPPERmRatBN7.2
Rnor_6.01211,703,772 - 11,703,939NCBIRnor6.0
Rnor_6.01211,053,723 - 11,053,890NCBIRnor6.0
Rnor_5.01213,145,577 - 13,145,744UniSTSRnor5.0
Rnor_5.01213,766,697 - 13,766,864UniSTSRnor5.0
RGSC_v3.4129,566,955 - 9,567,122UniSTSRGSC3.4
Celera1211,062,850 - 11,063,017UniSTS
Cytogenetic Map12p11UniSTS
RH132534  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,256,029 - 9,256,241 (+)MAPPERmRatBN7.2
Rnor_6.01211,703,808 - 11,704,019NCBIRnor6.0
Rnor_6.01211,053,759 - 11,053,970NCBIRnor6.0
Rnor_5.01213,766,733 - 13,766,944UniSTSRnor5.0
Rnor_5.01213,145,613 - 13,145,824UniSTSRnor5.0
RGSC_v3.4129,566,991 - 9,567,202UniSTSRGSC3.4
Celera1211,062,886 - 11,063,097UniSTS
RH 3.4 Map12102.2UniSTS
Cytogenetic Map12p11UniSTS
RH142381  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,285,598 - 9,285,757 (+)MAPPERmRatBN7.2
Rnor_6.01211,733,681 - 11,733,839NCBIRnor6.0
Rnor_6.01211,083,321 - 11,083,479NCBIRnor6.0
Rnor_5.01213,796,606 - 13,796,764UniSTSRnor5.0
Rnor_5.01213,175,175 - 13,175,333UniSTSRnor5.0
RGSC_v3.4129,596,553 - 9,596,711UniSTSRGSC3.4
Celera1211,091,516 - 11,091,674UniSTS
RH 3.4 Map12117.0UniSTS
Cytogenetic Map12p11UniSTS


Genetic Models
This gene Cyp3a23-3a1 is modified in the following models/strains:
SD-Cyp3a23/3a1em1Myliu,Cyp3a2em1Myliu    


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 6 21 47 50 37 15 37 81 26 16 13 21 13

Sequence


Ensembl Acc Id: ENSRNOT00000051244   ⟹   ENSRNOP00000041138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,015,383 - 9,285,008 (-)Ensembl
Rnor_6.0 Ensembl1211,703,598 - 11,733,099 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000071669   ⟹   ENSRNOP00000084956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,015,383 - 9,285,008 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087257   ⟹   ENSRNOP00000068625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,207,980 - 9,230,043 (-)Ensembl
Rnor_6.0 Ensembl1211,655,402 - 11,733,136 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099867   ⟹   ENSRNOP00000094020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,207,980 - 9,230,043 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100533   ⟹   ENSRNOP00000082425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1214,368,266 - 14,398,813 (-)Ensembl
mRatBN7.2 Ensembl129,254,475 - 9,285,030 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104663   ⟹   ENSRNOP00000084206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,254,475 - 9,283,058 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118926   ⟹   ENSRNOP00000088335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1214,368,266 - 14,396,698 (-)Ensembl
mRatBN7.2 Ensembl129,254,475 - 9,282,915 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119539   ⟹   ENSRNOP00000087895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1214,368,266 - 14,396,841 (-)Ensembl
mRatBN7.2 Ensembl129,254,475 - 9,283,058 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120620   ⟹   ENSRNOP00000098255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1214,321,771 - 14,343,857 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120621   ⟹   ENSRNOP00000098256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1214,321,771 - 14,343,857 (-)Ensembl
RefSeq Acc Id: NM_013105   ⟹   NP_037237
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81214,369,950 - 14,398,803 (-)NCBI
mRatBN7.2129,256,159 - 9,285,020 (-)NCBI
Rnor_6.01211,053,888 - 11,082,742 (-)NCBI
Rnor_5.01213,145,742 - 13,174,596 (-)NCBI
RGSC_v3.4129,567,120 - 9,595,974 (-)RGD
Celera1211,063,015 - 11,090,937 (-)RGD
Sequence:
RefSeq Acc Id: NP_037237   ⟸   NM_013105
- UniProtKB: A0A8I5ZUW6 (UniProtKB/TrEMBL),   A6K1D8 (UniProtKB/TrEMBL),   Q06884 (UniProtKB/TrEMBL),   Q6LEQ2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068625   ⟸   ENSRNOT00000087257
Ensembl Acc Id: ENSRNOP00000041138   ⟸   ENSRNOT00000051244
Ensembl Acc Id: ENSRNOP00000084206   ⟸   ENSRNOT00000104663
Ensembl Acc Id: ENSRNOP00000082425   ⟸   ENSRNOT00000100533
Ensembl Acc Id: ENSRNOP00000088335   ⟸   ENSRNOT00000118926
Ensembl Acc Id: ENSRNOP00000087895   ⟸   ENSRNOT00000119539
Ensembl Acc Id: ENSRNOP00000094020   ⟸   ENSRNOT00000099867
Ensembl Acc Id: ENSRNOP00000084956   ⟸   ENSRNOT00000071669
Ensembl Acc Id: ENSRNOP00000098255   ⟸   ENSRNOT00000120620
Ensembl Acc Id: ENSRNOP00000098256   ⟸   ENSRNOT00000120621

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04800-F1-model_v2 AlphaFold P04800 1-504 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628626 AgrOrtholog
BioCyc Gene G2FUF-20067 BioCyc
Ensembl Genes ENSRNOG00000032560 Ensembl
  ENSRNOG00000062027 Ensembl
  ENSRNOG00000067532 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000100533 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7370410 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_CYP3A UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-II UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_3A UniProtKB/Swiss-Prot
MGC_CLONE MGC:108757 IMAGE-MGC_LOAD
NCBI Gene Cyp3a23-3a1 ENTREZGENE
PANTHER CYTOCHROME P450 3A-RELATED UniProtKB/Swiss-Prot
  CYTOCHROME P450 FAMILY 3 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PharmGKB CYP3A4 RGD
PhenoGen Cyp3a23-3a1 PhenoGen
PRINTS EP450II UniProtKB/Swiss-Prot
  EP450IICYP3A UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032560 RatGTEx
  ENSRNOG00000062027 RatGTEx
  ENSRNOG00000067532 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
TIGR TC205966
UniProt A0A8I5ZUW6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIP2_RAT UniProtKB/TrEMBL
  A0A8I6GFL1_RAT UniProtKB/TrEMBL
  A0ABK0L3G0_RAT UniProtKB/TrEMBL
  A6K1D8 ENTREZGENE
  CP3A1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q06884 ENTREZGENE, UniProtKB/TrEMBL
  Q6LEQ2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q64580 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Cyp3a23-3a1  cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1  AABR07035343.1    Data merged from RGD:15014538 737654 PROVISIONAL
2021-03-09 Cyp3a23-3a1  cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1  LOC100910877  cytochrome P450 3A1-like  Data merged from RGD:6495986 737654 PROVISIONAL
2020-04-16 Cyp3a23-3a1  cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1  Cyp3a23-3a1  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1  Name changed 629549 APPROVED
2020-04-16 Cyp3a23-3a1  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1  Cyp3a23/3a1  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1  Symbol changed 629549 APPROVED
2019-11-08 AABR07035343.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2012-07-05 LOC100910877  cytochrome P450 3A1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-08 Cyp3a23/3a1  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1  Cyp3a23/3a1_retired  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1_retired  Data merged from RGD:2478 737654 APPROVED
2007-09-21 Cyp3a23/3a1  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1  Cyp3a1  cytochrome P450, family 3, subfamily a, polypeptide 1  Symbol and Name updated 1299863 APPROVED
2007-09-21 Cyp3a23/3a1_retired  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1_retired  Cyp3a23/3a1  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1  Symbol and Name updated 1299863 PROVISIONAL
2007-07-06 Cyp3a23/3a1  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1  Cyp3a3  cytochrome P450, subfamily 3A, polypeptide 3  Name updated 1299863 APPROVED
2005-09-08 Cyp3a1  cytochrome P450, family 3, subfamily a, polypeptide 1  Cyp3A1  cytochrome P-450PCN (PNCN inducible)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2003-02-27 Cyp3A1  cytochrome P-450PCN (PNCN inducible)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-11-06 Cyp3a3  cytochrome P450, subfamily 3A, polypeptide 3    Cytochrome P450, subfamily IIIA, polypeptide 3  Name updated 625702 APPROVED
2002-06-10 Cyp3a3  Cytochrome P450, subfamily IIIA, polypeptide 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs induced strongly by pregnenolone 16 alpha-carbonitrile and dexamethasone (DEX) and weakly by phenobarbital (PB) and triacetyloleandomycin 1298860
gene_expression expressed in liver 1298860