Prkch (protein kinase C, eta) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Prkch (protein kinase C, eta) Rattus norvegicus
Analyze
Symbol: Prkch
Name: protein kinase C, eta
RGD ID: 621888
Description: Enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity. Involved in phospholipase C/protein kinase C signal transduction. Predicted to be located in cell-cell junction; cytosol; and plasma membrane. Human ortholog(s) of this gene implicated in cerebral infarction. Orthologous to human PRKCH (protein kinase C eta); PARTICIPATES IN protein kinase C (PKC) signaling pathway; eicosanoid signaling pathway; endothelin signaling pathway; INTERACTS WITH (+)-pilocarpine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC93383; nPKC-eta; PKC-L; protein kinase C eta type; protein kinase C-eta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8698,027,830 - 98,226,486 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl698,027,646 - 98,226,477 (+)EnsemblGRCr8
mRatBN7.2692,292,000 - 92,490,663 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl692,292,000 - 92,490,654 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx692,681,221 - 92,880,182 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0692,980,754 - 93,179,715 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0692,408,607 - 92,607,569 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0696,479,243 - 96,677,368 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl696,479,430 - 96,676,225 (+)Ensemblrn6Rnor6.0
Rnor_5.06105,910,127 - 106,109,230 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4696,069,354 - 96,281,790 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera690,752,440 - 90,949,802 (+)NCBICelera
RGSC_v3.1696,072,809 - 96,285,242 (+)NCBI
Cytogenetic Map6q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-palmitoylglycerol  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
clotrimazole  (EXP)
cobalt dichloride  (EXP,ISO)
coumarin  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folpet  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
glucose  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
imiquimod  (ISO)
indometacin  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methoxyacetic acid  (EXP)
methoxychlor  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
orphenadrine  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
permethrin  (EXP)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
propanal  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell-cell junction  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Protein kinase C translocation and PKC-dependent protein phosphorylation during myocardial ischemia. Albert CJ and Ford DA, Am J Physiol. 1999 Feb;276(2 Pt 2):H642-50.
2. Protein kinase C eta mediates lipopolysaccharide-induced nitric-oxide synthase expression in primary astrocytes. Chen CC, etal., J Biol Chem. 1998 Jul 31;273(31):19424-30.
3. Biochemical properties of rat protein kinase C-eta expressed in COS cells. Dekker LV, etal., FEBS Lett 1992 Nov 9;312(2-3):195-9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Selective changes in protein kinase C isoforms and phosphorylation of endogenous substrate proteins in rat cerebral cortex during pre- and postnatal ethanol exposure. Mahadev K and Vemuri MC, Arch Biochem Biophys. 1998 Aug 15;356(2):249-57.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Protein kinase C: poised to signal. Newton AC Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402. Epub 2009 Nov 24.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10806212   PMID:11772428   PMID:12456804   PMID:15383279   PMID:15489334   PMID:15632189   PMID:17161867   PMID:17728398   PMID:18780722   PMID:19056867   PMID:19114660   PMID:20558593  
PMID:21346190   PMID:21820409   PMID:22304920   PMID:23793062   PMID:26199377   PMID:29482336   PMID:38115999  


Genomics

Comparative Map Data
Prkch
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8698,027,830 - 98,226,486 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl698,027,646 - 98,226,477 (+)EnsemblGRCr8
mRatBN7.2692,292,000 - 92,490,663 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl692,292,000 - 92,490,654 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx692,681,221 - 92,880,182 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0692,980,754 - 93,179,715 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0692,408,607 - 92,607,569 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0696,479,243 - 96,677,368 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl696,479,430 - 96,676,225 (+)Ensemblrn6Rnor6.0
Rnor_5.06105,910,127 - 106,109,230 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4696,069,354 - 96,281,790 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera690,752,440 - 90,949,802 (+)NCBICelera
RGSC_v3.1696,072,809 - 96,285,242 (+)NCBI
Cytogenetic Map6q24NCBI
PRKCH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381461,187,468 - 61,550,976 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1461,187,559 - 61,550,980 (+)Ensemblhg38GRCh38
GRCh371461,788,297 - 62,017,694 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361460,858,268 - 61,087,451 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341460,858,267 - 61,087,449NCBI
Celera1441,838,808 - 42,067,977 (+)NCBICelera
Cytogenetic Map14q23.1NCBI
HuRef1441,951,908 - 42,181,287 (+)NCBIHuRef
CHM1_11461,727,931 - 61,957,119 (+)NCBICHM1_1
T2T-CHM13v2.01455,394,377 - 55,757,580 (+)NCBIT2T-CHM13v2.0
Prkch
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391273,631,570 - 73,824,959 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1273,631,570 - 73,824,959 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381273,584,796 - 73,778,185 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1273,584,796 - 73,778,185 (+)Ensemblmm10GRCm38
MGSCv371274,686,028 - 74,879,172 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361274,503,879 - 74,697,023 (+)NCBIMGSCv36mm8
Celera1274,692,700 - 74,888,950 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1230.81NCBI
Prkch
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554668,176,876 - 8,393,446 (-)Ensembl
ChiLan1.0NW_0049554668,178,323 - 8,393,446 (-)NCBIChiLan1.0ChiLan1.0
PRKCH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21562,452,380 - 62,681,297 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11461,668,915 - 61,897,810 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01441,882,022 - 42,151,305 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11460,179,081 - 60,408,251 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1460,179,081 - 60,408,251 (+)EnsemblpanPan2panpan1.1
PRKCH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1836,185,430 - 36,452,893 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl836,219,212 - 36,451,777 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha835,972,166 - 36,205,993 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0836,452,192 - 36,686,164 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl836,452,206 - 36,686,159 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1836,062,559 - 36,296,413 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0836,139,874 - 36,373,616 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0836,501,849 - 36,735,387 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prkch
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864068,553,449 - 68,765,498 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364955,426,243 - 5,638,245 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364955,426,243 - 5,638,250 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKCH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1190,206,124 - 190,439,426 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11190,205,041 - 190,439,433 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21211,586,916 - 211,817,814 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKCH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12438,489,535 - 38,726,028 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2438,488,970 - 38,724,879 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605326,748,407 - 26,979,557 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkch
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473439,619,273 - 39,830,353 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473439,620,690 - 39,830,281 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Prkch
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1787,828,240 - 88,027,177 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prkch
1496 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:311
Count of miRNA genes:197
Interacting mature miRNAs:235
Transcripts:ENSRNOT00000006729
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat

Markers in Region
D6Rat63  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2692,484,482 - 92,484,655 (+)MAPPERmRatBN7.2
Rnor_6.0696,671,188 - 96,671,360NCBIRnor6.0
Rnor_5.06106,103,055 - 106,103,227UniSTSRnor5.0
RGSC_v3.4696,275,614 - 96,275,787RGDRGSC3.4
RGSC_v3.4696,275,615 - 96,275,787UniSTSRGSC3.4
Celera690,943,627 - 90,943,799UniSTS
RGSC_v3.1696,279,071 - 96,279,243RGD
RH 3.4 Map6663.8RGD
RH 3.4 Map6663.8UniSTS
RH 2.0 Map6855.3RGD
SHRSP x BN Map655.6199RGD
Cytogenetic Map6q24UniSTS
D6Got119  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2692,455,312 - 92,455,496 (+)MAPPERmRatBN7.2
Rnor_6.0696,642,029 - 96,642,212NCBIRnor6.0
Rnor_5.06106,073,139 - 106,073,322UniSTSRnor5.0
RGSC_v3.4696,245,470 - 96,245,654RGDRGSC3.4
RGSC_v3.4696,245,471 - 96,245,654UniSTSRGSC3.4
Celera690,914,468 - 90,914,651UniSTS
RGSC_v3.1696,248,927 - 96,249,110RGD
RH 3.4 Map6656.1UniSTS
RH 3.4 Map6656.1RGD
RH 2.0 Map6868.6RGD
Cytogenetic Map6q24UniSTS
BF387973  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2692,462,224 - 92,462,377 (+)MAPPERmRatBN7.2
Rnor_6.0696,648,941 - 96,649,093NCBIRnor6.0
Rnor_5.06106,080,051 - 106,080,203UniSTSRnor5.0
RGSC_v3.4696,252,383 - 96,252,535UniSTSRGSC3.4
Celera690,921,330 - 90,921,482UniSTS
RH 3.4 Map6658.4UniSTS
Cytogenetic Map6q24UniSTS
BF389700  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2692,294,043 - 92,294,204 (+)MAPPERmRatBN7.2
Rnor_6.0696,481,287 - 96,481,447NCBIRnor6.0
Rnor_5.06105,912,171 - 105,912,331UniSTSRnor5.0
RGSC_v3.4696,071,398 - 96,071,558UniSTSRGSC3.4
Celera690,754,484 - 90,754,644UniSTS
RH 3.4 Map6657.5UniSTS
Cytogenetic Map6q24UniSTS
AU047887  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2692,334,473 - 92,334,597 (+)MAPPERmRatBN7.2
Rnor_6.0696,521,722 - 96,521,845NCBIRnor6.0
Rnor_5.06105,952,591 - 105,952,714UniSTSRnor5.0
RGSC_v3.4696,111,812 - 96,111,935UniSTSRGSC3.4
Celera690,795,150 - 90,795,273UniSTS
Cytogenetic Map6q24UniSTS
RH135129  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2692,296,826 - 92,297,030 (+)MAPPERmRatBN7.2
Rnor_6.0696,484,070 - 96,484,273NCBIRnor6.0
Rnor_5.06105,914,954 - 105,915,157UniSTSRnor5.0
RGSC_v3.4696,074,181 - 96,074,384UniSTSRGSC3.4
Celera690,757,267 - 90,757,470UniSTS
RH 3.4 Map6658.5UniSTS
Cytogenetic Map6q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000006729   ⟹   ENSRNOP00000006729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl698,027,646 - 98,226,477 (+)Ensembl
mRatBN7.2 Ensembl692,292,000 - 92,490,654 (+)Ensembl
Rnor_6.0 Ensembl696,479,430 - 96,676,225 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106502   ⟹   ENSRNOP00000095346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl698,027,646 - 98,226,477 (+)Ensembl
mRatBN7.2 Ensembl692,292,000 - 92,490,654 (+)Ensembl
RefSeq Acc Id: NM_031085   ⟹   NP_112347
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8698,027,830 - 98,226,481 (+)NCBI
mRatBN7.2692,292,000 - 92,490,658 (+)NCBI
Rnor_6.0696,479,243 - 96,677,363 (+)NCBI
Rnor_5.06105,910,127 - 106,109,230 (+)NCBI
RGSC_v3.4696,069,354 - 96,281,790 (+)RGD
Celera690,752,440 - 90,949,802 (+)RGD
Sequence:
RefSeq Acc Id: XM_039112995   ⟹   XP_038968923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8698,032,734 - 98,226,486 (+)NCBI
mRatBN7.2692,296,908 - 92,490,663 (+)NCBI
Protein Sequences
Protein RefSeqs NP_112347 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968923 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH81782 (Get FASTA)   NCBI Sequence Viewer  
  CAA48466 (Get FASTA)   NCBI Sequence Viewer  
  EDM03619 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006729
  ENSRNOP00000006729.7
GenBank Protein Q64617 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112347   ⟸   NM_031085
- UniProtKB: Q64617 (UniProtKB/Swiss-Prot),   A6HC64 (UniProtKB/TrEMBL),   A0A8I6AMW9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006729   ⟸   ENSRNOT00000006729
RefSeq Acc Id: XP_038968923   ⟸   XM_039112995
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000095346   ⟸   ENSRNOT00000106502
Protein Domains
AGC-kinase C-terminal   C2   Phorbol-ester/DAG-type   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64617-F1-model_v2 AlphaFold Q64617 1-683 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621888 AgrOrtholog
BioCyc Gene G2FUF-37105 BioCyc
Ensembl Genes ENSRNOG00000004873 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006729 ENTREZGENE
  ENSRNOT00000006729.8 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot
  3.30.60.20 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5621110 IMAGE-MGC_LOAD
  IMAGE:7123785 IMAGE-MGC_LOAD
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  C1-like_sf UniProtKB/Swiss-Prot
  C2_dom UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  DAG/PE-bd UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  nPKC_eta UniProtKB/Swiss-Prot
  PE/DAG-bd UniProtKB/Swiss-Prot
  PKC_eta UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
  Prot_kin_PKC_delta UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:81749 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72415 IMAGE-MGC_LOAD
  MGC:93383 IMAGE-MGC_LOAD
NCBI Gene 81749 ENTREZGENE
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot
Pfam C1_1 UniProtKB/Swiss-Prot
  PF00168 UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
PhenoGen Prkch PhenoGen
PIRSF PKC_delta UniProtKB/Swiss-Prot
  Protein_kin_C_eta UniProtKB/Swiss-Prot
PRINTS DAGPEDOMAIN UniProtKB/Swiss-Prot
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  PS50004 UniProtKB/Swiss-Prot
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004873 RatGTEx
SMART S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
  SM00109 UniProtKB/Swiss-Prot
  SM00239 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
  SSF57889 UniProtKB/Swiss-Prot
UniProt A0A8I6AMW9 ENTREZGENE, UniProtKB/TrEMBL
  A6HC64 ENTREZGENE, UniProtKB/TrEMBL
  KPCL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Prkch  protein kinase C, eta    protein kinase C-eta  Name updated 1299863 APPROVED
2002-08-07 Prkch  protein kinase C-eta      Symbol and Name status set to provisional 70820 PROVISIONAL