Plcb2 (phospholipase C, beta 2) - Rat Genome Database

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Gene: Plcb2 (phospholipase C, beta 2) Rattus norvegicus
Analyze
Symbol: Plcb2
Name: phospholipase C, beta 2
RGD ID: 621004
Description: Enables G-protein beta/gamma-subunit complex binding activity; phosphatidylinositol-4,5-bisphosphate phospholipase C activity; and phospholipid binding activity. Involved in detection of chemical stimulus involved in sensory perception of bitter taste and phospholipase C-activating G protein-coupled receptor signaling pathway. Part of G-protein beta/gamma-subunit complex. Orthologous to human PLCB2 (phospholipase C beta 2); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; G protein mediated signaling pathway via Galphaq family; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2; phosphoinositide phospholipase C-beta-2; phospholipase C beta 2; phospholipase C-beta-2; PKC beta II; PLC-beta-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,134,925 - 126,158,303 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3126,138,736 - 126,158,221 (-)EnsemblGRCr8
mRatBN7.23105,683,676 - 105,704,384 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,684,815 - 105,704,302 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3109,357,684 - 109,377,152 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03117,953,248 - 117,972,712 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03115,613,610 - 115,633,075 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03110,497,760 - 110,517,563 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,498,114 - 110,517,163 (-)Ensemblrn6Rnor6.0
Rnor_5.03117,038,677 - 117,058,132 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43105,203,524 - 105,223,342 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3104,599,222 - 104,618,601 (-)NCBICelera
RGSC_v3.13105,099,951 - 105,119,770 (-)NCBI
Cytogenetic Map3q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Identification of phospholipase C beta isoforms and their location in cultured vascular smooth muscle cells of pig, human and rat. Blayney L, etal., Cardiovasc Res. 1998 Dec;40(3):564-72.
2. Stimulation of phospholipase Cbeta by membrane interactions, interdomain movement, and G protein binding--how many ways can you activate an enzyme? Drin G and Scarlata S, Cell Signal. 2007 Jul;19(7):1383-92. Epub 2007 Apr 29.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Subcellular localization of phospholipase C isoforms in vascular smooth muscle. LaBelle EF, etal., Biochim Biophys Acta. 2002 Aug 8;1583(3):273-8.
7. Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Li Z, etal., Science 2000 Feb 11;287(5455):1046-9.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Regulation of phosphoinositide-specific phospholipase C. Rhee SG Annu Rev Biochem. 2001;70:281-312.
15. Identification of a phospholipase C beta subtype in rat taste cells. Rossler P, etal., Eur J Cell Biol 1998 Nov;77(3):253-61.
16. Differential association of the pleckstrin homology domains of phospholipases C-beta 1, C-beta 2, and C-delta 1 with lipid bilayers and the beta gamma subunits of heterotrimeric G proteins. Wang T, etal., Biochemistry. 1999 Feb 2;38(5):1517-24.
17. Evidence for the involvement of a phospholipase C--protein kinase C signaling pathway in insulin stimulated glucose transport in skeletal muscle. Wright DC, etal., Life Sci 2003 May 23;73(1):61-71.
18. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Zhang Y, etal., Cell 2003 Feb 7;112(3):293-301.
Additional References at PubMed
PMID:8454637   PMID:8519600   PMID:15759003   PMID:18820027   PMID:20393598   PMID:21606356   PMID:23010799   PMID:23625927   PMID:36934663  


Genomics

Comparative Map Data
Plcb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,134,925 - 126,158,303 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3126,138,736 - 126,158,221 (-)EnsemblGRCr8
mRatBN7.23105,683,676 - 105,704,384 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,684,815 - 105,704,302 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3109,357,684 - 109,377,152 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03117,953,248 - 117,972,712 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03115,613,610 - 115,633,075 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03110,497,760 - 110,517,563 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,498,114 - 110,517,163 (-)Ensemblrn6Rnor6.0
Rnor_5.03117,038,677 - 117,058,132 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43105,203,524 - 105,223,342 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3104,599,222 - 104,618,601 (-)NCBICelera
RGSC_v3.13105,099,951 - 105,119,770 (-)NCBI
Cytogenetic Map3q35NCBI
PLCB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381540,284,256 - 40,307,935 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1540,278,176 - 40,307,941 (-)Ensemblhg38GRCh38
GRCh371540,580,110 - 40,600,136 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361538,367,390 - 38,387,466 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341538,367,401 - 38,387,330NCBI
Celera1517,346,090 - 17,366,157 (-)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1517,423,058 - 17,443,532 (-)NCBIHuRef
CHM1_11540,700,041 - 40,720,115 (-)NCBICHM1_1
T2T-CHM13v2.01538,091,173 - 38,114,815 (-)NCBIT2T-CHM13v2.0
Plcb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392118,535,484 - 118,559,140 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2118,537,998 - 118,558,919 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382118,705,003 - 118,728,661 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2118,707,517 - 118,728,438 (-)Ensemblmm10GRCm38
MGSCv372118,533,253 - 118,554,174 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362118,398,958 - 118,419,879 (-)NCBIMGSCv36mm8
Celera2119,861,823 - 119,882,734 (-)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.43NCBI
Plcb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554167,218,417 - 7,240,739 (-)Ensembl
ChiLan1.0NW_0049554167,221,326 - 7,240,743 (-)NCBIChiLan1.0ChiLan1.0
PLCB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21629,518,245 - 29,541,893 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11533,669,673 - 33,693,337 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01519,218,329 - 19,241,977 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11537,476,699 - 37,496,813 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1537,476,699 - 37,496,813 (-)EnsemblpanPan2panpan1.1
PLCB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1307,472,208 - 7,493,106 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl307,472,413 - 7,492,801 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha307,526,161 - 7,547,075 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0307,598,044 - 7,618,970 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl307,594,683 - 7,619,120 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1307,522,589 - 7,543,490 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0307,628,543 - 7,649,438 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0307,757,123 - 7,778,226 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Plcb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864085,908,907 - 85,928,377 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364713,756,970 - 3,776,392 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364713,756,978 - 3,776,452 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLCB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1131,005,408 - 131,028,689 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11131,005,408 - 131,031,864 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21146,286,447 - 146,302,118 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLCB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,706,462 - 42,727,516 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2642,707,625 - 42,727,145 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604898,236,858 - 98,257,092 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plcb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248047,591,844 - 7,612,645 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248047,593,956 - 7,612,860 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Plcb2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1596,863,183 - 96,882,661 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Plcb2
141 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3122654702136118980Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
Plcb2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83126,144,103 - 126,144,769 (+)Marker Load Pipeline
mRatBN7.23105,690,184 - 105,690,850 (+)MAPPERmRatBN7.2
Rnor_6.03110,503,144 - 110,503,809NCBIRnor6.0
Rnor_5.03117,044,015 - 117,044,680UniSTSRnor5.0
Celera3104,604,484 - 104,605,149UniSTS
Cytogenetic Map3q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 158 91 90 59 92 59 6 355 192 11 133 80 92 31 14 14

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001837051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005501996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010064706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ011035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ120505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ120506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB877226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB895860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC934635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC953269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000078037   ⟹   ENSRNOP00000070903
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3126,138,736 - 126,158,221 (-)Ensembl
mRatBN7.2 Ensembl3105,684,815 - 105,704,302 (-)Ensembl
Rnor_6.0 Ensembl3110,498,114 - 110,517,163 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105616   ⟹   ENSRNOP00000086367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3126,138,736 - 126,158,221 (-)Ensembl
mRatBN7.2 Ensembl3105,684,815 - 105,704,302 (-)Ensembl
RefSeq Acc Id: NM_053478   ⟹   NP_445930
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83126,138,736 - 126,158,221 (-)NCBI
mRatBN7.23105,684,815 - 105,704,302 (-)NCBI
Rnor_6.03110,497,760 - 110,517,261 (-)NCBI
Rnor_5.03117,038,677 - 117,058,132 (-)NCBI
RGSC_v3.43105,203,524 - 105,223,342 (-)RGD
Celera3104,599,222 - 104,618,601 (-)RGD
Sequence:
RefSeq Acc Id: XM_039105997   ⟹   XP_038961925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83126,147,508 - 126,158,303 (-)NCBI
mRatBN7.23105,693,589 - 105,704,384 (-)NCBI
RefSeq Acc Id: XM_063284733   ⟹   XP_063140803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83126,134,925 - 126,158,303 (-)NCBI
RefSeq Acc Id: XM_063284734   ⟹   XP_063140804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83126,134,925 - 126,156,475 (-)NCBI
RefSeq Acc Id: XM_063284735   ⟹   XP_063140805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83126,134,925 - 126,147,419 (-)NCBI
RefSeq Acc Id: XR_001837051
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83126,141,629 - 126,158,303 (-)NCBI
mRatBN7.23105,687,709 - 105,704,384 (-)NCBI
Rnor_6.03110,500,719 - 110,517,563 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005501996
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83126,145,623 - 126,158,303 (-)NCBI
mRatBN7.23105,691,708 - 105,704,384 (-)NCBI
RefSeq Acc Id: XR_010064706
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83126,141,629 - 126,158,303 (-)NCBI
RefSeq Acc Id: NP_445930   ⟸   NM_053478
- UniProtKB: O89040 (UniProtKB/Swiss-Prot),   A0A0G2JZ43 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070903   ⟸   ENSRNOT00000078037
RefSeq Acc Id: XP_038961925   ⟸   XM_039105997
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000086367   ⟸   ENSRNOT00000105616
RefSeq Acc Id: XP_063140803   ⟸   XM_063284733
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JZ43 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140804   ⟸   XM_063284734
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JZ43 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140805   ⟸   XM_063284735
- Peptide Label: isoform X3
- UniProtKB: A6HPB8 (UniProtKB/TrEMBL)
Protein Domains
C2   Phosphatidylinositol-specific phospholipase C X   PI-PLC X-box   PI-PLC Y-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O89040-F1-model_v2 AlphaFold O89040 1-1183 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621004 AgrOrtholog
BioCyc Gene G2FUF-48241 BioCyc
BioCyc Pathway PWY-6351 [D-myo-inositol (1,4,5)-trisphosphate biosynthesis] BioCyc
  PWY-6367 [D-myo-inositol-5-phosphate metabolism] BioCyc
  PWY-8052 [2-arachidonoylglycerol biosynthesis] BioCyc
BioCyc Pathway Image PWY-6351 BioCyc
  PWY-6367 BioCyc
  PWY-8052 BioCyc
Ensembl Genes ENSRNOG00000058337 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000078037 ENTREZGENE
  ENSRNOT00000078037.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1230.10 UniProtKB/Swiss-Prot
  2.30.29.240 UniProtKB/Swiss-Prot
  2.60.40.150 UniProtKB/Swiss-Prot
  3.20.20.190 UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
InterPro C2_Ca-dep UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  EF-hand-like_dom UniProtKB/Swiss-Prot
  Phospholipase_C_Pinositol-sp_C UniProtKB/Swiss-Prot
  Phospholipase_C_Pinositol-sp_Y UniProtKB/Swiss-Prot
  PLC-beta UniProtKB/Swiss-Prot
  PLC-beta2 UniProtKB/Swiss-Prot
  PLC-beta_C UniProtKB/Swiss-Prot
  PLC-beta_C_sf UniProtKB/Swiss-Prot
  PLC-beta_PH UniProtKB/Swiss-Prot
  PLC-like_Pdiesterase_TIM-brl UniProtKB/Swiss-Prot
  PLCB1-4-like_EFh UniProtKB/Swiss-Prot
  PLCbeta2_EF UniProtKB/Swiss-Prot
  PLipase_C_PInositol-sp_X_dom UniProtKB/Swiss-Prot
KEGG Report rno:85240 UniProtKB/Swiss-Prot
NCBI Gene 85240 ENTREZGENE
PANTHER PTHR10336 UniProtKB/Swiss-Prot
  PTHR10336:SF10 UniProtKB/Swiss-Prot
Pfam PF00168 UniProtKB/Swiss-Prot
  PH_14 UniProtKB/Swiss-Prot
  PI-PLC-X UniProtKB/Swiss-Prot
  PI-PLC-Y UniProtKB/Swiss-Prot
  PLC-beta_C UniProtKB/Swiss-Prot
  PLCB1-4-like_EFh UniProtKB/Swiss-Prot
PhenoGen Plcb2 PhenoGen
PIRSF PLC-beta UniProtKB/Swiss-Prot
PRINTS PHPHLIPASEC UniProtKB/Swiss-Prot
PROSITE PIPLC_X_DOMAIN UniProtKB/Swiss-Prot
  PIPLC_Y_DOMAIN UniProtKB/Swiss-Prot
  PS50004 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000058337 RatGTEx
SMART PLCXc UniProtKB/Swiss-Prot
  PLCYc UniProtKB/Swiss-Prot
  SM00239 UniProtKB/Swiss-Prot
Superfamily-SCOP C-terminal domain of PLC-beta UniProtKB/Swiss-Prot
  PH domain-like UniProtKB/Swiss-Prot
  PLC-like_Pdiesterase_TIM-brl UniProtKB/Swiss-Prot
  SSF47473 UniProtKB/Swiss-Prot
  SSF49562 UniProtKB/Swiss-Prot
UniProt A0A0G2JZ43 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GEV3_RAT UniProtKB/TrEMBL
  A6HPB8 ENTREZGENE, UniProtKB/TrEMBL
  A6HPB9_RAT UniProtKB/TrEMBL
  A6HPC0_RAT UniProtKB/TrEMBL
  O89040 ENTREZGENE, UniProtKB/Swiss-Prot
  Q45QJ6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Plcb2  phospholipase C, beta 2    phospholipase C beta 2  Name updated 1299863 APPROVED
2002-08-07 Plcb2  phospholipase C beta 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed exclusively in a subset of taste receptor cells of circumvallate papillae 729588