Ebp (EBP, cholestenol delta-isomerase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Ebp (EBP, cholestenol delta-isomerase) Rattus norvegicus
Analyze
Symbol: Ebp
Name: EBP, cholestenol delta-isomerase
RGD ID: 620957
Description: Enables C-8 sterol isomerase activity. Involved in cholesterol biosynthetic process. Predicted to be located in nuclear envelope. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in MEND syndrome; X-linked chondrodysplasia punctata 2; and chondrodysplasia punctata. Orthologous to human EBP (EBP cholestenol delta-isomerase); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; cholestenol Delta-isomerase; cholesterol-5,6-epoxide hydrolase subunit EBP; D8-D7 sterol isomerase; delta(8)-Delta(7) sterol isomerase; emopamil binding protein (sterol isomerase); emopamil-binding protein; phenylalkylamine Ca2+ antagonist (emopamil) binding protein; sterol 8-isomerase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X16,971,372 - 16,977,782 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX16,971,405 - 16,977,781 (+)EnsemblGRCr8
mRatBN7.2X14,299,427 - 14,305,826 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,299,448 - 14,305,826 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX19,112,990 - 19,119,361 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,963,718 - 20,970,092 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X17,228,913 - 17,235,289 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,049,394 - 15,055,782 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,049,462 - 15,055,781 (+)Ensemblrn6Rnor6.0
Rnor_5.0X15,832,710 - 15,839,093 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X26,331,199 - 26,337,542 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX14,384,941 - 14,391,269 (+)NCBICelera
RGSC_v3.1X26,384,667 - 26,391,010 (+)NCBI
Cytogenetic MapXq12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
arachidonic acid  (ISO)
Archazolid B  (ISO)
arsenite(3-)  (ISO)
avobenzone  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP,ISO)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (EXP)
Di-n-hexyl phthalate  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloromethane  (ISO)
Dicyclohexyl phthalate  (EXP)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dipentyl phthalate  (EXP)
diuron  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
Erionite  (ISO)
ethyl methanesulfonate  (ISO)
fluoxetine  (ISO)
flusilazole  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
isobutanol  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
nefazodone  (EXP)
nitrofen  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
piroxicam  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
triacsin C  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
Yessotoxin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Cholesterol biosynthesis from lanosterol: molecular cloning, chromosomal localization, functional expression and liver-specific gene regulation of rat sterol delta8-isomerase, a cholesterogenic enzyme with multiple functions. Bae S, etal., Biochem J 2001 Feb 1;353(Pt 3):689-99.
2. Mutations in a delta 8-delta 7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. jderry@immunex.com. Derry JM, etal., Nat Genet 1999 Jul;22(3):286-90.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes. Herman GE Hum Mol Genet. 2003 Apr 1;12 Spec No 1:R75-88.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
Additional References at PubMed
PMID:8798407   PMID:9894009   PMID:10391219   PMID:10406945   PMID:10987663  


Genomics

Comparative Map Data
Ebp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X16,971,372 - 16,977,782 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX16,971,405 - 16,977,781 (+)EnsemblGRCr8
mRatBN7.2X14,299,427 - 14,305,826 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,299,448 - 14,305,826 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX19,112,990 - 19,119,361 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,963,718 - 20,970,092 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X17,228,913 - 17,235,289 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,049,394 - 15,055,782 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,049,462 - 15,055,781 (+)Ensemblrn6Rnor6.0
Rnor_5.0X15,832,710 - 15,839,093 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X26,331,199 - 26,337,542 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX14,384,941 - 14,391,269 (+)NCBICelera
RGSC_v3.1X26,384,667 - 26,391,010 (+)NCBI
Cytogenetic MapXq12NCBI
EBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,521,808 - 48,528,716 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX48,521,089 - 48,528,716 (+)Ensemblhg38GRCh38
GRCh37X48,380,196 - 48,387,104 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,265,201 - 48,272,048 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X48,136,510 - 48,143,356NCBI
CeleraX53,278,627 - 53,285,567 (-)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX46,043,290 - 46,050,391 (+)NCBIHuRef
CHM1_1X48,411,425 - 48,418,366 (+)NCBICHM1_1
T2T-CHM13v2.0X47,930,820 - 47,937,730 (+)NCBIT2T-CHM13v2.0
Ebp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X8,051,568 - 8,059,751 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX8,051,568 - 8,059,751 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X8,185,329 - 8,193,512 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX8,185,329 - 8,193,512 (-)Ensemblmm10GRCm38
MGSCv37X7,762,457 - 7,770,638 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X7,342,290 - 7,350,471 (-)NCBIMGSCv36mm8
CeleraX3,276,541 - 3,284,699 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.7NCBI
Ebp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495554392,122 - 98,370 (+)Ensembl
ChiLan1.0NW_00495554392,553 - 98,370 (+)NCBIChiLan1.0ChiLan1.0
EBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X50,010,179 - 50,017,556 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X50,014,011 - 50,020,928 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X40,820,042 - 40,826,957 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X48,683,531 - 48,690,829 (+)NCBIPanPan1.1PanPan1.1panPan2
EBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,774,857 - 41,779,474 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,762,692 - 41,779,476 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX16,151,069 - 16,155,685 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X42,014,717 - 42,019,084 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX42,014,187 - 42,019,315 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X41,897,937 - 41,902,543 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X41,886,230 - 41,890,855 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X41,979,795 - 41,984,410 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ebp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,268,094 - 34,275,579 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936721509,374 - 515,918 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936721508,716 - 515,968 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,670,633 - 42,678,570 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X42,670,592 - 42,678,571 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,619,482 - 47,627,465 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X45,652,398 - 45,660,551 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX45,653,356 - 45,660,291 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607611,104,334 - 11,112,368 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ebp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624893341,129 - 347,717 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624893340,843 - 346,560 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ebp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X15,598,840 - 15,603,227 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ebp
21 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:46
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000007015
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149344939387Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X400149324470521Rat

Markers in Region
DXS7465E  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X16,970,183 - 16,970,285 (+)Marker Load Pipeline
mRatBN7.2X14,298,223 - 14,298,326 (+)MAPPERmRatBN7.2
Rnor_6.0X15,048,183 - 15,048,285NCBIRnor6.0
Rnor_5.0X15,831,494 - 15,831,596UniSTSRnor5.0
RGSC_v3.4X26,329,920 - 26,330,022UniSTSRGSC3.4
CeleraX14,383,662 - 14,383,764UniSTS
Cytogenetic MapXq13UniSTS
RH131140  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,305,517 - 14,305,704 (+)MAPPERmRatBN7.2
Rnor_6.0X15,055,474 - 15,055,660NCBIRnor6.0
Rnor_5.0X15,838,785 - 15,838,971UniSTSRnor5.0
RGSC_v3.4X26,337,234 - 26,337,420UniSTSRGSC3.4
CeleraX14,390,961 - 14,391,147UniSTS
Cytogenetic MapXq13UniSTS
RH131962  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,298,187 - 14,298,369 (+)MAPPERmRatBN7.2
Rnor_6.0X15,048,147 - 15,048,328NCBIRnor6.0
Rnor_5.0X15,831,458 - 15,831,639UniSTSRnor5.0
RGSC_v3.4X26,329,884 - 26,330,065UniSTSRGSC3.4
CeleraX14,383,626 - 14,383,807UniSTS
RH 3.4 MapX135.7UniSTS
Cytogenetic MapXq13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000007015   ⟹   ENSRNOP00000007015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX16,971,405 - 16,977,781 (+)Ensembl
mRatBN7.2 EnsemblX14,299,448 - 14,305,826 (+)Ensembl
Rnor_6.0 EnsemblX15,049,462 - 15,055,781 (+)Ensembl
RefSeq Acc Id: NM_057137   ⟹   NP_476478
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X16,971,462 - 16,977,782 (+)NCBI
mRatBN7.2X14,299,503 - 14,305,826 (+)NCBI
Rnor_6.0X15,049,462 - 15,055,782 (+)NCBI
Rnor_5.0X15,832,710 - 15,839,093 (+)NCBI
RGSC_v3.4X26,331,199 - 26,337,542 (+)RGD
CeleraX14,384,941 - 14,391,269 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256699   ⟹   XP_006256761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X16,971,372 - 16,977,782 (+)NCBI
mRatBN7.2X14,299,427 - 14,305,826 (+)NCBI
Rnor_6.0X15,049,394 - 15,055,782 (+)NCBI
Rnor_5.0X15,832,710 - 15,839,093 (+)NCBI
Sequence:
RefSeq Acc Id: NP_476478   ⟸   NM_057137
- UniProtKB: Q548M8 (UniProtKB/Swiss-Prot),   Q9JJ46 (UniProtKB/Swiss-Prot),   A6KP43 (UniProtKB/TrEMBL),   A6KP42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256761   ⟸   XM_006256699
- Peptide Label: isoform X1
- UniProtKB: Q548M8 (UniProtKB/Swiss-Prot),   Q9JJ46 (UniProtKB/Swiss-Prot),   A6KP43 (UniProtKB/TrEMBL),   A6KP42 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007015   ⟸   ENSRNOT00000007015
Protein Domains
EXPERA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJ46-F1-model_v2 AlphaFold Q9JJ46 1-230 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701728
Promoter ID:EPDNEW_R12252
Type:initiation region
Name:Ebp_1
Description:emopamil binding protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X15,049,448 - 15,049,508EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620957 AgrOrtholog
BioCyc Gene G2FUF-2949 BioCyc
Ensembl Genes ENSRNOG00000004903 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007015 ENTREZGENE
  ENSRNOT00000007015.7 UniProtKB/Swiss-Prot
InterPro EBP UniProtKB/Swiss-Prot
  EXPERA UniProtKB/Swiss-Prot
KEGG Report rno:117278 UniProtKB/Swiss-Prot
NCBI Gene 117278 ENTREZGENE
PANTHER 3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE UniProtKB/Swiss-Prot
  PTHR14207 UniProtKB/Swiss-Prot
Pfam EBP UniProtKB/Swiss-Prot
PhenoGen Ebp PhenoGen
PROSITE EXPERA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004903 RatGTEx
UniProt A6KP42 ENTREZGENE, UniProtKB/TrEMBL
  A6KP43 ENTREZGENE, UniProtKB/TrEMBL
  EBP_RAT UniProtKB/Swiss-Prot
  Q548M8 ENTREZGENE
  Q9JJ46 ENTREZGENE
UniProt Secondary Q548M8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-18 Ebp  EBP, cholestenol delta-isomerase  Ebp  emopamil binding protein (sterol isomerase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-17 Ebp  emopamil binding protein (sterol isomerase)  Ebp  phenylalkylamine Ca2+ antagonist (emopamil) binding protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Ebp  phenylalkylamine Ca2+ antagonist (emopamil) binding protein      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ebp  phenylalkylamine Ca2+ antagonist (emopamil) binding protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease mutations in the human homolog are associated with Conradi-Hunermann syndrome 628445
gene_drugs 25-hydroxycholesterol suppressed the mRNA in H4IIE cells, no effect observed in emopamil-treated cells 628445
gene_expression expressed in hepatocytes 628445
gene_function acts as a catalyst in the cholesterol pathway converting 8-ene isomer to 7-ene isomer 628445
gene_homology 87% and 80% amino-acid identity to mouse and human, respectively 628445
gene_other does not reqiure any additional reducing cofactor for its catalytic activities unlike any other cholesterol biosynthetic enzymes 628445
gene_pathway involved in the cholesterol binding pathway 628445
gene_product member of the Ebp family 628445
gene_protein 230 amino acids; 26.7 kDa 628445
gene_regulation transcription is regulated by an oestrogen receptor antagonist tamoxifen 628445