Nme2 (NME/NM23 nucleoside diphosphate kinase 2) - Rat Genome Database

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Gene: Nme2 (NME/NM23 nucleoside diphosphate kinase 2) Rattus norvegicus
Analyze
Symbol: Nme2
Name: NME/NM23 nucleoside diphosphate kinase 2
RGD ID: 619877
Description: Enables several functions, including identical protein binding activity; intermediate filament binding activity; and kinase activity. Involved in several processes, including cellular response to glucose stimulus; response to growth hormone; and ribonucleoside triphosphate biosynthetic process. Located in intermediate filament; mitochondrial membrane; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in teratoma. Orthologous to several human genes including NME2 (NME/NM23 nucleoside diphosphate kinase 2); PARTICIPATES IN adefovir pharmacokinetics pathway; de novo pyrimidine biosynthetic pathway; Glut1 deficiency syndrome pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: expressed in non-metastatic cells 2; histidine protein kinase NDKB; NDK B; NDKB; NDP kinase alpha; NDP kinase B; nm23-2; non-metastatic cells 2, protein (NM23B) expressed in; nucleoside diphosphate kinase; nucleoside diphosphate kinase B; P18; p18-12d
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Nme2-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81079,394,999 - 79,400,418 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2011,179,066 - 11,179,497 (-)EnsemblGRCr8
GRCr8 Ensembl1079,394,999 - 79,400,504 (-)EnsemblGRCr8
mRatBN7.21078,898,097 - 78,903,514 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2011,179,488 - 11,179,919 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1078,897,770 - 78,903,538 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1083,508,941 - 83,514,439 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01083,007,040 - 83,012,538 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01078,478,407 - 78,483,899 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01081,648,216 - 81,653,717 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1081,648,216 - 81,653,717 (-)Ensemblrn6Rnor6.0
Rnor_5.01081,478,178 - 81,483,679 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41082,582,766 - 82,588,269 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1077,694,496 - 77,700,026 (-)NCBICelera
RGSC_v3.11082,597,135 - 82,602,639 (-)NCBI
Cytogenetic Map10q26NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-bromohexadecanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
astaxanthin  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cocaine  (ISO)
cromoglycate(2-)  (EXP)
Cuprizon  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP)
eugenol  (EXP)
fentin chloride  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
indometacin  (EXP)
L-ethionine  (EXP)
L-methionine  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
Mesaconitine  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
mifepristone  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
Nonylphenol  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
omeprazole  (EXP)
ozone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (EXP)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (EXP)
pyrimidifen  (ISO)
quinoline  (ISO)
rotenone  (ISO)
sarin  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sulfadimethoxine  (EXP)
T-2 toxin  (EXP)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
triphenylstannane  (ISO)
trovafloxacin  (EXP)
tungsten  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell periphery  (ISO,ISS)
cytoplasm  (IEA,ISO,ISS)
cytosol  (ISO)
focal adhesion  (ISO,ISS)
intermediate filament  (IDA)
lamellipodium  (IEA,ISO,ISS)
mitochondrial membrane  (IDA)
nucleus  (IEA)
perinuclear region of cytoplasm  (IDA)
ruffle  (IEA,ISO,ISS)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Inhibition of nucleoside diphosphate kinase (NDPK/nm23) by cAMP analogues. Anciaux K, etal., FEBS Lett. 1997 Jan 2;400(1):75-9.
2. Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I. Baillat G, etal., J Biol Chem 2002 May 24;277(21):18961-6.
3. Growth hormone (GH) action in the developing lung: changes in lung proteins after adenoviral GH overexpression. Beyea JA, etal., Dev Dyn. 2005 Oct;234(2):404-12.
4. Capturing proteins that bind polyunsaturated fatty acids: demonstration using arachidonic acid and eicosanoids. Brock TG Lipids. 2008 Feb;43(2):161-9. Epub 2007 Dec 15.
5. Recombinant rat nucleoside diphosphate kinase isoforms (alpha and beta): purification, properties and application to immunological detection of native isoforms in rat tissues. Fukuchi T, etal., Biochim Biophys Acta. 1994 Mar 16;1205(1):113-22.
6. Decreased expression of nucleoside diphosphate kinase alpha isoform, an nm23-H2 gene homolog, is associated with metastatic potential of rat mammary-adenocarcinoma cells. Fukuda M, etal., Int J Cancer. 1996 Feb 8;65(4):531-7.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Oligomeric structure and autophosphorylation of nucleoside diphosphate kinase from rat mucosal mast cells. Hemmerich S and Pecht I, Biochemistry. 1992 May 19;31(19):4580-7.
9. A cromoglycate binding protein from rat mast cells of a leukemia line is a nucleoside diphosphate kinase. Hemmerich S, etal., Biochemistry 1992 May 19;31(19):4574-9.
10. Regulation of cardiac cAMP synthesis and contractility by nucleoside diphosphate kinase B/G protein beta gamma dimer complexes. Hippe HJ, etal., Circ Res. 2007 Apr 27;100(8):1191-9. Epub 2007 Mar 15.
11. De novo synthesis of pyrimidine nucleotides; emerging interfaces with signal transduction pathways. Huang M and Graves LM, Cell Mol Life Sci. 2003 Feb;60(2):321-36.
12. Overexpression of nucleoside diphosphate kinases induces neurite outgrowth and their substitution to inactive forms leads to suppression of nerve growth factor- and dibutyryl cyclic AMP-induced effects in PC12D cells. Ishijima Y, etal., FEBS Lett. 1999 Feb 19;445(1):155-9.
13. M-LDH serves as a regulatory subunit of the cytosolic substrate-channelling complex in vivo. Jovanovic S, etal., J Mol Biol. 2007 Aug 10;371(2):349-61. Epub 2007 Jun 2.
14. Analysis of nm23 gene expressions in human bladder and renal cancers. Kanayama H, etal., Int J Urol. 1994 Dec;1(4):324-31.
15. NM23-H2 involves in negative regulation of Diva and Bcl2L10 in apoptosis signaling. Kang Y, etal., Biochem Biophys Res Commun. 2007 Jul 20;359(1):76-82. doi: 10.1016/j.bbrc.2007.05.090. Epub 2007 May 24.
16. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
17. Isolation and characterization of a cDNA clone encoding rat nucleoside diphosphate kinase. Kimura N, etal., J Biol Chem 1990 Sep 15;265(26):15744-9.
18. Expression of nm23-H1 and nm23-H2 proteins in prostate carcinoma. Konishi N, etal., Jpn J Cancer Res. 1993 Oct;84(10):1050-4.
19. Localization and characterization of the mitochondrial isoform of the nucleoside diphosphate kinase in the pancreatic beta cell: evidence for its complexation with mitochondrial succinyl-CoA synthetase. Kowluru A, etal., Arch Biochem Biophys. 2002 Feb 15;398(2):160-9.
20. The human Nm23/nucleoside diphosphate kinases. Lacombe ML, etal., J Bioenerg Biomembr. 2000 Jun;32(3):247-58.
21. Increased activity of membrane-associated nucleoside diphosphate kinase and inhibition of cAMP synthesis in failing human myocardium. Lutz S, etal., Cardiovasc Res. 2001 Jan;49(1):48-55.
22. Expression of metastasis-related nm23-H1 and nm23-H2 genes in ovarian carcinomas: correlation with clinicopathology, EGFR, c-erbB-2, and c-erbB-3 genes, and sex steroid receptor expression. Mandai M, etal., Cancer Res. 1994 Apr 1;54(7):1825-30.
23. Nm23 expression in endometrial and cervical cancer: inverse correlation with lymph node involvement and myometrial invasion. Marone M, etal., Br J Cancer. 1996 Oct;74(7):1063-8.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Allelic loss and somatic differentiation in human male germ cell tumors. Murty VV, etal., Oncogene. 1994 Aug;9(8):2245-51.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. Menin, a gene product responsible for multiple endocrine neoplasia type 1, interacts with the putative tumor metastasis suppressor nm23. Ohkura N, etal., Biochem Biophys Res Commun. 2001 Apr 20;282(5):1206-10.
28. A new function of Nm23/NDP kinase as a differentiation inhibitory factor, which does not require it's kinase activity. Okabe-Kado J, etal., FEBS Lett. 1995 Apr 24;363(3):311-5.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
31. NM23-H2, an estrogen receptor beta-associated protein, shows diminished expression with progression of atherosclerosis. Rayner K, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R743-50. Epub 2006 Aug 3.
32. GOA pipeline RGD automated data pipeline
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Activated microglia modulate astroglial enzymes involved in oxidative and inflammatory stress and increase the resistance of astrocytes to oxidative stress in vitro. Rohl C, etal., Glia. 2008 Aug 1;56(10):1114-26.
35. Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma. Roymans D, etal., Exp Cell Res. 2000 Nov 25;261(1):127-38.
36. Alterations of the metastasis suppressor gene nm23 and the proto-oncogene c-myc in human testicular germ cell tumors. Schmidt B, etal., J Urol. 1997 Nov;158(5):2000-5.
37. Reduced metastatic potential and c-myc overexpression of colon adenocarcinoma cells (Colon 26 line) transfected with nm23-R2/rat nucleoside diphosphate kinase alpha isoform. Tagashira H, etal., Int J Mol Med. 1998 Jul;2(1):65-8.
38. Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer. Tan WL, etal., Cancer Biol Ther. 2011 Mar 15;11(6):599-608. Epub 2011 Mar 15.
39. Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and stimulates Il1a transcription in rat Sertoli cells. Tash JS, etal., Biol Reprod. 2008 Jun;78(6):1139-52. doi: 10.1095/biolreprod.107.062679. Epub 2008 Jan 23.
40. Down-regulation of expression and function of nucleoside diphosphate kinase in insulin-secreting beta-cells under in vitro conditions of glucolipotoxicity. Veluthakal R, etal., Mol Cell Biochem. 2009 Sep;329(1-2):121-9. Epub 2009 Apr 15.
41. Expression of nm23-H1 and nm23-H2 protein in endometrial carcinoma. Watanabe J, etal., Br J Cancer. 1995 Dec;72(6):1469-73.
42. Mapping the high-affinity binding domain of 5-substituted benzimidazoles to the proximal N-terminus of the GluN2B subunit of the NMDA receptor. Wee XK, etal., Br J Pharmacol. 2010 Jan 1;159(2):449-61. Epub 2010 Jan 15.
43. 12-O-tetradecanoylphorbol-13-acetate and UV radiation-induced nucleoside diphosphate protein kinase B mediates neoplastic transformation of epidermal cells. Wei SJ, etal., J Biol Chem. 2004 Feb 13;279(7):5993-6004. Epub 2003 Nov 17.
Additional References at PubMed
PMID:1321145   PMID:1851158   PMID:8392752   PMID:11277919   PMID:11919189   PMID:12477932   PMID:12972261   PMID:14651853   PMID:15489334   PMID:15616584   PMID:15703214   PMID:16862176  
PMID:17634366   PMID:18614015   PMID:19199708   PMID:19435876   PMID:20458337   PMID:21111809   PMID:21630459   PMID:22817458   PMID:22871113   PMID:23368879   PMID:23533145   PMID:25679041  


Genomics

Comparative Map Data
Nme2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81079,394,999 - 79,400,418 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2011,179,066 - 11,179,497 (-)EnsemblGRCr8
GRCr8 Ensembl1079,394,999 - 79,400,504 (-)EnsemblGRCr8
mRatBN7.21078,898,097 - 78,903,514 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2011,179,488 - 11,179,919 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1078,897,770 - 78,903,538 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1083,508,941 - 83,514,439 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01083,007,040 - 83,012,538 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01078,478,407 - 78,483,899 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01081,648,216 - 81,653,717 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1081,648,216 - 81,653,717 (-)Ensemblrn6Rnor6.0
Rnor_5.01081,478,178 - 81,483,679 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41082,582,766 - 82,588,269 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1077,694,496 - 77,700,026 (-)NCBICelera
RGSC_v3.11082,597,135 - 82,602,639 (-)NCBI
Cytogenetic Map10q26NCBI
NME2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381751,165,536 - 51,171,744 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1751,163,013 - 51,171,749 (+)Ensemblhg38GRCh38
GRCh371749,242,897 - 49,249,105 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361746,597,890 - 46,604,104 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341746,598,810 - 46,604,103NCBI
Celera1745,704,144 - 45,710,358 (+)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1744,612,062 - 44,618,375 (+)NCBIHuRef
CHM1_11749,307,431 - 49,313,740 (+)NCBICHM1_1
T2T-CHM13v2.01752,032,848 - 52,039,047 (+)NCBIT2T-CHM13v2.0
Nme2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391193,840,640 - 93,847,082 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1193,840,640 - 93,847,085 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381193,949,814 - 93,956,256 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1193,949,814 - 93,956,259 (-)Ensemblmm10GRCm38
MGSCv371193,811,129 - 93,817,321 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361193,765,904 - 93,772,097 (-)NCBIMGSCv36mm8
Celera11103,564,861 - 103,571,040 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1158.88NCBI
NME2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21967,353,449 - 67,359,441 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11772,160,643 - 72,166,512 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01745,255,982 - 45,261,541 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11750,126,867 - 50,131,776 (+)NCBIPanPan1.1PanPan1.1panPan2
NME2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1927,002,114 - 27,005,740 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl927,001,733 - 27,015,934 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha926,330,716 - 26,333,823 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0927,795,956 - 27,799,595 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl927,795,346 - 27,799,595 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1926,562,504 - 26,565,610 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0926,822,054 - 26,825,171 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0926,952,138 - 26,955,247 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nme2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560226,435,190 - 26,440,351 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649010,633,454 - 10,649,914 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649010,634,788 - 10,640,182 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NME2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1227,439,260 - 27,445,027 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11227,439,529 - 27,445,025 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21227,507,399 - 27,513,382 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103242911
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11642,176,690 - 42,182,041 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1642,176,524 - 42,182,019 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607712,886,379 - 12,891,712 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nme2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1951,573,624 - 51,579,064 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nme2
81 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:28
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000003611
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107870758585720738Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)107369533983061459Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)107369533983061459Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106413959783061459Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106184363383061236Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313384503487Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107395020983959619Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
D10Mgh23  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21078,899,655 - 78,899,894 (+)MAPPERmRatBN7.2
mRatBN7.21078,899,655 - 78,899,805 (+)MAPPERmRatBN7.2
Rnor_6.01081,649,775 - 81,649,924NCBIRnor6.0
Rnor_6.01081,649,775 - 81,650,013NCBIRnor6.0
Rnor_5.01081,479,737 - 81,479,975UniSTSRnor5.0
Rnor_5.01081,479,737 - 81,479,886UniSTSRnor5.0
Celera1077,696,055 - 77,696,204UniSTS
Celera1077,696,055 - 77,696,293UniSTS
RGSC_v3.11082,598,694 - 82,598,844RGD
RH 2.0 Map10835.7RGD
Cytogenetic Map10q26UniSTS
RH135179  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21078,902,553 - 78,902,753 (+)MAPPERmRatBN7.2
Rnor_6.01081,652,671 - 81,652,870NCBIRnor6.0
Rnor_5.01081,482,633 - 81,482,832UniSTSRnor5.0
RGSC_v3.41082,587,223 - 82,587,422UniSTSRGSC3.4
Celera1077,698,980 - 77,699,179UniSTS
RH 3.4 Map10631.4UniSTS
Cytogenetic Map10q26UniSTS
PMC312758P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21078,903,324 - 78,903,444 (+)MAPPERmRatBN7.2
Rnor_6.01081,653,442 - 81,653,561NCBIRnor6.0
Rnor_5.01081,483,404 - 81,483,523UniSTSRnor5.0
RGSC_v3.41082,587,994 - 82,588,113UniSTSRGSC3.4
Celera1077,699,751 - 77,699,870UniSTS
Cytogenetic Map10q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003611   ⟹   ENSRNOP00000003611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1079,394,999 - 79,400,504 (-)Ensembl
mRatBN7.2 Ensembl1078,897,770 - 78,903,538 (-)Ensembl
Rnor_6.0 Ensembl1081,648,216 - 81,653,717 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000037297   ⟹   ENSRNOP00000087780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2011,179,066 - 11,179,497 (-)Ensembl
mRatBN7.2 Ensembl2011,179,488 - 11,179,919 (-)Ensembl
RefSeq Acc Id: NM_031833   ⟹   NP_114021
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,394,999 - 79,400,418 (-)NCBI
mRatBN7.21078,898,097 - 78,903,514 (-)NCBI
Rnor_6.01081,648,216 - 81,653,717 (-)NCBI
Rnor_5.01081,478,178 - 81,483,679 (-)NCBI
RGSC_v3.41082,582,766 - 82,588,269 (-)RGD
Celera1077,694,496 - 77,700,026 (-)RGD
Sequence:
RefSeq Acc Id: NP_114021   ⟸   NM_031833
- UniProtKB: P19804 (UniProtKB/Swiss-Prot),   A6HI34 (UniProtKB/TrEMBL),   A0A8I6A4T4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003611   ⟸   ENSRNOT00000003611
Ensembl Acc Id: ENSRNOP00000087780   ⟸   ENSRNOT00000037297
Protein Domains
Nucleoside diphosphate kinase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19804-F1-model_v2 AlphaFold P19804 1-152 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697598
Promoter ID:EPDNEW_R8121
Type:initiation region
Name:Nme2_1
Description:NME/NM23 nucleoside diphosphate kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01081,653,604 - 81,653,664EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619877 AgrOrtholog
BIND 129608
BioCyc Gene G2FUF-23638 BioCyc
BioCyc Pathway PWY-7176 [UTP and CTP de novo biosynthesis] BioCyc
  PWY-7184 [pyrimidine deoxyribonucleotides de novo biosynthesis I] BioCyc
  PWY-7197 [pyrimidine deoxyribonucleotide phosphorylation] BioCyc
  PWY-7205 [CMP phosphorylation] BioCyc
  PWY-7210 [pyrimidine deoxyribonucleotides biosynthesis from CTP] BioCyc
  PWY-7221 [guanosine ribonucleotides de novo biosynthesis] BioCyc
  PWY-7224 [purine deoxyribonucleosides salvage] BioCyc
  PWY-7226 [guanosine deoxyribonucleotides de novo biosynthesis I] BioCyc
  PWY-7227 [adenosine deoxyribonucleotides de novo biosynthesis I] BioCyc
BioCyc Pathway Image PWY-7176 BioCyc
  PWY-7184 BioCyc
  PWY-7197 BioCyc
  PWY-7205 BioCyc
  PWY-7210 BioCyc
  PWY-7221 BioCyc
  PWY-7224 BioCyc
  PWY-7226 BioCyc
  PWY-7227 BioCyc
Ensembl Genes ENSRNOG00000001226 Ensembl
  ENSRNOG00000002671 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003611 ENTREZGENE
  ENSRNOT00000003611.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.141 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7312852 IMAGE-MGC_LOAD
InterPro NDK-like_dom UniProtKB/Swiss-Prot
  NDK-like_dom_sf UniProtKB/Swiss-Prot
  Nucleoside_diP_kinase UniProtKB/Swiss-Prot
  Nucleoside_diP_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:83782 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105386 IMAGE-MGC_LOAD
NCBI Gene 83782 ENTREZGENE
PANTHER NUCLEOSIDE DIPHOSPHATE KINASE UniProtKB/Swiss-Prot
Pfam NDK UniProtKB/Swiss-Prot
PhenoGen Nme2 PhenoGen
PRINTS NUCDPKINASE UniProtKB/Swiss-Prot
PROSITE NDP_KINASES UniProtKB/Swiss-Prot
  NDPK_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001226 RatGTEx
  ENSRNOG00000002671 RatGTEx
SMART NDK UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54919 UniProtKB/Swiss-Prot
UniProt A0A8I6A4T4 ENTREZGENE, UniProtKB/TrEMBL
  A6HI34 ENTREZGENE, UniProtKB/TrEMBL
  NDKB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-05 Nme2  NME/NM23 nucleoside diphosphate kinase 2  Nme2  non-metastatic cells 2, protein (NM23B) expressed in  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Nme2  non-metastatic cells 2, protein (NM23B) expressed in  Nme2  expressed in non-metastatic cells 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Nme2  expressed in non-metastatic cells 2    nucleoside diphosphate kinase  Name updated 1299863 APPROVED
2002-08-07 Nme2  nucleoside diphosphate kinase      Symbol and Name status set to provisional 70820 PROVISIONAL