Pfkfb3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3) - Rat Genome Database

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Gene: Pfkfb3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3) Rattus norvegicus
Analyze
Symbol: Pfkfb3
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
RGD ID: 619776
Description: Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Involved in fructose 2,6-bisphosphate metabolic process. Predicted to be located in nucleoplasm. Predicted to be part of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex. Predicted to be active in cytosol. Orthologous to human PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3); PARTICIPATES IN hypoxia inducible factor pathway; fructose and mannose metabolic pathway; glycolysis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K/Fru-2,6-P2ASE brain-type isozyme; PFK/FBPase 3; RB2K
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81771,893,320 - 71,974,526 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1771,893,416 - 71,975,052 (+)EnsemblGRCr8
mRatBN7.21766,983,629 - 67,064,702 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1766,983,686 - 67,063,125 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1770,521,180 - 70,548,342 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01774,350,000 - 74,377,164 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01768,393,012 - 68,420,173 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01770,632,778 - 70,713,736 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1770,684,134 - 70,713,726 (+)Ensemblrn6Rnor6.0
Rnor_5.01772,334,950 - 72,416,018 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41778,241,182 - 78,268,272 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1766,539,556 - 66,566,619 (+)NCBICelera
RGSC_v3.11778,252,014 - 78,279,105 (+)NCBI
Cytogenetic Map17q12.2NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,4-benzoquinone  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
ampicillin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcium silicate  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
chrysene  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hexadecanoic acid  (ISO)
hydrazines  (ISO)
indinavir  (ISO)
ivermectin  (ISO)
kenpaullone  (EXP)
lactacystin  (EXP)
lamivudine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
mercury dichloride  (EXP)
metacetamol  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
MitoTEMPO  (ISO)
molibresib  (ISO)
motexafin gadolinium  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
Pf-06840003  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resorcinol  (ISO)
Salinomycin  (ISO)
saquinavir  (ISO)
selenium atom  (ISO)
sevoflurane  (EXP)
sildenafil citrate  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tadalafil  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc dichloride  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase expression in rat brain during development. Goren N, etal., Brain Res Mol Brain Res. 2000 Jan 10;75(1):138-42.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Regulation of the regulatory enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Okar DA, etal., Adv Enzyme Regul. 2004;44:123-54. doi: 10.1016/j.advenzreg.2003.11.006.
7. Contributions of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 to the elevated glycolysis in hepatocytes from Zucker fa/fa rats. Payne VA, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R618-25. Epub 2007 Jun 6.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis. Rider MH, etal., Biochem J. 2004 Aug 1;381(Pt 3):561-79.
12. Ablation of endothelial Pfkfb3 protects mice from acute lung injury in LPS-induced endotoxemia. Wang L, etal., Pharmacol Res. 2019 Aug;146:104292. doi: 10.1016/j.phrs.2019.104292. Epub 2019 Jun 2.
13. Novel isoforms of rat brain fructose 6-phosphate 2-kinase/fructose 2,6-bisphosphatase are generated by tissue-specific alternative splicing. Watanabe F, etal., J Neurochem 1997 Jul;69(1):1-9.
Additional References at PubMed
PMID:2837207   PMID:9464277   PMID:10095107   PMID:14623077   PMID:15896703   PMID:15983194   PMID:18191036   PMID:19448625   PMID:19595670   PMID:22421967   PMID:23703029   PMID:26498254  
PMID:28235572   PMID:30132885   PMID:32841050   PMID:34016793   PMID:34490476   PMID:36916342   PMID:37162556  


Genomics

Comparative Map Data
Pfkfb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81771,893,320 - 71,974,526 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1771,893,416 - 71,975,052 (+)EnsemblGRCr8
mRatBN7.21766,983,629 - 67,064,702 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1766,983,686 - 67,063,125 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1770,521,180 - 70,548,342 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01774,350,000 - 74,377,164 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01768,393,012 - 68,420,173 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01770,632,778 - 70,713,736 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1770,684,134 - 70,713,726 (+)Ensemblrn6Rnor6.0
Rnor_5.01772,334,950 - 72,416,018 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41778,241,182 - 78,268,272 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1766,539,556 - 66,566,619 (+)NCBICelera
RGSC_v3.11778,252,014 - 78,279,105 (+)NCBI
Cytogenetic Map17q12.2NCBI
PFKFB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38106,144,921 - 6,326,637 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl106,144,928 - 6,254,644 (+)Ensemblhg38GRCh38
GRCh37106,186,884 - 6,296,611 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36106,284,901 - 6,317,501 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34106,284,900 - 6,317,500NCBI
Celera106,116,166 - 6,206,226 (+)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef106,113,180 - 6,203,192 (+)NCBIHuRef
CHM1_1106,186,886 - 6,276,773 (+)NCBICHM1_1
T2T-CHM13v2.0106,145,107 - 6,326,763 (+)NCBIT2T-CHM13v2.0
Pfkfb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39211,476,241 - 11,558,882 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl211,476,244 - 11,558,888 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38211,471,430 - 11,554,071 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl211,471,433 - 11,554,077 (-)Ensemblmm10GRCm38
MGSCv37211,393,057 - 11,475,556 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36211,389,288 - 11,419,920 (-)NCBIMGSCv36mm8
Celera211,389,848 - 11,473,089 (-)NCBICelera
Cytogenetic Map2A1NCBI
cM Map28.73NCBI
Pfkfb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542122,848,548 - 22,866,035 (+)Ensembl
ChiLan1.0NW_00495542122,762,290 - 22,868,677 (+)NCBIChiLan1.0ChiLan1.0
PFKFB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2818,698,130 - 18,807,520 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11018,703,539 - 18,812,843 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0106,185,415 - 6,294,641 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1106,167,841 - 6,257,263 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl106,167,841 - 6,275,940 (+)EnsemblpanPan2panpan1.1
PFKFB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1229,716,866 - 29,785,643 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl229,716,752 - 29,801,936 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha226,748,126 - 26,834,516 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0230,098,553 - 30,184,947 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl230,097,497 - 30,184,942 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1227,195,708 - 27,282,045 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0228,031,490 - 28,118,114 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0228,751,303 - 28,837,993 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pfkfb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934432,191,332 - 32,278,311 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364848,356,487 - 8,434,925 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364848,356,523 - 8,434,529 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PFKFB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1064,776,315 - 64,802,287 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11064,776,315 - 64,859,118 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21070,831,486 - 70,857,739 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PFKFB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.196,267,766 - 6,354,775 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl96,332,570 - 6,354,932 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605111,571,686 - 11,658,469 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pfkfb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247751,145,797 - 1,169,858 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247751,092,018 - 1,173,848 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pfkfb3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11417,505,557 - 17,535,962 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pfkfb3
642 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:305
Count of miRNA genes:158
Interacting mature miRNAs:171
Transcripts:ENSRNOT00000025700, ENSRNOT00000025731, ENSRNOT00000051067, ENSRNOT00000068354
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)177061350286062352Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175819406487388164Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)176515487293515804Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176855004093515804Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176369714782818564Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)176456982086954580Rat

Markers in Region
D17Rat96  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81771,957,615 - 71,957,818 (+)Marker Load Pipeline
mRatBN7.21767,047,777 - 67,047,980 (+)MAPPERmRatBN7.2
Rnor_6.01770,696,817 - 70,697,019NCBIRnor6.0
Rnor_5.01772,399,108 - 72,399,310UniSTSRnor5.0
RGSC_v3.41778,253,719 - 78,254,071RGDRGSC3.4
RGSC_v3.41778,253,865 - 78,254,067UniSTSRGSC3.4
Celera1766,552,212 - 66,552,414UniSTS
RGSC_v3.11778,264,552 - 78,264,904RGD
RH 3.4 Map17637.4UniSTS
RH 3.4 Map17637.4RGD
RH 2.0 Map17570.7RGD
SHRSP x BN Map1737.1399RGD
Cytogenetic Map17q12.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001439774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_057135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB006710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC141172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU034674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000025700   ⟹   ENSRNOP00000025700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1771,944,995 - 71,974,525 (+)Ensembl
mRatBN7.2 Ensembl1767,035,095 - 67,062,190 (+)Ensembl
Rnor_6.0 Ensembl1770,684,539 - 70,711,216 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000025731   ⟹   ENSRNOP00000025731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1771,944,995 - 71,975,045 (+)Ensembl
mRatBN7.2 Ensembl1767,035,095 - 67,062,190 (+)Ensembl
Rnor_6.0 Ensembl1770,684,134 - 70,707,555 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000051067   ⟹   ENSRNOP00000040928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1771,944,995 - 71,975,052 (+)Ensembl
mRatBN7.2 Ensembl1767,035,161 - 67,062,919 (+)Ensembl
Rnor_6.0 Ensembl1770,684,340 - 70,713,726 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000068354   ⟹   ENSRNOP00000062965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1771,944,996 - 71,974,532 (+)Ensembl
mRatBN7.2 Ensembl1767,035,095 - 67,062,190 (+)Ensembl
Rnor_6.0 Ensembl1770,684,134 - 70,711,224 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098811   ⟹   ENSRNOP00000097078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1771,893,416 - 71,974,533 (+)Ensembl
mRatBN7.2 Ensembl1766,983,686 - 67,062,919 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100481   ⟹   ENSRNOP00000096463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1771,944,995 - 71,974,527 (+)Ensembl
mRatBN7.2 Ensembl1767,035,095 - 67,063,125 (+)Ensembl
RefSeq Acc Id: NM_057135   ⟹   NP_476476
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81771,944,933 - 71,972,023 (+)NCBI
mRatBN7.21767,035,095 - 67,062,190 (+)NCBI
Rnor_6.01770,684,134 - 70,711,224 (+)NCBI
Rnor_5.01772,334,950 - 72,416,018 (+)NCBI
RGSC_v3.41778,241,182 - 78,268,272 (+)RGD
Celera1766,539,556 - 66,566,619 (+)RGD
Sequence:
RefSeq Acc Id: XM_006254192   ⟹   XP_006254254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81771,944,932 - 71,974,526 (+)NCBI
mRatBN7.21767,035,100 - 67,064,702 (+)NCBI
Rnor_6.01770,684,139 - 70,713,736 (+)NCBI
Rnor_5.01772,334,950 - 72,416,018 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254193   ⟹   XP_006254255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81771,944,932 - 71,974,526 (+)NCBI
mRatBN7.21767,035,100 - 67,064,702 (+)NCBI
Rnor_6.01770,684,139 - 70,713,736 (+)NCBI
Rnor_5.01772,334,950 - 72,416,018 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254196   ⟹   XP_006254258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81771,944,932 - 71,972,087 (+)NCBI
mRatBN7.21767,035,100 - 67,064,702 (+)NCBI
Rnor_6.01770,684,139 - 70,713,736 (+)NCBI
Rnor_5.01772,334,950 - 72,416,018 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254197   ⟹   XP_006254259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81771,944,932 - 71,974,526 (+)NCBI
mRatBN7.21767,035,100 - 67,064,702 (+)NCBI
Rnor_6.01770,684,139 - 70,713,736 (+)NCBI
Rnor_5.01772,334,950 - 72,416,018 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254198   ⟹   XP_006254260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81771,944,932 - 71,974,526 (+)NCBI
mRatBN7.21767,035,100 - 67,064,702 (+)NCBI
Rnor_6.01770,684,139 - 70,713,736 (+)NCBI
Rnor_5.01772,334,950 - 72,416,018 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600444   ⟹   XP_017455933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81771,893,320 - 71,972,094 (+)NCBI
mRatBN7.21766,983,629 - 67,064,702 (+)NCBI
Rnor_6.01770,632,778 - 70,711,151 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063276032   ⟹   XP_063132102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81771,893,436 - 71,974,526 (+)NCBI
RefSeq Acc Id: XM_063276033   ⟹   XP_063132103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81771,893,437 - 71,974,526 (+)NCBI
RefSeq Acc Id: XM_063276034   ⟹   XP_063132104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81771,893,436 - 71,974,526 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001426703 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426704 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426705 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426706 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426707 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426708 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426709 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426710 (Get FASTA)   NCBI Sequence Viewer  
  NP_476476 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254254 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254255 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254258 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254259 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254260 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455933 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132102 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132103 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132104 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABS88611 (Get FASTA)   NCBI Sequence Viewer  
  BAA21749 (Get FASTA)   NCBI Sequence Viewer  
  BAA21750 (Get FASTA)   NCBI Sequence Viewer  
  BAA21751 (Get FASTA)   NCBI Sequence Viewer  
  BAA21752 (Get FASTA)   NCBI Sequence Viewer  
  BAA21753 (Get FASTA)   NCBI Sequence Viewer  
  BAA21754 (Get FASTA)   NCBI Sequence Viewer  
  BAA21755 (Get FASTA)   NCBI Sequence Viewer  
  BAA21756 (Get FASTA)   NCBI Sequence Viewer  
  BAA22048 (Get FASTA)   NCBI Sequence Viewer  
  EDL78601 (Get FASTA)   NCBI Sequence Viewer  
  EDL78602 (Get FASTA)   NCBI Sequence Viewer  
  EDL78603 (Get FASTA)   NCBI Sequence Viewer  
  EDL78604 (Get FASTA)   NCBI Sequence Viewer  
  EDL78605 (Get FASTA)   NCBI Sequence Viewer  
  EDL78606 (Get FASTA)   NCBI Sequence Viewer  
  EDL78607 (Get FASTA)   NCBI Sequence Viewer  
  EDL78608 (Get FASTA)   NCBI Sequence Viewer  
  EDL78609 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025700
  ENSRNOP00000025700.4
  ENSRNOP00000025731
  ENSRNOP00000025731.5
  ENSRNOP00000040928
  ENSRNOP00000040928.4
  ENSRNOP00000062965
  ENSRNOP00000062965.1
  ENSRNOP00000097078
GenBank Protein O35552 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_476476   ⟸   NM_057135
- UniProtKB: Q9QWQ5 (UniProtKB/Swiss-Prot),   O35557 (UniProtKB/Swiss-Prot),   O35556 (UniProtKB/Swiss-Prot),   O35555 (UniProtKB/Swiss-Prot),   O35554 (UniProtKB/Swiss-Prot),   O35553 (UniProtKB/Swiss-Prot),   O35096 (UniProtKB/Swiss-Prot),   Q9QWQ6 (UniProtKB/Swiss-Prot),   O35552 (UniProtKB/Swiss-Prot),   A6JLS9 (UniProtKB/TrEMBL),   A6JLT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254255   ⟸   XM_006254193
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006254254   ⟸   XM_006254192
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006254258   ⟸   XM_006254196
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006254260   ⟸   XM_006254198
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006254259   ⟸   XM_006254197
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017455933   ⟸   XM_017600444
- Peptide Label: isoform X9
- UniProtKB: A6JLT1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000040928   ⟸   ENSRNOT00000051067
Ensembl Acc Id: ENSRNOP00000062965   ⟸   ENSRNOT00000068354
Ensembl Acc Id: ENSRNOP00000025700   ⟸   ENSRNOT00000025700
Ensembl Acc Id: ENSRNOP00000025731   ⟸   ENSRNOT00000025731
Ensembl Acc Id: ENSRNOP00000096463   ⟸   ENSRNOT00000100481
Ensembl Acc Id: ENSRNOP00000097078   ⟸   ENSRNOT00000098811
RefSeq Acc Id: XP_063132102   ⟸   XM_063276032
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063132104   ⟸   XM_063276034
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063132103   ⟸   XM_063276033
- Peptide Label: isoform X7
Protein Domains
6-phosphofructo-2-kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35552-F1-model_v2 AlphaFold O35552 1-555 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700558
Promoter ID:EPDNEW_R11081
Type:multiple initiation site
Name:Pfkfb3_1
Description:6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01770,684,196 - 70,684,256EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619776 AgrOrtholog
BioCyc Gene G2FUF-8796 BioCyc
BioCyc Pathway PWY66-423 [fructose 2,6-bisphosphate biosynthesis] BioCyc
BioCyc Pathway Image PWY66-423 BioCyc
Ensembl Genes ENSRNOG00000018911 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025700 ENTREZGENE
  ENSRNOT00000025700.5 UniProtKB/Swiss-Prot
  ENSRNOT00000025731 ENTREZGENE
  ENSRNOT00000025731.6 UniProtKB/Swiss-Prot
  ENSRNOT00000051067 ENTREZGENE
  ENSRNOT00000051067.5 UniProtKB/Swiss-Prot
  ENSRNOT00000068354 ENTREZGENE
  ENSRNOT00000068354.4 UniProtKB/Swiss-Prot
  ENSRNOT00000098811 ENTREZGENE
Gene3D-CATH 3.40.50.1240 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro 6Pfruct_kin UniProtKB/Swiss-Prot
  6Phosfructo_kin UniProtKB/Swiss-Prot
  His_Pase_superF_clade-1 UniProtKB/Swiss-Prot
  His_PPase_superfam UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  PG/BPGM_mutase_AS UniProtKB/Swiss-Prot
KEGG Report rno:117276 UniProtKB/Swiss-Prot
NCBI Gene 117276 ENTREZGENE
PANTHER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 3 UniProtKB/Swiss-Prot
  PTHR10606 UniProtKB/Swiss-Prot
Pfam 6PF2K UniProtKB/Swiss-Prot
  His_Phos_1 UniProtKB/Swiss-Prot
PhenoGen Pfkfb3 PhenoGen
PRINTS 6PFRUCTKNASE UniProtKB/Swiss-Prot
PROSITE PG_MUTASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018911 RatGTEx
SMART PGAM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
  SSF53254 UniProtKB/Swiss-Prot
UniProt A0A8I6AUG9 ENTREZGENE, UniProtKB/TrEMBL
  A6JLS4 ENTREZGENE, UniProtKB/TrEMBL
  A6JLS5 ENTREZGENE, UniProtKB/TrEMBL
  A6JLS6 ENTREZGENE, UniProtKB/TrEMBL
  A6JLS7 ENTREZGENE, UniProtKB/TrEMBL
  A6JLS8 ENTREZGENE, UniProtKB/TrEMBL
  A6JLS9 ENTREZGENE, UniProtKB/TrEMBL
  A6JLT0 ENTREZGENE, UniProtKB/TrEMBL
  A6JLT1 ENTREZGENE, UniProtKB/TrEMBL
  A6JLT2 ENTREZGENE, UniProtKB/TrEMBL
  A7UAK3_RAT UniProtKB/TrEMBL
  F263_RAT UniProtKB/Swiss-Prot
  O35096 ENTREZGENE
  O35552 ENTREZGENE
  O35553 ENTREZGENE
  O35554 ENTREZGENE
  O35555 ENTREZGENE
  O35556 ENTREZGENE
  O35557 ENTREZGENE
  Q9QWQ5 ENTREZGENE
  Q9QWQ6 ENTREZGENE
UniProt Secondary O35096 UniProtKB/Swiss-Prot
  O35553 UniProtKB/Swiss-Prot
  O35554 UniProtKB/Swiss-Prot
  O35555 UniProtKB/Swiss-Prot
  O35556 UniProtKB/Swiss-Prot
  O35557 UniProtKB/Swiss-Prot
  Q9QWQ5 UniProtKB/Swiss-Prot
  Q9QWQ6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Pfkfb3  6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Pfkfb3  6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression isozyme expressed specifically in brain 729510