Nme6 (NME/NM23 nucleoside diphosphate kinase 6) - Rat Genome Database

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Gene: Nme6 (NME/NM23 nucleoside diphosphate kinase 6) Rattus norvegicus
Analyze
Symbol: Nme6
Name: NME/NM23 nucleoside diphosphate kinase 6
RGD ID: 61896
Description: Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in negative regulation of cell growth; negative regulation of mitotic nuclear division; and pyrimidine ribonucleotide salvage. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human NME6 (NME/NM23 nucleoside diphosphate kinase 6); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: expressed in non-metastatic cells 6 (nucleoside-diphosphate kinase); expressed in non-metastatic cells 6 protein (nucleoside diphosphate kinase); expressed in non-metastatic cells 6, protein (nucleoside diphosphate kinase); NDK 6; NDP kinase 6; Nm23-R6; non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase); nucleoside diphosphate kinase 6; nucleoside diphosphate kinase type 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,708,092 - 118,717,756 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8118,711,036 - 118,718,288 (+)EnsemblGRCr8
mRatBN7.28109,832,085 - 109,839,301 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,832,589 - 109,839,301 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8115,448,071 - 115,454,782 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,647,251 - 113,653,963 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08111,490,053 - 111,496,765 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,920,912 - 117,928,148 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,920,944 - 117,928,195 (+)Ensemblrn6Rnor6.0
Rnor_5.08117,273,425 - 117,280,661 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48114,205,773 - 114,212,486 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8109,122,384 - 109,129,093 (+)NCBICelera
RGSC_v3.18114,227,550 - 114,231,941 (+)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The human Nm23/nucleoside diphosphate kinases. Lacombe ML, etal., J Bioenerg Biomembr. 2000 Jun;32(3):247-58.
3. NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3. Mehus JG, etal., Hum Genet 1999 Jun;104(6):454-9.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10618642   PMID:18614015  


Genomics

Comparative Map Data
Nme6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,708,092 - 118,717,756 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8118,711,036 - 118,718,288 (+)EnsemblGRCr8
mRatBN7.28109,832,085 - 109,839,301 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,832,589 - 109,839,301 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8115,448,071 - 115,454,782 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,647,251 - 113,653,963 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08111,490,053 - 111,496,765 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,920,912 - 117,928,148 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,920,944 - 117,928,195 (+)Ensemblrn6Rnor6.0
Rnor_5.08117,273,425 - 117,280,661 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48114,205,773 - 114,212,486 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8109,122,384 - 109,129,093 (+)NCBICelera
RGSC_v3.18114,227,550 - 114,231,941 (+)NCBI
Cytogenetic Map8q32NCBI
NME6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38348,287,640 - 48,301,367 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl348,290,288 - 48,301,685 (-)Ensemblhg38GRCh38
GRCh37348,333,807 - 48,342,857 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,310,580 - 48,317,852 (-)NCBIBuild 36Build 36hg18NCBI36
Celera348,285,973 - 48,293,245 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef348,389,609 - 48,396,882 (-)NCBIHuRef
CHM1_1348,287,901 - 48,295,173 (-)NCBICHM1_1
T2T-CHM13v2.0348,315,404 - 48,329,136 (-)NCBIT2T-CHM13v2.0
Nme6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399109,661,830 - 109,672,042 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9109,661,817 - 109,672,184 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm389109,832,722 - 109,842,974 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9109,832,749 - 109,843,116 (+)Ensemblmm10GRCm38
MGSCv379109,735,308 - 109,745,475 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369109,690,200 - 109,700,367 (+)NCBIMGSCv36mm8
Celera9109,552,378 - 109,569,972 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.79NCBI
Nme6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542024,301,081 - 24,306,493 (+)Ensembl
ChiLan1.0NW_00495542024,301,079 - 24,306,370 (+)NCBIChiLan1.0ChiLan1.0
NME6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2248,257,219 - 48,270,739 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1348,261,987 - 48,276,786 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0348,206,365 - 48,217,618 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1349,290,069 - 49,299,831 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl349,290,069 - 49,299,831 (-)EnsemblpanPan2panpan1.1
NME6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,769,394 - 40,778,802 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,769,501 - 40,776,496 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2040,686,890 - 40,694,118 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02041,255,019 - 41,262,246 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2041,255,055 - 41,262,406 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12040,495,557 - 40,502,784 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,896,726 - 40,903,952 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02041,177,530 - 41,184,765 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nme6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560263,328,435 - 63,335,781 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493652988,949 - 96,236 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493652988,929 - 96,207 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NME6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,046,948 - 31,053,130 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11331,048,367 - 31,053,285 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21334,295,023 - 34,299,910 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NME6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1229,685,583 - 9,692,993 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl229,681,953 - 9,692,172 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041157,402,956 - 157,410,607 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nme6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473073,414,798 - 73,419,261 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473073,414,124 - 73,421,161 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nme6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v18100,454,195 - 100,460,025 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nme6
87 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:193
Count of miRNA genes:145
Interacting mature miRNAs:158
Transcripts:ENSRNOT00000028125
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
RH133776  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,839,110 - 109,839,291 (+)MAPPERmRatBN7.2
Rnor_6.08117,927,939 - 117,928,119NCBIRnor6.0
Rnor_5.08117,280,452 - 117,280,632UniSTSRnor5.0
RGSC_v3.48114,212,296 - 114,212,476UniSTSRGSC3.4
Celera8109,128,903 - 109,129,083UniSTS
RH 3.4 Map81192.7UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 91 59 6 355 191 11 141 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001191884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF051943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000028125   ⟹   ENSRNOP00000028125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8118,711,036 - 118,718,288 (+)Ensembl
mRatBN7.2 Ensembl8109,832,589 - 109,839,301 (+)Ensembl
Rnor_6.0 Ensembl8117,920,944 - 117,928,195 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000134535   ⟹   ENSRNOP00000100564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8118,715,636 - 118,718,288 (+)Ensembl
RefSeq Acc Id: NM_001191884   ⟹   NP_001178813
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,711,044 - 118,717,756 (+)NCBI
mRatBN7.28109,832,589 - 109,839,301 (+)NCBI
Rnor_6.08117,921,416 - 117,928,129 (+)NCBI
Rnor_5.08117,273,425 - 117,280,661 (+)NCBI
Celera8109,122,384 - 109,129,093 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243847   ⟹   XP_006243909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,711,000 - 118,717,753 (+)NCBI
mRatBN7.28109,832,551 - 109,839,298 (+)NCBI
Rnor_6.08117,921,396 - 117,928,148 (+)NCBI
Rnor_5.08117,273,425 - 117,280,661 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243848   ⟹   XP_006243910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,708,092 - 118,717,753 (+)NCBI
mRatBN7.28109,832,085 - 109,839,298 (+)NCBI
Rnor_6.08117,921,365 - 117,928,148 (+)NCBI
Rnor_5.08117,273,425 - 117,280,661 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243849   ⟹   XP_006243911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,708,092 - 118,717,753 (+)NCBI
mRatBN7.28109,832,085 - 109,839,298 (+)NCBI
Rnor_6.08117,920,912 - 117,928,148 (+)NCBI
Rnor_5.08117,273,425 - 117,280,661 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243850   ⟹   XP_006243912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,711,008 - 118,717,753 (+)NCBI
mRatBN7.28109,832,571 - 109,839,298 (+)NCBI
Rnor_6.08117,921,398 - 117,928,148 (+)NCBI
Rnor_5.08117,273,425 - 117,280,661 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243851   ⟹   XP_006243913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,711,020 - 118,717,753 (+)NCBI
mRatBN7.28109,832,716 - 109,839,298 (+)NCBI
Rnor_6.08117,921,396 - 117,928,148 (+)NCBI
Rnor_5.08117,273,425 - 117,280,661 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595880   ⟹   XP_017451369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,711,173 - 118,717,753 (+)NCBI
mRatBN7.28109,832,591 - 109,839,298 (+)NCBI
Rnor_6.08117,921,397 - 117,928,148 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039082038   ⟹   XP_038937966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,711,005 - 118,717,753 (+)NCBI
mRatBN7.28109,832,552 - 109,839,298 (+)NCBI
RefSeq Acc Id: XM_039082039   ⟹   XP_038937967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,711,001 - 118,717,753 (+)NCBI
mRatBN7.28109,832,551 - 109,839,298 (+)NCBI
RefSeq Acc Id: XM_039082041   ⟹   XP_038937969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,711,010 - 118,717,753 (+)NCBI
mRatBN7.28109,832,572 - 109,839,298 (+)NCBI
RefSeq Acc Id: XM_063266049   ⟹   XP_063122119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,711,005 - 118,717,753 (+)NCBI
RefSeq Acc Id: XM_063266050   ⟹   XP_063122120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,711,001 - 118,717,753 (+)NCBI
RefSeq Acc Id: XM_063266051   ⟹   XP_063122121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,708,092 - 118,717,753 (+)NCBI
RefSeq Acc Id: XM_063266052   ⟹   XP_063122122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,711,173 - 118,717,753 (+)NCBI
RefSeq Acc Id: XM_063266053   ⟹   XP_063122123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,711,040 - 118,717,753 (+)NCBI
RefSeq Acc Id: XM_063266055   ⟹   XP_063122125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,711,009 - 118,717,753 (+)NCBI
RefSeq Acc Id: NP_001178813   ⟸   NM_001191884
- UniProtKB: O88426 (UniProtKB/Swiss-Prot),   R9PXW5 (UniProtKB/TrEMBL),   A6I3C2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243911   ⟸   XM_006243849
- Peptide Label: isoform X1
- UniProtKB: O88426 (UniProtKB/Swiss-Prot),   R9PXW5 (UniProtKB/TrEMBL),   A6I3C2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243910   ⟸   XM_006243848
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006243909   ⟸   XM_006243847
- Peptide Label: isoform X1
- UniProtKB: O88426 (UniProtKB/Swiss-Prot),   R9PXW5 (UniProtKB/TrEMBL),   A6I3C2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243912   ⟸   XM_006243850
- Peptide Label: isoform X1
- UniProtKB: O88426 (UniProtKB/Swiss-Prot),   R9PXW5 (UniProtKB/TrEMBL),   A6I3C2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243913   ⟸   XM_006243851
- Peptide Label: isoform X1
- UniProtKB: O88426 (UniProtKB/Swiss-Prot),   R9PXW5 (UniProtKB/TrEMBL),   A6I3C2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451369   ⟸   XM_017595880
- Peptide Label: isoform X2
- UniProtKB: O88426 (UniProtKB/Swiss-Prot),   A6I3C3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028125   ⟸   ENSRNOT00000028125
RefSeq Acc Id: XP_038937967   ⟸   XM_039082039
- Peptide Label: isoform X2
- UniProtKB: O88426 (UniProtKB/Swiss-Prot),   A6I3C3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937966   ⟸   XM_039082038
- Peptide Label: isoform X2
- UniProtKB: O88426 (UniProtKB/Swiss-Prot),   A6I3C3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937969   ⟸   XM_039082041
- Peptide Label: isoform X2
- UniProtKB: O88426 (UniProtKB/Swiss-Prot),   A6I3C3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122121   ⟸   XM_063266051
- Peptide Label: isoform X2
- UniProtKB: O88426 (UniProtKB/Swiss-Prot),   A6I3C3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122120   ⟸   XM_063266050
- Peptide Label: isoform X2
- UniProtKB: O88426 (UniProtKB/Swiss-Prot),   A6I3C3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122119   ⟸   XM_063266049
- Peptide Label: isoform X2
- UniProtKB: O88426 (UniProtKB/Swiss-Prot),   A6I3C3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122125   ⟸   XM_063266055
- Peptide Label: isoform X2
- UniProtKB: O88426 (UniProtKB/Swiss-Prot),   A6I3C3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122123   ⟸   XM_063266053
- Peptide Label: isoform X2
- UniProtKB: O88426 (UniProtKB/Swiss-Prot),   A6I3C3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122122   ⟸   XM_063266052
- Peptide Label: isoform X2
- UniProtKB: O88426 (UniProtKB/Swiss-Prot),   A6I3C3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000100564   ⟸   ENSRNOT00000134535
Protein Domains
Nucleoside diphosphate kinase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88426-F1-model_v2 AlphaFold O88426 1-175 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696323
Promoter ID:EPDNEW_R6848
Type:multiple initiation site
Name:Nme6_1
Description:NME/NM23 nucleoside diphosphate kinase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08117,921,408 - 117,921,468EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61896 AgrOrtholog
BioCyc Gene G2FUF-29086 BioCyc
BioCyc Pathway PWY-7176 [UTP and CTP de novo biosynthesis] BioCyc
  PWY-7184 [pyrimidine deoxyribonucleotides de novo biosynthesis I] BioCyc
  PWY-7197 [pyrimidine deoxyribonucleotide phosphorylation] BioCyc
  PWY-7205 [CMP phosphorylation] BioCyc
  PWY-7210 [pyrimidine deoxyribonucleotides biosynthesis from CTP] BioCyc
  PWY-7221 [guanosine ribonucleotides de novo biosynthesis] BioCyc
  PWY-7224 [purine deoxyribonucleosides salvage] BioCyc
  PWY-7226 [guanosine deoxyribonucleotides de novo biosynthesis I] BioCyc
  PWY-7227 [adenosine deoxyribonucleotides de novo biosynthesis I] BioCyc
BioCyc Pathway Image PWY-7176 BioCyc
  PWY-7184 BioCyc
  PWY-7197 BioCyc
  PWY-7205 BioCyc
  PWY-7210 BioCyc
  PWY-7221 BioCyc
  PWY-7224 BioCyc
  PWY-7226 BioCyc
  PWY-7227 BioCyc
Ensembl Genes ENSRNOG00000020721 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000028125 ENTREZGENE
Gene3D-CATH 3.30.70.141 UniProtKB/Swiss-Prot
InterPro NDK-like_dom UniProtKB/Swiss-Prot
  NDK-like_dom_sf UniProtKB/Swiss-Prot
  NDPk6 UniProtKB/Swiss-Prot
  Nucleoside_diP_kinase UniProtKB/Swiss-Prot
  Nucleoside_diP_kinase_AS UniProtKB/Swiss-Prot
NCBI Gene 58964 ENTREZGENE
PANTHER NUCLEOSIDE DIPHOSPHATE KINASE 6 UniProtKB/Swiss-Prot
  PTHR46956 UniProtKB/Swiss-Prot
Pfam NDK UniProtKB/Swiss-Prot
PhenoGen Nme6 PhenoGen
PRINTS NUCDPKINASE UniProtKB/Swiss-Prot
PROSITE NDP_KINASES UniProtKB/Swiss-Prot
  NDPK_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020721 RatGTEx
SMART NDK UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54919 UniProtKB/Swiss-Prot
TIGR TC206607
UniProt A0ABK0L7X0_RAT UniProtKB/TrEMBL
  A6I3C2 ENTREZGENE, UniProtKB/TrEMBL
  A6I3C3 ENTREZGENE, UniProtKB/TrEMBL
  A6I3C6_RAT UniProtKB/TrEMBL
  NDK6_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  R9PXW5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-05 Nme6  NME/NM23 nucleoside diphosphate kinase 6  Nme6  non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-19 Nme6  non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)  Nme6  expressed in non-metastatic cells 6 (nucleoside-diphosphate kinase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-17 Nme6  expressed in non-metastatic cells 6 (nucleoside-diphosphate kinase)  Nme6  expressed in non-metastatic cells 6, protein (nucleoside diphosphate kinase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Nme6  expressed in non-metastatic cells 6       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a nucleoside diphosphate (NDP) kinase motif 61672
gene_expression highly expressed in kidney, prostate, ovary, intestine, and spleen 61672
gene_function phosphorylation 61672
gene_homology high homology to the human protein 61672
gene_regulation unusual acidic motif YEEEEP at the COOH terminal 61672