Stxbp1 (syntaxin binding protein 1) - Rat Genome Database

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Gene: Stxbp1 (syntaxin binding protein 1) Rattus norvegicus
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Symbol: Stxbp1
Name: syntaxin binding protein 1
RGD ID: 3785
Description: Enables several functions, including enzyme binding activity; identical protein binding activity; and syntaxin-1 binding activity. Involved in several processes, including evoked neurotransmitter secretion; positive regulation of transport; and regulation of protein-containing complex assembly. Acts upstream of or within protein stabilization. Located in several cellular components, including perinuclear region of cytoplasm; postsynapse; and presynapse. Part of protein-containing complex. Colocalizes with plasma membrane. Human ortholog(s) of this gene implicated in West syndrome and developmental and epileptic encephalopathy 4. Orthologous to human STXBP1 (syntaxin binding protein 1); PARTICIPATES IN insulin secretion pathway; synaptic vesicle exocytosis - neurotransmitter release pathway; INTERACTS WITH 1,3-dinitrobenzene; 2-ethoxyethanol; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A; p67; protein unc-18 homolog 1; protein unc-18 homolog A; rbSec1; rbSec1A; rbSec1B; Sec1; syntaxin-binding protein 1; unc-18 homolog; unc-18-1; unc-18A; Unc18-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,474,428 - 36,536,120 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl336,474,428 - 36,536,058 (-)EnsemblGRCr8
mRatBN7.2316,076,725 - 16,138,431 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl316,076,391 - 16,138,369 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx319,144,972 - 19,206,215 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,729,979 - 27,791,223 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,981,796 - 26,042,989 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,823,779 - 11,885,479 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,823,785 - 11,885,417 (-)Ensemblrn6Rnor6.0
Rnor_5.0317,160,752 - 17,221,893 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4311,762,105 - 11,825,531 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera310,816,317 - 10,877,576 (-)NCBICelera
RGSC_v3.1311,658,476 - 11,721,903 (-)NCBI
RH 3.4 Map379.6RGD
Cytogenetic Map3p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetohydrazide  (ISO)
acetylsalicylic acid  (EXP)
aconitine  (EXP)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
DDE  (EXP)
decabromodiphenyl ether  (EXP,ISO)
deguelin  (ISO)
diallyl trisulfide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
fluoxetine  (EXP)
formaldehyde  (EXP)
furan  (EXP)
gamma-tocopherol  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glycine betaine  (EXP)
heroin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
linuron  (EXP)
Mesaconitine  (EXP)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
N-methyl-D-aspartic acid  (ISO)
okadaic acid  (ISO)
orphenadrine  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pinostrobin  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sunitinib  (ISO)
tetrahydropalmatine  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tocopherol  (ISO)
trichostatin A  (EXP,ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon target recognition  (ISO)
cellular response to type II interferon  (ISO)
developmental process involved in reproduction  (IMP)
evoked neurotransmitter secretion  (IMP)
exocytosis  (ISO)
intracellular protein transport  (IBA)
long-term synaptic depression  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein-containing complex assembly  (IDA)
negative regulation of SNARE complex assembly  (TAS)
negative regulation of synaptic transmission, GABAergic  (ISO)
neuromuscular synaptic transmission  (ISO)
neurotransmitter secretion  (ISO)
platelet aggregation  (IEA,ISO)
platelet degranulation  (IEA,ISO)
positive regulation of calcium ion-dependent exocytosis  (ISO)
positive regulation of exocytosis  (IMP)
positive regulation of glutamate secretion, neurotransmission  (IMP)
positive regulation of mast cell degranulation  (IEA,IMP)
positive regulation of synaptic vesicle priming  (IMP)
positive regulation of vesicle docking  (IDA)
positive regulation of vesicle fusion  (IMP)
presynaptic dense core vesicle exocytosis  (IBA)
protein localization to plasma membrane  (IEA,ISO)
protein stabilization  (IDA)
protein transport  (IEA)
regulation of acrosomal vesicle exocytosis  (IEA,ISO)
regulation of synaptic vesicle priming  (IDA,IMP)
regulation of vesicle fusion  (IDA)
response to estradiol  (IEP)
SNARE complex assembly  (IEA,ISO)
synaptic vesicle maturation  (ISO)
synaptic vesicle priming  (IEA,ISO)
vesicle docking involved in exocytosis  (IBA,ISO,ISS)
vesicle-mediated transport  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Co-purification and localization of Munc18-1 (p67) and Cdk5 with neuronal cytoskeletal proteins. Bhaskar K, etal., Neurochem Int. 2004 Jan;44(1):35-44.
2. Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation. Bin NR, etal., Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4610-5. doi: 10.1073/pnas.1214887110. Epub 2013 Mar 4.
3. Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide. Burkhardt P, etal., EMBO J. 2008 Apr 9;27(7):923-33. doi: 10.1038/emboj.2008.37. Epub 2008 Mar 13.
4. Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome. Datta P, etal., Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4400-9. doi: 10.1073/pnas.1510111112. Epub 2015 Jul 27.
5. Munc18-1 and the Syntaxin-1 N Terminus Regulate Open-Closed States in a t-SNARE Complex. Dawidowski D and Cafiso DS, Structure. 2016 Mar 1;24(3):392-400. doi: 10.1016/j.str.2016.01.005. Epub 2016 Feb 11.
6. Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming. Deak F, etal., J Cell Biol. 2009 Mar 9;184(5):751-64. Epub 2009 Mar 2.
7. Clinical spectrum of early-onset epileptic encephalopathies associated with STXBP1 mutations. Deprez L, etal., Neurology. 2010 Sep 28;75(13):1159-65. doi: 10.1212/WNL.0b013e3181f4d7bf.
8. Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins. Dulubova I, etal., Proc Natl Acad Sci U S A 2003 Jan 7;100(1):32-7.
9. Munc18-1 binds directly to the neuronal SNARE complex. Dulubova I, etal., Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2697-702. Epub 2007 Feb 14.
10. rbSec1A and B colocalize with syntaxin 1 and SNAP-25 throughout the axon, but are not in a stable complex with syntaxin. Garcia EP, etal., J Cell Biol 1995 Apr;129(1):105-20.
11. A rat brain Sec1 homologue related to Rop and UNC18 interacts with syntaxin. Garcia EP, etal., Proc Natl Acad Sci U S A 1994 Mar 15;91(6):2003-7.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes. Guan R, etal., Biochemistry. 2008 Feb 12;47(6):1474-81. Epub 2008 Jan 18.
14. Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Hata Y, etal., Nature 1993 Nov 25;366(6453):347-51.
15. Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation. Hu SH, etal., Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1040-5. doi: 10.1073/pnas.0914906108. Epub 2010 Dec 30.
16. Involvement of Rab3A in vesicle priming during exocytosis: interaction with Munc13-1 and Munc18-1. Huang CC, etal., Traffic. 2011 Oct;12(10):1356-70. doi: 10.1111/j.1600-0854.2011.01237.x. Epub 2011 Jul 20.
17. Munc18 plays an important role in the regulation of glutamate release during female puberty onset. Kim BU, etal., Mol Cells. 2006 Aug 31;22(1):30-5.
18. The Q-Soluble-N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor (Q-SNARE) SNAP-47 Regulates Trafficking of Selected Vesicle-Associated Membrane Proteins (VAMPs). Kuster A, etal., J Biol Chem. 2015 Sep 10. pii: jbc.M115.666362.
19. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
20. A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini. Lam PP, etal., Mol Biol Cell. 2007 Jul;18(7):2473-80. Epub 2007 Apr 18.
21. Munc-18-1 inhibits phospholipase D activity by direct interaction in an epidermal growth factor-reversible manner. Lee HY, etal., J Biol Chem. 2004 Apr 16;279(16):16339-48. Epub 2004 Jan 26.
22. Cloning of a putative vesicle transport-related protein, RA410, from cultured rat astrocytes and its expression in ischemic rat brain. Matsuo N, etal., J Biol Chem 1997 Jun 27;272(26):16438-44.
23. Complexins: cytosolic proteins that regulate SNAP receptor function. McMahon HT, etal., Cell 1995 Oct 6;83(1):111-9.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex. Misura KM, etal., Nature. 2000 Mar 23;404(6776):355-62.
26. Label-free mass spectrometric analysis reveals complex changes in the brain proteome from the mdx-4cv mouse model of Duchenne muscular dystrophy. Murphy S, etal., Clin Proteomics. 2015 Nov 23;12:27. doi: 10.1186/s12014-015-9099-0. eCollection 2015.
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. Mints, Munc18-interacting proteins in synaptic vesicle exocytosis. Okamoto M and Sudhof TC, J Biol Chem 1997 Dec 12;272(50):31459-64.
29. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
30. SNAREpin assembly by Munc18-1 requires previous vesicle docking by synaptotagmin 1. Parisotto D, etal., J Biol Chem. 2012 Sep 7;287(37):31041-9. doi: 10.1074/jbc.M112.386805. Epub 2012 Jul 18.
31. An extended helical conformation in domain 3a of Munc18-1 provides a template for SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex assembly. Parisotto D, etal., J Biol Chem. 2014 Apr 4;289(14):9639-50. doi: 10.1074/jbc.M113.514273. Epub 2014 Feb 14.
32. Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay. Perez-Branguli F, etal., Mol Cell Neurosci 2002 Jun;20(2):169-80.
33. n-Sec1: a neural-specific syntaxin-binding protein. Pevsner J, etal., Proc Natl Acad Sci U S A 1994 Feb 15;91(4):1445-9.
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy. Saitsu H, etal., Nat Genet. 2008 Jun;40(6):782-8. doi: 10.1038/ng.150. Epub 2008 May 11.
37. Nuclear localization of Munc18-1 (p67) in the adult rat brain and PC12 cells. Sharma VM, etal., Neurochem Int. 2005 Aug;47(3):225-34.
38. Vesicle fusion probability is determined by the specific interactions of munc18. Smyth AM, etal., J Biol Chem. 2010 Dec 3;285(49):38141-8. doi: 10.1074/jbc.M110.164038. Epub 2010 Aug 26.
39. Overexpression of neuronal Sec1 enhances axonal branching in hippocampal neurons. Steiner P, etal., Neuroscience 2002;113(4):893-905.
40. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
41. Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation. Toonen RF, etal., J Neurochem. 2005 Jun;93(6):1393-400.
42. Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins. Wang Z and Thurmond DC, J Cell Sci. 2009 Apr 1;122(Pt 7):893-903.
43. Reduction of seizure frequency after epilepsy surgery in a patient with STXBP1 encephalopathy and clinical description of six novel mutation carriers. Weckhuysen S, etal., Epilepsia. 2013 May;54(5):e74-80. doi: 10.1111/epi.12124. Epub 2013 Feb 14.
44. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
45. Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. Worst TJ, etal., J Neurosci Res 2005 May 15;80(4):529-38.
46. Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming. Yang X, etal., Nat Struct Mol Biol. 2015 Jul;22(7):547-54. doi: 10.1038/nsmb.3038. Epub 2015 Jun 1.
Additional References at PubMed
PMID:7536802   PMID:7768895   PMID:7890599   PMID:8631738   PMID:8996080   PMID:11036064   PMID:11545717   PMID:12058058   PMID:12477932   PMID:12730201   PMID:12773094   PMID:14651853  
PMID:15123626   PMID:15145078   PMID:15175344   PMID:15182301   PMID:15255974   PMID:15489334   PMID:15563604   PMID:17002520   PMID:17027648   PMID:17110441   PMID:17167098   PMID:17218264  
PMID:17293448   PMID:17543282   PMID:17617378   PMID:17634366   PMID:18077557   PMID:18703708   PMID:18829865   PMID:19056867   PMID:19144319   PMID:19344701   PMID:19483085   PMID:19573021  
PMID:19748891   PMID:19812250   PMID:19822743   PMID:21266332   PMID:21390273   PMID:21614099   PMID:21730064   PMID:21900493   PMID:21900502   PMID:22411134   PMID:22658674   PMID:22871113  
PMID:23091057   PMID:23223447   PMID:23258414   PMID:23525015   PMID:23761923   PMID:23821748   PMID:23904609   PMID:23962429   PMID:24835618   PMID:25517944   PMID:25716318   PMID:25716321  
PMID:26264872   PMID:26888187   PMID:27597756   PMID:28477408   PMID:28483813   PMID:28827281   PMID:29476059   PMID:29997244   PMID:30622273   PMID:31962145   PMID:32357304   PMID:32643828  
PMID:32669573   PMID:33159991   PMID:33468652   PMID:33590815   PMID:36335177   PMID:38755165  


Genomics

Comparative Map Data
Stxbp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,474,428 - 36,536,120 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl336,474,428 - 36,536,058 (-)EnsemblGRCr8
mRatBN7.2316,076,725 - 16,138,431 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl316,076,391 - 16,138,369 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx319,144,972 - 19,206,215 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,729,979 - 27,791,223 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,981,796 - 26,042,989 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,823,779 - 11,885,479 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,823,785 - 11,885,417 (-)Ensemblrn6Rnor6.0
Rnor_5.0317,160,752 - 17,221,893 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4311,762,105 - 11,825,531 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera310,816,317 - 10,877,576 (-)NCBICelera
RGSC_v3.1311,658,476 - 11,721,903 (-)NCBI
RH 3.4 Map379.6RGD
Cytogenetic Map3p11NCBI
STXBP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389127,611,912 - 127,696,029 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9127,579,370 - 127,696,027 (+)Ensemblhg38GRCh38
GRCh379130,374,191 - 130,458,308 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,414,390 - 129,494,816 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349127,454,121 - 127,534,549NCBI
Celera9101,025,378 - 101,105,881 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef999,990,647 - 100,071,101 (+)NCBIHuRef
CHM1_19130,525,679 - 130,606,190 (+)NCBICHM1_1
T2T-CHM13v2.09139,818,871 - 139,902,984 (+)NCBIT2T-CHM13v2.0
Stxbp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,677,619 - 32,737,249 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,677,614 - 32,737,257 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38232,787,607 - 32,847,237 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,787,602 - 32,847,245 (-)Ensemblmm10GRCm38
MGSCv37232,643,127 - 32,702,757 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36232,609,971 - 32,669,135 (-)NCBIMGSCv36mm8
Celera232,494,462 - 32,554,183 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Stxbp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955419963,829 - 1,000,759 (-)Ensembl
ChiLan1.0NW_004955419963,829 - 1,000,759 (-)NCBIChiLan1.0ChiLan1.0
STXBP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,662,956 - 11,743,095 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,665,339 - 11,745,425 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0998,731,527 - 98,811,608 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,434,080 - 127,483,971 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,434,080 - 127,486,152 (+)EnsemblpanPan2panpan1.1
STXBP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,690,939 - 55,768,008 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,678,264 - 55,727,680 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha954,884,147 - 54,958,397 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0956,612,796 - 56,687,174 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,581,112 - 56,723,342 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,372,644 - 55,447,116 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,687,749 - 55,761,958 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,778,988 - 55,853,304 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Stxbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,532,283 - 195,598,947 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,300,952 - 15,365,713 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648715,300,758 - 15,367,475 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STXBP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,116,120 - 268,205,778 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11268,116,124 - 268,205,805 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,023,293 - 302,098,188 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STXBP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11210,440,061 - 10,519,798 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1210,439,801 - 10,519,777 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660795,699,673 - 5,781,129 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stxbp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247607,842,640 - 7,914,484 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247607,843,741 - 7,914,444 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Stxbp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v152,791,366 - 2,852,502 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Stxbp1
514 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:238
Count of miRNA genes:159
Interacting mature miRNAs:182
Transcripts:ENSRNOT00000021178, ENSRNOT00000021189
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)33083238444921701Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
AI326233  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2316,078,026 - 16,078,111 (+)MAPPERmRatBN7.2
Rnor_6.0311,825,081 - 11,825,165NCBIRnor6.0
Rnor_5.0317,162,051 - 17,162,135UniSTSRnor5.0
RGSC_v3.4311,763,402 - 11,763,486UniSTSRGSC3.4
Celera310,817,614 - 10,817,698UniSTS
Cytogenetic Map3p11UniSTS
D45903  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2316,076,943 - 16,077,048 (+)MAPPERmRatBN7.2
Rnor_6.0311,823,998 - 11,824,102NCBIRnor6.0
Rnor_5.0317,160,968 - 17,161,072UniSTSRnor5.0
RGSC_v3.4311,762,319 - 11,762,423UniSTSRGSC3.4
Celera310,816,531 - 10,816,635UniSTS
Cytogenetic Map3p11UniSTS
RH132234  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2316,082,121 - 16,082,311 (+)MAPPERmRatBN7.2
Rnor_6.0311,829,176 - 11,829,365NCBIRnor6.0
Rnor_5.0317,166,146 - 17,166,335UniSTSRnor5.0
RGSC_v3.4311,767,497 - 11,767,686UniSTSRGSC3.4
Celera310,821,710 - 10,821,899UniSTS
RH 3.4 Map379.9UniSTS
Cytogenetic Map3p11UniSTS
RH144382  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2316,080,887 - 16,080,990 (+)MAPPERmRatBN7.2
Rnor_6.0311,827,941 - 11,828,043NCBIRnor6.0
Rnor_5.0317,164,911 - 17,165,013UniSTSRnor5.0
RGSC_v3.4311,766,262 - 11,766,364UniSTSRGSC3.4
Celera310,820,473 - 10,820,575UniSTS
RH 3.4 Map381.7UniSTS
Cytogenetic Map3p11UniSTS
RH139424  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2316,082,121 - 16,082,290 (+)MAPPERmRatBN7.2
Rnor_6.0311,829,176 - 11,829,344NCBIRnor6.0
Rnor_5.0317,166,146 - 17,166,314UniSTSRnor5.0
RGSC_v3.4311,767,497 - 11,767,665UniSTSRGSC3.4
Celera310,821,710 - 10,821,878UniSTS
RH 3.4 Map372.7UniSTS
Cytogenetic Map3p11UniSTS
Stxbp1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2316,077,599 - 16,077,844 (+)MAPPERmRatBN7.2
Rnor_6.0311,824,654 - 11,824,898NCBIRnor6.0
Rnor_5.0317,161,624 - 17,161,868UniSTSRnor5.0
RGSC_v3.4311,762,975 - 11,763,219UniSTSRGSC3.4
Celera310,817,187 - 10,817,431UniSTS
RH 3.4 Map379.6UniSTS
Cytogenetic Map3p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021178   ⟹   ENSRNOP00000021178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl336,474,428 - 36,536,058 (-)Ensembl
mRatBN7.2 Ensembl316,076,391 - 16,138,319 (-)Ensembl
Rnor_6.0 Ensembl311,823,785 - 11,885,417 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000021189   ⟹   ENSRNOP00000021189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl336,479,689 - 36,536,058 (-)Ensembl
mRatBN7.2 Ensembl316,078,344 - 16,138,369 (-)Ensembl
Rnor_6.0 Ensembl311,830,046 - 11,885,311 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106791   ⟹   ENSRNOP00000091076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl336,474,428 - 36,510,762 (-)Ensembl
mRatBN7.2 Ensembl316,076,391 - 16,113,068 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110071   ⟹   ENSRNOP00000089501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl316,082,227 - 16,138,369 (-)Ensembl
RefSeq Acc Id: NM_013038   ⟹   NP_037170
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,474,428 - 36,536,058 (-)NCBI
mRatBN7.2316,076,730 - 16,138,369 (-)NCBI
Rnor_6.0311,823,784 - 11,885,417 (-)NCBI
Rnor_5.0317,160,752 - 17,221,893 (-)NCBI
RGSC_v3.4311,762,105 - 11,825,531 (-)RGD
Celera310,816,317 - 10,877,576 (-)RGD
Sequence:
RefSeq Acc Id: XM_006233939   ⟹   XP_006234001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,476,096 - 36,536,120 (-)NCBI
mRatBN7.2316,076,725 - 16,138,431 (-)NCBI
Rnor_6.0311,823,779 - 11,885,479 (-)NCBI
Rnor_5.0317,160,752 - 17,221,893 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063283163   ⟹   XP_063139233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,479,728 - 36,536,120 (-)NCBI
RefSeq Acc Id: NP_037170   ⟸   NM_013038
- UniProtKB: P61765 (UniProtKB/Swiss-Prot),   A6JU89 (UniProtKB/TrEMBL),   A0A8I6ABE0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234001   ⟸   XM_006233939
- Peptide Label: isoform X1
- UniProtKB: A6JU90 (UniProtKB/TrEMBL),   A0A8I6A8W2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021189   ⟸   ENSRNOT00000021189
Ensembl Acc Id: ENSRNOP00000021178   ⟸   ENSRNOT00000021178
Ensembl Acc Id: ENSRNOP00000089501   ⟸   ENSRNOT00000110071
Ensembl Acc Id: ENSRNOP00000091076   ⟸   ENSRNOT00000106791
RefSeq Acc Id: XP_063139233   ⟸   XM_063283163
- Peptide Label: isoform X1
- UniProtKB: A6JU90 (UniProtKB/TrEMBL),   A0A8I6A8W2 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61765-F1-model_v2 AlphaFold P61765 1-594 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691996
Promoter ID:EPDNEW_R2521
Type:multiple initiation site
Name:Stxbp1_1
Description:syntaxin binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0311,885,426 - 11,885,486EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3785 AgrOrtholog
BIND 134444
  134446
  134479
  134480
BioCyc Gene G2FUF-50118 BioCyc
Ensembl Genes ENSRNOG00000015420 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021178 ENTREZGENE
  ENSRNOT00000021178.9 UniProtKB/Swiss-Prot
  ENSRNOT00000021189 ENTREZGENE
  ENSRNOT00000021189.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.60 UniProtKB/Swiss-Prot
  3.40.50.1910 UniProtKB/Swiss-Prot
  3.40.50.2060 UniProtKB/Swiss-Prot
  Syntaxin Binding Protein 1, Chain A, domain 2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7315868 IMAGE-MGC_LOAD
InterPro Sec-1-like_dom1 UniProtKB/Swiss-Prot
  Sec-1-like_dom2 UniProtKB/Swiss-Prot
  Sec-1-like_dom3a UniProtKB/Swiss-Prot
  Sec1-like UniProtKB/Swiss-Prot
  Sec1-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:25558 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105262 IMAGE-MGC_LOAD
NCBI Gene 25558 ENTREZGENE
PANTHER PTHR11679 UniProtKB/Swiss-Prot
Pfam Sec1 UniProtKB/Swiss-Prot
PhenoGen Stxbp1 PhenoGen
PIRSF VPS45_Sec1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015420 RatGTEx
Superfamily-SCOP SSF56815 UniProtKB/Swiss-Prot
TIGR TC228377
UniProt A0A8I6A8W2 ENTREZGENE
  A0A8I6ABE0 ENTREZGENE, UniProtKB/TrEMBL
  A6JU89 ENTREZGENE, UniProtKB/TrEMBL
  A6JU90 ENTREZGENE, UniProtKB/TrEMBL
  P61765 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q28208 UniProtKB/Swiss-Prot
  Q62759 UniProtKB/Swiss-Prot
  Q64320 UniProtKB/Swiss-Prot
  Q96TG8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Stxbp1  Syntaxin binding protein 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to cytosol and membranes in neuronal tissues 730116
gene_cellular_localization found along axonal plasmalemma in both soluble and membrane-associated forms 729999
gene_expression expressed in brain but not in non-neuronal tissues 1299067
gene_homology 65% identity to D. melanogaster rop; 59% identity to C. elegans unc-18; 27% identity to S. cerevisiae Sec1p 730116
gene_homology homolog of C. elegans gene unc-18 1299066
gene_physical_interaction binding to syntaxin requires N-terminus of syntaxin; binding to SNAP-25 requires C-terminus 1299066
gene_physical_interaction when created as a GST fusion protein, binds with syntaxin but not with SNAP-25 or synaptobrevin/VAMP 1299067
gene_physical_interaction binds syntaxins 1A and 1B 730238
gene_physical_interaction binds to syntaxin 1a, 2, and 3 fusion proteins but not to syntaxin 4 fusion protein 730116
gene_physical_interaction not part of the synaptic SNARE or syntaxin 1/SNAP-25 complexes in situ; associations with syntaxin may not be stable 729999
gene_process may be essential for synaptic vesicle docking and fusion 730116
gene_process may be essential for synaptic vesicle docking and fusion 1299066
gene_process may modulate formation of SNARE complexes in nerve endings 730238
gene_protein 593 amino acid protein 1299067
gene_transcript found as two alternatively spliced isoforms rbSec1A and rbSec1B in axon 729999
gene_transcript mRNA upregulated in frontal cortex of AA rat strain compared to ANA rat strain 1358772