Stat5a (signal transducer and activator of transcription 5A) - Rat Genome Database

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Gene: Stat5a (signal transducer and activator of transcription 5A) Rattus norvegicus
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Symbol: Stat5a
Name: signal transducer and activator of transcription 5A
RGD ID: 3773
Description: Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cell surface receptor signaling pathway via JAK-STAT; mammary gland development; and response to ethanol. Acts upstream of or within cellular response to cytokine stimulus. Predicted to be located in cytosol. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human STAT5A (signal transducer and activator of transcription 5A); PARTICIPATES IN Jak-Stat signaling pathway; erythropoietin signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; INTERACTS WITH (4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: mammary gland factor; signal transducer and activator of transcription 5; Stat5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau3 Pia10 Ciaa2
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,285,859 - 86,310,187 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1086,285,547 - 86,310,184 (+)EnsemblGRCr8
mRatBN7.21085,785,537 - 85,809,869 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,785,537 - 85,809,866 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1090,821,886 - 90,846,156 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,300,534 - 90,324,854 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,693,771 - 85,718,012 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,764,732 - 88,789,060 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,764,732 - 88,789,057 (+)Ensemblrn6Rnor6.0
Rnor_5.01088,558,936 - 88,583,264 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41089,795,404 - 89,819,732 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1084,503,376 - 84,527,708 (+)NCBICelera
RGSC_v3.11089,809,773 - 89,834,099 (+)NCBI
Cytogenetic Map10q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (EXP)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP,IEP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
alpinumisoflavone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzoates  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bromocriptine  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
chelerythrine  (EXP)
cholesterol  (ISO)
cisplatin  (ISO)
citalopram  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
dichloromethane  (ISO)
diethylstilbestrol  (EXP,ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
estriol  (ISO)
fluorescein 5-isothiocyanate  (ISO)
Garcinol  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Goe 6976  (EXP,ISO)
GSK-J4  (ISO)
immunological adjuvant  (EXP)
isoprenaline  (ISO)
lipopolysaccharide  (ISO)
melatonin  (ISO)
metam  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
methylphenidate  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
mycophenolic acid  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nicotinic acid  (EXP)
nitrates  (ISO)
nitric oxide  (ISO)
NORCANTHARIDIN  (ISO)
Nutlin-3  (ISO)
oxybenzone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pevonedistat  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP,IEP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphane  (EXP)
piperine  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
ponatinib  (ISO)
progesterone  (ISO)
propiconazole  (EXP)
prostaglandin F2alpha  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quizartinib  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sorafenib  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
titanium dioxide  (ISO)
tofacitinib  (EXP,ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell surface receptor signaling pathway via JAK-STAT  (IBA,IDA,IEA,ISO)
cellular response to cytokine stimulus  (IDA)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (ISO)
cytokine-mediated signaling pathway  (IBA,ISO)
defense response  (IBA)
development of secondary female sexual characteristics  (ISO)
development of secondary male sexual characteristics  (ISO)
eosinophil differentiation  (IEA,ISO)
epithelial cell differentiation involved in prostate gland development  (ISO)
female pregnancy  (ISO)
gene expression  (ISO)
gland development  (IEA)
growth hormone receptor signaling pathway via JAK-STAT  (IBA,IEA,ISO)
interleukin-15-mediated signaling pathway  (IEA,ISO)
interleukin-2-mediated signaling pathway  (IEA,ISO)
interleukin-3-mediated signaling pathway  (IEA,ISO)
interleukin-4-mediated signaling pathway  (IEA,ISO)
interleukin-5-mediated signaling pathway  (IEA,ISO)
interleukin-7-mediated signaling pathway  (IEA,ISO)
interleukin-9-mediated signaling pathway  (IEA,ISO)
lactation  (IEA,IEP,ISO)
lipid storage  (ISO)
luteinization  (ISO)
mammary gland development  (ISO)
mammary gland epithelium development  (ISO)
mammary gland involution  (IDA)
multicellular organismal reproductive process  (IEP)
natural killer cell differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of erythrocyte differentiation  (ISO)
negative regulation of mast cell apoptotic process  (ISO)
negative regulation of T-helper 17 cell lineage commitment  (IEA,ISO)
peptidyl-tyrosine phosphorylation  (ISO)
Peyer's patch development  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of B cell differentiation  (ISO)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of endothelial cell proliferation  (IEA,ISO)
positive regulation of gamma-delta T cell differentiation  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-2 production  (ISO)
positive regulation of lymphocyte differentiation  (ISO)
positive regulation of mast cell differentiation  (ISO)
positive regulation of mast cell proliferation  (ISO)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of natural killer cell differentiation  (ISO)
positive regulation of natural killer cell mediated cytotoxicity  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
prostate gland epithelium morphogenesis  (ISO)
reelin-mediated signaling pathway  (ISO)
regulation of cell adhesion  (ISO)
regulation of cell population proliferation  (IBA)
regulation of DNA-templated transcription  (IEA,TAS)
regulation of epithelial cell differentiation  (ISO)
regulation of multicellular organism growth  (IEA,ISO)
regulation of steroid metabolic process  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
response to ethanol  (IEP)
response to nutrient levels  (IEP)
response to peptide hormone  (IBA,ISO)
signal transduction  (IEA)
T cell differentiation in thymus  (ISO)
T cell homeostasis  (ISO)
taurine metabolic process  (ISO)
thrombopoietin-mediated signaling pathway  (IEA,ISO)
transcription by RNA polymerase II  (IDA,IEA)

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO,TAS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
RNA polymerase II transcription regulator complex  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Yin-yang 1 and glucocorticoid receptor participate in the Stat5-mediated growth hormone response of the serine protease inhibitor 2.1 gene. Bergad PL, etal., J Biol Chem. 2000 Mar 17;275(11):8114-20.
2. STAT 5a expression in various lesions of the breast. Bratthauer GL, etal., Virchows Arch. 2006 Feb;448(2):165-71. Epub 2005 Aug 19.
3. Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis. Farouk S, etal., PLoS One. 2018 Oct 22;13(10):e0206130. doi: 10.1371/journal.pone.0206130. eCollection 2018.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Activation of the Jak/Stat signal transduction pathway in GH-treated rat osteoblast-like cells in culture. Gerland K, etal., Mol Cell Endocrinol. 2000 Oct 25;168(1-2):1-9.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Identification of immune checkpoint inhibitors and biomarkers among STAT family in stomach adenocarcinoma. Guo L, etal., Am J Transl Res. 2020 Sep 15;12(9):4977-4997. eCollection 2020.
8. STAT5A/B gene locus undergoes amplification during human prostate cancer progression. Haddad BR, etal., Am J Pathol. 2013 Jun;182(6):2264-75. doi: 10.1016/j.ajpath.2013.02.044. Epub 2013 May 7.
9. Regulation of mammary gland factor/Stat5a during mammary gland development. Kazansky AV, etal., Mol Endocrinol 1995 Nov;9(11):1598-609.
10. Signaling through the JAK/STAT pathway, recent advances and future challenges. Kisseleva T, etal., Gene 2002 Feb 20;285(1-2):1-24.
11. Enhanced Hsa-miR-181d/p-STAT3 and Hsa-miR-181d/p-STAT5A Ratios Mediate the Anticancer Effect of Garcinol in STAT3/5A-Addicted Glioblastoma. Liu HW, etal., Cancers (Basel). 2019 Nov 27;11(12). pii: cancers11121888. doi: 10.3390/cancers11121888.
12. JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Lv N, etal., Exp Cell Res. 2009 Jul 15;315(12):2064-71. doi: 10.1016/j.yexcr.2009.04.021. Epub 2009 May 3.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Role of ERalpha in the differential response of Stat5a loss in susceptibility to mammary preneoplasia and DMBA-induced carcinogenesis. Miermont AM, etal., Carcinogenesis. 2010 Jun;31(6):1124-31. doi: 10.1093/carcin/bgq048. Epub 2010 Feb 24.
15. The JAK-STAT signaling pathway: input and output integration. Murray PJ J Immunol. 2007 Mar 1;178(5):2623-9.
16. Nuclear localization of STAT5A modified with O-linked N-acetylglucosamine and early involution in the mammary gland of Hirosaki hairless rat. Nanashima N, etal., J Biol Chem. 2005 Dec 30;280(52):43010-6. Epub 2005 Oct 14.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. De-regulated STAT5A/miR-202-5p/USP15/Caspase-6 regulatory axis suppresses CML cell apoptosis and contributes to Imatinib resistance. Nie ZY, etal., J Exp Clin Cancer Res. 2020 Jan 17;39(1):17. doi: 10.1186/s13046-019-1502-7.
19. Proliferation and apoptosis in PhIP-induced rat mammary gland carcinomas with elevated phosphotyrosine-STAT5a. Papaconstantinou AD and Snyderwine EG, FEBS Lett. 2007 Jan 9;581(1):29-33. Epub 2006 Dec 5.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. Loss of Stat5a delays mammary cancer progression in a mouse model. Ren S, etal., Oncogene. 2002 Jun 20;21(27):4335-9.
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. CrkL functions as a nuclear adaptor and transcriptional activator in Bcr-Abl-expressing cells. Rhodes J, etal., Exp Hematol. 2000 Mar;28(3):305-10.
25. Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements. Ripperger JA, etal., J Biol Chem 1995 Dec 15;270(50):29998-30006.
26. Possible role of Stat5a in rat mammary gland carcinogenesis. Shan L, etal., Breast Cancer Res Treat. 2004 Dec;88(3):263-72.
27. cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenzanthracene. Shan L, etal., Carcinogenesis. 2002 Oct;23(10):1561-8.
28. Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. Shan L, etal., Toxicol Pathol. 2005;33(7):768-75.
29. Physiologic and genomic analyses of nutrition-ethanol interactions during gestation: Implications for fetal ethanol toxicity. Shankar K, etal., Exp Biol Med (Maywood). 2006 Sep;231(8):1379-97.
30. Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. Shi SY, etal., J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.
31. JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. Slattery ML, etal., Mol Carcinog. 2013 Feb;52(2):155-66. doi: 10.1002/mc.21841. Epub 2011 Nov 28.
32. Mammary gland factor activated by prolactin on mammary epithelial cells and acute-phase response factor activated by interleukin-6 in liver cells share DNA binding and transactivation potential. Standke GJ, etal., Mol Endocrinol. 1994 Apr;8(4):469-77. doi: 10.1210/mend.8.4.7519723.
33. Proliferation and apoptosis in mammary epithelium during the rat oestrous cycle. Strange R, etal., Acta Physiol (Oxf). 2007 Jun;190(2):137-49. Epub 2007 Apr 13.
34. Modulation of signal transducers and activators of transcription (STAT) factor pathways during focal cerebral ischaemia: a gene expression array study in rat hippocampus after middle cerebral artery occlusion. Sun SL, etal., Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1097-101.
35. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
36. STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre-B Cell Growth in a CCL20-Dependent Manner. Tsuruyama T, etal., J Cell Biochem. 2016 Nov;117(11):2630-42. doi: 10.1002/jcb.25558. Epub 2016 Apr 14.
37. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. Wakao H, etal., EMBO J 1994 May 1;13(9):2182-91.
38. STAT5 signaling is required for the efficient induction and maintenance of CML in mice. Ye D, etal., Blood. 2006 Jun 15;107(12):4917-25. doi: 10.1182/blood-2005-10-4110. Epub 2006 Mar 7.
Additional References at PubMed
PMID:8702683   PMID:9630227   PMID:9841920   PMID:10072077   PMID:10323205   PMID:10485657   PMID:10652277   PMID:10757801   PMID:10908145   PMID:10979977   PMID:11254359   PMID:11406124  
PMID:11706048   PMID:12040017   PMID:12089354   PMID:12107179   PMID:12147240   PMID:12161450   PMID:12388746   PMID:12393611   PMID:12456807   PMID:12538627   PMID:14522949   PMID:14678947  
PMID:14684617   PMID:15294943   PMID:15471942   PMID:15746188   PMID:15855883   PMID:15857395   PMID:15947484   PMID:15958724   PMID:15963505   PMID:16110263   PMID:16357045   PMID:17353091  
PMID:17728251   PMID:18178618   PMID:18499741   PMID:18648510   PMID:19008912   PMID:19228956   PMID:19339209   PMID:19423653   PMID:19666510   PMID:19797429   PMID:20489169   PMID:21217760  
PMID:21363933   PMID:22125600   PMID:23610142   PMID:24463190   PMID:26670189   PMID:26802935   PMID:27145179   PMID:28712960   PMID:29581031   PMID:31158467   PMID:35143864   PMID:35320597  
PMID:36195691   PMID:37232379  


Genomics

Comparative Map Data
Stat5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,285,859 - 86,310,187 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1086,285,547 - 86,310,184 (+)EnsemblGRCr8
mRatBN7.21085,785,537 - 85,809,869 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,785,537 - 85,809,866 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1090,821,886 - 90,846,156 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,300,534 - 90,324,854 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,693,771 - 85,718,012 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,764,732 - 88,789,060 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,764,732 - 88,789,057 (+)Ensemblrn6Rnor6.0
Rnor_5.01088,558,936 - 88,583,264 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41089,795,404 - 89,819,732 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1084,503,376 - 84,527,708 (+)NCBICelera
RGSC_v3.11089,809,773 - 89,834,099 (+)NCBI
Cytogenetic Map10q31NCBI
STAT5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,287,439 - 42,311,943 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,287,547 - 42,311,943 (+)Ensemblhg38GRCh38
GRCh371740,439,457 - 40,463,961 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,693,091 - 37,717,484 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341737,693,090 - 37,717,484NCBI
Celera1737,094,449 - 37,118,845 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,204,247 - 36,228,642 (+)NCBIHuRef
CHM1_11740,675,279 - 40,699,663 (+)NCBICHM1_1
T2T-CHM13v2.01743,143,926 - 43,168,430 (+)NCBIT2T-CHM13v2.0
Stat5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,750,177 - 100,775,995 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,750,177 - 100,775,995 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811100,859,351 - 100,885,169 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,859,351 - 100,885,169 (+)Ensemblmm10GRCm38
MGSCv3711100,720,665 - 100,746,483 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611100,675,494 - 100,701,259 (+)NCBIMGSCv36mm8
MGSCv3611101,635,936 - 101,661,700 (+)NCBIMGSCv36mm8
Cytogenetic Map11DNCBI
cM Map1163.77NCBI
Stat5a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,305,363 - 16,318,534 (+)Ensembl
ChiLan1.0NW_00495545116,305,363 - 16,319,219 (+)NCBIChiLan1.0ChiLan1.0
LOC100988550
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,673,101 - 22,696,260 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,563,275 - 24,586,438 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,005,025 - 15,029,110 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11715,228,465 - 15,251,783 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,228,465 - 15,251,783 (-)EnsemblpanPan2panpan1.1
STAT5A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,616,041 - 20,638,523 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,617,151 - 20,638,103 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha920,077,547 - 20,099,955 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0921,335,685 - 21,357,957 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,288,139 - 21,357,497 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,120,814 - 20,142,574 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,387,762 - 20,409,305 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,490,411 - 20,512,845 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
STAT5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,474,227 - 20,499,138 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11220,474,221 - 20,498,785 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21224,563,982 - 24,581,115 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STAT5A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,959,265 - 63,986,627 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,960,515 - 63,985,026 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607734,770,565 - 34,795,956 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Stat5a
90 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:172
Count of miRNA genes:122
Interacting mature miRNAs:142
Transcripts:ENSRNOT00000026662
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
D10Got123  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,794,667 - 85,794,762 (+)MAPPERmRatBN7.2
Rnor_6.01088,773,862 - 88,773,954NCBIRnor6.0
Rnor_5.01088,568,066 - 88,568,158UniSTSRnor5.0
RGSC_v3.41089,804,533 - 89,804,626RGDRGSC3.4
RGSC_v3.41089,804,534 - 89,804,626UniSTSRGSC3.4
Celera1084,512,506 - 84,512,598UniSTS
RGSC_v3.11089,818,904 - 89,818,996RGD
RH 3.4 Map10831.6UniSTS
RH 3.4 Map10831.6RGD
RH 2.0 Map10968.6RGD
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000026662   ⟹   ENSRNOP00000026662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1086,285,547 - 86,310,184 (+)Ensembl
mRatBN7.2 Ensembl1085,785,537 - 85,809,866 (+)Ensembl
Rnor_6.0 Ensembl1088,764,732 - 88,789,057 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095278   ⟹   ENSRNOP00000097502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1086,285,547 - 86,309,851 (+)Ensembl
mRatBN7.2 Ensembl1085,785,537 - 85,809,533 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106423   ⟹   ENSRNOP00000087214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1086,285,547 - 86,310,184 (+)Ensembl
mRatBN7.2 Ensembl1085,785,537 - 85,809,866 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108368   ⟹   ENSRNOP00000096520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1086,285,547 - 86,310,184 (+)Ensembl
mRatBN7.2 Ensembl1085,785,537 - 85,809,866 (+)Ensembl
RefSeq Acc Id: NM_017064   ⟹   NP_058760
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,285,859 - 86,310,187 (+)NCBI
mRatBN7.21085,785,537 - 85,809,869 (+)NCBI
Rnor_6.01088,764,732 - 88,789,060 (+)NCBI
Rnor_5.01088,558,936 - 88,583,264 (+)NCBI
RGSC_v3.41089,795,404 - 89,819,732 (+)RGD
Celera1084,503,376 - 84,527,708 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058760 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA98843 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026662
GenBank Protein Q62771 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058760   ⟸   NM_017064
- UniProtKB: Q62771 (UniProtKB/Swiss-Prot),   G3V8K7 (UniProtKB/TrEMBL),   A6HJ62 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026662   ⟸   ENSRNOT00000026662
Ensembl Acc Id: ENSRNOP00000096520   ⟸   ENSRNOT00000108368
Ensembl Acc Id: ENSRNOP00000097502   ⟸   ENSRNOT00000095278
Ensembl Acc Id: ENSRNOP00000087214   ⟸   ENSRNOT00000106423
Protein Domains
SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62771-F1-model_v2 AlphaFold Q62771 1-793 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697734
Promoter ID:EPDNEW_R8259
Type:multiple initiation site
Name:Stat5a_1
Description:signal transducer and activator of transcription 5A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01088,764,672 - 88,764,732EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3773 AgrOrtholog
BioCyc Gene G2FUF-23211 BioCyc
Ensembl Genes ENSRNOG00000019496 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000026662 ENTREZGENE
Gene3D-CATH 1.10.532.10 UniProtKB/Swiss-Prot
  2.60.40.630 UniProtKB/Swiss-Prot
  3.30.505.10 UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
  STAT transcription factor, all-alpha domain UniProtKB/Swiss-Prot
InterPro p53-like_TF_DNA-bd UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  STAT UniProtKB/Swiss-Prot
  STAT5_CCD UniProtKB/Swiss-Prot
  STAT5a/5b UniProtKB/Swiss-Prot
  STAT_linker UniProtKB/Swiss-Prot
  STAT_N_sf UniProtKB/Swiss-Prot
  STAT_TF_alpha UniProtKB/Swiss-Prot
  STAT_TF_coiled-coil UniProtKB/Swiss-Prot
  STAT_TF_DNA-bd UniProtKB/Swiss-Prot
  STAT_TF_DNA-bd_N UniProtKB/Swiss-Prot
  STAT_TF_prot_interaction UniProtKB/Swiss-Prot
KEGG Report rno:24918 UniProtKB/Swiss-Prot
NCBI Gene 24918 ENTREZGENE
PANTHER PTHR11801 UniProtKB/Swiss-Prot
Pfam SH2 UniProtKB/Swiss-Prot
  STAT_alpha UniProtKB/Swiss-Prot
  STAT_bind UniProtKB/Swiss-Prot
  STAT_int UniProtKB/Swiss-Prot
  STAT_linker UniProtKB/Swiss-Prot
PhenoGen Stat5a PhenoGen
PROSITE SH2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019496 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot
  STAT_int UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47655 UniProtKB/Swiss-Prot
  SSF48092 UniProtKB/Swiss-Prot
  SSF49417 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
TIGR TC217562
UniProt A0A8I6A7C8_RAT UniProtKB/TrEMBL
  A0A8I6AQT9_RAT UniProtKB/TrEMBL
  A0A8I6AWF7_RAT UniProtKB/TrEMBL
  A6HJ62 ENTREZGENE, UniProtKB/TrEMBL
  G3V8K7 ENTREZGENE, UniProtKB/TrEMBL
  Q62771 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Stat5a  Signal transducer and activator of transcription 5a      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process may be associated with mammary gland development and lactation 730121
gene_protein protein masses 92 kDa 729990
gene_regulation exposure of H4 hepatoma cells to growth hormone (GH) results in a reversible time-, concentration- and growth hormone receptor concentration-dependent increase in tyrosine phosphorylation of STAT5 625493
gene_regulation translocated to the nucleus in most subpopulations of hypothalamic dopaminergic neurons following ovine prolactin activation of prolactin receptors 632713