Plcb1 (phospholipase C beta 1) - Rat Genome Database

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Gene: Plcb1 (phospholipase C beta 1) Rattus norvegicus
Analyze
Symbol: Plcb1
Name: phospholipase C beta 1
RGD ID: 3344
Description: Enables calcium ion binding activity; identical protein binding activity; and phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Involved in several processes, including cellular response to glyceraldehyde; cellular response to ionomycin; and learning or memory. Predicted to be located in chromatin and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including GABA-ergic synapse; nuclear speck; and postsynaptic cytosol. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in Alzheimer's disease; developmental and epileptic encephalopathy 12; and myelodysplastic syndrome. Orthologous to human PLCB1 (phospholipase C beta 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; 1-(3-chlorophenyl)piperazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1; Phosphb; phosphoinositide phospholipase C; phosphoinositide phospholipase C-beta-1; phospholipase C, beta 1; phospholipase C, beta 1 (phosphoinositide-specific); phospholipase C-beta-1; Phospholipase C-beta1; phospholipase C-I; PLC'1; PLC-154; PLC-beta-1; PLC-I; PLCbeta1; RATPHOSPHB
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Plcb1Tn(pb-Bhr2)1Wmukf
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83142,512,765 - 143,224,042 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3142,513,033 - 143,225,646 (+)EnsemblGRCr8
mRatBN7.23122,059,988 - 122,772,896 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3122,060,031 - 122,772,869 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3125,952,538 - 126,679,203 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03134,555,297 - 135,266,257 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03132,208,716 - 132,934,812 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03127,721,244 - 128,419,565 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3128,155,069 - 128,419,545 (+)Ensemblrn6Rnor6.0
Rnor_5.03134,211,557 - 134,908,321 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43122,797,718 - 123,523,675 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3120,808,920 - 121,513,252 (+)NCBICelera
RGSC_v3.13122,703,321 - 123,430,863 (+)NCBI
Cytogenetic Map3q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(R)-noradrenaline  (EXP)
1,2-dichloroethane  (ISO)
1-(3-chlorophenyl)piperazine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dihydroxyphenylethyleneglycol  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
acrylonitrile  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
alprazolam  (EXP)
aluminium trifluoride  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (ISO)
apocynin  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
barium(0)  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
calcitriol  (EXP)
Candesartan cilexetil  (EXP)
carbachol  (EXP)
carbon nanotube  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP)
D-glyceraldehyde  (EXP)
desipramine  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (EXP)
fipronil  (EXP)
fluoxetine  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
glucose  (EXP)
glyceraldehyde  (EXP)
glyphosate  (ISO)
guanosine 5'-[gamma-thio]triphosphate  (EXP)
indometacin  (ISO)
ionomycin  (EXP)
irinotecan  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
O-methyleugenol  (ISO)
oxaliplatin  (EXP)
oxytocin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctanoic acid  (ISO)
Phenelzine  (EXP)
phenylarsine oxide  (ISO)
phenylephrine  (EXP)
phenylpropanolamine  (ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
prazosin  (EXP)
progesterone  (ISO)
quercetin  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
tetraphene  (ISO)
theophylline  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
U-73122  (EXP,ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of meiosis involved in egg activation  (IEA,ISO,ISS)
cellular response to fluoride  (IDA)
cellular response to glyceraldehyde  (IDA)
cellular response to ionomycin  (IDA)
cellular response to peptide hormone stimulus  (IEA)
cellular response to vasopressin  (IDA)
cerebral cortex development  (IEA,ISO,ISS)
fat cell differentiation  (IEA,ISO)
G protein-coupled acetylcholine receptor signaling pathway  (IEA,ISO)
G protein-coupled receptor signaling pathway  (IBA)
G2/M transition of mitotic cell cycle  (IEA,ISO)
glutamate receptor signaling pathway  (IEA,ISO,ISS)
inositol trisphosphate metabolic process  (IDA,IEA)
insulin-like growth factor receptor signaling pathway  (IEA,ISO,ISS)
interleukin-1-mediated signaling pathway  (IEA,ISO)
interleukin-12-mediated signaling pathway  (IEA,ISO)
interleukin-15-mediated signaling pathway  (IEA,ISO)
intracellular signal transduction  (IEA)
learning  (IEP)
lipid catabolic process  (IEA)
lipid metabolic process  (IEA)
memory  (IBA,IEA,IEP,ISO)
negative regulation of DNA-templated transcription  (IEA,ISO,ISS)
negative regulation of monocyte extravasation  (IEA,ISO,ISS)
phosphatidylinositol catabolic process  (IDA,IEA)
phosphatidylinositol metabolic process  (IBA,IEA,IEP,ISO)
phosphatidylinositol-mediated signaling  (IBA)
phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway  (IEA,ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
positive regulation of acrosome reaction  (IEA,ISO)
positive regulation of developmental growth  (IEA,ISO,ISS)
positive regulation of DNA-templated transcription  (IEA,ISO,ISS)
positive regulation of embryonic development  (IEA,ISO)
positive regulation of G1/S transition of mitotic cell cycle  (IEA,ISO,ISS)
positive regulation of glycoprotein biosynthetic process  (IEA,ISO,ISS)
positive regulation of interleukin-12 production  (IEA,ISO,ISS)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of myoblast differentiation  (IEA,ISO,ISS)
postsynaptic modulation of chemical synaptic transmission  (IEA,ISO)
regulation of establishment of endothelial barrier  (IEA,ISO)
regulation of fertilization  (IEA,ISO)
regulation of G protein-coupled receptor signaling pathway  (IEA,ISO,ISS)
regulation of retrograde trans-synaptic signaling by endocanabinoid  (IEA,ISO)
release of sequestered calcium ion into cytosol  (IBA)
response to monosaccharide  (IDA)
response to peptide hormone  (IDA)
signal transduction  (IEA)

Cellular Component
chromatin  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO,ISS)
GABA-ergic synapse  (IEA,ISO)
glutamatergic synapse  (IEA,ISO)
membrane  (IEA)
nuclear membrane  (IEA)
nuclear speck  (IBA,IEA,ISO,ISS)
nucleus  (IEA,ISO,ISS)
postsynaptic cytosol  (IEA,ISO)
protein-containing complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway   (ISO)
Alzheimer's disease pathway  (IEA)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium/calcium-mediated signaling pathway  (IEA)
carvedilol pharmacodynamics pathway  (ISO)
Chagas disease pathway  (IEA)
chemokine mediated signaling pathway  (IEA)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
endothelin signaling pathway  (ISO)
Entamoebiasis pathway  (IEA)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galphaq family  (ISO)
glutamate signaling pathway  (IEA)
gonadotropin-releasing hormone signaling pathway   (IEA)
Huntington's disease pathway  (IEA)
ibutilide pharmacodynamics pathway  (ISO)
inositol phosphate metabolic pathway  (IEA)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
long term depression  (IEA)
long term potentiation  (IEA)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
phosphatidylinositol 3-kinase signaling pathway  (IEA)
phosphoinositide metabolic pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway   (ISO)
protein kinase C (PKC) signaling pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sleeping sickness pathway  (IEA)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)
Wnt signaling pathway  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Two forms of phospholipase C-beta 1 generated by alternative splicing. Bahk YY, etal., J Biol Chem 1994 Mar 18;269(11):8240-5.
2. G-protein-activated phospholipase C-beta, new partners for cell polarity proteins Par3 and Par6. Cai Y, etal., Oncogene. 2005 Jun 16;24(26):4293-300.
3. Phosphoinositide phospholipase Cbeta1 (PI-PLCbeta1) gene in myelodysplastic syndromes and cytogenetically normal acute myeloid leukemia: not a deletion, but increased PI-PLCbeta1 expression is an independent prognostic factor. Damm F, etal., J Clin Oncol. 2010 Aug 1;28(22):e384-7; author reply e388-9. doi: 10.1200/JCO.2010.28.6971. Epub 2010 Jun 1.
4. Stimulation of 5-HT(2) receptors in prefrontal pyramidal neurons inhibits Ca(v)1.2 L type Ca(2+) currents via a PLCbeta/IP3/calcineurin signaling cascade. Day M, etal., J Neurophysiol 2002 May;87(5):2490-504.
5. Metabotropic glutamate receptor 5 (mGluR5)-mediated phosphoinositide hydrolysis and NMDA-potentiating effects are blunted in the striatum of aged rats: a possible additional mechanism in striatal senescence. Domenici MR, etal., Eur J Neurosci 2003 May;17(10):2047-55.
6. Stimulation of phospholipase Cbeta by membrane interactions, interdomain movement, and G protein binding--how many ways can you activate an enzyme? Drin G and Scarlata S, Cell Signal. 2007 Jul;19(7):1383-92. Epub 2007 Apr 29.
7. Single and repeated stress-induced modulation of phospholipase C catalytic activity and expression: role in LH behavior. Dwivedi Y, etal., Neuropsychopharmacology. 2005 Mar;30(3):473-83.
8. Real-time PCR as a tool for quantitative analysis of PI-PLCbeta1 gene expression in myelodysplastic syndrome. Follo MY, etal., Int J Mol Med. 2006 Aug;18(2):267-71.
9. Synergistic induction of PI-PLCbeta1 signaling by azacitidine and valproic acid in high-risk myelodysplastic syndromes. Follo MY, etal., Leukemia. 2011 Feb;25(2):271-80. doi: 10.1038/leu.2010.266. Epub 2010 Nov 26.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Phospholipase C-beta1 expression correlates with neuronal differentiation and synaptic plasticity in rat somatosensory cortex. Hannan AJ, etal., Neuropharmacology. 1998 Apr-May;37(4-5):593-605.
13. Expression of Gq alpha and PLC-beta in scar and border tissue in heart failure due to myocardial infarction. Ju H, etal., Circulation. 1998 Mar 10;97(9):892-9.
14. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
15. Fuel and hormone regulation of phospholipase C beta 1 and delta 1 overexpressed in RINm5F pancreatic beta cells. Kelley GG, etal., Mol Cell Endocrinol. 2001 May 25;177(1-2):107-15.
16. Discrete subcellular localization of phosphoinositidase C beta, gamma and delta in PC12 rat pheochromocytoma cells. Mazzoni M, etal., Biochem Biophys Res Commun. 1992 Aug 31;187(1):114-20.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Effects of hyperoxia and acrylonitrile on the phospholipase C isozyme protein levels in rat heart and brain. Nagasawa K, etal., Life Sci 2003 Aug 1;73(11):1453-62.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Regulation of phosphoinositide-specific phospholipase C. Rhee SG Annu Rev Biochem. 2001;70:281-312.
28. TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Runnels LW, etal., Science 2001 Feb 9;291(5506):1043-7.
29. Signal transduction mechanisms in Alzheimer disease. Shimohama S and Matsushima H, Alzheimer Dis Assoc Disord. 1995;9 Suppl 2:15-22.
30. Phospholipase C may be involved in norepinephrine-induced cardiac hypertrophy. Singal T, etal., Biochem Biophys Res Commun. 2004 Jul 30;320(3):1015-9.
31. Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits. Smrcka AV and Sternweis PC, J Biol Chem. 1993 May 5;268(13):9667-74.
32. Phospholipase-C beta1 is predominantely expressed in the granular layer of rat cerebellar cortex. Vitale M, etal., Int J Mol Med. 2004 Aug;14(2):161-4.
33. Delay fear conditioning modifies phospholipase C-beta 1a signaling in the hippocampus and frontal cortex. Weeber EJ and Caldwell KK, Pharmacol Biochem Behav. 2004 May;78(1):155-64.
34. Phospholipase C-beta3 and -beta1 form homodimers, but not heterodimers, through catalytic and carboxyl-terminal domains. Zhang Y, etal., Mol Pharmacol. 2006 Sep;70(3):860-8. Epub 2006 Jun 8.
Additional References at PubMed
PMID:1322796   PMID:3390863   PMID:8454637   PMID:8872139   PMID:9187110   PMID:9305844   PMID:9444325   PMID:9500449   PMID:9762362   PMID:10913438   PMID:11118617   PMID:11224545  
PMID:11464583   PMID:11743656   PMID:12031797   PMID:12612139   PMID:12704654   PMID:12799190   PMID:12821674   PMID:14499343   PMID:15174099   PMID:15474310   PMID:15664177   PMID:15849202  
PMID:16339037   PMID:17022104   PMID:17065107   PMID:17634366   PMID:17725492   PMID:18390926   PMID:18493969   PMID:18692062   PMID:18694821   PMID:18820027   PMID:19028838   PMID:19199708  
PMID:19347873   PMID:19385066   PMID:19538471   PMID:19564249   PMID:19687358   PMID:19896516   PMID:20393598   PMID:21124736   PMID:21148417   PMID:21338571   PMID:22735577   PMID:22871113  
PMID:23376485   PMID:23503970   PMID:23665500   PMID:24760983   PMID:25185819   PMID:26521046   PMID:26747500   PMID:27353086   PMID:27379421   PMID:27624933   PMID:28131823   PMID:29401590  
PMID:32247043   PMID:34625112   PMID:35469845  


Genomics

Comparative Map Data
Plcb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83142,512,765 - 143,224,042 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3142,513,033 - 143,225,646 (+)EnsemblGRCr8
mRatBN7.23122,059,988 - 122,772,896 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3122,060,031 - 122,772,869 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3125,952,538 - 126,679,203 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03134,555,297 - 135,266,257 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03132,208,716 - 132,934,812 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03127,721,244 - 128,419,565 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3128,155,069 - 128,419,545 (+)Ensemblrn6Rnor6.0
Rnor_5.03134,211,557 - 134,908,321 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43122,797,718 - 123,523,675 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3120,808,920 - 121,513,252 (+)NCBICelera
RGSC_v3.13122,703,321 - 123,430,863 (+)NCBI
Cytogenetic Map3q36NCBI
PLCB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38208,132,266 - 8,884,900 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl208,077,251 - 8,968,360 (+)Ensemblhg38GRCh38
GRCh37208,112,913 - 8,865,547 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36208,061,296 - 8,813,547 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34208,061,295 - 8,813,547NCBI
Celera208,182,881 - 8,935,778 (+)NCBICelera
Cytogenetic Map20p12.3NCBI
HuRef208,064,325 - 8,817,514 (+)NCBIHuRef
CHM1_1208,113,481 - 8,866,748 (+)NCBICHM1_1
T2T-CHM13v2.0208,174,228 - 8,928,072 (+)NCBIT2T-CHM13v2.0
Plcb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392134,628,084 - 135,317,178 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2134,627,987 - 135,317,178 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382134,786,164 - 135,475,258 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2134,786,067 - 135,475,258 (+)Ensemblmm10GRCm38
MGSCv372134,611,900 - 135,300,994 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362134,477,971 - 135,163,863 (+)NCBIMGSCv36mm8
Celera2135,990,426 - 136,678,579 (+)NCBICelera
Cytogenetic Map2F3NCBI
cM Map265.66NCBI
Plcb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541518,210,662 - 18,915,158 (+)Ensembl
ChiLan1.0NW_00495541518,210,608 - 18,915,099 (+)NCBIChiLan1.0ChiLan1.0
PLCB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2219,032,494 - 9,784,094 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1209,029,321 - 9,780,921 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0208,106,665 - 8,858,572 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1207,887,773 - 8,636,019 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl207,887,960 - 8,636,019 (+)EnsemblpanPan2panpan1.1
PLCB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12413,337,285 - 13,996,218 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2413,322,296 - 13,995,539 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2413,161,289 - 13,837,418 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02413,744,297 - 14,413,598 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2413,745,444 - 14,413,611 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12413,354,731 - 14,024,546 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02413,455,648 - 14,132,727 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02413,793,592 - 14,463,037 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Plcb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640162,117,602 - 162,822,762 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648510,548,966 - 11,253,761 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648510,548,966 - 11,254,139 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLCB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1717,007,261 - 17,745,313 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11717,007,197 - 17,745,314 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21719,691,473 - 19,950,043 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLCB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1229,242,601 - 29,994,238 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl229,242,425 - 29,496,793 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607114,560,873 - 15,334,958 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plcb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247419,031,204 - 9,856,556 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247419,030,817 - 9,859,597 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Plcb1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15114,455,130 - 115,126,707 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Plcb1
3304 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:60
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000006389, ENSRNOT00000051184
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3136091420155634702Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
D3Wox22  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83143,224,340 - 143,224,552 (+)Marker Load Pipeline
mRatBN7.23122,771,586 - 122,771,840 (+)MAPPERmRatBN7.2
mRatBN7.23122,771,586 - 122,771,798 (+)MAPPERmRatBN7.2
Rnor_6.03128,419,864 - 128,420,193NCBIRnor6.0
Rnor_6.03128,419,864 - 128,420,075NCBIRnor6.0
Rnor_5.03134,908,640 - 134,908,969UniSTSRnor5.0
Rnor_5.03134,908,640 - 134,908,851UniSTSRnor5.0
RGSC_v3.43123,523,994 - 123,524,205UniSTSRGSC3.4
Celera3121,513,571 - 121,513,784UniSTS
Cytogenetic Map3q36UniSTS
D3Rat158  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83142,910,625 - 142,910,779 (+)Marker Load Pipeline
mRatBN7.23122,457,858 - 122,458,012 (+)MAPPERmRatBN7.2
Rnor_6.03128,120,751 - 128,120,904NCBIRnor6.0
Rnor_5.03134,608,322 - 134,608,475UniSTSRnor5.0
RGSC_v3.43123,202,756 - 123,203,100RGDRGSC3.4
RGSC_v3.43123,202,807 - 123,202,960UniSTSRGSC3.4
Celera3121,205,948 - 121,206,101UniSTS
RGSC_v3.13123,108,380 - 123,108,533RGD
RH 3.4 Map31069.6UniSTS
RH 3.4 Map31069.6RGD
RH 2.0 Map3718.3RGD
SHRSP x BN Map359.6699RGD
Cytogenetic Map3q36UniSTS
D3Mco10  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83142,864,478 - 142,864,803 (+)Marker Load Pipeline
mRatBN7.23122,411,707 - 122,412,032 (+)MAPPERmRatBN7.2
Rnor_6.03128,074,425 - 128,074,746NCBIRnor6.0
Rnor_5.03134,561,996 - 134,562,317UniSTSRnor5.0
RGSC_v3.43123,156,618 - 123,156,941RGDRGSC3.4
RGSC_v3.43123,156,620 - 123,156,941UniSTSRGSC3.4
Celera3121,159,818 - 121,160,139UniSTS
RGSC_v3.13123,062,191 - 123,062,514RGD
Cytogenetic Map3q36UniSTS
A007B46  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23122,769,721 - 122,769,918 (+)MAPPERmRatBN7.2
Rnor_6.03128,417,999 - 128,418,195NCBIRnor6.0
Rnor_5.03134,906,775 - 134,906,971UniSTSRnor5.0
RGSC_v3.43123,522,129 - 123,522,325UniSTSRGSC3.4
Celera3121,511,706 - 121,511,902UniSTS
Cytogenetic Map3q36UniSTS
AI132408  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23122,772,417 - 122,772,691 (+)MAPPERmRatBN7.2
Rnor_6.03128,420,813 - 128,421,086NCBIRnor6.0
Rnor_5.03134,909,589 - 134,909,862UniSTSRnor5.0
RGSC_v3.43123,524,825 - 123,525,098UniSTSRGSC3.4
Celera3121,514,404 - 121,514,677UniSTS
Cytogenetic Map3q36UniSTS
RH143123  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23122,301,585 - 122,301,695 (+)MAPPERmRatBN7.2
Rnor_6.03127,963,136 - 127,963,245NCBIRnor6.0
Rnor_5.03134,451,872 - 134,451,981UniSTSRnor5.0
RGSC_v3.43123,042,363 - 123,042,472UniSTSRGSC3.4
Celera3121,050,653 - 121,050,762UniSTS
RH 3.4 Map31074.6UniSTS
Cytogenetic Map3q36UniSTS
BE107717  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera3121,070,507 - 121,070,663UniSTS
RH 3.4 Map31077.7UniSTS
Cytogenetic Map3q36UniSTS
RH135213  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23122,431,214 - 122,431,409 (+)MAPPERmRatBN7.2
Rnor_6.03128,093,928 - 128,094,122NCBIRnor6.0
Rnor_5.03134,581,499 - 134,581,693UniSTSRnor5.0
RGSC_v3.43123,175,965 - 123,176,159UniSTSRGSC3.4
Celera3121,179,319 - 121,179,513UniSTS
RH 3.4 Map31069.6UniSTS
Cytogenetic Map3q36UniSTS
RH138108  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23122,266,922 - 122,267,059 (+)MAPPERmRatBN7.2
Rnor_6.03127,928,459 - 127,928,595NCBIRnor6.0
Rnor_5.03134,417,629 - 134,417,765UniSTSRnor5.0
RGSC_v3.43123,004,632 - 123,004,768UniSTSRGSC3.4
Celera3121,015,901 - 121,016,037UniSTS
RH 3.4 Map31074.7UniSTS
Cytogenetic Map3q36UniSTS
RH138884  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23122,269,326 - 122,269,498 (+)MAPPERmRatBN7.2
Rnor_6.03127,930,863 - 127,931,034NCBIRnor6.0
Rnor_5.03134,420,033 - 134,420,204UniSTSRnor5.0
RGSC_v3.43123,007,036 - 123,007,207UniSTSRGSC3.4
Celera3121,018,305 - 121,018,476UniSTS
RH 3.4 Map31074.7UniSTS
Cytogenetic Map3q36UniSTS
AU048499  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23122,681,618 - 122,681,812 (+)MAPPERmRatBN7.2
Rnor_6.03128,333,610 - 128,333,805NCBIRnor6.0
Rnor_5.03134,820,853 - 134,821,048UniSTSRnor5.0
RGSC_v3.43123,432,866 - 123,433,061UniSTSRGSC3.4
Celera3121,424,544 - 121,424,739UniSTS
Cytogenetic Map3q36UniSTS
AU048959  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23122,685,104 - 122,685,277 (+)MAPPERmRatBN7.2
Rnor_6.03128,337,098 - 128,337,270NCBIRnor6.0
Rnor_5.03134,824,341 - 134,824,513UniSTSRnor5.0
RGSC_v3.43123,436,354 - 123,436,526UniSTSRGSC3.4
Celera3121,428,032 - 121,428,204UniSTS
Cytogenetic Map3q36UniSTS
D8S1807  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23122,135,471 - 122,136,109 (+)MAPPERmRatBN7.2
mRatBN7.21573,241,271 - 73,242,912 (+)MAPPERmRatBN7.2
Rnor_6.01580,810,982 - 80,812,622NCBIRnor6.0
Rnor_6.03127,796,967 - 127,797,604NCBIRnor6.0
Rnor_5.01584,349,172 - 84,350,812UniSTSRnor5.0
Rnor_5.03134,287,614 - 134,288,251UniSTSRnor5.0
RGSC_v3.43122,874,247 - 122,874,884UniSTSRGSC3.4
RGSC_v3.41579,872,788 - 79,874,428UniSTSRGSC3.4
Celera1572,522,594 - 72,524,234UniSTS
Celera3120,884,308 - 120,884,945UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 82 59 6 346 182 11 142 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000006389   ⟹   ENSRNOP00000006389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3142,513,033 - 143,225,646 (+)Ensembl
mRatBN7.2 Ensembl3122,060,031 - 122,771,268 (+)Ensembl
Rnor_6.0 Ensembl3128,155,117 - 128,419,545 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000051184   ⟹   ENSRNOP00000042533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3142,513,033 - 143,225,646 (+)Ensembl
mRatBN7.2 Ensembl3122,060,031 - 122,772,869 (+)Ensembl
Rnor_6.0 Ensembl3128,155,069 - 128,349,864 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098292   ⟹   ENSRNOP00000085919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3142,513,033 - 143,142,402 (+)Ensembl
mRatBN7.2 Ensembl3122,111,601 - 122,689,381 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113879   ⟹   ENSRNOP00000078760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3142,944,344 - 143,225,646 (+)Ensembl
mRatBN7.2 Ensembl3122,491,581 - 122,772,869 (+)Ensembl
RefSeq Acc Id: NM_001077641   ⟹   NP_001071109
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83142,512,765 - 143,224,042 (+)NCBI
mRatBN7.23122,059,999 - 122,771,288 (+)NCBI
Rnor_6.03127,721,244 - 128,419,545 (+)NCBI
Rnor_5.03134,211,557 - 134,908,321 (+)NCBI
RGSC_v3.43122,797,718 - 123,523,675 (+)RGD
Celera3120,808,920 - 121,513,252 (+)RGD
Sequence:
RefSeq Acc Id: XM_017591467   ⟹   XP_017446956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83142,513,191 - 143,222,468 (+)NCBI
mRatBN7.23122,059,988 - 122,772,896 (+)NCBI
Rnor_6.03127,721,389 - 128,419,565 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001071109 (Get FASTA)   NCBI Sequence Viewer  
  XP_017446956 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41885 (Get FASTA)   NCBI Sequence Viewer  
  EDL80287 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006389
  ENSRNOP00000006389.7
  ENSRNOP00000042533
GenBank Protein P10687 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001071109   ⟸   NM_001077641
- UniProtKB: P10687 (UniProtKB/Swiss-Prot),   A6HQI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446956   ⟸   XM_017591467
- Peptide Label: isoform X1
- UniProtKB: R9PXY3 (UniProtKB/TrEMBL),   A0A8I6A2P4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006389   ⟸   ENSRNOT00000006389
Ensembl Acc Id: ENSRNOP00000042533   ⟸   ENSRNOT00000051184
Ensembl Acc Id: ENSRNOP00000085919   ⟸   ENSRNOT00000098292
Ensembl Acc Id: ENSRNOP00000078760   ⟸   ENSRNOT00000113879
Protein Domains
C2   PI-PLC X-box   PI-PLC Y-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10687-F1-model_v2 AlphaFold P10687 1-1216 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3344 AgrOrtholog
BioCyc Gene G2FUF-47740 BioCyc
BioCyc Pathway PWY-6351 [D-myo-inositol (1,4,5)-trisphosphate biosynthesis] BioCyc
  PWY-6367 [D-myo-inositol-5-phosphate metabolism] BioCyc
  PWY-8052 [2-arachidonoylglycerol biosynthesis] BioCyc
BioCyc Pathway Image PWY-6351 BioCyc
  PWY-6367 BioCyc
  PWY-8052 BioCyc
Ensembl Genes ENSRNOG00000004810 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006389 ENTREZGENE
  ENSRNOT00000006389.7 UniProtKB/Swiss-Prot
  ENSRNOT00000051184 ENTREZGENE
Gene3D-CATH 1.20.1230.10 UniProtKB/Swiss-Prot
  2.30.29.240 UniProtKB/Swiss-Prot
  2.60.40.150 UniProtKB/Swiss-Prot
  3.20.20.190 UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
InterPro C2_dom UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  EF-hand-dom_pair UniProtKB/Swiss-Prot
  PI-PLC_fam UniProtKB/Swiss-Prot
  PLC-beta UniProtKB/Swiss-Prot
  PLC-beta1 UniProtKB/Swiss-Prot
  PLC-beta_C UniProtKB/Swiss-Prot
  PLC-beta_C_sf UniProtKB/Swiss-Prot
  PLC-beta_PH UniProtKB/Swiss-Prot
  PLC-like_Pdiesterase_TIM-brl UniProtKB/Swiss-Prot
  PLCB1-4-like_EFh UniProtKB/Swiss-Prot
  PLipase_C_PInositol-sp_X_dom UniProtKB/Swiss-Prot
  PLipase_C_Pinositol-sp_Y UniProtKB/Swiss-Prot
KEGG Report rno:24654 UniProtKB/Swiss-Prot
NCBI Gene 24654 ENTREZGENE
PANTHER PTHR10336 UniProtKB/Swiss-Prot
  PTHR10336:SF12 UniProtKB/Swiss-Prot
Pfam PH_14 UniProtKB/Swiss-Prot
  PI-PLC-X UniProtKB/Swiss-Prot
  PI-PLC-Y UniProtKB/Swiss-Prot
  PLC-beta_C UniProtKB/Swiss-Prot
  PLCB1-4-like_EFh UniProtKB/Swiss-Prot
PhenoGen Plcb1 PhenoGen
PIRSF PLC-beta UniProtKB/Swiss-Prot
PRINTS PHPHLIPASEC UniProtKB/Swiss-Prot
PROSITE PIPLC_X_DOMAIN UniProtKB/Swiss-Prot
  PIPLC_Y_DOMAIN UniProtKB/Swiss-Prot
  PS50004 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004810 RatGTEx
SMART PLCXc UniProtKB/Swiss-Prot
  PLCYc UniProtKB/Swiss-Prot
  SM00239 UniProtKB/Swiss-Prot
Superfamily-SCOP C-terminal domain of PLC-beta UniProtKB/Swiss-Prot
  PH domain-like UniProtKB/Swiss-Prot
  SSF47473 UniProtKB/Swiss-Prot
  SSF49562 UniProtKB/Swiss-Prot
  SSF51695 UniProtKB/Swiss-Prot
UniProt A0A8I5ZP96_RAT UniProtKB/TrEMBL
  A0A8I6A2P4 ENTREZGENE, UniProtKB/TrEMBL
  A6HQI6 ENTREZGENE, UniProtKB/TrEMBL
  F1M084_RAT UniProtKB/TrEMBL
  P10687 ENTREZGENE, UniProtKB/Swiss-Prot
  R9PXY3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Plcb1  phospholipase C beta 1  Plcb1  phospholipase C, beta 1 (phosphoinositide-specific)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Plcb1  phospholipase C, beta 1 (phosphoinositide-specific)  Plcb1  phospholipase C, beta 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 Plcb1  phospholipase C, beta 1  LOC688139  similar to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (Phosphoinositide phospholipase C) (Phospholipase C-beta-1) (PLC-beta-1) (PLC-I) (PLC-154)  Data merged from RGD:1592421 1643240 APPROVED
2006-11-20 LOC688139  similar to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (Phosphoinositide phospholipase C) (Phospholipase C-beta-1) (PLC-beta-1) (PLC-I) (PLC-154)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Plcb1  Phospholipase C-beta1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease inhibition of pathway modulated by 5-HT(2) receptor activation via atypical neuroleptics may lead to alterations in serotonergic signaling and schizophrenia 633577
gene_expression expression levels significantly reduced in old neuronal striata 1299009
gene_expression expressed in brain 1299007
gene_pathway mediates intracellular Ca(2+), activation of calcineurin and inhibition of Ca(v)1.2 L-type Ca(2+) currents via upstream stimulation of 5-HT(2) receptors in prefrontal neurons 633577
gene_pathway may be involved in oxidative stress pathways 1299008
gene_process may play a role in myoblast differentiation 1299010
gene_transcript produced by alternative splicing of 5.4 kb transcript precursor 1299007