Pfkfb4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Pfkfb4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4) Rattus norvegicus
Analyze
Symbol: Pfkfb4
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
RGD ID: 3310
Description: Enables 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Part of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex. Orthologous to human PFKFB4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4); PARTICIPATES IN fructose and mannose metabolic pathway; glycolysis pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4-like; 6PF-2-K/Fru-2,6-P2ase 4; 6PF-2-K/Fru-2,6-P2ASE testis-type isozyme; LOC100911725; PFK/FBPase 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,522,371 - 118,565,478 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8118,522,365 - 118,565,468 (+)EnsemblGRCr8
mRatBN7.28109,643,558 - 109,687,006 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,643,937 - 109,685,634 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8115,262,543 - 115,300,538 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,461,728 - 113,499,717 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08111,304,523 - 111,342,518 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,733,347 - 117,776,525 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,737,117 - 117,775,386 (+)Ensemblrn6Rnor6.0
Rnor_5.08117,085,098 - 117,128,270 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48114,012,543 - 114,050,534 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8108,939,193 - 108,977,086 (+)NCBICelera
RGSC_v3.18114,031,997 - 114,069,989 (+)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Bufotalin  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (EXP)
diethyl malate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (EXP)
gentamycin  (EXP)
GSK-J4  (ISO)
hydralazine  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isobutanol  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
monosodium L-glutamate  (ISO)
motexafin gadolinium  (ISO)
nickel dichloride  (ISO)
Nonylphenol  (EXP)
okadaic acid  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
Pf-06840003  (ISO)
quercetin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenate  (ISO)
sotorasib  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
trametinib  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc acetate  (ISO)
zinc dichloride  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. The crystal structure of the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase reveals distinct domain homologies. Hasemann CA, etal., Structure. 1996 Sep 15;4(9):1017-29. doi: 10.1016/s0969-2126(96)00109-8.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Regulation of the regulatory enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Okar DA, etal., Adv Enzyme Regul. 2004;44:123-54. doi: 10.1016/j.advenzreg.2003.11.006.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis. Rider MH, etal., Biochem J. 2004 Aug 1;381(Pt 3):561-79.
11. Molecular cloning of the DNA and expression and characterization of rat testes fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase. Sakata J, etal., J Biol Chem 1991 Aug 25;266(24):15764-70.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:2837207   PMID:9464277   PMID:9890980   PMID:10095107   PMID:15896703   PMID:19595670   PMID:28235572  


Genomics

Comparative Map Data
Pfkfb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,522,371 - 118,565,478 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8118,522,365 - 118,565,468 (+)EnsemblGRCr8
mRatBN7.28109,643,558 - 109,687,006 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,643,937 - 109,685,634 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8115,262,543 - 115,300,538 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,461,728 - 113,499,717 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08111,304,523 - 111,342,518 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,733,347 - 117,776,525 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,737,117 - 117,775,386 (+)Ensemblrn6Rnor6.0
Rnor_5.08117,085,098 - 117,128,270 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48114,012,543 - 114,050,534 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8108,939,193 - 108,977,086 (+)NCBICelera
RGSC_v3.18114,031,997 - 114,069,989 (+)NCBI
Cytogenetic Map8q32NCBI
PFKFB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38348,517,684 - 48,563,136 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl348,517,684 - 48,562,015 (-)Ensemblhg38GRCh38
GRCh37348,555,117 - 48,598,562 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,530,121 - 48,569,231 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34348,530,122 - 48,569,231NCBI
Celera348,510,977 - 48,550,079 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef348,613,565 - 48,652,666 (-)NCBIHuRef
CHM1_1348,507,387 - 48,546,534 (-)NCBICHM1_1
T2T-CHM13v2.0348,546,648 - 48,592,093 (-)NCBIT2T-CHM13v2.0
Pfkfb4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,817,336 - 108,861,302 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,820,846 - 108,861,296 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm389108,988,272 - 109,032,236 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,991,778 - 109,032,228 (+)Ensemblmm10GRCm38
MGSCv379108,893,947 - 108,934,739 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369108,848,901 - 108,889,603 (+)NCBIMGSCv36mm8
Celera9108,549,891 - 108,591,002 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.63NCBI
Pfkfb4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955532606,643 - 644,027 (-)Ensembl
ChiLan1.0NW_004955532606,597 - 644,238 (-)NCBIChiLan1.0ChiLan1.0
PFKFB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2248,491,191 - 48,533,286 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1348,497,153 - 48,538,038 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0348,439,542 - 48,479,501 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1349,521,541 - 49,560,744 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl349,521,550 - 49,560,711 (-)EnsemblpanPan2panpan1.1
PFKFB4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,556,548 - 40,587,036 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,556,790 - 40,585,652 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2040,470,623 - 40,504,538 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02041,038,756 - 41,072,657 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2041,038,813 - 41,072,655 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12040,276,197 - 40,310,107 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,680,959 - 40,715,122 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02040,961,893 - 40,995,823 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pfkfb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560263,543,590 - 63,585,774 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936529303,843 - 342,935 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936529304,090 - 346,281 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PFKFB4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,212,552 - 31,259,749 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11331,212,553 - 31,259,785 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21334,457,005 - 34,504,235 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PFKFB4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1229,920,252 - 9,962,243 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl229,919,764 - 9,957,543 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041157,123,631 - 157,165,404 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pfkfb4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247302,519,678 - 2,563,059 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247302,519,661 - 2,566,664 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pfkfb4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v18100,268,043 - 100,305,787 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pfkfb4
527 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:48
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000028039
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 12 61 134 57 60 41 86 41 298 168 11 125 71 73 19 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001431583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005487907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010054021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010054022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU404101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU404102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU404103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M64797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000028039   ⟹   ENSRNOP00000028039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8118,526,519 - 118,565,468 (+)Ensembl
mRatBN7.2 Ensembl8109,647,686 - 109,685,634 (+)Ensembl
Rnor_6.0 Ensembl8117,737,117 - 117,775,153 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000037662   ⟹   ENSRNOP00000033343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8118,402,930 - 118,414,603 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000066305   ⟹   ENSRNOP00000061383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8118,392,773 - 118,414,603 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090164   ⟹   ENSRNOP00000074158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8118,526,080 - 118,565,468 (+)Ensembl
mRatBN7.2 Ensembl8109,643,937 - 109,685,634 (+)Ensembl
Rnor_6.0 Ensembl8117,737,387 - 117,775,386 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091573   ⟹   ENSRNOP00000075289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8118,526,516 - 118,564,010 (+)Ensembl
mRatBN7.2 Ensembl8109,648,036 - 109,685,532 (+)Ensembl
Rnor_6.0 Ensembl8117,737,467 - 117,775,051 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000153908   ⟹   ENSRNOP00000112787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8118,522,365 - 118,565,468 (+)Ensembl
RefSeq Acc Id: NM_019333   ⟹   NP_062206
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,526,166 - 118,564,112 (+)NCBI
mRatBN7.28109,647,686 - 109,685,634 (+)NCBI
Rnor_6.08117,737,117 - 117,775,153 (+)NCBI
Rnor_5.08117,085,098 - 117,128,270 (+)NCBI
RGSC_v3.48114,012,543 - 114,050,534 (+)RGD
Celera8108,939,193 - 108,977,086 (+)RGD
Sequence:
RefSeq Acc Id: XM_006243840   ⟹   XP_006243902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,522,371 - 118,565,478 (+)NCBI
mRatBN7.28109,643,891 - 109,687,006 (+)NCBI
Rnor_6.08117,733,347 - 117,776,525 (+)NCBI
Rnor_5.08117,085,098 - 117,128,270 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008766563   ⟹   XP_008764785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,524,984 - 118,565,478 (+)NCBI
mRatBN7.28109,647,036 - 109,687,006 (+)NCBI
Rnor_6.08117,737,106 - 117,776,525 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039082017   ⟹   XP_038937945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,542,411 - 118,565,478 (+)NCBI
mRatBN7.28109,663,925 - 109,687,006 (+)NCBI
RefSeq Acc Id: XM_039082018   ⟹   XP_038937946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,524,984 - 118,545,202 (+)NCBI
mRatBN7.28109,646,937 - 109,666,724 (+)NCBI
RefSeq Acc Id: XM_039082019   ⟹   XP_038937947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,524,984 - 118,544,734 (+)NCBI
mRatBN7.28109,646,973 - 109,666,248 (+)NCBI
RefSeq Acc Id: XM_063266037   ⟹   XP_063122107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,526,469 - 118,565,478 (+)NCBI
RefSeq Acc Id: XM_063266038   ⟹   XP_063122108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,526,469 - 118,565,478 (+)NCBI
RefSeq Acc Id: XM_063266039   ⟹   XP_063122109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,526,582 - 118,565,478 (+)NCBI
RefSeq Acc Id: XM_063266040   ⟹   XP_063122110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,543,000 - 118,565,478 (+)NCBI
RefSeq Acc Id: XR_005487907
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,524,984 - 118,545,848 (+)NCBI
mRatBN7.28109,646,991 - 109,667,369 (+)NCBI
RefSeq Acc Id: XR_010054021
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,524,984 - 118,563,779 (+)NCBI
RefSeq Acc Id: XR_010054022
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,522,371 - 118,545,848 (+)NCBI
RefSeq Acc Id: NP_062206   ⟸   NM_019333
- UniProtKB: P25114 (UniProtKB/Swiss-Prot),   A6I399 (UniProtKB/TrEMBL),   B0ZTI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243902   ⟸   XM_006243840
- Peptide Label: isoform X2
- UniProtKB: A0A8L2R9R3 (UniProtKB/TrEMBL),   B0ZTI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764785   ⟸   XM_008766563
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_038937946   ⟸   XM_039082018
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038937947   ⟸   XM_039082019
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038937945   ⟸   XM_039082017
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000074158   ⟸   ENSRNOT00000090164
Ensembl Acc Id: ENSRNOP00000075289   ⟸   ENSRNOT00000091573
Ensembl Acc Id: ENSRNOP00000028039   ⟸   ENSRNOT00000028039
Ensembl Acc Id: ENSRNOP00000033343   ⟸   ENSRNOT00000037662
Ensembl Acc Id: ENSRNOP00000061383   ⟸   ENSRNOT00000066305
RefSeq Acc Id: XP_063122107   ⟸   XM_063266037
- Peptide Label: isoform X3
- UniProtKB: B0ZTI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122108   ⟸   XM_063266038
- Peptide Label: isoform X3
- UniProtKB: B0ZTI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122109   ⟸   XM_063266039
- Peptide Label: isoform X3
- UniProtKB: B0ZTI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122110   ⟸   XM_063266040
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000112787   ⟸   ENSRNOT00000153908
Protein Domains
6-phosphofructo-2-kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7FKL9-F1-model_v2 AlphaFold F7FKL9 1-330 view protein structure
AF-P25114-F1-model_v2 AlphaFold P25114 1-469 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696327
Promoter ID:EPDNEW_R6843
Type:single initiation site
Name:Pfkfb4_1
Description:6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08117,737,444 - 117,737,504EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3310 AgrOrtholog
BioCyc Gene G2FUF-29099 BioCyc
BioCyc Pathway PWY66-423 [fructose 2,6-bisphosphate biosynthesis] BioCyc
BioCyc Pathway Image PWY66-423 BioCyc
Ensembl Genes ENSRNOG00000020656 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000048130 Ensembl
Ensembl Transcript ENSRNOT00000028039 ENTREZGENE
  ENSRNOT00000028039.5 UniProtKB/Swiss-Prot
  ENSRNOT00000090164 ENTREZGENE
  ENSRNOT00000153908 ENTREZGENE
Gene3D-CATH 3.40.50.1240 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro 6Pfruct_kin UniProtKB/Swiss-Prot
  6Phosfructo_kin UniProtKB/Swiss-Prot
  His_Pase_superF_clade-1 UniProtKB/Swiss-Prot
  His_PPase_superfam UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  PG/BPGM_mutase_AS UniProtKB/Swiss-Prot
KEGG Report rno:54283 UniProtKB/Swiss-Prot
NCBI Gene 54283 ENTREZGENE
PANTHER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 4 UniProtKB/Swiss-Prot
  PTHR10606 UniProtKB/Swiss-Prot
Pfam 6PF2K UniProtKB/Swiss-Prot
  His_Phos_1 UniProtKB/Swiss-Prot
PhenoGen Pfkfb4 PhenoGen
PIRSF 6PFK_2-Ptase UniProtKB/Swiss-Prot
PRINTS 6PFRUCTKNASE UniProtKB/Swiss-Prot
PROSITE PG_MUTASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020656 RatGTEx
  ENSRNOG00000048130 RatGTEx
SMART PGAM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
  SSF53254 UniProtKB/Swiss-Prot
TIGR TC212530
UniProt A0A8L2R9R3 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M714_RAT UniProtKB/TrEMBL
  A6I399 ENTREZGENE, UniProtKB/TrEMBL
  B0ZTH8_RAT UniProtKB/TrEMBL
  B0ZTH9_RAT UniProtKB/TrEMBL
  B0ZTI0 ENTREZGENE, UniProtKB/TrEMBL
  F264_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Pfkfb4  6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4  LOC100911725  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4-like  Data merged from RGD:6491338 737654 PROVISIONAL
2012-07-05 LOC100911725  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Pfkfb4  6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4      Name updated 70584 APPROVED