Pde4a (phosphodiesterase 4A) - Rat Genome Database

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Gene: Pde4a (phosphodiesterase 4A) Rattus norvegicus
Analyze
Symbol: Pde4a
Name: phosphodiesterase 4A
RGD ID: 3279
Description: Enables 3',5'-cyclic-AMP phosphodiesterase activity and TPR domain binding activity. Involved in cAMP catabolic process; modulation of chemical synaptic transmission; and response to xenobiotic stimulus. Located in cytosol and perinuclear region of cytoplasm. Is active in Schaffer collateral - CA1 synapse. Biomarker of brucellosis. Orthologous to human PDE4A (phosphodiesterase 4A); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 3,4-methylenedioxymethamphetamine; 3-Methoxynobiletin; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3',5'-cyclic-AMP phosphodiesterase 4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A; cAMP-specific phosphodiesterase 4A; DPDE2; PDE4A10 cAMP phosphodiesterase; PHOSA; phosphodiesterase 4A, cAMP specific; phosphodiesterase 4A, cAMP-specific; phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Pde4a_v1 ; Pde4a_v3 ; Pde4a_v2
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,966,978 - 28,029,721 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl827,966,996 - 28,046,924 (+)EnsemblGRCr8
mRatBN7.2819,690,816 - 19,753,538 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,703,290 - 19,751,961 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx823,710,208 - 23,772,977 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,008,068 - 22,070,826 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,920,490 - 19,983,225 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,189,533 - 22,234,036 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,189,600 - 22,233,748 (+)Ensemblrn6Rnor6.0
Rnor_5.0822,245,707 - 22,289,417 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4820,192,677 - 20,241,557 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera821,100,973 - 21,145,549 (+)NCBICelera
RGSC_v3.1820,192,676 - 20,241,557 (+)NCBI
Cytogenetic Map8q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Methoxynobiletin  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitrophenyl beta-D-xyloside  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
albuterol  (ISO)
all-trans-retinoic acid  (ISO)
ammonia  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromacil  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
cyanazine  (ISO)
deisopropylatrazine  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dimethomorph  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
fluoxetine  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
haloperidol  (EXP)
heptanal  (ISO)
hexanal  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
nonanal  (ISO)
octanal  (ISO)
ozone  (EXP)
paracetamol  (ISO)
pentanal  (ISO)
pirinixic acid  (ISO)
pravastatin  (EXP,ISO)
prometon  (ISO)
propanal  (ISO)
propazine  (ISO)
roflumilast  (EXP,ISO)
rolipram  (EXP,ISO)
rotenone  (EXP)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simazine  (ISO)
sodium arsenite  (ISO)
sodium chlorate  (EXP)
Soman  (EXP)
Terbacil  (ISO)
testosterone enanthate  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triadimefon  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)
Yessotoxin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A phosphodiesterase 2A isoform localized to mitochondria regulates respiration. Acin-Perez R, etal., J Biol Chem. 2011 Sep 2;286(35):30423-32. doi: 10.1074/jbc.M111.266379. Epub 2011 Jul 1.
2. Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases. Bolger GB, etal., Gene 1994 Nov 18;149(2):237-44.
3. Alternative splicing of cAMP-specific phosphodiesterase mRNA transcripts. Characterization of a novel tissue-specific isoform, RNPDE4A8. Bolger GB, etal., J Biol Chem 1996 Jan 12;271(2):1065-71.
4. Attenuation of the Activity of the cAMP-specific Phosphodiesterase PDE4A5 by Interaction with the Immunophilin XAP2. Bolger GB, etal., J Biol Chem 2003 Aug 29;278(35):33351-63.
5. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Conti M and Beavo J, Annu Rev Biochem. 2007;76:481-511.
6. Differential expression and regulation of the cAMP-selective phosphodiesterase type 4A splice variants in rat brain by chronic antidepressant administration. D'Sa C, etal., Eur J Neurosci. 2005 Sep;22(6):1463-75.
7. Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene. Davis RL, etal., Proc Natl Acad Sci U S A 1989 May;86(10):3604-8.
8. The effects of increased cAMP content on inflammation, oxidative stress and PDE4 transcripts during Brucella melitensis infection. Erdogan S, etal., Res Vet Sci. 2008 Feb;84(1):18-25. Epub 2007 Mar 29.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory. Havekes R, etal., J Neurosci. 2016 Aug 24;36(34):8936-46. doi: 10.1523/JNEUROSCI.0248-16.2016.
12. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
13. Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation. MacKenzie KF, etal., Biochem J. 2011 May 1;435(3):755-69. doi: 10.1042/BJ20101184.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10. Rena G, etal., Mol Pharmacol 2001 May;59(5):996-1011.
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Determination of the structure of the N-terminal splice region of the cyclic AMP-specific phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and identification of the membrane association domain using chimeric constructs. Smith KJ, etal., J Biol Chem 1996 Jul 12;271(28):16703-11.
20. Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes. Swinnen JV, etal., Proc Natl Acad Sci U S A 1989 Jul;86(14):5325-9.
21. Activation and induction of cyclic AMP phosphodiesterase (PDE4) in rat pulmonary microvascular endothelial cells. Zhu B, etal., Biochem Pharmacol. 2004 Aug 1;68(3):479-91.
Additional References at PubMed
PMID:8413254   PMID:8761480   PMID:11267656   PMID:16581183   PMID:17210463   PMID:17404263   PMID:17704206   PMID:18095939   PMID:18721873   PMID:18923023   PMID:19305400   PMID:21151982  
PMID:21670503   PMID:21898905   PMID:23008439   PMID:23094097   PMID:23887098   PMID:23986500   PMID:33184031   PMID:35219697   PMID:37004962  


Genomics

Comparative Map Data
Pde4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,966,978 - 28,029,721 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl827,966,996 - 28,046,924 (+)EnsemblGRCr8
mRatBN7.2819,690,816 - 19,753,538 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,703,290 - 19,751,961 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx823,710,208 - 23,772,977 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,008,068 - 22,070,826 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,920,490 - 19,983,225 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,189,533 - 22,234,036 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,189,600 - 22,233,748 (+)Ensemblrn6Rnor6.0
Rnor_5.0822,245,707 - 22,289,417 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4820,192,677 - 20,241,557 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera821,100,973 - 21,145,549 (+)NCBICelera
RGSC_v3.1820,192,676 - 20,241,557 (+)NCBI
Cytogenetic Map8q13NCBI
PDE4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,416,773 - 10,469,631 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,416,773 - 10,469,630 (+)Ensemblhg38GRCh38
GRCh371910,527,449 - 10,580,307 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,424,637 - 10,441,306 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341910,424,636 - 10,441,306NCBI
Celera1910,426,030 - 10,475,005 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,107,514 - 10,160,337 (+)NCBIHuRef
CHM1_11910,528,205 - 10,581,112 (+)NCBICHM1_1
T2T-CHM13v2.01910,543,231 - 10,596,068 (+)NCBIT2T-CHM13v2.0
Pde4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,076,998 - 21,124,544 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,073,005 - 21,124,544 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38921,165,700 - 21,213,248 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,165,714 - 21,213,248 (+)Ensemblmm10GRCm38
MGSCv37920,970,158 - 21,017,692 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36920,916,193 - 20,962,012 (+)NCBIMGSCv36mm8
Celera918,434,443 - 18,481,980 (+)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.73NCBI
Pde4a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,663,011 - 1,691,810 (+)Ensembl
ChiLan1.0NW_0049554951,659,499 - 1,693,609 (+)NCBIChiLan1.0ChiLan1.0
PDE4A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22015,322,999 - 15,387,120 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11914,321,606 - 14,385,731 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,956,019 - 10,020,538 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,635,827 - 10,683,940 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,632,273 - 10,681,944 (+)EnsemblpanPan2panpan1.1
PDE4A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,672,012 - 50,723,318 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,672,363 - 50,811,160 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2050,543,839 - 50,590,408 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02051,194,942 - 51,241,814 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,196,595 - 51,241,799 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,401,492 - 50,448,153 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,829,833 - 50,877,183 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,070,685 - 51,117,859 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pde4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,585,776 - 209,632,221 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659732,893 - 768,620 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936659742,969 - 770,473 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,225,708 - 69,266,702 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1269,225,403 - 69,268,327 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,575,206 - 69,621,539 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE4A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,455,471 - 9,503,809 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607410,496,519 - 10,547,679 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde4a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,543,809 - 2,572,945 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248282,540,121 - 2,574,706 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pde4a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1817,428,546 - 17,477,759 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pde4a
457 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:595
Count of miRNA genes:111
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000028272, ENSRNOT00000041381, ENSRNOT00000061099, ENSRNOT00000061100, ENSRNOT00000074313
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat

Markers in Region
RH94489  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,751,674 - 19,751,838 (+)MAPPERmRatBN7.2
Rnor_6.0822,233,774 - 22,233,937NCBIRnor6.0
Rnor_5.0822,289,155 - 22,289,318UniSTSRnor5.0
RGSC_v3.4820,241,295 - 20,241,458UniSTSRGSC3.4
Celera821,145,287 - 21,145,450UniSTS
Cytogenetic Map8q13UniSTS
BF391741  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,720,335 - 19,720,499 (+)MAPPERmRatBN7.2
Rnor_6.0822,203,819 - 22,203,982NCBIRnor6.0
Rnor_5.0822,258,526 - 22,258,689UniSTSRnor5.0
Celera821,114,675 - 21,114,838UniSTS
Cytogenetic Map8q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 91 59 6 355 191 11 139 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001393735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF110461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU856767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L27057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L27062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L36467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M28411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000061100   ⟹   ENSRNOP00000057815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl827,982,820 - 28,029,721 (+)Ensembl
mRatBN7.2 Ensembl819,706,642 - 19,751,905 (+)Ensembl
Rnor_6.0 Ensembl822,189,600 - 22,233,748 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096283   ⟹   ENSRNOP00000082776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl827,966,996 - 28,028,088 (+)Ensembl
mRatBN7.2 Ensembl819,703,290 - 19,751,910 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099405   ⟹   ENSRNOP00000096417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl827,982,820 - 28,029,721 (+)Ensembl
mRatBN7.2 Ensembl819,706,642 - 19,751,905 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109272   ⟹   ENSRNOP00000085157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl827,999,413 - 28,029,721 (+)Ensembl
mRatBN7.2 Ensembl819,722,903 - 19,751,910 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112455   ⟹   ENSRNOP00000082374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,012,737 - 28,029,721 (+)Ensembl
mRatBN7.2 Ensembl819,736,618 - 19,751,905 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115099   ⟹   ENSRNOP00000089924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl827,996,986 - 28,046,924 (+)Ensembl
mRatBN7.2 Ensembl819,720,828 - 19,751,910 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117416   ⟹   ENSRNOP00000087070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,014,683 - 28,028,144 (+)Ensembl
mRatBN7.2 Ensembl819,738,502 - 19,751,961 (+)Ensembl
RefSeq Acc Id: NM_001393735   ⟹   NP_001380664
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,999,413 - 28,029,721 (+)NCBI
mRatBN7.2819,723,227 - 19,753,538 (+)NCBI
RefSeq Acc Id: NM_001393736   ⟹   NP_001380665
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,966,987 - 28,029,721 (+)NCBI
mRatBN7.2819,690,816 - 19,753,538 (+)NCBI
RefSeq Acc Id: NM_001393737   ⟹   NP_001380666
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,012,737 - 28,029,721 (+)NCBI
mRatBN7.2819,736,556 - 19,753,538 (+)NCBI
RefSeq Acc Id: NM_013101   ⟹   NP_037233
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,982,820 - 28,029,721 (+)NCBI
mRatBN7.2819,706,649 - 19,753,538 (+)NCBI
Rnor_6.0822,189,533 - 22,234,036 (+)NCBI
Rnor_5.0822,245,707 - 22,289,417 (+)NCBI
RGSC_v3.4820,192,677 - 20,241,557 (+)RGD
Celera821,100,973 - 21,145,549 (+)RGD
Sequence:
RefSeq Acc Id: XM_063264965   ⟹   XP_063121035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,996,981 - 28,029,721 (+)NCBI
RefSeq Acc Id: XM_063264966   ⟹   XP_063121036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,966,978 - 28,029,721 (+)NCBI
RefSeq Acc Id: XM_063264967   ⟹   XP_063121037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,966,990 - 28,029,721 (+)NCBI
RefSeq Acc Id: XM_063264968   ⟹   XP_063121038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,999,760 - 28,029,721 (+)NCBI
RefSeq Acc Id: XM_063264969   ⟹   XP_063121039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,997,074 - 28,029,721 (+)NCBI
RefSeq Acc Id: XM_063264970   ⟹   XP_063121040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,983,061 - 28,029,721 (+)NCBI
RefSeq Acc Id: XM_063264971   ⟹   XP_063121041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,966,978 - 28,029,721 (+)NCBI
RefSeq Acc Id: XM_063264972   ⟹   XP_063121042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,969,988 - 28,029,721 (+)NCBI
RefSeq Acc Id: XM_063264973   ⟹   XP_063121043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,006,578 - 28,029,721 (+)NCBI
RefSeq Acc Id: XM_063264974   ⟹   XP_063121044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,014,786 - 28,029,721 (+)NCBI
RefSeq Acc Id: XM_063264975   ⟹   XP_063121045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,996,981 - 28,029,721 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001380664 (Get FASTA)   NCBI Sequence Viewer  
  NP_001380665 (Get FASTA)   NCBI Sequence Viewer  
  NP_001380666 (Get FASTA)   NCBI Sequence Viewer  
  NP_037233 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121035 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121036 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121037 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121038 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121039 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121040 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121041 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121042 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121043 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121044 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121045 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41101 (Get FASTA)   NCBI Sequence Viewer  
  AAA41102 (Get FASTA)   NCBI Sequence Viewer  
  AAA41823 (Get FASTA)   NCBI Sequence Viewer  
  AAA41848 (Get FASTA)   NCBI Sequence Viewer  
  AAA56859 (Get FASTA)   NCBI Sequence Viewer  
  AAB00357 (Get FASTA)   NCBI Sequence Viewer  
  AAC27098 (Get FASTA)   NCBI Sequence Viewer  
  AAC37699 (Get FASTA)   NCBI Sequence Viewer  
  AAF14352 (Get FASTA)   NCBI Sequence Viewer  
  ACF98289 (Get FASTA)   NCBI Sequence Viewer  
  EDL78316 (Get FASTA)   NCBI Sequence Viewer  
  EDL78317 (Get FASTA)   NCBI Sequence Viewer  
  EDL78318 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000057815
  ENSRNOP00000082374
  ENSRNOP00000082776
  ENSRNOP00000085157
  ENSRNOP00000089924
GenBank Protein P54748 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037233   ⟸   NM_013101
- Peptide Label: isoform 1
- UniProtKB: Q9EQR7 (UniProtKB/Swiss-Prot),   P54748 (UniProtKB/Swiss-Prot),   P14645 (UniProtKB/Swiss-Prot),   F1M8I9 (UniProtKB/TrEMBL),   A6JNP9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000057815   ⟸   ENSRNOT00000061100
Ensembl Acc Id: ENSRNOP00000082374   ⟸   ENSRNOT00000112455
Ensembl Acc Id: ENSRNOP00000085157   ⟸   ENSRNOT00000109272
Ensembl Acc Id: ENSRNOP00000096417   ⟸   ENSRNOT00000099405
Ensembl Acc Id: ENSRNOP00000082776   ⟸   ENSRNOT00000096283
Ensembl Acc Id: ENSRNOP00000089924   ⟸   ENSRNOT00000115099
Ensembl Acc Id: ENSRNOP00000087070   ⟸   ENSRNOT00000117416
RefSeq Acc Id: NP_001380665   ⟸   NM_001393736
- Peptide Label: isoform 3
- UniProtKB: Q9EQR7 (UniProtKB/Swiss-Prot),   P54748 (UniProtKB/Swiss-Prot),   P14645 (UniProtKB/Swiss-Prot),   A0A8I5ZV79 (UniProtKB/TrEMBL),   A6JNP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380664   ⟸   NM_001393735
- Peptide Label: isoform 2
- UniProtKB: Q9EQR7 (UniProtKB/Swiss-Prot),   P54748 (UniProtKB/Swiss-Prot),   P14645 (UniProtKB/Swiss-Prot),   A6JNQ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380666   ⟸   NM_001393737
- Peptide Label: isoform 4
- UniProtKB: A0A8I5ZUU0 (UniProtKB/TrEMBL),   A0A8I6GFN4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121036   ⟸   XM_063264966
- Peptide Label: isoform X2
- UniProtKB: Q9EQR7 (UniProtKB/Swiss-Prot),   P54748 (UniProtKB/Swiss-Prot),   P14645 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063121041   ⟸   XM_063264971
- Peptide Label: isoform X4
- UniProtKB: Q9EQR7 (UniProtKB/Swiss-Prot),   P54748 (UniProtKB/Swiss-Prot),   P14645 (UniProtKB/Swiss-Prot),   A0A8I5ZV79 (UniProtKB/TrEMBL),   A6JNP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121037   ⟸   XM_063264967
- Peptide Label: isoform X2
- UniProtKB: Q9EQR7 (UniProtKB/Swiss-Prot),   P54748 (UniProtKB/Swiss-Prot),   P14645 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063121042   ⟸   XM_063264972
- Peptide Label: isoform X4
- UniProtKB: Q9EQR7 (UniProtKB/Swiss-Prot),   P54748 (UniProtKB/Swiss-Prot),   P14645 (UniProtKB/Swiss-Prot),   A0A8I5ZV79 (UniProtKB/TrEMBL),   A6JNP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121040   ⟸   XM_063264970
- Peptide Label: isoform X3
- UniProtKB: Q9EQR7 (UniProtKB/Swiss-Prot),   P54748 (UniProtKB/Swiss-Prot),   P14645 (UniProtKB/Swiss-Prot),   A0A8I5ZZJ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121045   ⟸   XM_063264975
- Peptide Label: isoform X7
- UniProtKB: Q9EQR7 (UniProtKB/Swiss-Prot),   P54748 (UniProtKB/Swiss-Prot),   P14645 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063121035   ⟸   XM_063264965
- Peptide Label: isoform X1
- UniProtKB: Q9EQR7 (UniProtKB/Swiss-Prot),   P54748 (UniProtKB/Swiss-Prot),   P14645 (UniProtKB/Swiss-Prot),   A0A8I6ALZ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121039   ⟸   XM_063264969
- Peptide Label: isoform X3
- UniProtKB: Q9EQR7 (UniProtKB/Swiss-Prot),   P54748 (UniProtKB/Swiss-Prot),   P14645 (UniProtKB/Swiss-Prot),   A0A8I5ZZJ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121038   ⟸   XM_063264968
- Peptide Label: isoform X3
- UniProtKB: Q9EQR7 (UniProtKB/Swiss-Prot),   P54748 (UniProtKB/Swiss-Prot),   P14645 (UniProtKB/Swiss-Prot),   A0A8I5ZZJ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121043   ⟸   XM_063264973
- Peptide Label: isoform X5
- UniProtKB: Q9EQR7 (UniProtKB/Swiss-Prot),   P54748 (UniProtKB/Swiss-Prot),   P14645 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063121044   ⟸   XM_063264974
- Peptide Label: isoform X6
Protein Domains
PDEase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54748-F1-model_v2 AlphaFold P54748 1-844 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3279 AgrOrtholog
BioCyc Gene G2FUF-31433 BioCyc
Ensembl Genes ENSRNOG00000020828 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000061100 ENTREZGENE
  ENSRNOT00000096283 ENTREZGENE
  ENSRNOT00000109272 ENTREZGENE
  ENSRNOT00000112455 ENTREZGENE
  ENSRNOT00000115099 ENTREZGENE
Gene3D-CATH 1.10.1300.10 UniProtKB/Swiss-Prot
InterPro HD/PDEase_dom UniProtKB/Swiss-Prot
  PDE4_UCR UniProtKB/Swiss-Prot
  PDEase UniProtKB/Swiss-Prot
  PDEase_catalytic_dom UniProtKB/Swiss-Prot
  PDEase_catalytic_dom_sf UniProtKB/Swiss-Prot
  PDEase_CS UniProtKB/Swiss-Prot
KEGG Report rno:25638 UniProtKB/Swiss-Prot
NCBI Gene 25638 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/Swiss-Prot
Pfam PDE4_UCR UniProtKB/Swiss-Prot
  PDEase_I UniProtKB/Swiss-Prot
PharmGKB PDE4A RGD
PhenoGen Pde4a PhenoGen
PRINTS PDIESTERASE1 UniProtKB/Swiss-Prot
PROSITE PDEASE_I_1 UniProtKB/Swiss-Prot
  PDEASE_I_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020828 RatGTEx
SMART HDc UniProtKB/Swiss-Prot
Superfamily-SCOP HD-domain/PDEase-like UniProtKB/Swiss-Prot
UniProt A0A8I5ZUU0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZV79 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZZJ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ALZ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASF6_RAT UniProtKB/TrEMBL
  A0A8I6GFN4 ENTREZGENE, UniProtKB/TrEMBL
  A6JNP8 ENTREZGENE, UniProtKB/TrEMBL
  A6JNP9 ENTREZGENE, UniProtKB/TrEMBL
  A6JNQ0 ENTREZGENE, UniProtKB/TrEMBL
  F1M8I9 ENTREZGENE, UniProtKB/TrEMBL
  P14645 ENTREZGENE
  P54748 ENTREZGENE, UniProtKB/Swiss-Prot
  Q9EQR7 ENTREZGENE
UniProt Secondary P14645 UniProtKB/Swiss-Prot
  Q9EQR7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Pde4a  phosphodiesterase 4A  Pde4a  phosphodiesterase 4A, cAMP-specific  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Pde4a  phosphodiesterase 4A, cAMP-specific  Pde4a  phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-08-29 Pde4a  phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)  Pde4a  phosphodiesterase 4A, cAMP specific  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Pde4a  phosphodiesterase 4A, cAMP specific    phosphodiesterase 4A  Name updated 1299863 APPROVED
2002-06-10 Pde4a  Phosphodiesterase 4A      Symbol and Name status set to approved 70586 APPROVED