Neurod1 (neuronal differentiation 1) - Rat Genome Database

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Gene: Neurod1 (neuronal differentiation 1) Rattus norvegicus
Analyze
Symbol: Neurod1
Name: neuronal differentiation 1
RGD ID: 3165
Description: Enables double-stranded DNA binding activity. Involved in several processes, including cellular response to glucose stimulus; positive regulation of neuron differentiation; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in glucose intolerance; hyperglycemia; maturity-onset diabetes of the young type 6; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human NEUROD1 (neuronal differentiation 1); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: basic helix-loop-helix factor 1; BHF-1; neurogenic differentiation 1; neurogenic differentiation factor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8384,766,483 - 84,770,454 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl384,764,725 - 84,770,810 (-)EnsemblGRCr8
mRatBN7.2364,359,554 - 64,363,526 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl364,359,395 - 64,363,649 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx367,711,247 - 67,715,219 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0376,294,848 - 76,298,820 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0374,041,670 - 74,045,642 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0366,414,314 - 66,417,617 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl366,414,308 - 66,417,741 (-)Ensemblrn6Rnor6.0
Rnor_5.0372,974,876 - 72,978,179 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4362,224,633 - 62,227,936 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera363,819,711 - 63,823,202 (-)NCBICelera
RGSC_v3.1362,121,017 - 62,124,302 (-)NCBI
Cytogenetic Map3q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amacrine cell differentiation  (ISO,ISS)
anterior/posterior pattern specification  (ISO)
axon development  (IBA)
camera-type eye development  (ISO)
cell differentiation  (IEA)
cell fate commitment  (ISO)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to glucose stimulus  (IDA)
central nervous system development  (IEA)
cerebellum development  (IEP,ISO)
dentate gyrus development  (ISO,ISS)
embryonic organ morphogenesis  (ISO)
endocrine pancreas development  (ISO,ISS)
enteroendocrine cell differentiation  (ISO,ISS)
glucose homeostasis  (ISO)
hindbrain development  (ISO)
inner ear development  (ISO,ISS)
insulin secretion  (ISO)
negative regulation of receptor signaling pathway via JAK-STAT  (ISO)
negative regulation of type B pancreatic cell apoptotic process  (ISO)
nervous system development  (IEA)
nucleocytoplasmic transport  (IDA)
obsolete positive regulation of DNA-binding transcription factor activity  (ISO)
pancreatic A cell fate commitment  (ISO)
pancreatic PP cell fate commitment  (ISO)
positive regulation of apoptotic process  (ISO,ISS)
positive regulation of cell differentiation  (ISO,ISS)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of insulin secretion  (ISO)
positive regulation of neuron differentiation  (IDA,ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,ISO)
regulation of DNA-templated transcription  (IEA)
regulation of intestinal epithelial structure maintenance  (ISO,ISS)
regulation of neuron differentiation  (ISO)
response to glucose  (ISO)
sensory organ development  (IBA)
signal transduction involved in regulation of gene expression  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. NeuroD1 gene and interleukin-18 gene polymorphisms in type 1 diabetes in Dalmatian population of Southern Croatia. Boraska V, etal., Croat Med J. 2006 Aug;47(4):571-8.
2. Thyroid hormone regulates the expression of NeuroD/BHF1 during the development of rat cerebellum. Chantoux F and Francon J, Mol Cell Endocrinol. 2002 Aug 30;194(1-2):157-63.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Autosomal inheritance of diabetes in two families characterized by obesity and a novel H241Q mutation in NEUROD1. Gonsorcikova L, etal., Pediatr Diabetes. 2008 Aug;9(4 Pt 2):367-72. Epub 2008 Mar 5.
6. Polymorphic variations in the neurogenic differentiation-1, neurogenin-3, and hepatocyte nuclear factor-1alpha genes contribute to glucose intolerance in a South Indian population. Jackson AE, etal., Diabetes. 2004 Aug;53(8):2122-5.
7. Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation. Kaneto H, etal., J Biol Chem 2002 Apr 12;277(15):12998-3006.
8. Ala45Thr polymorphism of the NEUROD1 gene and diabetes susceptibility: a meta-analysis. Kavvoura FK and Ioannidis JP, Hum Genet. 2005 Feb;116(3):192-9. Epub 2004 Dec 11.
9. Cloning and expression of a rat brain basic helix-loop-helix factor. Kawakami H, etal., Biochem Biophys Res Commun 1996 Apr 5;221(1):199-204.
10. MODY in Iceland is associated with mutations in HNF-1alpha and a novel mutation in NeuroD1. Kristinsson SY, etal., Diabetologia. 2001 Nov;44(11):2098-103.
11. Transcriptional response to the neuroleptic-like compound Ampullosporin A in the rat ketamine model. Krugel H, etal., J Neurochem. 2006 Apr;97 Suppl 1:74-81.
12. Ala45Thr variation in neuroD1 gene is associated with early-onset type 2 diabetes with or without diabetic pedigree in Chinese. Liu L, etal., Mol Cell Biochem. 2006 Oct;290(1-2):199-204. Epub 2006 Jun 14.
13. A novel mutation, Ser159Pro in the NeuroD1/BETA2 gene contributes to the development of diabetes in a Chinese potential MODY family. Liu L, etal., Mol Cell Biochem. 2007 Sep;303(1-2):115-20. Epub 2007 Apr 18.
14. Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Malecki MT, etal., Nat Genet. 1999 Nov;23(3):323-8.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Endocrine pancreatic tissue plasticity in obese humans is associated with cytoplasmic expression of PBX-1 in pancreatic ductal cells. Muharram G, etal., Biochem Biophys Res Commun. 2005 Aug 12;333(4):1153-9.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Overexpression of NeuroD in PC12 cells alters morphology and enhances expression of the adenylate kinase isozyme 1 gene. Noma T, etal., Brain Res Mol Brain Res 1999 Apr 6;67(1):53-63.
19. The Ala45Thr polymorphism of NEUROD1 is associated with type 1 diabetes in Brazilian women. Oliveira CS, etal., Diabetes Metab. 2005 Dec;31(6):599-602.
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. Glucose induced MAPK signalling influences NeuroD1-mediated activation and nuclear localization. Petersen HV, etal., FEBS Lett 2002 Sep 25;528(1-3):241-5.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. Mutations of maturity-onset diabetes of the young (MODY) genes in Thais with early-onset type 2 diabetes mellitus. Plengvidhya N, etal., Clin Endocrinol (Oxf). 2009 Jun;70(6):847-53. Epub 2008 Sep 22.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Comprehensive gene review and curation RGD comprehensive gene curation
28. Lack of association of the Ala(45)Thr polymorphism and other common variants of the NeuroD gene with type 1 diabetes. Vella A, etal., Diabetes. 2004 Apr;53(4):1158-61.
Additional References at PubMed
PMID:9308961   PMID:9512516   PMID:10398678   PMID:10639171   PMID:10804213   PMID:10868931   PMID:11152640   PMID:11861467   PMID:11891657   PMID:11981044   PMID:12368292   PMID:12477932  
PMID:14697366   PMID:14741104   PMID:14752053   PMID:15121856   PMID:15701640   PMID:15793245   PMID:16055439   PMID:16321656   PMID:16368089   PMID:17941991   PMID:17988662   PMID:18007592  
PMID:18388149   PMID:18462699   PMID:18848628   PMID:19272376   PMID:19619559   PMID:22513373   PMID:24338128   PMID:33340723  


Genomics

Comparative Map Data
Neurod1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8384,766,483 - 84,770,454 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl384,764,725 - 84,770,810 (-)EnsemblGRCr8
mRatBN7.2364,359,554 - 64,363,526 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl364,359,395 - 64,363,649 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx367,711,247 - 67,715,219 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0376,294,848 - 76,298,820 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0374,041,670 - 74,045,642 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0366,414,314 - 66,417,617 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl366,414,308 - 66,417,741 (-)Ensemblrn6Rnor6.0
Rnor_5.0372,974,876 - 72,978,179 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4362,224,633 - 62,227,936 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera363,819,711 - 63,823,202 (-)NCBICelera
RGSC_v3.1362,121,017 - 62,124,302 (-)NCBI
Cytogenetic Map3q24NCBI
NEUROD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382181,668,295 - 181,680,517 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2181,668,295 - 181,680,827 (-)Ensemblhg38GRCh38
GRCh372182,533,022 - 182,545,244 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362182,249,439 - 182,253,626 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342182,366,700 - 182,370,760NCBI
Celera2176,137,248 - 176,141,434 (-)NCBICelera
Cytogenetic Map2q31.3NCBI
HuRef2174,397,426 - 174,401,985 (-)NCBIHuRef
CHM1_12182,546,618 - 182,551,246 (-)NCBICHM1_1
T2T-CHM13v2.02182,158,398 - 182,170,625 (-)NCBIT2T-CHM13v2.0
Neurod1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39279,282,981 - 79,286,980 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl279,282,865 - 79,287,095 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38279,452,637 - 79,456,636 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl279,452,521 - 79,456,751 (-)Ensemblmm10GRCm38
MGSCv37279,292,798 - 79,296,793 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36279,253,480 - 79,257,475 (-)NCBIMGSCv36mm8
Celera281,111,974 - 81,115,969 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map247.58NCBI
Neurod1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540315,595,888 - 15,600,040 (+)Ensembl
ChiLan1.0NW_00495540315,595,888 - 15,600,040 (+)NCBIChiLan1.0ChiLan1.0
NEUROD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21384,325,674 - 84,329,958 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B84,339,191 - 84,344,931 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B68,939,341 - 68,943,516 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B186,749,155 - 186,753,541 (-)NCBIPanPan1.1PanPan1.1panPan2
NEUROD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13624,853,591 - 24,857,886 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3624,876,367 - 24,880,645 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03625,015,921 - 25,020,202 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3625,017,362 - 25,018,352 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13625,105,431 - 25,109,707 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03625,071,760 - 25,074,709 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03625,205,991 - 25,210,288 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Neurod1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303141,867,918 - 141,872,050 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650910,423,126 - 10,424,196 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650910,421,821 - 10,425,927 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEUROD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1587,175,765 - 87,179,959 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11587,175,629 - 87,179,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21596,661,749 - 96,664,352 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEUROD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11067,203,714 - 67,208,644 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1067,205,141 - 67,206,211 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040132,367,194 - 132,371,760 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Neurod1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248443,494,677 - 3,497,759 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248443,493,819 - 3,497,814 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Neurod1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1556,676,479 - 56,680,550 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Neurod1
33 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir383rno-miR-383-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Mir30c1rno-miR-30c-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:63
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000007662
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)37359251285062403Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
UniSTS:158749  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2364,360,878 - 64,361,382 (+)MAPPERmRatBN7.2
Rnor_6.0366,414,971 - 66,415,474NCBIRnor6.0
Rnor_5.0372,975,533 - 72,976,036UniSTSRnor5.0
RGSC_v3.4362,225,290 - 62,225,793UniSTSRGSC3.4
Celera363,820,368 - 63,820,871UniSTS
Cytogenetic Map3q24-q32UniSTS
RH80773  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2364,360,692 - 64,360,878 (+)MAPPERmRatBN7.2
Rnor_6.0366,414,785 - 66,414,970NCBIRnor6.0
Rnor_5.0372,975,347 - 72,975,532UniSTSRnor5.0
RGSC_v3.4362,225,104 - 62,225,289UniSTSRGSC3.4
Celera363,820,182 - 63,820,367UniSTS
Cytogenetic Map3q24-q32UniSTS
U28068  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2364,360,590 - 64,360,743 (+)MAPPERmRatBN7.2
Rnor_6.0366,414,683 - 66,414,835NCBIRnor6.0
Rnor_5.0372,975,245 - 72,975,397UniSTSRnor5.0
RGSC_v3.4362,225,002 - 62,225,154UniSTSRGSC3.4
Celera363,820,080 - 63,820,232UniSTS
Cytogenetic Map3q24-q32UniSTS
PMC85623P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2364,363,750 - 64,363,905 (+)MAPPERmRatBN7.2
Rnor_6.0366,417,842 - 66,417,996NCBIRnor6.0
Rnor_5.0372,978,404 - 72,978,558UniSTSRnor5.0
RGSC_v3.4362,228,161 - 62,228,315UniSTSRGSC3.4
Celera363,823,427 - 63,823,581UniSTS
Cytogenetic Map3q24-q32UniSTS
PMC140695P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8384,767,757 - 84,768,143 (+)Marker Load Pipeline
mRatBN7.2364,360,827 - 64,361,214 (+)MAPPERmRatBN7.2
Rnor_6.0366,414,920 - 66,415,306NCBIRnor6.0
Rnor_5.0372,975,482 - 72,975,868UniSTSRnor5.0
RGSC_v3.4362,225,239 - 62,225,625UniSTSRGSC3.4
Celera363,820,317 - 63,820,703UniSTS
Cytogenetic Map3q24-q32UniSTS
PMC85623P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2364,360,835 - 64,361,122 (+)MAPPERmRatBN7.2
Rnor_6.0366,414,928 - 66,415,214NCBIRnor6.0
Rnor_5.0372,975,490 - 72,975,776UniSTSRnor5.0
RGSC_v3.4362,225,247 - 62,225,533UniSTSRGSC3.4
Celera363,820,325 - 63,820,611UniSTS
Cytogenetic Map3q24-q32UniSTS
UniSTS:274183  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2364,361,295 - 64,361,524 (+)MAPPERmRatBN7.2
Rnor_6.0366,415,388 - 66,415,616NCBIRnor6.0
Rnor_5.0372,975,950 - 72,976,178UniSTSRnor5.0
RGSC_v3.4362,225,707 - 62,225,935UniSTSRGSC3.4
Celera363,820,785 - 63,821,013UniSTS
Cytogenetic Map3q24-q32UniSTS
Neurod1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2364,360,893 - 64,361,106 (+)MAPPERmRatBN7.2
Rnor_6.0366,414,986 - 66,415,198NCBIRnor6.0
Rnor_5.0372,975,548 - 72,975,760UniSTSRnor5.0
RGSC_v3.4362,225,305 - 62,225,517UniSTSRGSC3.4
Celera363,820,383 - 63,820,595UniSTS
Cytogenetic Map3q24-q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
18 5 3 142 19 15 9 7 9 2 67 17 1 136 18 43 6 31 31

Sequence


Ensembl Acc Id: ENSRNOT00000007662   ⟹   ENSRNOP00000007662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl384,766,323 - 84,770,810 (-)Ensembl
mRatBN7.2 Ensembl364,359,395 - 64,363,649 (-)Ensembl
Rnor_6.0 Ensembl366,414,308 - 66,417,741 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl366,414,318 - 66,417,611 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000159286   ⟹   ENSRNOP00000101657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl384,766,139 - 84,770,776 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000162126   ⟹   ENSRNOP00000108550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl384,764,725 - 84,770,615 (-)Ensembl
RefSeq Acc Id: NM_019218   ⟹   NP_062091
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8384,766,483 - 84,770,454 (-)NCBI
mRatBN7.2364,359,554 - 64,363,526 (-)NCBI
Rnor_6.0366,414,314 - 66,417,617 (-)NCBI
Rnor_5.0372,974,876 - 72,978,179 (-)NCBI
RGSC_v3.4362,224,633 - 62,227,936 (-)RGD
Celera363,819,711 - 63,823,202 (-)RGD
Sequence:
RefSeq Acc Id: NP_062091   ⟸   NM_019218
- UniProtKB: Q569P0 (UniProtKB/Swiss-Prot),   Q64289 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007662   ⟸   ENSRNOT00000007662
Ensembl Acc Id: ENSRNOP00000108550   ⟸   ENSRNOT00000162126
Ensembl Acc Id: ENSRNOP00000101657   ⟸   ENSRNOT00000159286
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64289-F1-model_v2 AlphaFold Q64289 1-357 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692176
Promoter ID:EPDNEW_R2692
Type:single initiation site
Name:Neurod1_1
Description:neuronal differentiation 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0366,417,629 - 66,417,689EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3165 AgrOrtholog
BioCyc Gene G2FUF-49239 BioCyc
Ensembl Genes ENSRNOG00000005609 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007662.8 UniProtKB/Swiss-Prot
  ENSRNOT00000162126 ENTREZGENE
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7312547 IMAGE-MGC_LOAD
  IMAGE:7318277 IMAGE-MGC_LOAD
InterPro bHLH_dom UniProtKB/Swiss-Prot
  bHLH_transcription_factors UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
  Neurogenic_DUF UniProtKB/Swiss-Prot
  TF_bHLH_NeuroD UniProtKB/Swiss-Prot
KEGG Report rno:29458 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105447 IMAGE-MGC_LOAD
  MGC:105448 IMAGE-MGC_LOAD
NCBI Gene 29458 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED UniProtKB/Swiss-Prot
  PTHR19290:SF88 UniProtKB/Swiss-Prot
Pfam HLH UniProtKB/Swiss-Prot
  Neuro_bHLH UniProtKB/Swiss-Prot
PhenoGen Neurod1 PhenoGen
PIRSF bHLH_NeuroD UniProtKB/Swiss-Prot
PROSITE BHLH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005609 RatGTEx
SMART HLH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
UniProt A6HML3_RAT UniProtKB/TrEMBL
  NDF1_RAT UniProtKB/Swiss-Prot
  Q569P0 ENTREZGENE
  Q64289 ENTREZGENE
UniProt Secondary Q569P0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-05 Neurod1  neuronal differentiation 1  Neurod1  neurogenic differentiation 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Neurod1  neurogenic differentiation 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process activates Adenylate kinase isozyme 1 (AK1) expression in PC12 cells 727267