Mir133b (microRNA 133b) - Rat Genome Database

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Gene: Mir133b (microRNA 133b) Rattus norvegicus
Analyze
Symbol: Mir133b
Name: microRNA 133b
RGD ID: 2325527
Description: Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Orthologous to human MIR133B (microRNA 133b); INTERACTS WITH amphetamine; bleomycin A2; cadmium atom.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-133b; rno-mir-133b
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8930,594,582 - 30,594,665 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl930,594,582 - 30,594,665 (+)EnsemblGRCr8
mRatBN7.2923,098,134 - 23,098,217 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl923,098,134 - 23,098,217 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx931,595,664 - 31,595,747 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0936,716,388 - 36,716,471 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0935,031,659 - 35,031,742 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0926,795,649 - 26,795,732 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl926,795,649 - 26,795,732 (+)Ensemblrn6Rnor6.0
Rnor_5.0925,652,099 - 25,652,182 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera920,677,985 - 20,678,068 (+)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. SF3B4 is regulated by microRNA-133b and promotes cell proliferation and metastasis in hepatocellular carcinoma. Liu Z, etal., EBioMedicine. 2018 Dec;38:57-68. doi: 10.1016/j.ebiom.2018.10.067. Epub 2018 Nov 1.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Label-free quantitative proteomics identifies Smarca4 is involved in vascular calcification. Wang C, etal., Ren Fail. 2019 Nov;41(1):220-228. doi: 10.1080/0886022X.2019.1591997.
Additional References at PubMed
PMID:16274478   PMID:16381832   PMID:17604727   PMID:17656374   PMID:19188439   PMID:19695767   PMID:20403161   PMID:22000014   PMID:22101014   PMID:23337359   PMID:24205035   PMID:25451078  
PMID:25591767   PMID:26187577   PMID:26202011   PMID:26280272   PMID:26627004   PMID:27012608   PMID:28000044   PMID:29568969   PMID:31858564   PMID:33215437   PMID:33436530   PMID:34553456  
PMID:34688806   PMID:37702447  


Genomics

Comparative Map Data
Mir133b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8930,594,582 - 30,594,665 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl930,594,582 - 30,594,665 (+)EnsemblGRCr8
mRatBN7.2923,098,134 - 23,098,217 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl923,098,134 - 23,098,217 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx931,595,664 - 31,595,747 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0936,716,388 - 36,716,471 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0935,031,659 - 35,031,742 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0926,795,649 - 26,795,732 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl926,795,649 - 26,795,732 (+)Ensemblrn6Rnor6.0
Rnor_5.0925,652,099 - 25,652,182 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera920,677,985 - 20,678,068 (+)NCBICelera
Cytogenetic Map9q13NCBI
MIR133B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,148,923 - 52,149,041 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl652,148,923 - 52,149,041 (+)Ensemblhg38GRCh38
GRCh37652,013,721 - 52,013,839 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,121,679 - 52,121,797 (+)NCBIBuild 36Build 36hg18NCBI36
Celera653,674,858 - 53,674,976 (+)NCBICelera
Cytogenetic Map6p12.2NCBI
HuRef651,844,715 - 51,844,833 (+)NCBIHuRef
CHM1_1652,015,930 - 52,016,048 (+)NCBICHM1_1
T2T-CHM13v2.0651,987,631 - 51,987,749 (+)NCBIT2T-CHM13v2.0
Mir133b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39120,752,993 - 20,753,111 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl120,752,993 - 20,753,111 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38120,682,769 - 20,682,887 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl120,682,769 - 20,682,887 (+)Ensemblmm10GRCm38
MGSCv37120,672,850 - 20,672,968 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera120,557,615 - 20,557,733 (+)NCBICelera
Cytogenetic Map1A4NCBI
cM Map16.41NCBI
MIR133B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1219,705,912 - 19,705,995 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01220,308,697 - 20,308,780 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1220,308,697 - 20,308,780 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11219,814,126 - 19,814,209 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01219,917,082 - 19,917,165 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01220,055,101 - 20,055,184 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
MIR133B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl745,980,138 - 45,980,217 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1745,980,138 - 45,980,217 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,430,290 - 52,430,369 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status (No longer updated)

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Klf15rno-miR-133b-3pMirtarbaseexternal_infoWestern blotFunctional MTI19720047
Slc2a4rno-miR-133b-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19720047

Predicted Targets
Summary Value
Count of predictions:10350
Count of gene targets:6384
Count of transcripts:6900
Interacting mature miRNAs:rno-miR-133b-3p, rno-miR-133b-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat


Expression

RNA-SEQ Expression

appendage
ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
11 9 4 8 3 3 19 4 8 4 9 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_032117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl930,594,582 - 30,594,665 (+)Ensembl
mRatBN7.2 Ensembl923,098,134 - 23,098,217 (+)Ensembl
Rnor_6.0 Ensembl926,795,649 - 26,795,732 (+)Ensembl
RefSeq Acc Id: NR_032117
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8930,594,582 - 30,594,665 (+)NCBI
mRatBN7.2923,098,134 - 23,098,217 (+)NCBI
Rnor_6.0926,795,649 - 26,795,732 (+)NCBI
Rnor_5.0925,652,099 - 25,652,182 (+)NCBI
Celera920,677,985 - 20,678,068 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325527 AgrOrtholog
BioCyc Gene G2FUF-28035 BioCyc
Ensembl Genes ENSRNOG00000035571 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053694 ENTREZGENE
miRBase MI0003490 ENTREZGENE
NCBI Gene 100314078 ENTREZGENE
PhenoGen Mir133b PhenoGen
RatGTEx ENSRNOG00000035571 RatGTEx
RNAcentral URS000032BD73 RNACentral
  URS000075C14E RNACentral
  URS000075C15C RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir133b  microRNA 133b  Mir133b  microRNA mir-133b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir133b  microRNA mir-133b      Symbol and Name status set to provisional 70820 PROVISIONAL