Mir377 (microRNA 377) - Rat Genome Database

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Gene: Mir377 (microRNA 377) Rattus norvegicus
Analyze
Symbol: Mir377
Name: microRNA 377
RGD ID: 2325344
Description: Enables mRNA base-pairing post-transcriptional repressor activity. Involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Orthologous to human MIR377 (microRNA 377); INTERACTS WITH atrazine; cadmium atom; cadmium dichloride.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-377; rno-mir-377
RGD Orthologs
Human
Mouse
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86134,576,456 - 134,576,527 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.26128,755,051 - 128,755,122 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx6128,934,290 - 128,934,361 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06129,230,122 - 129,230,193 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06128,591,747 - 128,591,818 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06133,890,690 - 133,890,761 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6133,890,646 - 133,890,779 (+)Ensemblrn6Rnor6.0
Rnor_5.06143,053,047 - 143,053,118 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera6126,339,430 - 126,339,501 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. miR-377 inhibited tumorous behaviors of non-small cell lung cancer through directly targeting CDK6. Zhang J, etal., Eur Rev Med Pharmacol Sci. 2016 Nov;20(21):4494-4499.
Additional References at PubMed
PMID:16274478   PMID:16381832   PMID:20403161   PMID:25251394   PMID:25746774   PMID:26822703   PMID:28569430   PMID:37864623  


Genomics

Comparative Map Data
Mir377
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86134,576,456 - 134,576,527 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.26128,755,051 - 128,755,122 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx6128,934,290 - 128,934,361 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06129,230,122 - 129,230,193 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06128,591,747 - 128,591,818 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06133,890,690 - 133,890,761 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6133,890,646 - 133,890,779 (+)Ensemblrn6Rnor6.0
Rnor_5.06143,053,047 - 143,053,118 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera6126,339,430 - 126,339,501 (+)NCBICelera
Cytogenetic Map6q32NCBI
MIR377
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814101,062,050 - 101,062,118 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14101,062,050 - 101,062,118 (+)Ensemblhg38GRCh38
GRCh3714101,528,387 - 101,528,455 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,598,139 - 100,598,207 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1481,584,448 - 81,584,516 (+)NCBICelera
Cytogenetic Map14q32.31NCBI
HuRef1481,711,760 - 81,711,828 (+)NCBIHuRef
CHM1_114101,467,409 - 101,467,477 (+)NCBICHM1_1
T2T-CHM13v2.01495,297,436 - 95,297,504 (+)NCBIT2T-CHM13v2.0
Mir377
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912109,706,944 - 109,707,011 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12109,706,944 - 109,707,011 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812109,740,510 - 109,740,577 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12109,740,510 - 109,740,577 (+)Ensemblmm10GRCm38
MGSCv3712110,978,720 - 110,978,787 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera12110,937,740 - 110,937,807 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.56NCBI
MIR377
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1869,290,937 - 69,291,005 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha868,809,084 - 68,809,152 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0869,572,589 - 69,572,657 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1869,236,132 - 69,236,200 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0869,302,226 - 69,302,294 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0869,700,224 - 69,700,292 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0

miRNA Target Status (No longer updated)

Predicted Targets
Summary Value
Count of predictions:15990
Count of gene targets:8171
Count of transcripts:8767
Interacting mature miRNAs:rno-miR-377-3p, rno-miR-377-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6131392689143944780Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 4 19 101 59 47 35 7 35 6 93 46 81 2 39 12

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_032114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6133,890,646 - 133,890,779 (+)Ensembl
RefSeq Acc Id: NR_032114
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86134,576,456 - 134,576,527 (+)NCBI
mRatBN7.26128,755,051 - 128,755,122 (+)NCBI
Rnor_6.06133,890,690 - 133,890,761 (+)NCBI
Rnor_5.06143,053,047 - 143,053,118 (+)NCBI
Celera6126,339,430 - 126,339,501 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325344 AgrOrtholog
BioCyc Gene G2FUF-35928 BioCyc
Ensembl Genes ENSRNOG00000035610 Ensembl
miRBase MI0003487 ENTREZGENE
NCBI Gene 100314283 ENTREZGENE
PhenoGen Mir377 PhenoGen
RatGTEx ENSRNOG00000035610 RatGTEx
RNAcentral URS000036BEF1 RNACentral
  URS000075A2BA RNACentral
  URS000075B583 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir377  microRNA 377  Mir377  microRNA mir-377  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir377  microRNA mir-377      Symbol and Name status set to provisional 70820 PROVISIONAL