Bcl2l1 (Bcl2-like 1) - Rat Genome Database

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Gene: Bcl2l1 (Bcl2-like 1) Rattus norvegicus
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Symbol: Bcl2l1
Name: Bcl2-like 1
RGD ID: 2200
Description: Enables several functions, including GTPase binding activity; MDM2/MDM4 family protein binding activity; and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of transport; and regulation of apoptotic process. Located in cytosol; mitochondrial outer membrane; and presynapse. Is active in synaptic vesicle. Colocalizes with clathrin-coated pit; mitochondrial membrane; and synaptic vesicle membrane. Used to study amyotrophic lateral sclerosis; artery disease (multiple); endometriosis; gastric ulcer; and impotence. Biomarker of several diseases, including acute kidney failure; brain ischemia; hepatocellular carcinoma; ocular hypertension; and status epilepticus. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); leukemia (multiple); and pancreatic cancer. Orthologous to human BCL2L1 (BCL2 like 1); PARTICIPATES IN intrinsic apoptotic pathway; erythropoietin signaling pathway; interleukin-3 signaling pathway; INTERACTS WITH (R)-carnitine; (R)-lipoic acid; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: apoptosis regulator Bcl-X; B cell lymphoma 2 like; B cell lymphoma like X; bcl-2-like protein 1; bcl-X; Bcl-xl; bcl2-L-1; Bcl2l; Bclx
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau4
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,713,777 - 161,764,844 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3161,745,540 - 161,764,907 (-)EnsemblGRCr8
GRCr8 Ensembl1166,455,719 - 166,456,231 (-)EnsemblGRCr8
mRatBN7.23141,253,508 - 141,304,582 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1157,043,792 - 157,044,304 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl3141,253,523 - 141,303,479 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3145,158,456 - 145,209,456 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,742,281 - 153,793,281 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,482,052 - 151,532,840 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03148,259,594 - 148,314,191 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,259,596 - 148,313,810 (-)Ensemblrn6Rnor6.0
Rnor_5.03154,662,586 - 154,716,802 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43143,129,087 - 143,180,199 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3140,002,906 - 140,053,959 (-)NCBICelera
RGSC_v3.13143,082,602 - 143,084,431 (-)NCBI
Cytogenetic Map3q41NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (IEP)
acute kidney failure  (IEP)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenoma  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (IMP,ISO)
amyotrophic lateral sclerosis type 1  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
Brain Hypoxia-Ischemia  (IDA)
brain ischemia  (IEP)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cerebral Hemorrhage  (ISO)
cervical cancer  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
colorectal adenocarcinoma  (ISO)
cryptorchidism  (ISO)
depressive disorder  (IEP)
dilated cardiomyopathy  (IEP)
endometrial cancer  (ISO)
endometriosis  (IDA)
Experimental Diabetes Mellitus  (IDA,ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (IDA)
gastric ulcer  (IDA)
Head and Neck Neoplasms  (ISO)
Hearing Loss  (ISO)
hematopoietic system disease  (ISO)
Hemorrhagic Shock  (IEP)
hepatocellular carcinoma  (IEP,ISO)
hereditary breast ovarian cancer syndrome  (ISO)
impotence  (IDA,ISO)
leiomyoma  (ISO)
liver disease  (ISO)
Liver Reperfusion Injury  (IEP)
Lung Neoplasms  (ISO)
lymphoid leukemia  (ISO)
melanoma  (ISO)
multiple myeloma  (ISO)
myocardial infarction  (IMP,ISO)
Myocardial Reperfusion Injury  (IDA)
nephroblastoma  (ISO)
ocular hypertension  (IEP)
oral squamous cell carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
plasma cell neoplasm  (ISO)
polycythemia vera  (ISO)
prostate carcinoma  (ISO)
pulmonary hypertension  (IDA)
renal cell carcinoma  (ISO)
Retina Reperfusion Injury  (IEP)
status epilepticus  (IEP)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
stroke  (ISO)
toxic encephalopathy  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
uterus interstitial leiomyoma  (ISO)
Viral Bronchiolitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(20R)-protopanaxadiol  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
(R)-salsolinol  (EXP)
(R,R)-tramadol  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-amphetamine  (EXP,ISO)
(S)-colchicine  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,3-dinitrobenzene  (EXP,ISO)
1,3-Dinitropyrene  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-bromopropane  (EXP,ISO)
1-nitropyrene  (ISO)
10-Hydroxycamptothecin  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dichloroindophenol  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-deoxy-D-glucose  (ISO)
2-ethoxyethanol  (EXP)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-methoxyethanol  (EXP)
2-palmitoylglycerol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,4-Methylenedioxyamphetamine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-nitropropanoic acid  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-Aminobenzamide  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylthioamphetamine  (ISO)
4-nitro-m-cresol  (ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-Hydroxycapric acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-oxocampestanol  (ISO)
7,8-diacetoxy-4-methylcoumarin  (ISO)
8-OH-DPAT  (ISO)
9,10-anthraquinone  (ISO)
9-Methoxycamptothecin  (ISO)
[6]-Shogaol  (ISO)
ABT-737  (ISO)
acetochlor  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrylamide  (EXP)
acrylonitrile  (ISO)
actinomycin D  (ISO)
adenosine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
AH23848  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP)
alginic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allicin  (ISO)
alloxan  (EXP)
alpha-Solamarine  (ISO)
alpha-Zearalanol  (ISO)
aluminium atom  (ISO)
aluminium oxide  (ISO)
aluminium(0)  (ISO)
alvocidib  (ISO)
amino acid  (ISO)
ammonium chloride  (EXP,ISO)
amosite asbestos  (ISO)
amphibole asbestos  (ISO)
amsacrine  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
ANTIMYCIN  (ISO)
antirheumatic drug  (ISO)
Antrocin  (ISO)
AP20187  (ISO)
apigenin  (EXP)
apocynin  (ISO)
arachidonic acid  (ISO)
arecoline  (EXP)
aripiprazole  (ISO)
arjunolic acid  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atazanavir sulfate  (ISO)
Atipamezole  (EXP)
Atranorin  (ISO)
atrazine  (EXP,ISO)
Auriculasin  (ISO)
azadirachtin A  (ISO)
azathioprine  (ISO)
azilsartan  (ISO)
Azoxymethane  (EXP)
Bay-K-8644  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[b]fluoranthene  (ISO)
benzophenanthridine  (ISO)
benzothiazoles  (ISO)
Berbamine  (ISO)
berberine  (ISO)
beta-D-glucan  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
Beta-Solamarine  (ISO)
betaxolol  (ISO)
Betulonic acid  (ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
bortezomib  (ISO)
brassinin  (ISO)
brassinolide  (ISO)
Bromoenol lactone  (EXP)
Brusatol  (ISO)
bufalin  (ISO)
Bufotalin  (ISO)
buta-1,3-diene  (ISO)
butein  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
C60 fullerene  (EXP)
cadmium acetate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cafestol  (ISO)
caffeine  (ISO)
Calcimycin  (EXP)
calciol  (ISO)
calcitriol  (EXP,ISO)
calyculin A  (ISO)
camalexin  (ISO)
camptothecin  (EXP,ISO)
Candesartan cilexetil  (EXP)
cannabidiol  (ISO)
cannabigerol  (ISO)
capillarisin  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (EXP,ISO)
carmustine  (EXP,ISO)
carvedilol  (EXP)
casticin  (ISO)
cefaloridine  (EXP)
celecoxib  (ISO)
cetrorelix  (ISO)
chenodeoxycholic acid  (ISO)
chloroprene  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (EXP)
chromium(6+)  (EXP,ISO)
chrysazin  (ISO)
chrysin  (EXP)
chrysin 5,7-dimethyl ether  (EXP)
ciguatoxin CTX1B  (ISO)
Cirsimarin  (ISO)
cisplatin  (EXP,ISO)
citalopram  (EXP)
citric acid  (ISO)
Clivoline  (ISO)
clofarabine  (ISO)
clofibrate  (ISO)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (EXP)
colistin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
cordycepin  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (EXP,ISO)
CU-O LINKAGE  (ISO)
cucurbitacin B  (ISO)
cucurbitacin E  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
cytarabine  (ISO)
D-glucose  (EXP)
dactolisib  (ISO)
daidzein  (ISO)
deguelin  (ISO)
dehydroepiandrosterone  (EXP)
dehydroepiandrosterone sulfate  (EXP)
delphinidin  (ISO)
demethoxycurcumin  (ISO)
demethoxyfumitremorgin C  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
depsipeptide  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
dextromethorphan  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
diazoxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
Dictamnine  (ISO)
dieldrin  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
dipyridamole  (ISO)
diquat  (ISO)
disulfiram  (ISO)
dizocilpine maleate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
elemental selenium  (EXP,ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
erdosteine  (ISO)
Erionite  (ISO)
escitalopram  (EXP)
esculetin  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP)
etoposide  (ISO)
eugenol  (ISO)
Evodiamine  (ISO)
farrerol  (ISO)
fenofibrate  (ISO)
fenvalerate  (ISO)
finasteride  (EXP)
fisetin  (ISO)
flavonoids  (EXP,ISO)
flubendazole  (ISO)
flufenoxuron  (ISO)
fluoxetine  (EXP)
flutamide  (ISO)
folic acid  (ISO)
fructose  (EXP)
fucoxanthin  (ISO)
fulvestrant  (EXP)
furan  (EXP)
Fusarenone X  (ISO)
galangin  (ISO)
gallein  (EXP)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gamma-tocopherol  (ISO)
Gastrodin  (ISO)
gefitinib  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
geraniol  (EXP)
Ginkgoic acid  (ISO)
Ginkgolide C  (EXP)
ginsenoside Re  (ISO)
glucose  (EXP)
glutathione  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypin  (ISO)
gossypol  (ISO)
GW 6471  (ISO)
Gyrophoric acid  (ISO)
haloperidol  (EXP)
homoeriodictyol  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxamic acid  (ISO)
hydroxyurea  (EXP)
ibrutinib  (ISO)
ibuprofen  (ISO)
idelalisib  (ISO)
Idoxifene  (EXP)
Ilimaquinone  (ISO)
imidacloprid  (EXP)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron dextran  (ISO)
iron(0)  (ISO)
isoflavones  (ISO)
isoflurane  (EXP)
Isoliensinine  (ISO)
isoliquiritigenin  (ISO)
isopimaric acid  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
isotretinoin  (ISO)
kaempferol  (ISO)
kurarinol  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (EXP)
lactacystin  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP)
leptomycin B  (ISO)
linalool  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
lonafarnib  (ISO)
lonidamine  (ISO)
lovastatin  (EXP)
lutein  (ISO)
luteolin  (ISO)
Luteolin 7-methyl ether  (EXP)
luteolin 7-O-beta-D-glucoside  (ISO)
LY 379268  (EXP)
LY294002  (EXP,ISO)
maneb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
melamine  (ISO)
melatonin  (EXP,ISO)
mercaptopurine  (ISO)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methidathion  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
methylmercury(1+)  (EXP)
methylparaben  (ISO)
metoprolol  (EXP)
mevalonic acid  (EXP)
mifepristone  (EXP)
minocycline  (ISO)
mitomycin C  (ISO)
MitoTEMPO  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (EXP)
monocrotaline  (ISO)
morin  (EXP,ISO)
morphine  (EXP)
morusin  (ISO)
Myrtucommulone A  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-dimethylformamide  (EXP,ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nefazodone  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nitric oxide  (EXP,ISO)
nitrobenzenes  (EXP)
nitrofen  (ISO)
nitroprusside  (EXP)
Nodularin  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
NORCANTHARIDIN  (ISO)
NSC 23766  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP,ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oltipraz  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
oxybenzone  (EXP)
oxybuprocaine  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (EXP)
paricalcitol  (ISO)
parthenolide  (ISO)
PCB138  (ISO)
Pentoxifylline  (ISO)
pepstatin A  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP)
pevonedistat  (ISO)
pexidartinib  (ISO)
PF-3758309  (ISO)
PHA-665752  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenol red  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phloretin  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
picrotoxin  (EXP)
pifithrin-alpha hydrobromide  (EXP,ISO)
pirinixic acid  (ISO)
PK-11195  (ISO)
platycodin D  (ISO)
plumbagin  (ISO)
potassium dichromate  (EXP)
Pranoprofen  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (EXP)
progesterone  (EXP)
promethazine  (ISO)
propiconazole  (ISO)
propofol  (EXP)
propylparaben  (ISO)
prostaglandin E2  (EXP)
protein kinase inhibitor  (ISO)
Psymberin  (ISO)
pterostilbene  (ISO)
purine-6-thiol  (ISO)
puromycin  (ISO)
pyrethrins  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
ritonavir  (ISO)
Ro 31-8220  (EXP)
romidepsin  (ISO)
rosmarinic acid  (EXP)
rotenone  (ISO)
rottlerin  (ISO)
rubimaillin  (ISO)
rucaparib  (ISO)
rutin  (EXP)
Salinomycin  (ISO)
Salvianolic acid A  (EXP,ISO)
salvianolic acid B  (EXP)
sarin  (EXP,ISO)
SB 203580  (EXP)
SB 431542  (ISO)
SCH772984  (ISO)
sclareol  (ISO)
scutellarin  (EXP)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (EXP,ISO)
semilicoisoflavone B  (ISO)
senecionine  (ISO)
sevoflurane  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
silmitasertib  (ISO)
simazine  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
SNX-2112  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sodium dichromate  (EXP,ISO)
sorafenib  (ISO)
spironolactone  (EXP)
stattic  (ISO)
staurosporine  (EXP,ISO)
stavudine  (EXP)
streptozocin  (EXP,ISO)
styrene  (ISO)
styrene oxide  (ISO)
succimer  (ISO)
succinic acid  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
Sunset Yellow FCF  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (ISO)
talazoparib  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
tartrazine  (EXP,ISO)
taurine  (EXP)
tauroursodeoxycholic acid  (EXP)
Tautomycin  (ISO)
temozolomide  (ISO)
TEMPO  (EXP,ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
Thiotepa  (ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
thymoquinone  (ISO)
tin(II) chloride (anhydrous)  (EXP)
titanium dioxide  (ISO)
tocopherol  (ISO)
Tomentosin  (ISO)
toosendanin  (ISO)
topotecan  (ISO)
tramadol  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (EXP,ISO)
triclosan  (ISO)
trimethyltin  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
Tylophorine  (ISO)
tyrphostin AG 1478  (EXP)
valproic acid  (ISO)
veliparib  (ISO)
vemurafenib  (ISO)
venetoclax  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (EXP,ISO)
vorinostat  (EXP,ISO)
wortmannin  (ISO)
Xanthorrhizol  (ISO)
XAV939  (ISO)
XMU-MP-1  (ISO)
zerumbone  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc protoporphyrin  (EXP,ISO)
zinc pyrithione  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)
zolmitriptan  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
apoptotic process in bone marrow cell  (ISO)
cell population proliferation  (ISO)
cellular response to alkaloid  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to astaxanthin  (IEP)
cellular response to cAMP  (IEP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to erythropoietin  (IEP)
cellular response to gamma radiation  (ISO)
cellular response to hypoxia  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to nitric oxide  (IEP)
cellular response to prolactin  (IEP)
cellular response to tumor necrosis factor  (IEP)
cellular response to xenobiotic stimulus  (IEP)
cerebral cortex development  (IEP)
endocytosis  (IEA)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,ISO)
fertilization  (ISO)
germ cell development  (ISO)
gonad development  (IEA)
hepatocyte apoptotic process  (ISO)
in utero embryonic development  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IBA,ISO)
male gonad development  (ISO)
mitochondrion organization  (ISO)
negative regulation of anoikis  (ISO)
negative regulation of apoptotic process  (IDA,IEA,IMP,ISO)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO,ISS)
negative regulation of execution phase of apoptosis  (ISO,ISS)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein localization to plasma membrane  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO)
neuron apoptotic process  (ISO)
ovarian follicle development  (IEA,IMP,ISO)
positive regulation of apoptotic process  (IBA,IMP,ISO)
positive regulation of ATP biosynthetic process  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of synaptic vesicle clustering  (IMP)
positive regulation of synaptic vesicle endocytosis  (IMP)
positive regulation of synaptic vesicle exocytosis  (IMP)
regulation of apoptotic process  (IDA,IEA)
regulation of cytokinesis  (ISO,ISS)
regulation of growth  (ISO)
regulation of long-term synaptic depression  (IMP)
regulation of mitochondrial membrane permeability  (ISO)
regulation of mitochondrial membrane potential  (ISO)
regulation of synaptic vesicle endocytosis  (IDA,IEP,IMP)
release of cytochrome c from mitochondria  (IBA,ISO)
response to anesthetic  (IEP)
response to cycloheximide  (ISO)
response to cytokine  (ISO)
response to electrical stimulus  (IEP)
response to endoplasmic reticulum stress  (IEP)
response to erythropoietin  (IEP)
response to haloperidol  (IEP)
response to hydrogen peroxide  (IEP)
response to hypoxia  (IEP)
response to ischemia  (IDA)
response to ketone  (IEA)
response to lead ion  (IEP)
response to lipopolysaccharide  (IEP)
response to other organism  (IEA)
response to oxidative stress  (IEP)
response to peptide hormone  (IEP)
response to radiation  (ISO)
response to stress  (IEA)
response to virus  (ISO)
response to xenobiotic stimulus  (IEP)
spermatogenesis  (ISO)
synaptic vesicle recycling via endosome  (IMP)
transmembrane transport  (IEA)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Altered Bad localization and interaction between Bad and Bcl-xL in the hippocampus after transient global ischemia. Abe T, etal., Brain Res. 2004 May 29;1009(1-2):159-68.
2. The Bcl-2 apoptotic switch in cancer development and therapy. Adams JM and Cory S, Oncogene. 2007 Feb 26;26(9):1324-37.
3. Bcl-xL expression and regulation in the progression, recurrence, and cisplatin resistance of oral cancer. Alam M and Mishra R, Life Sci. 2021 Sep 1;280:119705. doi: 10.1016/j.lfs.2021.119705. Epub 2021 Jun 8.
4. Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to beta-cell apoptosis. Allagnat F, etal., Cell Death Differ. 2011 Feb;18(2):328-37. doi: 10.1038/cdd.2010.105. Epub 2010 Aug 27.
5. Transduction of anti-cell death protein FNK protects isolated rat hearts from myocardial infarction induced by ischemia/reperfusion. Arakawa M, etal., Life Sci. 2007 May 8;80(22):2076-84. Epub 2007 Apr 1.
6. Bcl-xL and Mcl-1 are involved in prevention of in vitro apoptosis in rat late-stage erythroblasts derived from bone marrow. Asano H, etal., J Toxicol Sci. 2012 Feb;37(1):23-31.
7. Cytokines tumor necrosis factor-alpha and interferon-gamma induce pancreatic beta-cell apoptosis through STAT1-mediated Bim protein activation. Barthson J, etal., J Biol Chem. 2011 Nov 11;286(45):39632-43. doi: 10.1074/jbc.M111.253591. Epub 2011 Sep 21.
8. Significance of proto-oncogene Bcl-X(S/L) expression in Wilms tumor. Basta-Jovanovic G, etal., Ren Fail. 2005;27(1):13-8.
9. Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer. Bishayee A, etal., Int J Cancer. 2013 Sep 1;133(5):1054-63. doi: 10.1002/ijc.28108. Epub 2013 Mar 29.
10. Optimizing chemotherapy for transitional cell carcinoma by application of bcl-2 and bcl-xL antisense oligodeoxynucleotides. Bolenz C, etal., Urol Oncol. 2007 Nov-Dec;25(6):476-82.
11. Expression and prognostic significance of Bcl-2 family proteins in myelodysplastic syndromes. Boudard D, etal., Am J Hematol. 2002 Jun;70(2):115-25.
12. In Vivo Delivery of a Bcl-xL Fusion Protein Containing the TAT Protein Transduction Domain Protects against Ischemic Brain Injury and Neuronal Apoptosis. Cao G, etal., J Neurosci 2002 Jul 1;22(13):5423-31.
13. Hypotensive hemorrhage increases calcium uptake capacity and Bcl-XL content of liver mitochondria. Carlson DE, etal., Shock. 2007 Feb;27(2):192-8.
14. Determination of the in vivo effects of prednisone on Bcl-2 family protein expression in childhood acute lymphoblastic leukemia. Casale F, etal., Int J Oncol. 2003 Jan;22(1):123-8.
15. Lead-induced alterations of apoptosis and neurotrophic factor mRNA in the developing rat cortex, hippocampus, and cerebellum. Chao SL, etal., J Biochem Mol Toxicol. 2007;21(5):265-72.
16. Stat3 activation in human endometrial and cervical cancers. Chen CL, etal., Br J Cancer. 2007 Feb 26;96(4):591-9.
17. Pancortin-2 interacts with WAVE1 and Bcl-xL in a mitochondria-associated protein complex that mediates ischemic neuronal death. Cheng A, etal., J Neurosci. 2007 Feb 14;27(7):1519-28.
18. Pravastatin attenuates carboplatin-induced cardiotoxicity via inhibition of oxidative stress associated apoptosis. Cheng CF, etal., Apoptosis. 2008 May 16;.
19. Apaf-1, Bcl-xL, cytochrome c, and caspase-9 form the critical elements for cerebral vascular protection by erythropoietin. Chong ZZ, etal., J Cereb Blood Flow Metab 2003 Mar;23(3):320-30.
20. Recombinant human erythropoietin prevents lipopolysaccharide-induced vascular hyporeactivity in the rat. di Villa Bianca Rd, etal., Shock. 2009 May;31(5):529-34. doi: 10.1097/SHK.0b013e31818909c0.
21. Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion. Du YC, etal., PLoS Biol. 2007 Oct 16;5(10):e276.
22. 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells. Duan Z, etal., Mol Pharmacol. 2007 Nov;72(5):1137-45. Epub 2007 Aug 3.
23. Lactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulation. Fujinaka Y, etal., J Biol Chem. 2007 Oct 19;282(42):30707-17. Epub 2007 Aug 29.
24. Heat shock protein 90 protects rat mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis via the PI3K/Akt and ERK1/2 pathways. Gao F, etal., J Zhejiang Univ Sci B. 2010 Aug;11(8):608-17. doi: 10.1631/jzus.B1001007.
25. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
26. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
27. Apoptosis and expression of Bcl-2, Bcl-XL, and Bax in renal cell carcinomas. Gobe G, etal., Cancer Invest. 2002;20(3):324-32.
28. BAX/BCL-XL gene expression ratio inversely correlates with disease progression in chronic myeloid leukemia. Gonzalez MS, etal., Blood Cells Mol Dis. 2010 Oct 15;45(3):192-6. doi: 10.1016/j.bcmd.2010.07.011. Epub 2010 Aug 21.
29. The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy. Grabenstatter HL, etal., Neurobiol Dis. 2014 Feb;62:73-85. doi: 10.1016/j.nbd.2013.09.003. Epub 2013 Sep 16.
30. p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress. Gurzov EN, etal., J Biol Chem. 2010 Jun 25;285(26):19910-20. doi: 10.1074/jbc.M110.122374. Epub 2010 Apr 26.
31. Bcl-XL and Bcl-2 Expression in Bilharzial Squamous Cell Carcinoma of the Urinary Bladder: Which Protein Is Prognostic? Hameed DA, etal., Urology. 2008 Mar 14;.
32. Loss of Bcl-x in Ph+ B-ALL increases cellular proliferation and does not inhibit leukemogenesis. Harb JG, etal., Blood. 2008 Apr 1;111(7):3760-9. doi: 10.1182/blood-2007-08-108803. Epub 2008 Jan 23.
33. Bak deficiency inhibits liver carcinogenesis: a causal link between apoptosis and carcinogenesis. Hikita H, etal., J Hepatol. 2012 Jul;57(1):92-100. doi: 10.1016/j.jhep.2012.01.027. Epub 2012 Mar 10.
34. BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Hsu SY, etal., Mol Endocrinol 1998 Sep;12(9):1432-40.
35. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Hsu SY, etal., Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12401-6.
36. Cytoprotective effect of American ginseng in a rat ethanol gastric ulcer model. Huang CC, etal., Molecules. 2013 Dec 27;19(1):316-26. doi: 10.3390/molecules19010316.
37. Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription. Huseby S, etal., Cell Death Dis. 2011 Dec 8;2:e237. doi: 10.1038/cddis.2011.124.
38. Erythropoietin, but not asialoerythropoietin or carbamyl-erythropoietin, attenuates monocrotaline-induced pulmonary hypertension in rats. Ikarashi N, etal., Clin Exp Hypertens. 2012;34(8):575-81. doi: 10.3109/10641963.2012.681728. Epub 2012 May 4.
39. The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein. Imaizumi K, etal., J Biol Chem 1999 Mar 19;274(12):7975-81.
40. Bcl-2-related protein family gene expression during oligodendroglial differentiation. Itoh T, etal., J Neurochem 2003 Jun;85(6):1500-12.
41. Antitumorigenic effect of plumbagin by induction of SH2-containing protein tyrosine phosphatase 1 in human gastric cancer cells. Joo MK, etal., Int J Oncol. 2015;46(6):2380-8. doi: 10.3892/ijo.2015.2935. Epub 2015 Mar 26.
42. Cluster analysis of mRNA expression levels identifies multiple sequential patterns following focal cerebral ischemia. Kaido T, etal., Turk Neurosurg. 2012;22(4):441-7. doi: 10.5137/1019-5149.JTN.5523-11.0.
43. Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane. Kaufmann T, etal., J Cell Biol 2003 Jan 6;160(1):53-64.
44. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
45. Endogenous Bcl-xL is essential for Myc-driven lymphomagenesis in mice. Kelly PN, etal., Blood. 2011 Dec 8;118(24):6380-6. doi: 10.1182/blood-2011-07-367672. Epub 2011 Oct 12.
46. Piceatannol attenuates hydrogen-peroxide- and peroxynitrite-induced apoptosis of PC12 cells by blocking down-regulation of Bcl-X(L) and activation of JNK. Kim HJ, etal., J Nutr Biochem. 2007 Sep 12;.
47. Alteration of retinal intrinsic survival signal and effect of alpha2-adrenergic receptor agonist in the retina of the chronic ocular hypertension rat. Kim HS, etal., Vis Neurosci. 2007 Mar-Apr;24(2):127-39.
48. N-acetylcysteine attenuates glycerol-induced acute kidney injury by regulating MAPKs and Bcl-2 family proteins. Kim JH, etal., Nephrol Dial Transplant. 2010 May;25(5):1435-43. doi: 10.1093/ndt/gfp659. Epub 2009 Dec 27.
49. Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease. Kitamura Y, etal., Brain Res. 1998 Jan 12;780(2):260-9.
50. Prolactin regulation of Bcl-2 family members: increased expression of bcl-xL but not mcl-1 or bad in Nb2-T cells. Kochendoerfer SK, etal., J Endocrinol. 2003 Aug;178(2):265-73.
51. Streptozotocin-induced diabetes increases the interaction of Bad/Bcl-XL and decreases the binding of pBad/14-3-3 in rat testis. Koh PO Life Sci. 2007 Sep 8;81(13):1079-84. Epub 2007 Aug 25.
52. Lactogens protect rodent and human beta cells against glucolipotoxicity-induced cell death through Janus kinase-2 (JAK2)/signal transducer and activator of transcription-5 (STAT5) signalling. Kondegowda NG, etal., Diabetologia. 2012 Jun;55(6):1721-32. doi: 10.1007/s00125-012-2501-9. Epub 2012 Mar 3.
53. Repeated Unpredictable Stress and Antidepressants Differentially Regulate Expression of the Bcl-2 Family of Apoptotic Genes in Rat Cortical, Hippocampal, and Limbic Brain Structures. Kosten TA, etal., Neuropsychopharmacology. 2007 Aug 15;.
54. Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas. Krajewska M, etal., Cancer Res. 1996 May 15;56(10):2422-7.
55. Aging alters acute apoptotic response to azoxymethane in the colon of rats. Kwon Y and Magnuson BA, Exp Gerontol. 2007 Dec;42(12):1154-61. Epub 2007 Oct 10.
56. Brimonidine blocks glutamate excitotoxicity-induced oxidative stress and preserves mitochondrial transcription factor a in ischemic retinal injury. Lee D, etal., PLoS One. 2012;7(10):e47098. doi: 10.1371/journal.pone.0047098. Epub 2012 Oct 9.
57. A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Li H, etal., Nat Cell Biol. 2013 Jul;15(7):773-85. doi: 10.1038/ncb2791. Epub 2013 Jun 23.
58. Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons. Li H, etal., Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2169-74. doi: 10.1073/pnas.0711647105. Epub 2008 Feb 4.
59. Ginkgolic acid (GA) suppresses gastric cancer growth by inducing apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS. Liang JR and Yang H, Biomed Pharmacother. 2020 May;125:109585. doi: 10.1016/j.biopha.2019.109585. Epub 2020 Feb 25.
60. Targeted overexpression of Bcl-XL in B-lymphoid cells results in lymphoproliferative disease and plasma cell malignancies. Linden M, etal., Blood. 2004 Apr 1;103(7):2779-86. Epub 2003 Dec 4.
61. ABL-MYC retroviral infection elicits bone marrow plasma cell tumors in Bcl-X(L) transgenic mice. Linden M, etal., Leuk Res. 2005 Apr;29(4):435-44. Epub 2004 Dec 18.
62. Defining the role of the Bcl-2 family of proteins in the nervous system. Lindsten T, etal., Neuroscientist. 2005 Feb;11(1):10-5.
63. A high soy diet reduces programmed cell death and enhances bcl-xL expression in experimental stroke. Lovekamp-Swan T, etal., Neuroscience. 2007 Sep 7;148(3):644-52. Epub 2007 Jul 17.
64. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
65. Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1beta-induced apoptosis via Bim/A1 imbalance. Miani M, etal., Cell Death Dis. 2013 Jul 4;4:e701. doi: 10.1038/cddis.2013.236.
66. p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition. Nair VD, etal., J Biol Chem. 2006 Dec 22;281(51):39550-60. Epub 2006 Oct 23.
67. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
68. Long-lasting production of TGF-beta1 by alveolar macrophages exposed to low doses of asbestos without apoptosis. Nishimura Y, etal., Int J Immunopathol Pharmacol. 2007 Oct-Dec;20(4):661-7.
69. Therapeutic benefits of intrathecal protein therapy in a mouse model of amyotrophic lateral sclerosis. Ohta Y, etal., J Neurosci Res. 2008 Oct;86(13):3028-37. doi: 10.1002/jnr.21747.
70. Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression. Onoue S, etal., FEBS J. 2008 Nov;275(22):5542-51.
71. Intrabursal Administration of the Antiangiopoietin 1 Antibody Produces a Delay in Rat Follicular Development Associated with an Increase in Ovarian Apoptosis Mediated by Changes in the Expression of BCL2 Related Genes. Parborell F, etal., Biol Reprod. 2007 Nov 7;.
72. The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia. Pasdois P, etal., Biochem J. 2011 Jun 1;436(2):493-505. doi: 10.1042/BJ20101957.
73. Erythropoietin Prevents Haloperidol Treatment-Induced Neuronal Apoptosis through Regulation of BDNF. Pillai A, etal., Neuropsychopharmacology. 2007 Sep 5;.
74. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
75. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
76. Transcription of genes of p53-dependent apoptosis in acute leukaemia. Racay P, etal., Int J Mol Med. 2008 Dec;22(6):833-9.
77. BGP-15 - a novel poly(ADP-ribose) polymerase inhibitor - protects against nephrotoxicity of cisplatin without compromising its antitumor activity. Racz I, etal., Biochem Pharmacol. 2002 Mar 15;63(6):1099-111.
78. GOA pipeline RGD automated data pipeline
79. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
80. Licochalcone B Ameliorates Liver Cancer via Targeting of Apoptotic Genes, DNA Repair Systems, and Cell Cycle Control. Sadek K, etal., Iran J Pharm Res. 2020 Fall;19(4):372-386. doi: 10.22037/ijpr.2020.1101292.
81. The prognostic value of Bcl-XL gene expression for remission induction is influenced by cytogenetics in adult acute myeloid leukemia. Schaich M, etal., Haematologica. 2001 May;86(5):470-7.
82. Tissue microarray analysis of FAS, Bcl-2, Bcl-x, ER, PgR, Hsp60, p53 and Her2-neu in breast carcinoma. Sebastiani V, etal., Anticancer Res. 2006 Jul-Aug;26(4B):2983-7.
83. Involvement of caspases and their upstream regulators in myocardial apoptosis in a rat model of selenium deficiency-induced dilated cardiomyopathy. Shan H, etal., J Trace Elem Med Biol. 2015;31:85-91. doi: 10.1016/j.jtemb.2015.03.005. Epub 2015 Apr 16.
84. Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. Shi SY, etal., J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.
85. Differential expression of rat brain bcl-2 family proteins in development and aging. Shimohama S, etal., Biochem Biophys Res Commun. 1998 Nov 9;252(1):92-6.
86. An additional form of rat Bcl-x, Bcl-xbeta, generated by an unspliced RNA, promotes apoptosis in promyeloid cells. Shiraiwa N, etal., J Biol Chem 1996 May 31;271(22):13258-65.
87. Effects of acute ethanol exposure on regulatory mechanisms of Bcl-2-associated apoptosis promoter, bad, in neonatal rat cerebellum: differential effects during vulnerable and resistant developmental periods. Siler-Marsiglio KI, etal., Alcohol Clin Exp Res. 2006 Jun;30(6):1031-8. doi: 10.1111/j.1530-0277.2006.000126.x.
88. Expression of Bcl-x in erythroid precursors from patients with polycythemia vera. Silva M, etal., N Engl J Med. 1998 Feb 26;338(9):564-71.
89. Identification of Bax-interacting proteins in oligodendrocyte progenitors during glutamate excitotoxicity and perinatal hypoxia-ischemia. Simonishvili S, etal., ASN Neuro. 2013 Dec 23;5(5):e00131. doi: 10.1042/AN20130027.
90. Changes in cell ultrastructure and inhibition of JAK1/STAT3 signaling pathway in CBRH-7919 cells with astaxanthin. Song X, etal., Toxicol Mech Methods. 2012 Nov;22(9):679-86. doi: 10.3109/15376516.2012.717119.
91. Efficient tumor cell lysis mediated by a Bcl-X(L) specific T cell clone isolated from a breast cancer patient. Sorensen RB, etal., Cancer Immunol Immunother. 2007 Apr;56(4):527-33. Epub 2006 Jul 19.
92. A novel angiogenesis inhibitor bevacizumab induces apoptosis in the rat endometriosis model. Soysal D, etal., Balkan J Med Genet. 2015 Apr 10;17(2):73-80. doi: 10.2478/bjmg-2014-0077. eCollection 2014 Dec.
93. Prosurvival Bcl-2 proteins stabilize pancreatic mitochondria and protect against necrosis in experimental pancreatitis. Sung KF, etal., Exp Cell Res. 2009 Jul 1;315(11):1975-89. doi: 10.1016/j.yexcr.2009.01.009. Epub 2009 Jan 24.
94. Regulation of Bcl-xL expression in lung vascular smooth muscle. Suzuki YJ, etal., Am J Respir Cell Mol Biol. 2007 Jun;36(6):678-87. Epub 2007 Feb 1.
95. Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins. Torii S, etal., Cell Death Differ. 2011 Nov;18(11):1711-25. doi: 10.1038/cdd.2011.47. Epub 2011 May 6.
96. Regulation of Bcl-xL expression by H2O2 in cardiac myocytes. Valks DM, etal., J Biol Chem 2003 Jul 11;278(28):25542-7.
97. Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis. Vukosavic S, etal., J Neurochem. 1999 Dec;73(6):2460-8.
98. Neuroprotective effects of caffeic acid phenethyl ester against sevoflurane‑induced neuronal degeneration in the hippocampus of neonatal rats involve MAPK and PI3K/Akt signaling pathways. Wang LY, etal., Mol Med Rep. 2016 Oct;14(4):3403-12. doi: 10.3892/mmr.2016.5586. Epub 2016 Aug 4.
99. Suppression of Bcl-xL expression by a novel tumor-specific RNA interference system inhibits proliferation and enhances radiosensitivity in prostatic carcinoma cells. Wang R, etal., Cancer Chemother Pharmacol. 2007 Jul 26;.
100. Venlafaxine modulates depression-induced behaviour and the expression of Bax mRNA and Bcl-xl mRNA in both hippocampus and myocardium. Wang Y, etal., Hum Psychopharmacol. 2011 Mar;26(2):95-101. doi: 10.1002/hup.1177. Epub 2011 Feb 9.
101. Aberrant expression of apoptosis proteins and ultrastructural aberrations in uterine leiomyomas from patients with hereditary leiomyomatosis and renal cell carcinoma. Wortham NC, etal., Fertil Steril. 2006 Oct;86(4):961-71. Epub 2006 Sep 7.
102. Oxidative stress-induced apoptotic insults to rat osteoblasts are attenuated by nitric oxide pretreatment via GATA-5-involved regulation of Bcl-X L gene expression and protein translocation. Wu GJ, etal., Arch Toxicol. 2016 Apr;90(4):905-16. doi: 10.1007/s00204-015-1491-z. Epub 2015 Mar 1.
103. Loss of anti-apoptotic genes in aging rat crura. Yamanaka M, etal., J Urol. 2002 Nov;168(5):2296-300.
104. Genetic redox preconditioning differentially modulates AP-1 and NF kappa B responses following cardiac ischemia/reperfusion injury and protects against necrosis and apoptosis. Yang J, etal., Mol Ther. 2003 Mar;7(3):341-53.
105. Rho-kinase-dependent pathway mediates the hepatoprotective effects of sorafenib against ischemia/reperfusion liver injury in rats with nonalcoholic steatohepatitis. Yang YY, etal., Liver Transpl. 2012 Nov;18(11):1371-83. doi: 10.1002/lt.23520.
106. Silencing of FGFR4 could influence the biological features of gastric cancer cells and its therapeutic value in gastric cancer. Ye Y, etal., Tumour Biol. 2016 Mar;37(3):3185-95. doi: 10.1007/s13277-015-4100-0. Epub 2015 Oct 2.
107. Delayed apoptosis by neutrophils from COPD patients is associated with altered Bak, Bcl-xl, and Mcl-1 mRNA expression. Zhang J, etal., Diagn Pathol. 2012 Jun 11;7:65. doi: 10.1186/1746-1596-7-65.
108. Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma. Zhuang L, etal., Mod Pathol. 2007 Apr;20(4):416-26.
Additional References at PubMed
PMID:7607090   PMID:7650367   PMID:7650488   PMID:7753802   PMID:7828536   PMID:7834748   PMID:8625820   PMID:8798158   PMID:8798452   PMID:8918887   PMID:9096145   PMID:9176392  
PMID:9184696   PMID:9346936   PMID:9388232   PMID:9843949   PMID:9867803   PMID:10618441   PMID:10894153   PMID:11146504   PMID:11150333   PMID:11717309   PMID:11721745   PMID:11980919  
PMID:12011449   PMID:12115603   PMID:12477932   PMID:12496370   PMID:12667443   PMID:12785016   PMID:12931191   PMID:12967636   PMID:14517295   PMID:14532118   PMID:14651853   PMID:14676192  
PMID:14999001   PMID:15006356   PMID:15121179   PMID:15131699   PMID:15149850   PMID:15231831   PMID:15545017   PMID:15574729   PMID:15596800   PMID:15720830   PMID:15901672   PMID:16085054  
PMID:16111822   PMID:16133871   PMID:16205321   PMID:16301318   PMID:16428456   PMID:16603546   PMID:16608847   PMID:16723699   PMID:16815550   PMID:17052454   PMID:17073802   PMID:17132701  
PMID:17267035   PMID:17289999   PMID:17428862   PMID:17600519   PMID:17644076   PMID:18053090   PMID:18163394   PMID:18221257   PMID:18347331   PMID:18497705   PMID:18923682   PMID:18980715  
PMID:19082728   PMID:19339209   PMID:19767770   PMID:19862336   PMID:19885947   PMID:19938943   PMID:20106970   PMID:20457187   PMID:20499358   PMID:20671748   PMID:20673843   PMID:21041309  
PMID:21199865   PMID:21567405   PMID:21639858   PMID:21710144   PMID:21740920   PMID:21840391   PMID:21856303   PMID:21861389   PMID:21863631   PMID:21926988   PMID:22292018   PMID:22294442  
PMID:22366758   PMID:22424444   PMID:22871113   PMID:23015448   PMID:23530063   PMID:23731686   PMID:24096434   PMID:24326522   PMID:24444606   PMID:24787232   PMID:25681439   PMID:26109654  
PMID:26254736   PMID:26582200   PMID:27815660   PMID:27830683   PMID:28320275   PMID:28320276   PMID:28478796   PMID:28597245   PMID:29507230   PMID:33340237   PMID:36982731  


Genomics

Comparative Map Data
Bcl2l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,713,777 - 161,764,844 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3161,745,540 - 161,764,907 (-)EnsemblGRCr8
GRCr8 Ensembl1166,455,719 - 166,456,231 (-)EnsemblGRCr8
mRatBN7.23141,253,508 - 141,304,582 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1157,043,792 - 157,044,304 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl3141,253,523 - 141,303,479 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3145,158,456 - 145,209,456 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,742,281 - 153,793,281 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,482,052 - 151,532,840 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03148,259,594 - 148,314,191 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,259,596 - 148,313,810 (-)Ensemblrn6Rnor6.0
Rnor_5.03154,662,586 - 154,716,802 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43143,129,087 - 143,180,199 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3140,002,906 - 140,053,959 (-)NCBICelera
RGSC_v3.13143,082,602 - 143,084,431 (-)NCBI
Cytogenetic Map3q41NCBI
BCL2L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382031,664,452 - 31,723,963 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2031,664,452 - 31,723,989 (-)Ensemblhg38GRCh38
GRCh372030,252,255 - 30,311,766 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362029,715,922 - 29,774,317 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342029,715,923 - 29,774,317NCBI
Celera2027,008,611 - 27,067,007 (-)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2027,040,965 - 27,099,720 (-)NCBIHuRef
CHM1_12030,156,171 - 30,214,537 (-)NCBICHM1_1
T2T-CHM13v2.02033,388,711 - 33,448,575 (-)NCBIT2T-CHM13v2.0
Bcl2l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,600,652 - 152,673,632 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2152,622,588 - 152,673,648 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382152,758,732 - 152,833,803 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,780,668 - 152,831,728 (-)Ensemblmm10GRCm38
MGSCv372152,606,404 - 152,657,418 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362152,472,109 - 152,523,123 (-)NCBIMGSCv36mm8
Celera2158,596,643 - 158,647,694 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.41NCBI
Bcl2l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542229,254,216 - 29,308,174 (+)Ensembl
ChiLan1.0NW_00495542229,254,440 - 29,307,104 (+)NCBIChiLan1.0ChiLan1.0
BCL2L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22137,358,784 - 37,419,063 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12037,351,882 - 37,412,161 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02027,955,688 - 28,015,950 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12029,088,055 - 29,147,066 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2029,088,055 - 29,146,585 (-)EnsemblpanPan2panpan1.1
BCL2L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12421,145,214 - 21,209,425 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2421,145,215 - 21,196,355 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2420,792,367 - 20,843,516 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02421,828,012 - 21,896,118 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2421,831,867 - 21,896,046 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12421,109,822 - 21,160,959 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02421,214,910 - 21,266,211 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02421,645,527 - 21,696,882 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bcl2l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640170,222,682 - 170,275,934 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648518,654,003 - 18,707,339 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648518,654,046 - 18,707,324 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCL2L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,366,143 - 35,414,694 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11735,366,139 - 35,415,798 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21740,303,991 - 40,304,598 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCL2L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1236,059,024 - 36,118,332 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl236,058,919 - 36,116,470 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605090,796,126 - 90,855,484 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcl2l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624741789,355 - 839,507 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624741788,445 - 838,513 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Bcl2l1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15132,108,601 - 132,158,316 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bcl2l1
317 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:464
Count of miRNA genes:238
Interacting mature miRNAs:299
Transcripts:ENSRNOT00000010762, ENSRNOT00000024954, ENSRNOT00000047416
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3160357340167835660Rat

Markers in Region
D3Got106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23141,282,112 - 141,282,245 (+)MAPPERmRatBN7.2
Rnor_6.03148,291,418 - 148,291,550NCBIRnor6.0
Rnor_5.03154,694,410 - 154,694,542UniSTSRnor5.0
RGSC_v3.43143,157,804 - 143,157,937RGDRGSC3.4
RGSC_v3.43143,157,805 - 143,157,937UniSTSRGSC3.4
Celera3140,031,529 - 140,031,661UniSTS
RGSC_v3.13143,063,427 - 143,063,559RGD
RH 3.4 Map31253.4UniSTS
RH 3.4 Map31253.4RGD
RH 2.0 Map3852.1RGD
Cytogenetic Map3q41.2UniSTS
BM383754  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23141,254,537 - 141,254,715 (+)MAPPERmRatBN7.2
mRatBN7.21157,043,338 - 157,043,516 (+)MAPPERmRatBN7.2
Rnor_6.01167,764,587 - 167,764,764NCBIRnor6.0
Rnor_6.03148,260,624 - 148,260,801NCBIRnor6.0
Rnor_5.03154,663,616 - 154,663,793UniSTSRnor5.0
Rnor_5.01173,950,019 - 173,950,196UniSTSRnor5.0
RGSC_v3.41160,253,614 - 160,253,791UniSTSRGSC3.4
RGSC_v3.43143,130,117 - 143,130,294UniSTSRGSC3.4
Celera3140,003,936 - 140,004,113UniSTS
Celera1155,108,435 - 155,108,612UniSTS
RH 3.4 Map11288.3UniSTS
Cytogenetic Map3q41.2UniSTS
Cytogenetic Map1q32UniSTS
PMC196230P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21157,043,771 - 157,044,307 (+)MAPPERmRatBN7.2
Rnor_6.01167,765,020 - 167,765,555NCBIRnor6.0
Rnor_5.01173,950,452 - 173,950,987UniSTSRnor5.0
RGSC_v3.41160,254,047 - 160,254,582UniSTSRGSC3.4
Celera1155,108,868 - 155,109,403UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map3q41.2UniSTS
PMC316415P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21157,043,795 - 157,044,019 (+)MAPPERmRatBN7.2
Rnor_6.01167,765,044 - 167,765,267NCBIRnor6.0
Rnor_5.01173,950,476 - 173,950,699UniSTSRnor5.0
RGSC_v3.41160,254,071 - 160,254,294UniSTSRGSC3.4
Celera1155,108,892 - 155,109,115UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map3q41.2UniSTS
PMC123054P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21157,043,981 - 157,044,400 (+)MAPPERmRatBN7.2
mRatBN7.23141,302,549 - 141,302,968 (+)MAPPERmRatBN7.2
Rnor_6.03148,311,851 - 148,312,269NCBIRnor6.0
Rnor_6.01167,765,230 - 167,765,648NCBIRnor6.0
Rnor_5.03154,714,843 - 154,715,261UniSTSRnor5.0
Rnor_5.01173,950,662 - 173,951,080UniSTSRnor5.0
RGSC_v3.41160,254,257 - 160,254,675UniSTSRGSC3.4
RGSC_v3.43143,178,240 - 143,178,658UniSTSRGSC3.4
Celera3140,052,000 - 140,052,418UniSTS
Celera1155,109,078 - 155,109,496UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map3q41.2UniSTS
PMC20354P5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23141,302,370 - 141,302,627 (+)MAPPERmRatBN7.2
Rnor_6.03148,311,672 - 148,311,928NCBIRnor6.0
Rnor_5.03154,714,664 - 154,714,920UniSTSRnor5.0
RGSC_v3.43143,178,061 - 143,178,317UniSTSRGSC3.4
Celera3140,051,821 - 140,052,077UniSTS
Cytogenetic Map3q41.2UniSTS
PMC262691P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23141,302,331 - 141,302,513 (+)MAPPERmRatBN7.2
Rnor_6.03148,311,633 - 148,311,814NCBIRnor6.0
Rnor_5.03154,714,625 - 154,714,806UniSTSRnor5.0
RGSC_v3.43143,178,022 - 143,178,203UniSTSRGSC3.4
Celera3140,051,782 - 140,051,963UniSTS
Cytogenetic Map3q41.2UniSTS
UniSTS:224427  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21157,043,475 - 157,043,629 (+)MAPPERmRatBN7.2
mRatBN7.23141,254,674 - 141,254,828 (+)MAPPERmRatBN7.2
Rnor_6.01167,764,724 - 167,764,877NCBIRnor6.0
Rnor_6.03148,260,761 - 148,260,914NCBIRnor6.0
Rnor_5.03154,663,753 - 154,663,906UniSTSRnor5.0
Rnor_5.01173,950,156 - 173,950,309UniSTSRnor5.0
RGSC_v3.41160,253,751 - 160,253,904UniSTSRGSC3.4
RGSC_v3.43143,130,254 - 143,130,407UniSTSRGSC3.4
Celera3140,004,073 - 140,004,226UniSTS
Celera1155,108,572 - 155,108,725UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map3q41.2UniSTS
Bcl2l  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21157,043,768 - 157,044,343 (+)MAPPERmRatBN7.2
Rnor_6.01167,765,017 - 167,765,591NCBIRnor6.0
Rnor_5.01173,950,449 - 173,951,023UniSTSRnor5.0
RGSC_v3.41160,254,044 - 160,254,618UniSTSRGSC3.4
Celera1155,108,865 - 155,109,439UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map3q41.2UniSTS
Bcl2l1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23141,302,496 - 141,302,847 (+)MAPPERmRatBN7.2
mRatBN7.21157,043,910 - 157,044,279 (+)MAPPERmRatBN7.2
Rnor_6.01167,765,159 - 167,765,527NCBIRnor6.0
Rnor_5.01173,950,591 - 173,950,959UniSTSRnor5.0
Celera1155,109,007 - 155,109,375UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map3q41.2UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001033670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001033671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001033672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010064563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF136230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF279286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ495801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY141038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC094213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S76513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S78284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U10579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U34963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U72349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U72350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X82537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000010762   ⟹   ENSRNOP00000010762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3141,253,523 - 141,303,465 (-)Ensembl
Rnor_6.0 Ensembl3148,259,596 - 148,313,810 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000024954   ⟹   ENSRNOP00000024954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1166,455,719 - 166,456,231 (-)Ensembl
mRatBN7.2 Ensembl1157,043,792 - 157,044,304 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000047416   ⟹   ENSRNOP00000043542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3161,761,099 - 161,763,385 (-)Ensembl
mRatBN7.2 Ensembl3141,300,833 - 141,303,119 (-)Ensembl
Rnor_6.0 Ensembl3148,310,134 - 148,312,420 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081272   ⟹   ENSRNOP00000071164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3148,310,592 - 148,312,420 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091419   ⟹   ENSRNOP00000069758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3141,298,581 - 141,303,479 (-)Ensembl
Rnor_6.0 Ensembl3148,310,134 - 148,312,791 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000129836   ⟹   ENSRNOP00000106948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3161,745,540 - 161,764,907 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000170561   ⟹   ENSRNOP00000105017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3161,761,099 - 161,763,756 (-)Ensembl
RefSeq Acc Id: NM_001033670   ⟹   NP_001028842
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,713,777 - 161,764,775 (-)NCBI
mRatBN7.23141,253,508 - 141,304,509 (-)NCBI
Rnor_6.03148,259,594 - 148,313,810 (-)NCBI
Rnor_5.03154,662,586 - 154,716,802 (-)NCBI
RGSC_v3.43143,129,087 - 143,180,199 (-)RGD
Celera3140,002,906 - 140,053,959 (-)RGD
Sequence:
RefSeq Acc Id: NM_001033671   ⟹   NP_001028843
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,713,777 - 161,763,250 (-)NCBI
mRatBN7.23141,253,508 - 141,302,984 (-)NCBI
Rnor_6.03148,259,594 - 148,312,285 (-)NCBI
Rnor_5.03154,662,586 - 154,716,802 (-)NCBI
RGSC_v3.43143,129,087 - 143,180,199 (-)RGD
Celera3140,002,906 - 140,052,434 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001033672   ⟹   NP_001028844
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,761,099 - 161,763,756 (-)NCBI
mRatBN7.23141,300,833 - 141,303,490 (-)NCBI
Rnor_6.03148,310,134 - 148,312,791 (-)NCBI
Rnor_5.03154,662,586 - 154,716,802 (-)NCBI
RGSC_v3.43143,129,087 - 143,180,199 (-)RGD
Celera3140,050,283 - 140,052,940 (-)NCBI
Sequence:
RefSeq Acc Id: NM_031535   ⟹   NP_113723
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,761,099 - 161,763,385 (-)NCBI
mRatBN7.23141,300,833 - 141,303,119 (-)NCBI
Rnor_6.03148,310,134 - 148,312,420 (-)NCBI
Rnor_5.03154,662,586 - 154,716,802 (-)NCBI
RGSC_v3.43143,129,087 - 143,180,199 (-)RGD
Celera3140,050,283 - 140,052,569 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006235264   ⟹   XP_006235326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,738,388 - 161,764,844 (-)NCBI
mRatBN7.23141,291,473 - 141,304,582 (-)NCBI
Rnor_6.03148,298,309 - 148,314,191 (-)NCBI
Rnor_5.03154,662,586 - 154,716,802 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006235265   ⟹   XP_006235327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,713,777 - 161,764,808 (-)NCBI
mRatBN7.23141,253,508 - 141,304,131 (-)NCBI
Rnor_6.03148,259,594 - 148,313,460 (-)NCBI
Rnor_5.03154,662,586 - 154,716,802 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591478   ⟹   XP_017446967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,738,388 - 161,764,808 (-)NCBI
mRatBN7.23141,291,473 - 141,304,131 (-)NCBI
Rnor_6.03148,298,309 - 148,313,488 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591479   ⟹   XP_017446968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,738,388 - 161,764,804 (-)NCBI
mRatBN7.23141,291,473 - 141,304,572 (-)NCBI
Rnor_6.03148,298,309 - 148,314,191 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591480   ⟹   XP_017446969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,738,388 - 161,763,514 (-)NCBI
mRatBN7.23141,291,473 - 141,303,196 (-)NCBI
Rnor_6.03148,298,309 - 148,312,537 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104290   ⟹   XP_038960218
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,713,777 - 161,764,808 (-)NCBI
mRatBN7.23141,253,508 - 141,304,131 (-)NCBI
RefSeq Acc Id: XM_039104291   ⟹   XP_038960219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,713,777 - 161,763,535 (-)NCBI
mRatBN7.23141,253,508 - 141,303,197 (-)NCBI
RefSeq Acc Id: XM_039104292   ⟹   XP_038960220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,713,777 - 161,764,808 (-)NCBI
mRatBN7.23141,253,508 - 141,304,131 (-)NCBI
RefSeq Acc Id: XM_063283115   ⟹   XP_063139185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,713,777 - 161,764,820 (-)NCBI
RefSeq Acc Id: XM_063283116   ⟹   XP_063139186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,713,777 - 161,763,445 (-)NCBI
RefSeq Acc Id: XM_063283117   ⟹   XP_063139187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,713,777 - 161,764,808 (-)NCBI
RefSeq Acc Id: XM_063283118   ⟹   XP_063139188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,713,777 - 161,764,844 (-)NCBI
RefSeq Acc Id: XM_063283119   ⟹   XP_063139189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,713,777 - 161,763,471 (-)NCBI
RefSeq Acc Id: XM_063283120   ⟹   XP_063139190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,713,777 - 161,764,805 (-)NCBI
RefSeq Acc Id: XR_010064563
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,717,415 - 161,764,808 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001028842 (Get FASTA)   NCBI Sequence Viewer  
  NP_001028843 (Get FASTA)   NCBI Sequence Viewer  
  NP_001028844 (Get FASTA)   NCBI Sequence Viewer  
  NP_113723 (Get FASTA)   NCBI Sequence Viewer  
  XP_006235326 (Get FASTA)   NCBI Sequence Viewer  
  XP_006235327 (Get FASTA)   NCBI Sequence Viewer  
  XP_017446967 (Get FASTA)   NCBI Sequence Viewer  
  XP_017446968 (Get FASTA)   NCBI Sequence Viewer  
  XP_017446969 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960218 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960219 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960220 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139185 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139186 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139187 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139188 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139189 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139190 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA19257 (Get FASTA)   NCBI Sequence Viewer  
  AAA77686 (Get FASTA)   NCBI Sequence Viewer  
  AAB17352 (Get FASTA)   NCBI Sequence Viewer  
  AAB17353 (Get FASTA)   NCBI Sequence Viewer  
  AAC60701 (Get FASTA)   NCBI Sequence Viewer  
  AAC60702 (Get FASTA)   NCBI Sequence Viewer  
  AAD33683 (Get FASTA)   NCBI Sequence Viewer  
  AAF81262 (Get FASTA)   NCBI Sequence Viewer  
  AAH94213 (Get FASTA)   NCBI Sequence Viewer  
  AAN17784 (Get FASTA)   NCBI Sequence Viewer  
  CAA57886 (Get FASTA)   NCBI Sequence Viewer  
  CAA57887 (Get FASTA)   NCBI Sequence Viewer  
  CAD42238 (Get FASTA)   NCBI Sequence Viewer  
  EDL86039 (Get FASTA)   NCBI Sequence Viewer  
  EDL86042 (Get FASTA)   NCBI Sequence Viewer  
  EDL86043 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010762.4
  ENSRNOP00000043542
  ENSRNOP00000105017
  ENSRNOP00000106948
GenBank Protein P53563 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001028842   ⟸   NM_001033670
- Peptide Label: isoform 2
- UniProtKB: Q64087 (UniProtKB/Swiss-Prot),   Q62836 (UniProtKB/Swiss-Prot),   Q62678 (UniProtKB/Swiss-Prot),   Q52KS0 (UniProtKB/Swiss-Prot),   P70614 (UniProtKB/Swiss-Prot),   P70613 (UniProtKB/Swiss-Prot),   Q64128 (UniProtKB/Swiss-Prot),   P53563 (UniProtKB/Swiss-Prot),   A6KHR4 (UniProtKB/TrEMBL),   A6KHR2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001028843   ⟸   NM_001033671
- Peptide Label: isoform 3
- UniProtKB: Q548R7 (UniProtKB/TrEMBL),   E9PU78 (UniProtKB/TrEMBL),   Q9WUI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001028844   ⟸   NM_001033672
- Peptide Label: isoform 1
- UniProtKB: Q7TS62 (UniProtKB/TrEMBL),   A6KHR6 (UniProtKB/TrEMBL),   A0A0G2JW63 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_113723   ⟸   NM_031535
- Peptide Label: isoform 1
- UniProtKB: Q7TS62 (UniProtKB/TrEMBL),   A6KHR6 (UniProtKB/TrEMBL),   A0A0G2JW63 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235327   ⟸   XM_006235265
- Peptide Label: isoform X2
- UniProtKB: Q64087 (UniProtKB/Swiss-Prot),   Q62836 (UniProtKB/Swiss-Prot),   Q62678 (UniProtKB/Swiss-Prot),   Q52KS0 (UniProtKB/Swiss-Prot),   P70614 (UniProtKB/Swiss-Prot),   P70613 (UniProtKB/Swiss-Prot),   Q64128 (UniProtKB/Swiss-Prot),   P53563 (UniProtKB/Swiss-Prot),   A6KHR4 (UniProtKB/TrEMBL),   A6KHR2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235326   ⟸   XM_006235264
- Peptide Label: isoform X1
- UniProtKB: Q7TS62 (UniProtKB/TrEMBL),   A6KHR6 (UniProtKB/TrEMBL),   A0A0G2JW63 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446968   ⟸   XM_017591479
- Peptide Label: isoform X1
- UniProtKB: Q7TS62 (UniProtKB/TrEMBL),   A6KHR6 (UniProtKB/TrEMBL),   A0A0G2JW63 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446967   ⟸   XM_017591478
- Peptide Label: isoform X1
- UniProtKB: Q7TS62 (UniProtKB/TrEMBL),   A6KHR6 (UniProtKB/TrEMBL),   A0A0G2JW63 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446969   ⟸   XM_017591480
- Peptide Label: isoform X1
- UniProtKB: Q7TS62 (UniProtKB/TrEMBL),   A6KHR6 (UniProtKB/TrEMBL),   A0A0G2JW63 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043542   ⟸   ENSRNOT00000047416
Ensembl Acc Id: ENSRNOP00000069758   ⟸   ENSRNOT00000091419
Ensembl Acc Id: ENSRNOP00000071164   ⟸   ENSRNOT00000081272
Ensembl Acc Id: ENSRNOP00000010762   ⟸   ENSRNOT00000010762
RefSeq Acc Id: XP_038960220   ⟸   XM_039104292
- Peptide Label: isoform X3
- UniProtKB: Q548R7 (UniProtKB/TrEMBL),   E9PU78 (UniProtKB/TrEMBL),   Q9WUI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960218   ⟸   XM_039104290
- Peptide Label: isoform X2
- UniProtKB: Q64087 (UniProtKB/Swiss-Prot),   Q62836 (UniProtKB/Swiss-Prot),   Q62678 (UniProtKB/Swiss-Prot),   Q52KS0 (UniProtKB/Swiss-Prot),   P70614 (UniProtKB/Swiss-Prot),   P70613 (UniProtKB/Swiss-Prot),   P53563 (UniProtKB/Swiss-Prot),   Q64128 (UniProtKB/Swiss-Prot),   A6KHR4 (UniProtKB/TrEMBL),   A6KHR2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960219   ⟸   XM_039104291
- Peptide Label: isoform X2
- UniProtKB: Q64087 (UniProtKB/Swiss-Prot),   Q62836 (UniProtKB/Swiss-Prot),   Q62678 (UniProtKB/Swiss-Prot),   Q52KS0 (UniProtKB/Swiss-Prot),   P70614 (UniProtKB/Swiss-Prot),   P70613 (UniProtKB/Swiss-Prot),   P53563 (UniProtKB/Swiss-Prot),   Q64128 (UniProtKB/Swiss-Prot),   A6KHR4 (UniProtKB/TrEMBL),   A6KHR2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139188   ⟸   XM_063283118
- Peptide Label: isoform X3
- UniProtKB: Q548R7 (UniProtKB/TrEMBL),   E9PU78 (UniProtKB/TrEMBL),   Q9WUI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139185   ⟸   XM_063283115
- Peptide Label: isoform X2
- UniProtKB: Q64128 (UniProtKB/Swiss-Prot),   Q64087 (UniProtKB/Swiss-Prot),   Q62836 (UniProtKB/Swiss-Prot),   Q62678 (UniProtKB/Swiss-Prot),   Q52KS0 (UniProtKB/Swiss-Prot),   P70614 (UniProtKB/Swiss-Prot),   P70613 (UniProtKB/Swiss-Prot),   P53563 (UniProtKB/Swiss-Prot),   A6KHR4 (UniProtKB/TrEMBL),   A6KHR2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139187   ⟸   XM_063283117
- Peptide Label: isoform X3
- UniProtKB: Q548R7 (UniProtKB/TrEMBL),   E9PU78 (UniProtKB/TrEMBL),   Q9WUI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139190   ⟸   XM_063283120
- Peptide Label: isoform X3
- UniProtKB: Q548R7 (UniProtKB/TrEMBL),   E9PU78 (UniProtKB/TrEMBL),   Q9WUI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139189   ⟸   XM_063283119
- Peptide Label: isoform X3
- UniProtKB: Q548R7 (UniProtKB/TrEMBL),   E9PU78 (UniProtKB/TrEMBL),   Q9WUI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139186   ⟸   XM_063283116
- Peptide Label: isoform X2
- UniProtKB: Q64128 (UniProtKB/Swiss-Prot),   Q64087 (UniProtKB/Swiss-Prot),   Q62836 (UniProtKB/Swiss-Prot),   Q62678 (UniProtKB/Swiss-Prot),   Q52KS0 (UniProtKB/Swiss-Prot),   P70614 (UniProtKB/Swiss-Prot),   P70613 (UniProtKB/Swiss-Prot),   P53563 (UniProtKB/Swiss-Prot),   A6KHR4 (UniProtKB/TrEMBL),   A6KHR2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000024954   ⟸   ENSRNOT00000024954
Ensembl Acc Id: ENSRNOP00000105017   ⟸   ENSRNOT00000170561
Ensembl Acc Id: ENSRNOP00000106948   ⟸   ENSRNOT00000129836
Protein Domains
Apoptosis regulator Bcl-2 family BH4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P53563-F1-model_v2 AlphaFold P53563 1-233 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692551
Promoter ID:EPDNEW_R3075
Type:initiation region
Name:Bcl2l1_1
Description:Bcl2-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R3076  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03148,312,776 - 148,312,836EPDNEW
RGD ID:13692552
Promoter ID:EPDNEW_R3076
Type:initiation region
Name:Bcl2l1_2
Description:Bcl2-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R3075  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03148,313,845 - 148,313,905EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2200 AgrOrtholog
BioCyc Gene G2FUF-47248 BioCyc
Ensembl Genes ENSRNOG00000007946 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000018503 Ensembl
Ensembl Transcript ENSRNOT00000010762.8 UniProtKB/Swiss-Prot
  ENSRNOT00000047416 ENTREZGENE
  ENSRNOT00000129836 ENTREZGENE
  ENSRNOT00000170561 ENTREZGENE
Gene3D-CATH 1.10.437.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7314572 IMAGE-MGC_LOAD
InterPro Apop_reg_BclX UniProtKB/Swiss-Prot
  Bcl-2_BH1-3 UniProtKB/Swiss-Prot
  Bcl2-like UniProtKB/Swiss-Prot
  Bcl2/BclX UniProtKB/Swiss-Prot
  Bcl2_BH1_motif_CS UniProtKB/Swiss-Prot
  Bcl2_BH2_motif_CS UniProtKB/Swiss-Prot
  Bcl2_BH3_motif_CS UniProtKB/Swiss-Prot
  Bcl2_BH4 UniProtKB/Swiss-Prot
  Bcl2_BH4_motif_CS UniProtKB/Swiss-Prot
  Blc2-like_sf UniProtKB/Swiss-Prot
  Blc2_fam UniProtKB/Swiss-Prot
KEGG Report rno:24888 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105402 IMAGE-MGC_LOAD
NCBI Gene 24888 ENTREZGENE
PANTHER PTHR11256 UniProtKB/Swiss-Prot
  PTHR11256:SF12 UniProtKB/Swiss-Prot
Pfam Bcl-2 UniProtKB/Swiss-Prot
  BH4 UniProtKB/Swiss-Prot
PhenoGen Bcl2l1 PhenoGen
PRINTS APOPREGBCLX UniProtKB/Swiss-Prot
  BCL2FAMILY UniProtKB/Swiss-Prot
PROSITE BCL2_FAMILY UniProtKB/Swiss-Prot
  BH1 UniProtKB/Swiss-Prot
  BH2 UniProtKB/Swiss-Prot
  BH3 UniProtKB/Swiss-Prot
  BH4_1 UniProtKB/Swiss-Prot
  BH4_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007946 RatGTEx
  ENSRNOG00000018503 RatGTEx
SMART BCL UniProtKB/Swiss-Prot
  BH4 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56854 UniProtKB/Swiss-Prot
UniProt A0A0G2JW63 ENTREZGENE, UniProtKB/TrEMBL
  A6KHR2 ENTREZGENE, UniProtKB/TrEMBL
  A6KHR4 ENTREZGENE, UniProtKB/TrEMBL
  A6KHR6 ENTREZGENE
  B2CL1_RAT UniProtKB/Swiss-Prot
  E9PU78 ENTREZGENE, UniProtKB/TrEMBL
  P53563 ENTREZGENE
  P70613 ENTREZGENE
  P70614 ENTREZGENE
  Q52KS0 ENTREZGENE
  Q548R7 ENTREZGENE, UniProtKB/TrEMBL
  Q62678 ENTREZGENE
  Q62836 ENTREZGENE
  Q64087 ENTREZGENE
  Q64128 ENTREZGENE
  Q7TS62 ENTREZGENE, UniProtKB/TrEMBL
  Q9WUI5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P70613 UniProtKB/Swiss-Prot
  P70614 UniProtKB/Swiss-Prot
  Q52KS0 UniProtKB/Swiss-Prot
  Q62678 UniProtKB/Swiss-Prot
  Q62836 UniProtKB/Swiss-Prot
  Q64087 UniProtKB/Swiss-Prot
  Q64128 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Bcl2l1  Bcl2-like 1  Bcl2l  B cell lymphoma 2 like  Symbol and Name updated 629477 APPROVED
2002-06-10 Bcl2l  B cell lymphoma 2 like      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the mitochondrial outer membrane 631757
gene_cellular_localization integral membrane protein localized to the mitochondrial membrane and nuclear envelope 628531
gene_expression expressed in the embryonic and adult neurons of the CNS 628531
gene_function anti-apoptotic factor 631757
gene_process involved in protecting cells from apoptosis and in controlling mitochondrial membrane permeability 631757
gene_process prevents neuronal apoptosis by blocking cytochrome c release 628531
gene_process may inhibit staurosporin induced neuronal apoptosis 628531
gene_product member of the anti-apoptotic Bcl-2 family 628531