Mir133a-1 (microRNA 133a-1) - Rat Genome Database

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Gene: Mir133a-1 (microRNA 133a-1) Mus musculus
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Symbol: Mir133a-1
Name: microRNA 133a-1
RGD ID: 1615488
MGI Page MGI
Description: Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; negative regulation of osteoblast differentiation; and regulation of gene expression. Predicted to be part of RISC complex. Is expressed in heart; lung; tongue muscle; and vertebral axis musculature. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MIR133A1 (microRNA 133a-1).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-133; mir-133a-1; Mirn; Mirn13; Mirn133; Mirn133a-1
RGD Orthologs
Human
Rat
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391810,782,909 - 10,782,976 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1810,782,909 - 10,782,976 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381810,782,909 - 10,782,976 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1810,782,909 - 10,782,976 (-)Ensemblmm10GRCm38
MGSCv371810,782,907 - 10,782,974 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera1810,812,893 - 10,812,960 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map185.4NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MiR-320a contributes to atherogenesis by augmenting multiple risk factors and down-regulating SRF. Chen C, etal., J Cell Mol Med. 2015 May;19(5):970-85. doi: 10.1111/jcmm.12483. Epub 2015 Feb 27.
2. A conserved MADS-box phosphorylation motif regulates differentiation and mitochondrial function in skeletal, cardiac, and smooth muscle cells. Mughal W, etal., Cell Death Dis. 2015 Oct 29;6:e1944. doi: 10.1038/cddis.2015.306.
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. MiR-133a acts as an anti-oncogene in Hepatocellular carcinoma by inhibiting FOSL2 through TGF-β/Smad3 signaling pathway. Sun L, etal., Biomed Pharmacother. 2018 Nov;107:168-176. doi: 10.1016/j.biopha.2018.07.151. Epub 2018 Aug 6.
Additional References at PubMed
PMID:12007417   PMID:16381832   PMID:16582102   PMID:17008435   PMID:17210790   PMID:17369397   PMID:17397913   PMID:17604727   PMID:18256189   PMID:18282110   PMID:18452032   PMID:19015276  
PMID:19188439   PMID:19398036   PMID:19521018   PMID:19559694   PMID:19726871   PMID:20173049   PMID:20215419   PMID:20378849   PMID:20413612   PMID:20439489   PMID:20947829   PMID:20974915  
PMID:21030712   PMID:21037258   PMID:21256124   PMID:21267068   PMID:21379568   PMID:21418519   PMID:21615921   PMID:21628588   PMID:21737882   PMID:21768366   PMID:21822254   PMID:22000014  
PMID:22195016   PMID:22367207   PMID:22614019   PMID:22842467   PMID:22875923   PMID:22911796   PMID:22996663   PMID:23071657   PMID:23166348   PMID:23183523   PMID:23395168   PMID:23410519  
PMID:23798596   PMID:23874225   PMID:24058688   PMID:24068960   PMID:24205035   PMID:24371146   PMID:24401233   PMID:24428157   PMID:24513286   PMID:24920580   PMID:25112884   PMID:25317675  
PMID:25415383   PMID:25492026   PMID:25512392   PMID:25534971   PMID:25826570   PMID:25868726   PMID:25918244   PMID:26013661   PMID:26440278   PMID:26681446   PMID:27109382   PMID:27458245  
PMID:27458709   PMID:27794430   PMID:28104982   PMID:28117277   PMID:28941704   PMID:29359964   PMID:29511336   PMID:29789398   PMID:30146725   PMID:30185650   PMID:30572760   PMID:30613267  
PMID:30936836   PMID:31152485   PMID:31207343   PMID:31298344   PMID:32196613   PMID:32387677   PMID:33131307   PMID:33606210   PMID:33962226   PMID:34350837   PMID:34498707   PMID:35595956  
PMID:35886863   PMID:38659015   PMID:38670210   PMID:38982418   PMID:39258536  


Genomics

Comparative Map Data
Mir133a-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391810,782,909 - 10,782,976 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1810,782,909 - 10,782,976 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381810,782,909 - 10,782,976 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1810,782,909 - 10,782,976 (-)Ensemblmm10GRCm38
MGSCv371810,782,907 - 10,782,974 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera1810,812,893 - 10,812,960 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map185.4NCBI
MIR133A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381821,825,698 - 21,825,785 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1821,825,698 - 21,825,785 (-)Ensemblhg38GRCh38
GRCh371819,405,659 - 19,405,746 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361817,659,656 - 17,659,743 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1816,211,722 - 16,211,809 (-)NCBICelera
Cytogenetic Map18q11.2NCBI
HuRef1816,253,046 - 16,253,133 (-)NCBIHuRef
CHM1_11819,332,764 - 19,332,851 (-)NCBICHM1_1
T2T-CHM13v2.01822,010,746 - 22,010,833 (-)NCBIT2T-CHM13v2.0
Mir133a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8182,157,872 - 2,157,958 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.2181,885,082 - 1,885,168 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx182,114,722 - 2,114,808 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0182,902,423 - 2,902,509 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0182,116,604 - 2,116,690 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,052,478 - 2,052,564 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0182,085,457 - 2,085,543 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera181,764,873 - 1,764,959 (-)NCBICelera
Cytogenetic Map18p13NCBI
MIR133A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1766,217,486 - 66,217,572 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl766,217,486 - 66,217,572 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha765,672,066 - 65,672,152 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0766,282,216 - 66,282,302 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl766,282,216 - 66,282,302 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1765,948,146 - 65,948,232 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0765,971,074 - 65,971,160 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0766,271,441 - 66,271,527 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
MIR133A-2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6106,998,896 - 106,998,982 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16106,998,899 - 106,998,971 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2699,485,213 - 99,485,285 (+)NCBISscrofa10.2Sscrofa10.2susScr3


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142127Rafaril_mRafar interacting locus (mouse)Not determined18123108555Mouse
14928307Manh83_mmandible shape 83 (mouse)18126902168Mouse
12801458Intmrm3_mintima/media ratio modifier 3 (mouse)18131720756Mouse
11354953Mom21_mmodifier of Min 21 (mouse)18128893823Mouse
12801462Intim3_mintima modifier 3 (mouse)18131720756Mouse
4142250Idd21.3_minsulin dependent diabetes susceptibility 21.3 (mouse)Not determined18610840421646477Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
13207585Mwmlpt3_mMorris water maze latency to platform, training, 3 (mouse)18133547739Mouse
13207589Mwmlpa3_mMorris water maze latency to platform, all, 3 (mouse)18133547739Mouse
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse
1558873Hrtfm7_mheart failure modifier 7 (mouse)Not determined18808696442087106Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000083465
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1810,782,909 - 10,782,976 (-)Ensembl
GRCm38.p6 Ensembl1810,782,909 - 10,782,976 (-)Ensembl
RefSeq Acc Id: NR_029547
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391810,782,909 - 10,782,976 (-)NCBI
GRCm381810,782,909 - 10,782,976 (-)ENTREZGENE
MGSCv371810,782,907 - 10,782,974 (-)RGD
Celera1810,812,893 - 10,812,960 (-)RGD
cM Map18 ENTREZGENE
Sequence:
Promoters
RGD ID:13677100
Promoter ID:EPDNEW_M22699
Type:single initiation site
Name:Mir133a-1_1
Description:Mus musculus microRNA 133a-1 (Mir133a-1), microRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381810,782,910 - 10,782,970EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2676818 AgrOrtholog
Ensembl Genes ENSMUSG00000065399 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000083465 ENTREZGENE
MGD MGI:2676818 ENTREZGENE
miRBase MI0000159 ENTREZGENE
NCBI Gene 387151 ENTREZGENE
PhenoGen Mir133a-1 PhenoGen
RNAcentral URS000030913C RNACentral
  URS00004C9052 RNACentral
  URS000075EEA8 RNACentral