Tgap1 (GTPase activating protein testicular GAP1) - Rat Genome Database

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Pathways
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Gene: Tgap1 (GTPase activating protein testicular GAP1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Tgap1
Name: GTPase activating protein testicular GAP1
RGD ID: 1359558
Description: Predicted to enable GTPase activator activity. Predicted to be involved in regulation of Rho protein signal transduction and signal transduction; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Alliance Genes
More Info homologs ...
Related Pseudogenes: Tgap1-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8292,270,181 - 92,343,792 (+)NCBIGRCr8
mRatBN7.2290,362,772 - 90,436,415 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl290,372,611 - 90,436,378 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx296,879,664 - 96,936,169 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0295,000,685 - 95,057,193 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0290,057,533 - 90,114,039 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0292,549,413 - 92,625,942 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl292,549,479 - 92,625,948 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02112,310,439 - 112,387,931 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4292,167,010 - 92,225,043 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1292,125,043 - 92,170,002 (+)NCBI
Celera286,009,234 - 86,065,696 (+)NCBICelera
Cytogenetic Map2q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A novel testicular RhoGAP-domain protein induces apoptosis. Modarressi MH, etal., Biol Reprod 2004 Dec;71(6):1980-90. Epub 2004 Aug 11.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Tgap1
837 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:39
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000033404, ENSRNOT00000065774
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)259324377103795077Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)259324377103795077Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)259324719102755241Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)27478666494359546Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)27478666494359546Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)259846005104846005Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)264366971109366971Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)276539322102785628Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)276539322102785628Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat

Markers in Region
AU048045  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2290,422,441 - 90,422,672 (+)MAPPERmRatBN7.2
mRatBN7.2290,422,441 - 90,422,692 (+)MAPPERmRatBN7.2
Rnor_6.0292,603,052 - 92,603,411NCBIRnor6.0
Rnor_6.0292,603,052 - 92,603,280NCBIRnor6.0
Rnor_5.02112,363,974 - 112,364,202UniSTSRnor5.0
Rnor_5.02112,363,974 - 112,364,333UniSTSRnor5.0
RGSC_v3.4292,209,645 - 92,209,873UniSTSRGSC3.4
RGSC_v3.4133,192,664 - 33,192,874UniSTSRGSC3.4
Celera286,051,843 - 86,052,071UniSTS
Cytogenetic Map2q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 1 3 2 2 3 10 7 2
Below cutoff 2 6 26 11 13 11 5 6 12 11 16 3 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000033404   ⟹   ENSRNOP00000032200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl290,379,809 - 90,436,378 (+)Ensembl
Rnor_6.0 Ensembl292,559,929 - 92,625,928 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000065774   ⟹   ENSRNOP00000063864
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl292,573,004 - 92,625,928 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082912   ⟹   ENSRNOP00000073694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl290,372,611 - 90,436,378 (+)Ensembl
Rnor_6.0 Ensembl292,549,479 - 92,625,948 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089422   ⟹   ENSRNOP00000069229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl292,574,038 - 92,608,805 (+)Ensembl
RefSeq Acc Id: NM_001007635   ⟹   NP_001007636
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8292,287,219 - 92,343,787 (+)NCBI
mRatBN7.2290,379,812 - 90,436,386 (+)NCBI
Rnor_6.0292,559,932 - 92,625,921 (+)NCBI
Rnor_5.02112,310,439 - 112,387,931 (+)NCBI
RGSC_v3.4292,167,010 - 92,225,043 (+)RGD
Celera286,009,234 - 86,065,696 (+)RGD
Sequence:
RefSeq Acc Id: XM_039101957   ⟹   XP_038957885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8292,270,181 - 92,343,792 (+)NCBI
mRatBN7.2290,362,772 - 90,436,415 (+)NCBI
RefSeq Acc Id: XM_039101958   ⟹   XP_038957886
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8292,280,067 - 92,343,792 (+)NCBI
mRatBN7.2290,372,659 - 90,436,415 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001007636   ⟸   NM_001007635
- UniProtKB: G3V905 (UniProtKB/TrEMBL),   A6IH33 (UniProtKB/TrEMBL),   Q5Y9B8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073694   ⟸   ENSRNOT00000082912
RefSeq Acc Id: ENSRNOP00000032200   ⟸   ENSRNOT00000033404
RefSeq Acc Id: ENSRNOP00000069229   ⟸   ENSRNOT00000089422
RefSeq Acc Id: ENSRNOP00000063864   ⟸   ENSRNOT00000065774
RefSeq Acc Id: XP_038957885   ⟸   XM_039101957
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K665 (UniProtKB/TrEMBL),   Q5Y9B8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957886   ⟸   XM_039101958
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K665 (UniProtKB/TrEMBL),   Q5Y9B8 (UniProtKB/TrEMBL)
Protein Domains
Rho-GAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K665-F1-model_v2 AlphaFold A0A0G2K665 1-1387 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691230
Promoter ID:EPDNEW_R1753
Type:initiation region
Name:tGap1_1
Description:GTPase activating protein testicular GAP1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0292,559,914 - 92,559,974EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359558 AgrOrtholog
BioCyc Gene G2FUF-53781 BioCyc
Ensembl Genes ENSRNOG00000022511 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033404 ENTREZGENE
  ENSRNOT00000033404.8 UniProtKB/TrEMBL
  ENSRNOT00000082912.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro ARHGAP20-like_RhoGAP UniProtKB/TrEMBL
  PH/PTB_dom UniProtKB/TrEMBL
  RA_dom UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
KEGG Report rno:294892 UniProtKB/TrEMBL
NCBI Gene 294892 ENTREZGENE
PANTHER GENE 1527-RELATED UniProtKB/TrEMBL
  T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED UniProtKB/TrEMBL
Pfam PF00788 UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
PhenoGen Tgap1 PhenoGen
PROSITE RHOGAP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022511 RatGTEx
SMART RhoGAP UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  Rho_GAP UniProtKB/TrEMBL
UniProt A0A0G2K665 ENTREZGENE, UniProtKB/TrEMBL
  A6IH33 ENTREZGENE, UniProtKB/TrEMBL
  G3V905 ENTREZGENE, UniProtKB/TrEMBL
  Q5Y9B8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-03-14 Tgap1  GTPase activating protein testicular GAP1  tGap1  GTPase activating protein testicular GAP1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 tGap1  GTPase activating protein testicular GAP1      Symbol and Name status set to provisional 70820 PROVISIONAL