MIR133B (microRNA 133b) - Rat Genome Database

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Gene: MIR133B (microRNA 133b) Homo sapiens
Analyze
Symbol: MIR133B
Name: microRNA 133b
RGD ID: 1352188
HGNC Page HGNC:31759
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing post-transcriptional repressor activity. Involved in several processes, including miRNA-mediated gene silencing by inhibition of translation; negative regulation of blood vessel endothelial cell migration; and negative regulation of vascular endothelial cell proliferation. Predicted to be located in axon. Predicted to be part of RISC complex. Biomarker of hepatocellular carcinoma.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-133b; MIRN133B; miRNA133B
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,148,923 - 52,149,041 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl652,148,923 - 52,149,041 (+)Ensemblhg38GRCh38
GRCh37652,013,721 - 52,013,839 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,121,679 - 52,121,797 (+)NCBIBuild 36Build 36hg18NCBI36
Celera653,674,858 - 53,674,976 (+)NCBICelera
Cytogenetic Map6p12.2NCBI
HuRef651,844,715 - 51,844,833 (+)NCBIHuRef
CHM1_1652,015,930 - 52,016,048 (+)NCBICHM1_1
T2T-CHM13v2.0651,987,631 - 51,987,749 (+)NCBIT2T-CHM13v2.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (ISO)
RISC complex  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. SF3B4 is regulated by microRNA-133b and promotes cell proliferation and metastasis in hepatocellular carcinoma. Liu Z, etal., EBioMedicine. 2018 Dec;38:57-68. doi: 10.1016/j.ebiom.2018.10.067. Epub 2018 Nov 1.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Label-free quantitative proteomics identifies Smarca4 is involved in vascular calcification. Wang C, etal., Ren Fail. 2019 Nov;41(1):220-228. doi: 10.1080/0886022X.2019.1591997.
Additional References at PubMed
PMID:12624257   PMID:16381832   PMID:17604727   PMID:17761882   PMID:19654003   PMID:20029200   PMID:20075508   PMID:20468068   PMID:20505319   PMID:21037258   PMID:21351259   PMID:21573504  
PMID:21637854   PMID:21645416   PMID:22179829   PMID:22308266   PMID:22407299   PMID:22532850   PMID:22713968   PMID:22883469   PMID:23196799   PMID:23206218   PMID:23229283   PMID:23296701  
PMID:23936094   PMID:24330809   PMID:24391788   PMID:24443799   PMID:24594999   PMID:24610824   PMID:24613927   PMID:24714873   PMID:24742361   PMID:24870791   PMID:24885383   PMID:24935473  
PMID:24967583   PMID:24975488   PMID:25120799   PMID:25125495   PMID:25280517   PMID:25355491   PMID:25433493   PMID:25501363   PMID:25743594   PMID:26005035   PMID:26113018   PMID:26198874  
PMID:26276722   PMID:26322174   PMID:26365938   PMID:26375444   PMID:26396496   PMID:26617770   PMID:26755652   PMID:26790441   PMID:26823832   PMID:26840046   PMID:26945106   PMID:26980745  
PMID:27090017   PMID:27166997   PMID:27412702   PMID:27470555   PMID:27593229   PMID:27696637   PMID:27710896   PMID:27894087   PMID:27938481   PMID:28069586   PMID:28098895   PMID:28117027  
PMID:28376685   PMID:28377929   PMID:28454695   PMID:28503944   PMID:28582847   PMID:28586051   PMID:28641694   PMID:28675056   PMID:28748780   PMID:28869447   PMID:28881788   PMID:28901466  
PMID:29096746   PMID:29130660   PMID:29271992   PMID:29324314   PMID:29327946   PMID:29328427   PMID:29344640   PMID:29494956   PMID:29689091   PMID:29786744   PMID:29940748   PMID:30006541  
PMID:30125566   PMID:30317571   PMID:30581003   PMID:30591241   PMID:30594787   PMID:30861177   PMID:30862136   PMID:31333145   PMID:31344855   PMID:31525340   PMID:31545240   PMID:31545407  
PMID:31675755   PMID:31699187   PMID:31842978   PMID:31858564   PMID:32033332   PMID:32052927   PMID:32377748   PMID:32627968   PMID:32661199   PMID:33267766   PMID:33290799   PMID:33378019  
PMID:33541136   PMID:33687637   PMID:33854048   PMID:33971546   PMID:34034626   PMID:34115259   PMID:34230450   PMID:34355586   PMID:34623553   PMID:34711122   PMID:34821090   PMID:34918563  
PMID:35015112   PMID:35048795   PMID:35545336   PMID:35638462   PMID:35861544   PMID:36181243   PMID:36198257   PMID:36717039   PMID:37522976   PMID:38069061  


Genomics

Comparative Map Data
MIR133B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,148,923 - 52,149,041 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl652,148,923 - 52,149,041 (+)Ensemblhg38GRCh38
GRCh37652,013,721 - 52,013,839 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,121,679 - 52,121,797 (+)NCBIBuild 36Build 36hg18NCBI36
Celera653,674,858 - 53,674,976 (+)NCBICelera
Cytogenetic Map6p12.2NCBI
HuRef651,844,715 - 51,844,833 (+)NCBIHuRef
CHM1_1652,015,930 - 52,016,048 (+)NCBICHM1_1
T2T-CHM13v2.0651,987,631 - 51,987,749 (+)NCBIT2T-CHM13v2.0
Mir133b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39120,752,993 - 20,753,111 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl120,752,993 - 20,753,111 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38120,682,769 - 20,682,887 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl120,682,769 - 20,682,887 (+)Ensemblmm10GRCm38
MGSCv37120,672,850 - 20,672,968 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera120,557,615 - 20,557,733 (+)NCBICelera
Cytogenetic Map1A4NCBI
cM Map16.41NCBI
Mir133b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8930,594,582 - 30,594,665 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl930,594,582 - 30,594,665 (+)EnsemblGRCr8
mRatBN7.2923,098,134 - 23,098,217 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl923,098,134 - 23,098,217 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx931,595,664 - 31,595,747 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0936,716,388 - 36,716,471 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0935,031,659 - 35,031,742 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0926,795,649 - 26,795,732 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl926,795,649 - 26,795,732 (+)Ensemblrn6Rnor6.0
Rnor_5.0925,652,099 - 25,652,182 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera920,677,985 - 20,678,068 (+)NCBICelera
Cytogenetic Map9q13NCBI
MIR133B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1219,705,912 - 19,705,995 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01220,308,697 - 20,308,780 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1220,308,697 - 20,308,780 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11219,814,126 - 19,814,209 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01219,917,082 - 19,917,165 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01220,055,101 - 20,055,184 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
MIR133B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl745,980,138 - 45,980,217 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1745,980,138 - 45,980,217 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,430,290 - 52,430,369 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p12.3-11.2(chr6:50971182-57432788)x1 copy number loss See cases [RCV000134922] Chr6:50971182..57432788 [GRCh38]
Chr6:50938895..57297586 [GRCh37]
Chr6:51046854..57405545 [NCBI36]
Chr6:6p12.3-11.2		 pathogenic
GRCh38/hg38 6p12.3-12.1(chr6:51093754-53859634)x4 copy number gain See cases [RCV000137095] Chr6:51093754..53859634 [GRCh38]
Chr6:51061467..53724432 [GRCh37]
Chr6:51169426..53832391 [NCBI36]
Chr6:6p12.3-12.1		 pathogenic
GRCh38/hg38 6p12.2(chr6:51803422-52698500)x1 copy number loss See cases [RCV000136613] Chr6:51803422..52698500 [GRCh38]
Chr6:51668220..52563298 [GRCh37]
Chr6:51776179..52671257 [NCBI36]
Chr6:6p12.2		 pathogenic
GRCh38/hg38 6p21.1-12.1(chr6:45681671-54212044)x1 copy number loss See cases [RCV000138349] Chr6:45681671..54212044 [GRCh38]
Chr6:45649408..54076842 [GRCh37]
Chr6:45757386..54184801 [NCBI36]
Chr6:6p21.1-12.1		 pathogenic|uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1		 pathogenic
GRCh37/hg19 6p12.3-12.2(chr6:51637152-52303162)x3 copy number gain not provided [RCV000849320] Chr6:51637152..52303162 [GRCh37]
Chr6:6p12.3-12.2		 uncertain significance
GRCh37/hg19 6p12.3-12.2(chr6:51695623-52371918) copy number loss Autosomal recessive polycystic kidney disease [RCV001195156] Chr6:51695623..52371918 [GRCh37]
Chr6:6p12.3-12.2		 pathogenic
GRCh37/hg19 6p12.3-12.1(chr6:48626041-55575545)x1 copy number loss See cases [RCV001263045] Chr6:48626041..55575545 [GRCh37]
Chr6:6p12.3-12.1		 likely pathogenic
NC_000006.11:g.(?_51930764)_(52906034_?)del deletion not provided [RCV001346439] Chr6:51930764..52906034 [GRCh37]
Chr6:6p12.2-12.1		 uncertain significance
GRCh37/hg19 6p21.1-q12(chr6:43636308-64947206)x3 copy number gain not provided [RCV002221457] Chr6:43636308..64947206 [GRCh37]
Chr6:6p21.1-q12		 likely pathogenic
GRCh37/hg19 6p12.3-12.1(chr6:50181657-55538355)x1 copy number loss not provided [RCV003485511] Chr6:50181657..55538355 [GRCh37]
Chr6:6p12.3-12.1		 pathogenic
miRNA Target Status (No longer updated)

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
BCL2L2hsa-miR-133bMirtarbaseexternal_infoWestern blot//Luciferase reporter assayFunctional MTI19654003
BCL2L2hsa-miR-133bMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20056941
PKMhsa-miR-133bMirtarbaseexternal_infoImmunohistochemistryFunctional MTI (Weak)18464261
PITX3hsa-miR-133bMirtarbaseexternal_infoFACS//Luciferase reporter assayFunctional MTI17761882
FSCN1hsa-miR-133bMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI20198616
FSCN1hsa-miR-133bMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCRFunctional MTI21351259
PTBP2hsa-miR-133bMirtarbaseexternal_infoReporter assayFunctional MTI17210790
IGF1Rhsa-miR-133bMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19695767
KCNH2hsa-miR-133bMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI17344217
FAIMhsa-miR-133bMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI22532850
EGFRhsa-miR-133bMirtarbaseexternal_infoFlow//In situ hybridization//Luciferase reporter aFunctional MTI22883469
FGFR1hsa-miR-133bMirtarbaseexternal_infoLuciferase reporter assay//Western blot//ImmunohisFunctional MTI23296701
CDK13hsa-miR-133bMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23451058
PRDM16hsa-miR-133bMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23395168
METhsa-miR-133bMirtarbaseexternal_infoReporter assayFunctional MTI20505319
ERGhsa-miR-133bMirtarbaseexternal_infoReporter assayFunctional MTI17344217
HCN2hsa-miR-133bMirtarbaseexternal_infoReporter assayFunctional MTI18458081
HCN4hsa-miR-133bMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCR;OtherFunctional MTI18458081
PKMhsa-miR-133bTarbaseexternal_infoOtherPOSITIVE
HCN4hsa-miR-133bTarbaseexternal_infoReporter GeneNEGATIVE
ERGhsa-miR-133bTarbaseexternal_infoReporter GenePOSITIVE
FSCN1hsa-miR-133bTarbaseexternal_infoqPCRPOSITIVE
FSCN1hsa-miR-133bTarbaseexternal_infoWesternblitPOSITIVE
PTBP2hsa-miR-133bMirecordsexternal_infoNANA17210790
PITX3hsa-miR-133bMirecordsexternal_infoNANA17761882
PKMhsa-miR-133bMirecordsexternal_infoNANA18464261
FGFR1hsa-miR-133bOncomiRDBexternal_infoNANA23296701
EGFRhsa-miR-133bOncomiRDBexternal_infoNANA23206218
EGFRhsa-miR-133bOncomiRDBexternal_infoNANA22883469
FAIMhsa-miR-133bOncomiRDBexternal_infoNANA22532850
STK3hsa-miR-133bOncomiRDBexternal_infoNANA22179829
FSCN1hsa-miR-133bOncomiRDBexternal_infoNANA21351259
METhsa-miR-133bOncomiRDBexternal_infoNANA20505319
MCL1hsa-miR-133bOncomiRDBexternal_infoNANA19654003
KLF15hsa-miR-133bMirecordsexternal_info{unchanged}NA19720047

Predicted Targets
Summary Value
Count of predictions:19893
Count of gene targets:9701
Count of transcripts:18301
Interacting mature miRNAs:hsa-miR-133b
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
8 17 506 7 22 7 16 1 16 9 14 548 48 5 17 22 20 9 16

Sequence


Ensembl Acc Id: ENST00000362210
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl652,148,923 - 52,149,041 (+)Ensembl
RefSeq Acc Id: NR_029903
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38652,148,923 - 52,149,041 (+)NCBI
GRCh37652,013,721 - 52,013,839 (+)RGD
Celera653,674,858 - 53,674,976 (+)RGD
HuRef651,844,715 - 51,844,833 (+)ENTREZGENE
CHM1_1652,015,930 - 52,016,048 (+)NCBI
T2T-CHM13v2.0651,987,631 - 51,987,749 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31759 AgrOrtholog
COSMIC MIR133B COSMIC
Ensembl Genes ENSG00000199080 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000362210 ENTREZGENE
GTEx ENSG00000199080 GTEx
HGNC ID HGNC:31759 ENTREZGENE
Human Proteome Map MIR133B Human Proteome Map
miRBase MI0000822 ENTREZGENE
NCBI Gene 442890 ENTREZGENE
OMIM 610946 OMIM
PharmGKB PA164722479 PharmGKB
RNAcentral URS000032BD73 RNACentral
  URS000075DAC1 RNACentral