MIR9-2 (microRNA 9-2) - Rat Genome Database

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Gene: MIR9-2 (microRNA 9-2) Homo sapiens
Analyze
Symbol: MIR9-2
Name: microRNA 9-2
RGD ID: 1347128
HGNC Page HGNC:31642
Description: Enables mRNA 3'-UTR binding activity; mRNA base-pairing post-transcriptional repressor activity; and single-stranded RNA binding activity. Involved in several processes, including miRNA-mediated post-transcriptional gene silencing; negative regulation of cholesterol efflux; and negative regulation of signal transduction. Acts upstream of or within negative regulation of gene expression. Located in cytoplasm and nucleus.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-9-2; mir-9-2; MIRN9-2; miRNA9-2
RGD Orthologs
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38588,666,853 - 88,666,939 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl588,666,853 - 88,666,939 (-)Ensemblhg38GRCh38
GRCh37587,962,671 - 87,962,757 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36587,998,426 - 87,998,512 (-)NCBIBuild 36Build 36hg18NCBI36
Celera583,855,628 - 83,855,714 (-)NCBICelera
Cytogenetic Map5q14.3NCBI
HuRef583,167,570 - 83,167,656 (-)NCBIHuRef
CHM1_1587,395,718 - 87,395,804 (-)NCBICHM1_1
T2T-CHM13v2.0589,147,984 - 89,148,070 (-)NCBIT2T-CHM13v2.0
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular hyperosmotic salinity response  (ISO)
cellular response to ethanol  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
interneuron axon guidance  (ISO)
long-term synaptic potentiation  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (IDA)
miRNA-mediated gene silencing by mRNA destabilization  (IDA,IMP)
miRNA-mediated post-transcriptional gene silencing  (IDA,IEA)
negative regulation of cell adhesion  (ISS)
negative regulation of cell migration  (IDA)
negative regulation of cell population proliferation  (IDA)
negative regulation of cholesterol efflux  (IMP)
negative regulation of extracellular matrix assembly  (IMP)
negative regulation of gene expression  (IDA)
negative regulation of lipid biosynthetic process  (IMP)
negative regulation of myofibroblast differentiation  (IMP)
negative regulation of non-canonical NF-kappaB signal transduction  (IDA)
negative regulation of osteoblast differentiation  (ISS)
negative regulation of osteoblast proliferation  (ISS)
negative regulation of receptor signaling pathway via JAK-STAT  (IDA)
negative regulation of transforming growth factor beta receptor signaling pathway  (IMP)
negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane  (IGI)
olfactory bulb interneuron differentiation  (ISO)
positive regulation of lymphangiogenesis  (IMP)
regulation of gene expression  (ISO)
regulation of neuron differentiation  (ISO)
regulatory ncRNA-mediated gene silencing  (IDA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12007417   PMID:16381832   PMID:17604727   PMID:20022054   PMID:20167074   PMID:20624818   PMID:21037258   PMID:21368052   PMID:21858175   PMID:21931274   PMID:22407312   PMID:22723919  
PMID:23459718   PMID:23547834   PMID:23722670   PMID:23985560   PMID:24019037   PMID:24141785   PMID:24332650   PMID:24412053   PMID:24794206   PMID:25344913   PMID:25375090   PMID:25552204  
PMID:25696812   PMID:25809226   PMID:25937343   PMID:25940709   PMID:25978320   PMID:26152689   PMID:26337487   PMID:26416703   PMID:26813876   PMID:26840256   PMID:26898797   PMID:26983891  
PMID:27345415   PMID:27694005   PMID:27725294   PMID:27903254   PMID:28059050   PMID:28107581   PMID:28260112   PMID:28345661   PMID:28397066   PMID:28431233   PMID:28534369   PMID:28667418  
PMID:28696247   PMID:28750499   PMID:28882698   PMID:29073595   PMID:29286096   PMID:29518216   PMID:30166527   PMID:30301563   PMID:30637864   PMID:30794820   PMID:30795814   PMID:30803553  
PMID:30899277   PMID:30965609   PMID:31140050   PMID:31158449   PMID:31378886   PMID:31389603   PMID:31432701   PMID:31434288   PMID:31499059   PMID:31539118   PMID:31597449   PMID:31822638  
PMID:31957822   PMID:31978557   PMID:32108454   PMID:32120025   PMID:32248435   PMID:32321579   PMID:32375032   PMID:32389806   PMID:32446370   PMID:32482375   PMID:32544883   PMID:32703504  
PMID:32819588   PMID:32894569   PMID:33015156   PMID:33015774   PMID:33028108   PMID:33038536   PMID:33067948   PMID:33159015   PMID:33253710   PMID:33581109   PMID:33596811   PMID:34021445  
PMID:34048187   PMID:34723712   PMID:36333293   PMID:38243118   PMID:38310615  


Genomics

Comparative Map Data
MIR9-2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38588,666,853 - 88,666,939 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl588,666,853 - 88,666,939 (-)Ensemblhg38GRCh38
GRCh37587,962,671 - 87,962,757 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36587,998,426 - 87,998,512 (-)NCBIBuild 36Build 36hg18NCBI36
Celera583,855,628 - 83,855,714 (-)NCBICelera
Cytogenetic Map5q14.3NCBI
HuRef583,167,570 - 83,167,656 (-)NCBIHuRef
CHM1_1587,395,718 - 87,395,804 (-)NCBICHM1_1
T2T-CHM13v2.0589,147,984 - 89,148,070 (-)NCBIT2T-CHM13v2.0
Mir9-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391383,886,933 - 83,887,004 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1383,886,933 - 83,887,004 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381383,738,814 - 83,738,885 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1383,738,814 - 83,738,885 (+)Ensemblmm10GRCm38
MGSCv371383,878,419 - 83,878,490 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera1385,993,462 - 85,993,533 (+)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1343.68NCBI
MIR9-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1319,997,697 - 19,997,756 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl319,997,682 - 19,997,768 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha321,364,369 - 21,364,428 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0319,906,504 - 19,906,563 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl319,906,489 - 19,906,575 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1319,884,450 - 19,884,509 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0319,848,389 - 19,848,448 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0320,134,703 - 20,134,762 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
MIR9-2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1296,076,352 - 96,076,438 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2298,744,572 - 98,744,658 (-)NCBISscrofa10.2Sscrofa10.2susScr3


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q14.3-21.1(chr5:87376883-101524443)x1 copy number loss See cases [RCV000050945] Chr5:87376883..101524443 [GRCh38]
Chr5:86672700..100860147 [GRCh37]
Chr5:86708456..100888046 [NCBI36]
Chr5:5q14.3-21.1		 pathogenic
GRCh38/hg38 5q14.3(chr5:85876480-88958682)x1 copy number loss See cases [RCV000051010] Chr5:85876480..88958682 [GRCh38]
Chr5:85172298..88254499 [GRCh37]
Chr5:85208054..88290255 [NCBI36]
Chr5:5q14.3		 pathogenic
GRCh38/hg38 5q13.3-22.1(chr5:74163186-110809453)x3 copy number gain See cases [RCV000051839] Chr5:74163186..110809453 [GRCh38]
Chr5:73459011..110145153 [GRCh37]
Chr5:73494767..110173052 [NCBI36]
Chr5:5q13.3-22.1		 pathogenic
GRCh38/hg38 5q14.3-15(chr5:87124838-93383020)x3 copy number gain See cases [RCV000051840] Chr5:87124838..93383020 [GRCh38]
Chr5:86420655..92718726 [GRCh37]
Chr5:86456411..92744482 [NCBI36]
Chr5:5q14.3-15		 pathogenic
GRCh38/hg38 5q14.3(chr5:86343721-88779835)x1 copy number loss See cases [RCV000053475] Chr5:86343721..88779835 [GRCh38]
Chr5:85639539..88075652 [GRCh37]
Chr5:85675295..88111408 [NCBI36]
Chr5:5q14.3		 pathogenic
GRCh38/hg38 5q14.3(chr5:86743723-92337264)x1 copy number loss See cases [RCV000053477] Chr5:86743723..92337264 [GRCh38]
Chr5:86039540..91633081 [GRCh37]
Chr5:86075296..91668837 [NCBI36]
Chr5:5q14.3		 pathogenic
GRCh38/hg38 5q14.3-21.1(chr5:85966055-101335711)x1 copy number loss See cases [RCV000135748] Chr5:85966055..101335711 [GRCh38]
Chr5:85261873..100671415 [GRCh37]
Chr5:85297629..100699314 [NCBI36]
Chr5:5q14.3-21.1		 pathogenic
GRCh38/hg38 5q14.3(chr5:87191898-89957449)x1 copy number loss See cases [RCV000135596] Chr5:87191898..89957449 [GRCh38]
Chr5:86487715..89253266 [GRCh37]
Chr5:86523471..89289022 [NCBI36]
Chr5:5q14.3		 pathogenic
GRCh38/hg38 5q14.3-15(chr5:88197732-93193163)x3 copy number gain See cases [RCV000136732] Chr5:88197732..93193163 [GRCh38]
Chr5:87493549..92528869 [GRCh37]
Chr5:87529305..92554625 [NCBI36]
Chr5:5q14.3-15		 pathogenic
GRCh38/hg38 5q14.3-22.1(chr5:84603580-111435081)x1 copy number loss See cases [RCV000139656] Chr5:84603580..111435081 [GRCh38]
Chr5:83899398..110770779 [GRCh37]
Chr5:83935154..110798678 [NCBI36]
Chr5:5q14.3-22.1		 pathogenic
GRCh38/hg38 5q14.3(chr5:86766959-92148845)x1 copy number loss See cases [RCV000141419] Chr5:86766959..92148845 [GRCh38]
Chr5:86062776..91444662 [GRCh37]
Chr5:86098532..91480418 [NCBI36]
Chr5:5q14.3		 pathogenic
GRCh38/hg38 5q14.3(chr5:88368289-92363231)x1 copy number loss See cases [RCV000140963] Chr5:88368289..92363231 [GRCh38]
Chr5:87664106..91698938 [GRCh37]
Chr5:87699862..91724694 [NCBI36]
Chr5:5q14.3		 pathogenic
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV004561496]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2		 pathogenic
GRCh37/hg19 5q14.3(chr5:86530415-88893604)x1 copy number loss See cases [RCV000446445] Chr5:86530415..88893604 [GRCh37]
Chr5:5q14.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q14.3(chr5:87764485-90147447)x1 copy number loss See cases [RCV000511258] Chr5:87764485..90147447 [GRCh37]
Chr5:5q14.3		 pathogenic
GRCh37/hg19 5q14.3(chr5:86621337-89204392)x3 copy number gain See cases [RCV000510982] Chr5:86621337..89204392 [GRCh37]
Chr5:5q14.3		 likely pathogenic
GRCh37/hg19 5q14.3-15(chr5:87399001-92675748)x3 copy number gain not provided [RCV000682576] Chr5:87399001..92675748 [GRCh37]
Chr5:5q14.3-15		 likely pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q14.3-15(chr5:87512314-95096562)x1 copy number loss not provided [RCV000744913] Chr5:87512314..95096562 [GRCh37]
Chr5:5q14.3-15		 pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32		 uncertain significance
GRCh37/hg19 5q14.3(chr5:83497559-88416354)x1 copy number loss not provided [RCV000849702] Chr5:83497559..88416354 [GRCh37]
Chr5:5q14.3		 pathogenic
GRCh37/hg19 5q13.2-15(chr5:72790061-97478870)x3 copy number gain not provided [RCV001005683] Chr5:72790061..97478870 [GRCh37]
Chr5:5q13.2-15		 pathogenic
GRCh37/hg19 5q14.3(chr5:87611415-89975436)x3 copy number gain not provided [RCV001005698] Chr5:87611415..89975436 [GRCh37]
Chr5:5q14.3		 uncertain significance
GRCh37/hg19 5q14.3-21.3(chr5:87792844-109221844)x3 copy number gain See cases [RCV001007415] Chr5:87792844..109221844 [GRCh37]
Chr5:5q14.3-21.3		 likely pathogenic
NC_000005.9:g.(?_87776690)_(88119605_?)del deletion Intellectual disability, autosomal dominant 20 [RCV001382343] Chr5:87776690..88119605 [GRCh37]
Chr5:5q14.3		 pathogenic
GRCh37/hg19 5q14.2-14.3(chr5:82185951-90110454) copy number loss not specified [RCV002053507] Chr5:82185951..90110454 [GRCh37]
Chr5:5q14.2-14.3		 pathogenic
GRCh38/hg38 5q14.3-15(chr5:88189536-93784597)x1 copy number loss Intellectual disability, autosomal dominant 20 [RCV003327617] Chr5:88189536..93784597 [GRCh38]
Chr5:5q14.3-15		 pathogenic
GRCh38/hg38 5q14.3(chr5:86235182-91734581) copy number loss 5q14.3 microdeletion [RCV004555166] Chr5:86235182..91734581 [GRCh38]
Chr5:5q14.3		 pathogenic
GRCh37/hg19 5q14.1-15(chr5:80522053-92353965)x3 copy number gain not provided [RCV004819278] Chr5:80522053..92353965 [GRCh37]
Chr5:5q14.1-15		 likely pathogenic
GRCh38/hg38 5q14.3-15(chr5:87973188-93211127)x3 copy number gain Microduplication syndrome [RCV005255042] Chr5:87973188..93211127 [GRCh38]
Chr5:5q14.3-15		 likely pathogenic
miRNA Target Status (No longer updated)

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
RCOR1hsa-miR-9-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19118166
ITGB1hsa-miR-9-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23530058
CAMTA1hsa-miR-9-3pOncomiRDBexternal_infoNANA21857646
SOX2hsa-miR-9-3pOncomiRDBexternal_infoNANA21531766

Predicted Targets
Summary Value
Count of predictions:13502
Count of gene targets:5712
Count of transcripts:10643
Interacting mature miRNAs:hsa-miR-9-3p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
A008L33  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37587,962,236 - 87,962,362UniSTSGRCh37
Build 36587,997,992 - 87,998,118RGDNCBI36
Celera583,855,193 - 83,855,319RGD
Cytogenetic Map5q14.3UniSTS
HuRef583,167,135 - 83,167,261UniSTS
GeneMap99-GB4 RH Map5401.24UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENST00000384838
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl588,666,853 - 88,666,939 (-)Ensembl
RefSeq Acc Id: NR_030741
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38588,666,853 - 88,666,939 (-)NCBI
GRCh37587,962,671 - 87,962,757 (-)RGD
Celera583,855,628 - 83,855,714 (-)RGD
HuRef583,167,570 - 83,167,656 (-)RGD
CHM1_1587,395,718 - 87,395,804 (-)NCBI
T2T-CHM13v2.0589,147,984 - 89,148,070 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31642 AgrOrtholog
COSMIC MIR9-2 COSMIC
Ensembl Genes ENSG00000284447 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384838 ENTREZGENE
GTEx ENSG00000284447 GTEx
HGNC ID HGNC:31642 ENTREZGENE
Human Proteome Map MIR9-2 Human Proteome Map
miRBase MI0000467 ENTREZGENE
NCBI Gene 407047 ENTREZGENE
OMIM 611187 OMIM
PharmGKB PA164722996 PharmGKB
RNAcentral URS00003496BE RNACentral
  URS00003FA6CD RNACentral
  URS00004208C5 RNACentral