Dll4 (delta like canonical Notch ligand 4) - Rat Genome Database

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Gene: Dll4 (delta like canonical Notch ligand 4) Rattus norvegicus
Analyze
Symbol: Dll4
Name: delta like canonical Notch ligand 4
RGD ID: 1309740
Description: Predicted to enable Notch binding activity and receptor ligand activity. Involved in several processes, including cellular response to cholesterol; chondrocyte differentiation; and luteolysis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Biomarker of diabetes mellitus; ischemia (multiple); lung carcinoma (multiple); polycystic kidney disease; and retinopathy of prematurity. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and limb ischemia. Orthologous to human DLL4 (delta like canonical Notch ligand 4); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: delta-like 4; delta-like 4 (Drosophila); delta-like protein 4; delta4; drosophila Delta homolog 4; LOC311332
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,770,945 - 126,780,769 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3126,770,794 - 126,780,763 (+)EnsemblGRCr8
mRatBN7.23106,317,114 - 106,327,004 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3106,316,986 - 106,326,931 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3109,990,303 - 110,000,143 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03118,585,843 - 118,595,685 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03116,246,228 - 116,256,068 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03111,135,011 - 111,146,746 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3111,135,021 - 111,145,986 (+)Ensemblrn6Rnor6.0
Rnor_5.03117,685,724 - 117,695,772 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43105,844,671 - 105,854,738 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3105,230,387 - 105,240,148 (+)NCBICelera
RGSC_v3.13105,741,099 - 105,750,240 (+)NCBI
Cytogenetic Map3q35NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
BQ 123  (ISO)
Bufotalin  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
cannabidiol  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cypermethrin  (ISO)
DDE  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
hydrogen cyanide  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
mono(5-carboxy-2-ethylpentyl) phthalate  (ISO)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
picoxystrobin  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
propranolol  (ISO)
prostaglandin F2alpha  (EXP)
pyrimidifen  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
tetrachloromethane  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
animal organ development  (IEA)
aortic valve morphogenesis  (IEA,ISO)
blood vessel lumenization  (IEA,ISO)
blood vessel remodeling  (IEA,ISO)
branching involved in blood vessel morphogenesis  (IEA,ISO)
cardiac atrium morphogenesis  (IEA,ISO)
cardiac ventricle morphogenesis  (IEA,ISO)
cell communication  (IEA)
cell differentiation  (IEA)
cellular response to cholesterol  (IEP)
cellular response to fibroblast growth factor stimulus  (IEA,ISO)
cellular response to hypoxia  (IEP)
cellular response to vascular endothelial growth factor stimulus  (IEA,ISO)
chondrocyte differentiation  (IEP)
dorsal aorta morphogenesis  (IEA,ISO)
luteolysis  (IEP)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IEA,ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (IEA,ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of endothelial cell migration  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of Notch signaling pathway  (IBA,IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
Notch signaling pathway  (IBA,IEA,ISO)
pericardium morphogenesis  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of neural precursor cell proliferation  (IEA,ISO)
positive regulation of Notch signaling pathway  (IEA,ISO)
regulation of neural retina development  (IEA,ISO)
regulation of neurogenesis  (ISO)
system development  (IEA)
T cell differentiation  (IEA,ISO)
tissue development  (IEA)
ventral spinal cord interneuron fate commitment  (IEA,ISO)
ventricular trabecula myocardium morphogenesis  (IEA,ISO)

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The Notch Signaling System Is Involved in the Regulation of Reparative Angiogenesis in the Zone of Stasis. Abbas OL, etal., J Burn Care Res. 2017 Nov/Dec;38(6):e923-e933. doi: 10.1097/BCR.0000000000000522.
2. The Notch pathway is a critical regulator of angiogenesis in a skin model of ischemia. Abbas OL, etal., Vasc Med. 2015 Jun;20(3):205-11. doi: 10.1177/1358863X15570723. Epub 2015 Apr 1.
3. Inhibition of delta-like-4-mediated signaling impairs reparative angiogenesis after ischemia. Al Haj Zen A, etal., Circ Res. 2010 Jul 23;107(2):283-93. doi: 10.1161/CIRCRESAHA.110.221663. Epub 2010 May 27.
4. Distinct gene expression profiles associated with Notch ligands Delta-like 4 and Jagged1 in plaque material from peripheral artery disease patients: a pilot study. Aquila G, etal., J Transl Med. 2017 May 4;15(1):98. doi: 10.1186/s12967-017-1199-3.
5. Notch ligand delta-like 4 blockade alleviates experimental autoimmune encephalomyelitis by promoting regulatory T cell development. Bassil R, etal., J Immunol. 2011 Sep 1;187(5):2322-8. doi: 10.4049/jimmunol.1100725. Epub 2011 Aug 3.
6. Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin Secretion. Billiard F, etal., Cell Rep. 2018 Jan 23;22(4):895-904. doi: 10.1016/j.celrep.2017.12.076. Epub 2018 Jan 28.
7. Murine Model of Cardiac Defects Observed in Adams-Oliver Syndrome Driven by Delta-Like Ligand-4 Haploinsufficiency. De Zoysa P, etal., Stem Cells Dev. 2021 Jun 15;30(12):611-621. doi: 10.1089/scd.2021.0058. Epub 2021 May 31.
8. Influence of Dll4 via HIF-1α-VEGF signaling on the angiogenesis of choroidal neovascularization under hypoxic conditions. Dong X, etal., PLoS One. 2011 Apr 19;6(4):e18481. doi: 10.1371/journal.pone.0018481.
9. VEGF promotes cartilage angiogenesis by phospho-ERK1/2 activation of Dll4 signaling in temporomandibular joint osteoarthritis caused by chronic sleep disturbance in Wistar rats. Dong Y, etal., Oncotarget. 2017 Mar 14;8(11):17849-17861. doi: 10.18632/oncotarget.14874.
10. Adipose mesenchymal stem cells combined with platelet-rich plasma accelerate diabetic wound healing by modulating the Notch pathway. Ebrahim N, etal., Stem Cell Res Ther. 2021 Jul 13;12(1):392. doi: 10.1186/s13287-021-02454-y.
11. MicroRNA-384-5p Promotes Endothelial Progenitor Cell Proliferation and Angiogenesis in Cerebral Ischemic Stroke through the Delta-Likeligand 4-Mediated Notch Signaling Pathway. Fan J, etal., Cerebrovasc Dis. 2020;49(1):39-54. doi: 10.1159/000503950. Epub 2020 Jan 10.
12. Thalidomide-induced angiopoietin 2, Notch1 and Dll4 downregulation under hypoxic condition in tissues with gastrointestinal vascular malformation and human umbilical vein endothelial cells. Feng Q, etal., J Dig Dis. 2014 Feb;15(2):85-95. doi: 10.1111/1751-2980.12114.
13. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
14. Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Fukuda D, etal., Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):E1868-77. doi: 10.1073/pnas.1116889109. Epub 2012 Jun 13.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Effect of Notch activation on the regenerative response to acute renal failure. Gupta S, etal., Am J Physiol Renal Physiol. 2010 Jan;298(1):F209-15. doi: 10.1152/ajprenal.00451.2009. Epub 2009 Oct 14.
18. Concomitant genetic defects potentiate the adverse impact of prenatal alcohol exposure on cardiac outflow tract maturation. Harvey DC, etal., Birth Defects Res. 2022 Feb;114(3-4):105-115. doi: 10.1002/bdr2.1968. Epub 2021 Dec 3.
19. Blockade of the sonic hedgehog signalling pathway inhibits choroidal neovascularization in a laser-induced rat model. He H, etal., J Huazhong Univ Sci Technolog Med Sci. 2010 Oct;30(5):659-65. doi: 10.1007/s11596-010-0560-z. Epub 2010 Nov 10.
20. Total Flavonoids in Caragana (TFC) Promotes Angiogenesis and Enhances Cerebral Perfusion in a Rat Model of Ischemic Stroke. He Q, etal., Front Neurosci. 2018 Sep 12;12:635. doi: 10.3389/fnins.2018.00635. eCollection 2018.
21. Role of the DLL4-NOTCH system in PGF2alpha-induced luteolysis in the pregnant rat. Hernandez F, etal., Biol Reprod. 2011 May;84(5):859-65. doi: 10.1095/biolreprod.110.088708. Epub 2011 Jan 5.
22. Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer. Jubb AM, etal., Am J Pathol. 2010 Apr;176(4):2019-28. doi: 10.2353/ajpath.2010.090908. Epub 2010 Feb 18.
23. Analysis of Molecular Mechanism of YiqiChutan Formula Regulating DLL4-Notch Signaling to Inhibit Angiogenesis in Lung Cancer. Li J, etal., Biomed Res Int. 2021 Feb 12;2021:8875503. doi: 10.1155/2021/8875503. eCollection 2021.
24. Xuan Bi Tong Yu Fang Promotes Angiogenesis via VEGF-Notch1/Dll4 Pathway in Myocardial Ischemic Rats. Li S, etal., Evid Based Complement Alternat Med. 2020 Feb 5;2020:5041629. doi: 10.1155/2020/5041629. eCollection 2020.
25. Protective effect of Soluble Epoxide Hydrolase Inhibition in Retinal Vasculopathy associated with Polycystic Kidney Disease. Lin J, etal., Theranostics. 2020 Jun 22;10(17):7857-7871. doi: 10.7150/thno.43154. eCollection 2020.
26. Inhibition of Notch signaling by Dll4-Fc promotes reperfusion of acutely ischemic tissues. Liu R, etal., Biochem Biophys Res Commun. 2012 Feb 3;418(1):173-9. doi: 10.1016/j.bbrc.2012.01.002. Epub 2012 Jan 9.
27. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
28. NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy. Miloudi K, etal., Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4538-4547. doi: 10.1073/pnas.1814711116. Epub 2019 Feb 20.
29. Delivery of VEGF and delta-like 4 to synergistically regenerate capillaries and arterioles in ischemic limbs. Niu H, etal., Acta Biomater. 2022 Apr 15;143:295-309. doi: 10.1016/j.actbio.2022.03.021. Epub 2022 Mar 14.
30. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Noguera-Troise I, etal., Nature. 2006 Dec 21;444(7122):1032-7. doi: 10.1038/nature05355.
31. Activation of multiple angiogenic signaling pathways in hemangiopericytoma. Pierscianek D, etal., Brain Tumor Pathol. 2016 Jul;33(3):200-8. doi: 10.1007/s10014-016-0256-6. Epub 2016 Mar 7.
32. Study of angiogenic signaling pathways in hemangioblastoma. Pierscianek D, etal., Neuropathology. 2017 Feb;37(1):3-11. doi: 10.1111/neup.12316. Epub 2016 Jul 7.
33. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
34. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
35. Si-Miao-Yong-An on promoting the maturation of Vasa Vasorum and stabilizing atherosclerotic plaque in ApoE-/- mice： An experimental study. Qi Z, etal., Biomed Pharmacother. 2019 Jun;114:108785. doi: 10.1016/j.biopha.2019.108785. Epub 2019 Mar 23.
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. BIBF1120 (Vargatef) Inhibits Preretinal Neovascularization and Enhances Normal Vascularization in a Model of Vasoproliferative Retinopathy. Rivera JC, etal., Invest Ophthalmol Vis Sci. 2015 Dec;56(13):7897-907. doi: 10.1167/iovs.15-17146.
39. Downregulation of the endothelial genes Notch1 and ephrinB2 in patients with nodular regenerative hyperplasia. Rothweiler S, etal., Liver Int. 2014 Apr;34(4):594-603. doi: 10.1111/liv.12261. Epub 2013 Jul 21.
40. Gamma-Secretase Inhibitor, DAPT, Prevents the Development of Retinopathy of Prematurity in a Rat Model by Regulating the Delta-Like Ligand 4/Notch Homolog-1 (DLL4/Notch-1) Pathway. Sun W, etal., Med Sci Monit. 2019 Jan 17;25:492-499. doi: 10.12659/MSM.913828.
41. Arterialization and anomalous vein wall remodeling in varicose veins is associated with upregulated FoxC2-Dll4 pathway. Surendran S, etal., Lab Invest. 2016 Apr;96(4):399-408. doi: 10.1038/labinvest.2015.167. Epub 2016 Jan 25.
42. The role of HIF-1, angiopoietin-2, Dll4 and Notch1 in bleeding gastrointestinal vascular malformations and thalidomide-associated actions: a pilot in vivo study. Tan HH, etal., J Dig Dis. 2011 Oct;12(5):349-56. doi: 10.1111/j.1751-2980.2011.00506.x.
43. MicroRNA-30a promotes chondrogenic differentiation of mesenchymal stem cells through inhibiting Delta-like 4 expression. Tian Y, etal., Life Sci. 2016 Mar 1;148:220-8. doi: 10.1016/j.lfs.2016.02.031. Epub 2016 Feb 9.
44. Reduced Notch1 Cleavage Promotes the Development of Pulmonary Hypertension. Wang S, etal., Hypertension. 2022 Jan;79(1):79-92. doi: 10.1161/HYPERTENSIONAHA.120.16065. Epub 2021 Nov 5.
45. Phase II study of pazopanib as second-line treatment after sunitinib in patients with metastatic renal cell carcinoma: a Southern China Urology Cancer Consortium Trial. Xie M, etal., Eur J Cancer. 2015 Mar;51(5):595-603. doi: 10.1016/j.ejca.2015.01.005. Epub 2015 Jan 21.
46. Chronic DLL4 blockade induces vascular neoplasms. Yan M, etal., Nature. 2010 Feb 11;463(7282):E6-7. doi: 10.1038/nature08751.
47. Activation of the Notch signaling pathway disturbs the CD4+/CD8+, Th17/Treg balance in rats with experimental autoimmune uveitis. Yin X, etal., Inflamm Res. 2019 Sep;68(9):761-774. doi: 10.1007/s00011-019-01260-w. Epub 2019 Jun 17.
48. Olmesartan attenuates cardiac remodeling through DLL4/Notch1 pathway activation in pressure overload mice. You J, etal., J Cardiovasc Pharmacol. 2013 Feb;61(2):142-51. doi: 10.1097/FJC.0b013e31827a0278.
49. Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes. Zheng X, etal., Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6985-6994. doi: 10.1073/pnas.1900351116. Epub 2019 Mar 18.
50. Sema3E/PlexinD1 signaling inhibits postischemic angiogenesis by regulating endothelial DLL4 and filopodia formation in a rat model of ischemic stroke. Zhou YF, etal., FASEB J. 2019 Apr;33(4):4947-4961. doi: 10.1096/fj.201801706RR. Epub 2019 Jan 17.
51. Correlation of serum delta-like ligand-4 level with the severity of diabetic retinopathy. Zhu Y, etal., BMC Endocr Disord. 2021 Aug 6;21(1):157. doi: 10.1186/s12902-021-00814-6.
Additional References at PubMed
PMID:10837024   PMID:15146182   PMID:15466159   PMID:15466160   PMID:17728344   PMID:18559979   PMID:19389377   PMID:20616313   PMID:20947685   PMID:22323600   PMID:23388056   PMID:23918385  
PMID:24667410   PMID:25180956   PMID:25700513   PMID:25931508   PMID:26114479   PMID:26491108   PMID:29674611   PMID:37848121  


Genomics

Comparative Map Data
Dll4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,770,945 - 126,780,769 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3126,770,794 - 126,780,763 (+)EnsemblGRCr8
mRatBN7.23106,317,114 - 106,327,004 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3106,316,986 - 106,326,931 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3109,990,303 - 110,000,143 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03118,585,843 - 118,595,685 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03116,246,228 - 116,256,068 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03111,135,011 - 111,146,746 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3111,135,021 - 111,145,986 (+)Ensemblrn6Rnor6.0
Rnor_5.03117,685,724 - 117,695,772 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43105,844,671 - 105,854,738 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3105,230,387 - 105,240,148 (+)NCBICelera
RGSC_v3.13105,741,099 - 105,750,240 (+)NCBI
Cytogenetic Map3q35NCBI
DLL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381540,929,340 - 40,939,073 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1540,929,338 - 40,939,078 (+)Ensemblhg38GRCh38
GRCh371541,221,538 - 41,231,271 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361539,008,839 - 39,018,529 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341539,008,838 - 39,018,529NCBI
Celera1517,989,410 - 17,999,137 (+)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1518,070,066 - 18,079,793 (+)NCBIHuRef
CHM1_11541,339,420 - 41,349,204 (+)NCBICHM1_1
T2T-CHM13v2.01538,735,323 - 38,745,058 (+)NCBIT2T-CHM13v2.0
Dll4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392119,156,286 - 119,166,145 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2119,156,265 - 119,166,443 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382119,325,784 - 119,335,666 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2119,325,784 - 119,335,962 (+)Ensemblmm10GRCm38
MGSCv372119,151,520 - 119,161,402 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362119,017,270 - 119,027,097 (+)NCBIMGSCv36mm8
Celera2120,476,206 - 120,486,045 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.97NCBI
Dll4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554167,807,049 - 7,817,420 (+)Ensembl
ChiLan1.0NW_0049554167,807,049 - 7,816,346 (+)NCBIChiLan1.0ChiLan1.0
DLL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21630,171,696 - 30,182,800 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11534,323,041 - 34,334,142 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01519,871,584 - 19,881,817 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11538,121,238 - 38,130,950 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1538,121,574 - 38,129,471 (+)EnsemblpanPan2panpan1.1
DLL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1308,059,463 - 8,068,742 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl308,059,512 - 8,067,940 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha308,114,087 - 8,123,649 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0308,188,070 - 8,197,632 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl308,185,217 - 8,197,617 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1308,111,270 - 8,120,832 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0308,217,668 - 8,227,235 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0308,349,053 - 8,358,618 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dll4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864086,472,876 - 86,482,195 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364714,320,933 - 4,330,253 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364714,320,235 - 4,330,251 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1130,376,721 - 130,386,411 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11130,376,720 - 130,386,411 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21145,539,044 - 145,548,860 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DLL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,056,473 - 42,066,283 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2642,056,331 - 42,065,828 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604898,919,102 - 98,929,217 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dll4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248048,179,731 - 8,191,284 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248048,179,729 - 8,189,001 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dll4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1597,504,934 - 97,514,351 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dll4
104 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:598
Count of miRNA genes:270
Interacting mature miRNAs:340
Transcripts:ENSRNOT00000018970
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3122654702136118980Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
D3Mgh11  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83126,773,960 - 126,774,118 (+)Marker Load Pipeline
mRatBN7.23106,320,129 - 106,320,287 (+)MAPPERmRatBN7.2
Rnor_6.03111,138,035 - 111,138,192NCBIRnor6.0
Rnor_5.03117,688,754 - 117,688,911UniSTSRnor5.0
RGSC_v3.43105,847,686 - 105,847,844RGDRGSC3.4
RGSC_v3.43105,847,687 - 105,847,844UniSTSRGSC3.4
Celera3105,233,403 - 105,233,560UniSTS
RGSC_v3.13105,744,115 - 105,744,272RGD
RH 3.4 Map3913.7UniSTS
RH 3.4 Map3913.7RGD
RH 2.0 Map3587.4RGD
FHH x ACI Map360.54RGD
Cytogenetic Map3q35UniSTS
UniSTS:465451  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23106,323,950 - 106,324,210 (+)MAPPERmRatBN7.2
Rnor_6.03111,141,856 - 111,142,115NCBIRnor6.0
Rnor_5.03117,692,789 - 117,693,048UniSTSRnor5.0
RGSC_v3.43105,851,759 - 105,852,018UniSTSRGSC3.4
Celera3105,237,169 - 105,237,428UniSTS
Cytogenetic Map3q35UniSTS
UniSTS:465450  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23106,323,948 - 106,325,383 (+)MAPPERmRatBN7.2
Rnor_6.03111,141,854 - 111,143,287NCBIRnor6.0
Rnor_5.03117,692,787 - 117,694,220UniSTSRnor5.0
RGSC_v3.43105,851,757 - 105,853,190UniSTSRGSC3.4
Celera3105,237,167 - 105,238,600UniSTS
Cytogenetic Map3q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 156 91 90 59 36 59 6 298 136 11 135 79 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000018970   ⟹   ENSRNOP00000018970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3126,770,794 - 126,779,308 (+)Ensembl
mRatBN7.2 Ensembl3106,316,986 - 106,325,478 (+)Ensembl
Rnor_6.0 Ensembl3111,135,021 - 111,145,986 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117478   ⟹   ENSRNOP00000091766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3126,770,794 - 126,780,763 (+)Ensembl
mRatBN7.2 Ensembl3106,316,986 - 106,326,931 (+)Ensembl
RefSeq Acc Id: NM_001107760   ⟹   NP_001101230
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83126,770,945 - 126,780,761 (+)NCBI
mRatBN7.23106,317,114 - 106,326,931 (+)NCBI
Rnor_6.03111,135,019 - 111,144,835 (+)NCBI
Rnor_5.03117,685,724 - 117,695,772 (+)NCBI
RGSC_v3.43105,844,671 - 105,854,738 (+)RGD
Celera3105,230,387 - 105,240,148 (+)RGD
Sequence:
RefSeq Acc Id: XM_006234765   ⟹   XP_006234827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83126,771,190 - 126,780,769 (+)NCBI
mRatBN7.23106,317,359 - 106,327,004 (+)NCBI
Rnor_6.03111,135,011 - 111,146,746 (+)NCBI
Rnor_5.03117,685,724 - 117,695,772 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001101230 (Get FASTA)   NCBI Sequence Viewer  
  NP_001418638 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234827 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZHH1 (Get FASTA)   NCBI Sequence Viewer  
  EDL79901 (Get FASTA)   NCBI Sequence Viewer  
  EDL79902 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000091766
  ENSRNOP00000091766.1
RefSeq Acc Id: NP_001101230   ⟸   NM_001107760
- Peptide Label: precursor
- UniProtKB: A6HPF0 (UniProtKB/TrEMBL),   A0A8L2Q9H8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234827   ⟸   XM_006234765
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000018970   ⟸   ENSRNOT00000018970
Ensembl Acc Id: ENSRNOP00000091766   ⟸   ENSRNOT00000117478
Protein Domains
DSL   EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZHH1-F1-model_v2 AlphaFold D3ZHH1 1-686 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692325
Promoter ID:EPDNEW_R2850
Type:single initiation site
Name:Dll4_1
Description:delta like canonical Notch ligand 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03111,135,011 - 111,135,071EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309740 AgrOrtholog
BioCyc Gene G2FUF-48206 BioCyc
Ensembl Genes ENSRNOG00000014011 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000117478 ENTREZGENE
  ENSRNOT00000117478.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.25.140 UniProtKB/Swiss-Prot
  2.60.40.3510 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro DSL UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_CS UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  Growth_fac_rcpt_ UniProtKB/Swiss-Prot
  NOTCH_homolog UniProtKB/Swiss-Prot
  Notch_ligand_N UniProtKB/Swiss-Prot
NCBI Gene 311332 ENTREZGENE
PANTHER C-TYPE LECTIN UniProtKB/Swiss-Prot
  EGF-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam DSL UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
  hEGF UniProtKB/Swiss-Prot
  JAG1-like_EGF2 UniProtKB/Swiss-Prot
  MNNL UniProtKB/Swiss-Prot
PhenoGen Dll4 PhenoGen
PRINTS EGFBLOOD UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  DSL UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014011 RatGTEx
SMART DSL UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
UniProt A0A8L2Q9H8 ENTREZGENE, UniProtKB/TrEMBL
  A6HPF0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZHH1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-20 Dll4  delta like canonical Notch ligand 4  Dll4  delta-like 4 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Dll4  delta-like 4 (Drosophila)   Dll4_predicted  delta-like 4 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dll4_predicted  delta-like 4 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED