Gadd45b (growth arrest and DNA-damage-inducible, beta) - Rat Genome Database

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Gene: Gadd45b (growth arrest and DNA-damage-inducible, beta) Rattus norvegicus
Analyze
Symbol: Gadd45b
Name: growth arrest and DNA-damage-inducible, beta
RGD ID: 1309080
Description: Predicted to be involved in positive regulation of MAPK cascade; positive regulation of apoptotic process; and regulation of cell cycle. Predicted to act upstream of or within positive regulation of MAPK cascade. Predicted to be active in cytoplasm and nucleus. Orthologous to human GADD45B (growth arrest and DNA damage inducible beta); PARTICIPATES IN interleukin-12 signaling pathway; p38 MAPK signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH (S)-colchicine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: growth arrest and DNA damage-inducible protein GADD45 beta; growth arrest and DNA-damage-inducible 45 beta; LOC299626; MGC105966
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,428,689 - 9,430,991 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl79,428,689 - 9,430,718 (-)EnsemblGRCr8
mRatBN7.278,778,004 - 8,780,306 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,778,007 - 8,780,046 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx711,662,083 - 11,664,112 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,537,577 - 13,539,606 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,404,118 - 11,406,147 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,646,283 - 11,648,338 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,646,269 - 11,648,322 (-)Ensemblrn6Rnor6.0
Rnor_5.0711,813,536 - 11,815,569 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4710,289,073 - 10,291,102 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera76,964,215 - 6,966,244 (-)NCBICelera
RGSC_v3.1710,289,072 - 10,291,102 (-)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(E)-thiamethoxam  (ISO)
(S)-colchicine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (EXP,ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
androstane  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
azoxystrobin  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[ghi]perylene  (ISO)
benzoates  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
Botulinum toxin type A  (ISO)
bromobenzene  (EXP)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (ISO)
DDE  (ISO)
DDT  (ISO)
depsipeptide  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
fenofibrate  (EXP)
fenpyroximate  (ISO)
fentin chloride  (EXP)
ferric oxide  (ISO)
fipronil  (EXP)
fluoranthene  (ISO)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gardiquimod  (ISO)
gentamycin  (EXP)
glycine betaine  (ISO)
glyphosate  (ISO)
graphite  (EXP)
griseofulvin  (ISO)
GSK-J4  (ISO)
hexadecanoic acid  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
inulin  (ISO)
iron dichloride  (ISO)
kaempferol  (ISO)
kainic acid  (ISO)
kenpaullone  (EXP)
kojic acid  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
luteolin  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
nevirapine  (EXP,ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
niclosamide  (ISO)
nitrofen  (EXP)
nonanoic acid  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
Octicizer  (ISO)
oxaliplatin  (EXP)
oxazepam  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
peptidoglycan  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
pevonedistat  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
sertraline  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
sorafenib  (ISO)
starch  (EXP)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulfasalazine  (EXP)
sunitinib  (ISO)
tebuconazole  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thiamethoxam  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
versicolorin A  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (EXP)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9827804   PMID:12124778   PMID:12213961   PMID:12477932   PMID:16528573   PMID:18977442   PMID:20154065   PMID:23948959   PMID:25324012   PMID:25678854   PMID:25728234   PMID:26676568  
PMID:26698301   PMID:26882903   PMID:27086974   PMID:27590577   PMID:31043581   PMID:33421485   PMID:33784505   PMID:37988908  


Genomics

Comparative Map Data
Gadd45b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,428,689 - 9,430,991 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl79,428,689 - 9,430,718 (-)EnsemblGRCr8
mRatBN7.278,778,004 - 8,780,306 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,778,007 - 8,780,046 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx711,662,083 - 11,664,112 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,537,577 - 13,539,606 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,404,118 - 11,406,147 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,646,283 - 11,648,338 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,646,269 - 11,648,322 (-)Ensemblrn6Rnor6.0
Rnor_5.0711,813,536 - 11,815,569 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4710,289,073 - 10,291,102 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera76,964,215 - 6,966,244 (-)NCBICelera
RGSC_v3.1710,289,072 - 10,291,102 (-)NCBI
Cytogenetic Map7q11NCBI
GADD45B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,476,127 - 2,478,257 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,476,122 - 2,478,805 (+)Ensemblhg38GRCh38
GRCh37192,476,125 - 2,478,255 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,427,135 - 2,429,257 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34192,427,256 - 2,429,255NCBI
Celera192,413,616 - 2,415,750 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef192,247,727 - 2,249,861 (+)NCBIHuRef
CHM1_1192,475,705 - 2,477,840 (+)NCBICHM1_1
T2T-CHM13v2.0192,451,914 - 2,454,045 (+)NCBIT2T-CHM13v2.0
Gadd45b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,765,925 - 80,768,038 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,765,907 - 80,768,038 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381080,930,091 - 80,932,204 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,930,073 - 80,932,204 (+)Ensemblmm10GRCm38
MGSCv371080,392,836 - 80,394,949 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361080,333,220 - 80,335,333 (+)NCBIMGSCv36mm8
Celera1081,949,491 - 81,951,604 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Gadd45b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,864,868 - 4,867,658 (+)Ensembl
ChiLan1.0NW_0049554954,864,932 - 4,866,728 (+)NCBIChiLan1.0ChiLan1.0
GADD45B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2206,858,791 - 6,863,365 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1196,090,497 - 6,092,629 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0191,489,263 - 1,491,391 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1192,451,837 - 2,453,992 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,451,837 - 2,453,992 (+)EnsemblpanPan2panpan1.1
GADD45B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,627,915 - 56,629,960 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2056,628,485 - 56,629,730 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2056,423,662 - 56,425,720 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02057,360,968 - 57,363,023 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2057,361,502 - 57,363,100 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12056,413,407 - 56,415,463 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,898,545 - 56,900,597 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,098,808 - 57,100,864 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gadd45b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,355,340 - 216,357,217 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,477,476 - 1,479,457 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365881,476,580 - 1,479,444 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GADD45B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,107,929 - 76,111,479 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1276,107,928 - 76,111,458 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,659,395 - 76,662,926 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GADD45B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,248,566 - 2,250,718 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl62,248,583 - 2,250,889 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660816,407,398 - 6,410,196 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gadd45b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,663,485 - 5,665,666 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248285,663,604 - 5,665,666 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gadd45b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11153,951,059 - 153,953,108 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gadd45b
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:60
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000026871
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
UniSTS:546779  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,778,604 - 8,778,937 (+)MAPPERmRatBN7.2
Rnor_6.0711,646,884 - 11,647,216NCBIRnor6.0
Rnor_5.0711,814,137 - 11,814,469UniSTSRnor5.0
Celera76,964,816 - 6,965,148UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000026871   ⟹   ENSRNOP00000026871
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl79,428,689 - 9,430,718 (-)Ensembl
mRatBN7.2 Ensembl78,778,007 - 8,780,046 (-)Ensembl
Rnor_6.0 Ensembl711,646,269 - 11,648,322 (-)Ensembl
RefSeq Acc Id: NM_001008321   ⟹   NP_001008322
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,428,689 - 9,430,718 (-)NCBI
mRatBN7.278,778,004 - 8,780,033 (-)NCBI
Rnor_6.0711,646,283 - 11,648,312 (-)NCBI
Rnor_5.0711,813,536 - 11,815,569 (-)NCBI
RGSC_v3.4710,289,073 - 10,291,102 (-)RGD
Celera76,964,215 - 6,966,244 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240888   ⟹   XP_006240950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,429,172 - 9,430,991 (-)NCBI
mRatBN7.278,778,004 - 8,780,306 (-)NCBI
Rnor_6.0711,646,283 - 11,648,338 (-)NCBI
Rnor_5.0711,813,536 - 11,815,569 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001008322 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240950 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85337 (Get FASTA)   NCBI Sequence Viewer  
  EDL89208 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026871
  ENSRNOP00000026871.2
RefSeq Acc Id: NP_001008322   ⟸   NM_001008321
- UniProtKB: Q5U3Z2 (UniProtKB/TrEMBL),   F7FLQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240950   ⟸   XM_006240888
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000026871   ⟸   ENSRNOT00000026871
Protein Domains
Ribosomal protein eL8/eL30/eS12/Gadd45

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U3Z2-F1-model_v2 AlphaFold Q5U3Z2 1-160 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694995
Promoter ID:EPDNEW_R5520
Type:single initiation site
Name:Gadd45b_1
Description:growth arrest and DNA-damage-inducible, beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,648,321 - 11,648,381EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309080 AgrOrtholog
BioCyc Gene G2FUF-34980 BioCyc
Ensembl Genes ENSRNOG00000019822 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026871 ENTREZGENE
  ENSRNOT00000026871.6 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1330.30 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7302492 IMAGE-MGC_LOAD
InterPro GADD45 UniProtKB/TrEMBL
  L30e-like UniProtKB/TrEMBL
  Ribosomal_L7Ae/L30e/S12e/Gad45 UniProtKB/TrEMBL
KEGG Report rno:299626 UniProtKB/TrEMBL
MGC_CLONE MGC:105966 IMAGE-MGC_LOAD
NCBI Gene 299626 ENTREZGENE
PANTHER GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 BETA UniProtKB/TrEMBL
  PTHR10411 UniProtKB/TrEMBL
Pfam Ribosomal_L7Ae UniProtKB/TrEMBL
PhenoGen Gadd45b PhenoGen
RatGTEx ENSRNOG00000019822 RatGTEx
Superfamily-SCOP SSF55315 UniProtKB/TrEMBL
UniProt F7FLQ8 ENTREZGENE, UniProtKB/TrEMBL
  Q5U3Z2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-14 Gadd45b  growth arrest and DNA-damage-inducible, beta  Gadd45b  growth arrest and DNA-damage-inducible 45 beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Gadd45b  growth arrest and DNA-damage-inducible 45 beta  Gadd45b_predicted  growth arrest and DNA-damage-inducible 45 beta (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Gadd45b_predicted  growth arrest and DNA-damage-inducible 45 beta (predicted)      Symbol and Name status set to approved 70820 APPROVED