Dhcr24 (24-dehydrocholesterol reductase) - Rat Genome Database

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Gene: Dhcr24 (24-dehydrocholesterol reductase) Rattus norvegicus
Analyze
Symbol: Dhcr24
Name: 24-dehydrocholesterol reductase
RGD ID: 1306529
Description: Predicted to enable enzyme binding activity; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; and peptide antigen binding activity. Involved in several processes, including Ras protein signal transduction; negative regulation of cell population proliferation; and steroid metabolic process. Predicted to be located in endoplasmic reticulum and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in lipid metabolism disorder. Orthologous to human DHCR24 (24-dehydrocholesterol reductase); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-beta-hydroxysterol delta-24-reductase; delta(24)-sterol reductase; LOC298298; seladin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85126,573,366 - 126,599,940 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5126,573,338 - 126,599,936 (+)EnsemblGRCr8
mRatBN7.25121,344,552 - 121,371,124 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5121,344,575 - 121,371,137 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5123,957,501 - 123,981,506 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05125,680,549 - 125,704,554 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05125,731,821 - 125,755,826 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05126,164,708 - 126,188,926 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5126,164,674 - 126,191,206 (+)Ensemblrn6Rnor6.0
Rnor_5.05130,011,465 - 130,034,921 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45127,637,438 - 127,662,621 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5120,093,779 - 120,117,321 (+)NCBICelera
RGSC_v3.15127,592,941 - 127,670,118 (+)NCBI
Cytogenetic Map5q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
amiodarone  (EXP)
amphetamine  (EXP)
Archazolid B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzalkonium chloride  (ISO)
benzatropine  (ISO)
benzbromarone  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfide  (ISO)
caffeine  (EXP)
calcitriol  (ISO)
celecoxib  (ISO)
cerium trichloride  (ISO)
cetrorelix  (ISO)
cholesterol  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
dehydroepiandrosterone  (ISO)
desmosterol  (ISO)
desogestrel  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloromethane  (ISO)
diclofenac  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dutasteride  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
Febrifugine  (ISO)
fenthion  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycidyl methacrylate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK-J4  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
leflunomide  (EXP)
lucanthone  (ISO)
methamphetamine  (EXP)
methidathion  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury(1+)  (EXP)
methylseleninic acid  (ISO)
miconazole  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nebivolol  (ISO)
nickel dichloride  (EXP,ISO)
nicotine  (ISO)
nitrates  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
omeprazole  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
rifampicin  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
selenium atom  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitexin  (ISO)
vorinostat  (ISO)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Seladin-1 expression in rat adrenal gland: effect of adrenocorticotropic hormone treatment. Battista MC, etal., J Endocrinol. 2007 Jan;192(1):53-66.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes. Herman GE Hum Mol Genet. 2003 Apr 1;12 Spec No 1:R75-88.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. From integrative signalling to metabolic disorders. Otis M, etal., J Steroid Biochem Mol Biol. 2008 Apr;109(3-5):224-9. Epub 2008 Mar 8.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
15. Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis. Waterham HR, etal., Am J Hum Genet. 2001 Oct;69(4):685-94. Epub 2001 Aug 22.
16. Regulation of cellular response to oncogenic and oxidative stress by Seladin-1. Wu C, etal., Nature. 2004 Dec 2;432(7017):640-5.
Additional References at PubMed
PMID:11007892   PMID:12457401   PMID:12477932   PMID:14684813   PMID:15688385   PMID:16321981   PMID:16407971   PMID:16410790   PMID:16513830   PMID:19520779   PMID:19946888   PMID:24842139  
PMID:24916565   PMID:33450132   PMID:34338991  


Genomics

Comparative Map Data
Dhcr24
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85126,573,366 - 126,599,940 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5126,573,338 - 126,599,936 (+)EnsemblGRCr8
mRatBN7.25121,344,552 - 121,371,124 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5121,344,575 - 121,371,137 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5123,957,501 - 123,981,506 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05125,680,549 - 125,704,554 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05125,731,821 - 125,755,826 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05126,164,708 - 126,188,926 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5126,164,674 - 126,191,206 (+)Ensemblrn6Rnor6.0
Rnor_5.05130,011,465 - 130,034,921 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45127,637,438 - 127,662,621 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5120,093,779 - 120,117,321 (+)NCBICelera
RGSC_v3.15127,592,941 - 127,670,118 (+)NCBI
Cytogenetic Map5q34NCBI
DHCR24
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38154,849,627 - 54,887,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl154,849,627 - 54,887,207 (-)Ensemblhg38GRCh38
GRCh37155,315,300 - 55,352,868 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36155,087,888 - 55,125,509 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34155,027,320 - 55,064,926NCBI
Celera153,602,965 - 53,640,513 (-)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef153,429,205 - 53,466,807 (-)NCBIHuRef
CHM1_1155,431,045 - 55,468,571 (-)NCBICHM1_1
T2T-CHM13v2.0154,729,905 - 54,767,373 (-)NCBIT2T-CHM13v2.0
Dhcr24
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394106,418,279 - 106,446,310 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4106,418,235 - 106,446,310 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384106,561,038 - 106,589,113 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4106,561,038 - 106,589,113 (+)Ensemblmm10GRCm38
MGSCv374106,233,643 - 106,261,718 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364106,059,082 - 106,084,718 (+)NCBIMGSCv36mm8
Celera4104,921,880 - 104,950,010 (+)NCBICelera
Cytogenetic Map4C7NCBI
cM Map449.67NCBI
Dhcr24
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554644,533,928 - 4,558,133 (+)Ensembl
ChiLan1.0NW_0049554644,533,928 - 4,557,893 (+)NCBIChiLan1.0ChiLan1.0
DHCR24
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21171,944,470 - 171,984,159 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11171,087,542 - 171,125,109 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0154,126,170 - 54,163,713 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1155,714,693 - 55,752,075 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl155,714,693 - 55,754,698 (-)EnsemblpanPan2panpan1.1
DHCR24
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1554,294,055 - 54,324,389 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl554,294,046 - 54,321,921 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha554,362,817 - 54,393,132 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0554,481,753 - 54,512,044 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl554,481,728 - 54,545,270 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1554,478,780 - 54,509,047 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0554,368,590 - 54,398,883 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0554,757,309 - 54,787,616 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dhcr24
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505868,968,931 - 68,992,733 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365226,423,561 - 6,444,814 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365226,423,561 - 6,447,363 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHCR24
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6157,483,783 - 157,519,061 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16157,483,794 - 157,519,060 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26145,547,688 - 145,582,947 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DHCR24
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12078,052,565 - 78,088,918 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2078,052,607 - 78,086,303 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603339,196,929 - 39,233,564 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dhcr24
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248624,995,720 - 5,020,850 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248624,995,836 - 5,022,395 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dhcr24
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1148,217,656 - 48,244,095 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dhcr24
479 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:79
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000009402
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)584630798129630798Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1582230Bw78Body weight QTL 783.20.0016epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)5124314582133270832Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)584630798129630798Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584630798129630798Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)595062526133270832Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)582032155127032155Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)597492524133270832Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)595062526133270832Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
RH129237  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25121,370,904 - 121,371,123 (+)MAPPERmRatBN7.2
Rnor_6.05126,190,978 - 126,191,196NCBIRnor6.0
Rnor_5.05130,036,973 - 130,037,191UniSTSRnor5.0
RGSC_v3.45127,664,673 - 127,664,891UniSTSRGSC3.4
Celera5120,119,373 - 120,119,591UniSTS
RH 3.4 Map5806.2UniSTS
Cytogenetic Map5q34UniSTS
RH128821  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25121,370,912 - 121,371,124 (+)MAPPERmRatBN7.2
Rnor_6.05126,190,986 - 126,191,197NCBIRnor6.0
Rnor_5.05130,036,981 - 130,037,192UniSTSRnor5.0
RGSC_v3.45127,664,681 - 127,664,892UniSTSRGSC3.4
Celera5120,119,381 - 120,119,592UniSTS
RH 3.4 Map5804.7UniSTS
Cytogenetic Map5q34UniSTS
RH129232  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25121,370,904 - 121,371,121 (+)MAPPERmRatBN7.2
Rnor_6.05126,190,978 - 126,191,194NCBIRnor6.0
Rnor_5.05130,036,973 - 130,037,189UniSTSRnor5.0
RGSC_v3.45127,664,673 - 127,664,889UniSTSRGSC3.4
Celera5120,119,373 - 120,119,589UniSTS
RH 3.4 Map5804.5UniSTS
Cytogenetic Map5q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000009402   ⟹   ENSRNOP00000009402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5126,573,338 - 126,599,936 (+)Ensembl
mRatBN7.2 Ensembl5121,344,575 - 121,371,137 (+)Ensembl
Rnor_6.0 Ensembl5126,164,674 - 126,191,206 (+)Ensembl
RefSeq Acc Id: NM_001080148   ⟹   NP_001073617
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85126,573,366 - 126,599,940 (+)NCBI
mRatBN7.25121,344,552 - 121,371,124 (+)NCBI
Rnor_6.05126,164,708 - 126,188,926 (+)NCBI
Rnor_5.05130,011,465 - 130,034,921 (+)NCBI
RGSC_v3.45127,637,438 - 127,662,621 (+)RGD
Celera5120,093,779 - 120,117,321 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001073617 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAS66628 (Get FASTA)   NCBI Sequence Viewer  
  AAX29968 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009402
  ENSRNOP00000009402.4
GenBank Protein Q5BQE6 (Get FASTA)   NCBI Sequence Viewer  
  QST78217 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001073617   ⟸   NM_001080148
- Peptide Label: precursor
- UniProtKB: Q5BQE6 (UniProtKB/Swiss-Prot),   A6JYN2 (UniProtKB/TrEMBL),   A1KXK4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009402   ⟸   ENSRNOT00000009402
Protein Domains
FAD-binding PCMH-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BQE6-F1-model_v2 AlphaFold Q5BQE6 1-516 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693879
Promoter ID:EPDNEW_R4404
Type:initiation region
Name:Dhcr24_1
Description:24-dehydrocholesterol reductase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05126,164,623 - 126,164,683EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306529 AgrOrtholog
BioCyc Gene G2FUF-40450 BioCyc
BioCyc Pathway PWY66-4 [cholesterol biosynthesis III (via desmosterol)] BioCyc
BioCyc Pathway Image PWY66-4 BioCyc
Ensembl Genes ENSRNOG00000006787 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009402 ENTREZGENE
  ENSRNOT00000009402.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.465.10 UniProtKB/Swiss-Prot
InterPro Diminuto-like UniProtKB/Swiss-Prot
  FAD-bd_PCMH UniProtKB/Swiss-Prot
  FAD-bd_PCMH-like_sf UniProtKB/Swiss-Prot
  FAD-bd_PCMH_sub2 UniProtKB/Swiss-Prot
  Oxid_FAD_bind_N UniProtKB/Swiss-Prot
KEGG Report rno:298298 UniProtKB/Swiss-Prot
NCBI Gene 298298 ENTREZGENE
PANTHER DELTA(24)-STEROL REDUCTASE UniProtKB/Swiss-Prot
  PTHR10801 UniProtKB/Swiss-Prot
Pfam FAD_binding_4 UniProtKB/Swiss-Prot
PhenoGen Dhcr24 PhenoGen
PROSITE FAD_PCMH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006787 RatGTEx
Superfamily-SCOP SSF56176 UniProtKB/Swiss-Prot
UniProt A0A8A1UCK8_RAT UniProtKB/TrEMBL
  A1KXK4 ENTREZGENE, UniProtKB/TrEMBL
  A6JYN2 ENTREZGENE, UniProtKB/TrEMBL
  DHC24_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Dhcr24  24-dehydrocholesterol reductase  Dhcr24_predicted  24-dehydrocholesterol reductase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Dhcr24_predicted  24-dehydrocholesterol reductase (predicted)      Symbol and Name status set to approved 70820 APPROVED