Ppid (peptidylprolyl isomerase D) - Rat Genome Database

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Gene: Ppid (peptidylprolyl isomerase D) Rattus norvegicus
Analyze
Symbol: Ppid
Name: peptidylprolyl isomerase D
RGD ID: 1303174
Description: Enables cyclosporin A binding activity; enzyme binding activity; and peptidyl-prolyl cis-trans isomerase activity. Involved in negative regulation of apoptotic process; regulation of mitochondrial membrane potential; and response to oxidative stress. Predicted to be located in nucleolus. Predicted to be active in cytosol. Orthologous to human PPID (peptidylprolyl isomerase D); PARTICIPATES IN estrogen signaling pathway; calcium/calcium-mediated signaling pathway; Huntington's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 40 kDa peptidyl-prolyl cis-trans isomerase; Cyclophilin D; cyclophilin-40; Cyp-40; CypD; MGC93768; peptidyl-prolyl cis-trans isomerase D; peptidylprolyl isomerase D (cyclophilin D); PPIase; PPIase D; rotamase; rotamase D
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Ppid-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Note: This gene encodes a 370 aa protein that is found in the cytoplasm. In some databases, it has been labeled incorrectly as 'cyclophilin D'. This same name has also been applied to a different protein, found in the mitochondrion, which is represented by GeneID 282819, Ppif. [13 Feb 2013]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82167,025,985 - 167,037,998 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2167,025,931 - 167,054,493 (+)EnsemblGRCr8
mRatBN7.22164,727,803 - 164,740,168 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2164,727,779 - 164,740,221 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2171,946,017 - 171,958,079 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02169,962,054 - 169,974,115 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02164,570,896 - 164,582,957 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02178,354,830 - 178,366,843 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2178,354,890 - 178,366,685 (+)Ensemblrn6Rnor6.0
Rnor_5.02197,690,283 - 197,702,296 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42170,995,919 - 171,007,932 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2158,824,413 - 158,836,426 (+)NCBICelera
RGSC_v3.12170,946,024 - 170,958,036 (+)NCBI
Cytogenetic Map2q33NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
acrylamide  (ISO)
albendazole  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcium dichloride  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cocaine  (ISO)
cyclosporin A  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
ivermectin  (ISO)
LY294002  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
Mesaconitine  (EXP)
methotrexate  (ISO)
methylglyoxal  (EXP)
methylmercury chloride  (ISO)
N-phosphocreatine  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
oxaliplatin  (EXP)
oxidopamine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
rutin  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
trovafloxacin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vitexin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
cytosol  (IBA,ISO)
nucleolus  (IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Mitochondrial targeted cyclophilin d protects cells from cell death by peptidyl prolyl isomerization. Lin DT and Lechleiter JD, J Biol Chem 2002 Aug 23;277(34):31134-41.
3. Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation. Malouitre S, etal., Biochem J. 2009 Dec 14;425(1):137-48. doi: 10.1042/BJ20090332.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. Schinzel AC, etal., Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12005-10. Epub 2005 Aug 15.
9. Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions. Smith DF and Toft DO, Mol Endocrinol. 2008 Oct;22(10):2229-40. Epub 2008 May 1.
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11. The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent. Whitesell L, etal., Mol Cell Biol. 1998 Mar;18(3):1517-24.
Additional References at PubMed
PMID:9659917   PMID:9660753   PMID:11350175   PMID:11525244   PMID:12145316   PMID:15489334   PMID:18708059   PMID:19932913   PMID:20676357   PMID:21332552   PMID:21711559   PMID:22647578  
PMID:23220213   PMID:25617357   PMID:28131823  


Genomics

Comparative Map Data
Ppid
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82167,025,985 - 167,037,998 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2167,025,931 - 167,054,493 (+)EnsemblGRCr8
mRatBN7.22164,727,803 - 164,740,168 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2164,727,779 - 164,740,221 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2171,946,017 - 171,958,079 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02169,962,054 - 169,974,115 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02164,570,896 - 164,582,957 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02178,354,830 - 178,366,843 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2178,354,890 - 178,366,685 (+)Ensemblrn6Rnor6.0
Rnor_5.02197,690,283 - 197,702,296 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42170,995,919 - 171,007,932 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2158,824,413 - 158,836,426 (+)NCBICelera
RGSC_v3.12170,946,024 - 170,958,036 (+)NCBI
Cytogenetic Map2q33NCBI
PPID
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384158,709,127 - 158,723,396 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4158,709,127 - 158,723,406 (-)Ensemblhg38GRCh38
GRCh374159,630,279 - 159,644,548 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364159,849,729 - 159,864,002 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344159,987,884 - 160,002,157NCBI
Celera4156,971,120 - 156,985,388 (-)NCBICelera
Cytogenetic Map4q32.1NCBI
HuRef4155,380,101 - 155,394,369 (-)NCBIHuRef
CHM1_14159,606,748 - 159,621,040 (-)NCBICHM1_1
T2T-CHM13v2.04162,059,876 - 162,074,164 (-)NCBIT2T-CHM13v2.0
Ppid
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39379,498,644 - 79,511,117 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl379,498,649 - 79,510,957 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38379,591,337 - 79,603,810 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl379,591,342 - 79,603,650 (+)Ensemblmm10GRCm38
MGSCv37379,395,311 - 79,407,572 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36379,677,316 - 79,689,577 (+)NCBIMGSCv36mm8
Celera379,629,272 - 79,641,797 (+)NCBICelera
Cytogenetic Map3E3NCBI
cM Map334.91NCBI
Ppid
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547112,305,236 - 12,323,198 (-)Ensembl
ChiLan1.0NW_00495547112,309,224 - 12,323,198 (-)NCBIChiLan1.0ChiLan1.0
PPID
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23156,576,389 - 156,591,385 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14156,931,638 - 156,945,686 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04151,029,144 - 151,043,151 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14162,839,247 - 162,853,245 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4162,839,247 - 162,853,245 (-)EnsemblpanPan2panpan1.1
PPID
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11555,781,284 - 55,794,951 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1555,781,508 - 55,794,921 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1556,143,095 - 56,156,751 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01556,524,518 - 56,538,194 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1556,524,519 - 56,538,141 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11555,763,299 - 55,776,959 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01555,862,665 - 55,876,303 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01556,176,117 - 56,189,771 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppid
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530134,366,979 - 34,384,940 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365765,161,914 - 5,179,961 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365765,165,815 - 5,179,928 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPID
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl847,656,273 - 47,702,748 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1847,656,269 - 47,702,805 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2850,060,936 - 50,075,100 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPID
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17105,241,579 - 105,266,761 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603784,959,522 - 84,973,814 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppid
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248483,674,512 - 3,689,225 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248483,674,512 - 3,689,244 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ppid
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1373,801,145 - 73,813,574 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ppid
169 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:336
Count of miRNA genes:206
Interacting mature miRNAs:239
Transcripts:ENSRNOT00000037890
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085178247591Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2154723085178247591Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085178247591Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085178247591Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085178247591Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2154723085178247591Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149806826170653323Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2145807215173074435Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat

Markers in Region
RH128961  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29112,844,790 - 112,844,970 (+)MAPPERmRatBN7.2
mRatBN7.22164,739,652 - 164,739,832 (+)MAPPERmRatBN7.2
Rnor_6.02178,366,646 - 178,366,825NCBIRnor6.0
Rnor_6.09121,457,850 - 121,458,029NCBIRnor6.0
Rnor_5.09120,904,093 - 120,904,272UniSTSRnor5.0
Rnor_5.02197,702,099 - 197,702,278UniSTSRnor5.0
RGSC_v3.42171,007,735 - 171,007,914UniSTSRGSC3.4
RGSC_v3.49112,263,241 - 112,263,420UniSTSRGSC3.4
Celera9109,959,120 - 109,959,299UniSTS
Celera2158,836,229 - 158,836,408UniSTS
Cytogenetic Map9q38UniSTS
Cytogenetic Map2q32UniSTS
BE106923  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22164,728,089 - 164,728,256 (+)MAPPERmRatBN7.2
Rnor_6.02178,355,083 - 178,355,249NCBIRnor6.0
Rnor_5.02197,690,536 - 197,690,702UniSTSRnor5.0
RGSC_v3.42170,996,172 - 170,996,338UniSTSRGSC3.4
Celera2158,824,666 - 158,824,832UniSTS
RH 3.4 Map21057.9UniSTS
Cytogenetic Map2q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000037890   ⟹   ENSRNOP00000035797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2167,025,931 - 167,038,314 (+)Ensembl
mRatBN7.2 Ensembl2164,727,807 - 164,739,838 (+)Ensembl
Rnor_6.0 Ensembl2178,354,890 - 178,366,685 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097015   ⟹   ENSRNOP00000093695
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2167,025,931 - 167,038,314 (+)Ensembl
mRatBN7.2 Ensembl2164,727,779 - 164,740,221 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000126174   ⟹   ENSRNOP00000100311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2167,025,931 - 167,050,023 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000149977   ⟹   ENSRNOP00000100355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2167,025,931 - 167,038,181 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000158126   ⟹   ENSRNOP00000099845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2167,025,931 - 167,054,493 (+)Ensembl
RefSeq Acc Id: NM_001004279   ⟹   NP_001004279
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82167,025,985 - 167,037,998 (+)NCBI
mRatBN7.22164,727,837 - 164,739,850 (+)NCBI
Rnor_6.02178,354,830 - 178,366,843 (+)NCBI
Rnor_5.02197,690,283 - 197,702,296 (+)NCBI
RGSC_v3.42170,995,919 - 171,007,932 (+)RGD
Celera2158,824,413 - 158,836,426 (+)RGD
Sequence:
RefSeq Acc Id: XM_063282116   ⟹   XP_063138186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82167,027,998 - 167,037,998 (+)NCBI
RefSeq Acc Id: XM_063282117   ⟹   XP_063138187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82167,029,969 - 167,037,998 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001004279 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138186 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138187 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH76386 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000093695
GenBank Protein Q6DGG0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001004279   ⟸   NM_001004279
- UniProtKB: Q6DGG0 (UniProtKB/Swiss-Prot),   A0A8I6GKS0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035797   ⟸   ENSRNOT00000037890
Ensembl Acc Id: ENSRNOP00000093695   ⟸   ENSRNOT00000097015
RefSeq Acc Id: XP_063138186   ⟸   XM_063282116
- Peptide Label: isoform X1
- UniProtKB: A6J5S1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138187   ⟸   XM_063282117
- Peptide Label: isoform X1
- UniProtKB: A6J5S1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000100311   ⟸   ENSRNOT00000126174
Ensembl Acc Id: ENSRNOP00000099845   ⟸   ENSRNOT00000158126
Ensembl Acc Id: ENSRNOP00000100355   ⟸   ENSRNOT00000149977
Protein Domains
PPIase cyclophilin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6DGG0-F1-model_v2 AlphaFold Q6DGG0 1-370 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691385
Promoter ID:EPDNEW_R1909
Type:initiation region
Name:Ppid_1
Description:peptidylprolyl isomerase D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02178,354,793 - 178,354,853EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303174 AgrOrtholog
BioCyc Gene G2FUF-52728 BioCyc
Ensembl Genes ENSRNOG00000027408 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000097015 ENTREZGENE
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot
  2.40.100.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7108860 IMAGE-MGC_LOAD
InterPro Cyclophilin-like_dom_sf UniProtKB/Swiss-Prot
  Cyclophilin-type_PPIase_CS UniProtKB/Swiss-Prot
  Cyclophilin-type_PPIase_dom UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
  TPR_repeat UniProtKB/Swiss-Prot
KEGG Report rno:361967 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93768 IMAGE-MGC_LOAD
NCBI Gene 361967 ENTREZGENE
PANTHER PEPTIDYL-PROLYL CIS-TRANS ISOMERASE UniProtKB/Swiss-Prot
  PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED UniProtKB/Swiss-Prot
Pfam Pro_isomerase UniProtKB/Swiss-Prot
PhenoGen Ppid PhenoGen
PRINTS CSAPPISMRASE UniProtKB/Swiss-Prot
PROSITE CSA_PPIASE_1 UniProtKB/Swiss-Prot
  CSA_PPIASE_2 UniProtKB/Swiss-Prot
  TPR UniProtKB/Swiss-Prot
  TPR_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000027408 RatGTEx
SMART TPR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot
  SSF50891 UniProtKB/Swiss-Prot
UniProt A0A8I6GKS0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QI97_RAT UniProtKB/TrEMBL
  A0ABK0L5M2_RAT UniProtKB/TrEMBL
  A0ABK0L779_RAT UniProtKB/TrEMBL
  A0ABK0LB14_RAT UniProtKB/TrEMBL
  A6J5S1 ENTREZGENE, UniProtKB/TrEMBL
  PPID_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-09-29 Ppid  peptidylprolyl isomerase D  Ppid  peptidylprolyl isomerase D (cyclophilin D)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ppid  peptidylprolyl isomerase D (cyclophilin D)    peptidylprolyl isomerase D  Name updated 1299863 APPROVED
2005-07-14 Ppid  peptidylprolyl isomerase D      Symbol and Name status set to provisional 70820 PROVISIONAL