Hamp (hepcidin antimicrobial peptide) - Rat Genome Database

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Gene: Hamp (hepcidin antimicrobial peptide) Rattus norvegicus
Analyze
Symbol: Hamp
Name: hepcidin antimicrobial peptide
RGD ID: 70971
Description: Predicted to enable copper ion binding activity; hormone activity; and iron ion transmembrane transporter inhibitor activity. Involved in several processes, including cellular response to X-ray; cellular response to bile acid; and cellular response to cytokine stimulus. Located in apical cortex; extracellular space; and intercalated disc. Used to study anemia and hepatocellular carcinoma. Biomarker of several diseases, including anemia (multiple); end stage renal disease; extrahepatic cholestasis; liver disease (multiple); and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in hemochromatosis; hemochromatosis type 2B; and hepatocellular carcinoma. Orthologous to human HAMP (hepcidin antimicrobial peptide); PARTICIPATES IN iron efflux pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Hepc; hepcidin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Hamp em1Jfcol    Hamp em2Jfcol    Hamp em3Jfcol    Hamp em4Jfcol   
Genetic Models: SD-Hamp em1Jfcol +/- SD-Hamp em1Jfcol -/- SD-Hamp em2Jfcol +/- SD-Hamp em4Jfcol -/- SD-Hamp em3Jfcol +/- SD-Hamp em3Jfcol -/- SD-Hamp em4Jfcol +/- SD-Hamp em2Jfcol -/-
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8195,298,332 - 95,300,271 (-)NCBIGRCr8
mRatBN7.2186,170,926 - 86,172,865 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,170,901 - 86,172,891 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx191,591,061 - 91,592,997 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01100,057,225 - 100,059,161 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0193,349,359 - 93,351,295 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0189,368,021 - 89,369,960 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,368,021 - 89,369,960 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,523,506 - 90,525,473 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,978,120 - 85,980,059 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1186,056,230 - 86,058,170 (-)NCBI
Celera180,539,771 - 80,541,710 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,10-phenanthroline  (ISO)
10-(beta-Dimethylaminopropionyl)phenothiazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-bipyridine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,4,5,3',4',5'-Hexachlorobiphenyl  (EXP)
3,7-dihydropurine-6-thione  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
acetaldehyde  (ISO)
acrolein  (EXP)
acrylamide  (EXP)
Actein  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (EXP)
apomorphine  (ISO)
aristolochic acid A  (ISO)
aurantio-obtusin  (ISO)
Benzamil  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
cantharidin  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
CGS 15943  (ISO)
chlorpyrifos  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
desferrioxamine B  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibenzofurans  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl maleate  (ISO)
diltiazem  (ISO)
dioxygen  (EXP,ISO)
diquat  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
ethanol  (ISO)
etoposide  (ISO)
ferric ammonium citrate  (ISO)
flutamide  (EXP)
fomepizole  (ISO)
fructose  (EXP,ISO)
furan  (EXP)
gadolinium trichloride  (EXP)
genistein  (ISO)
glucose  (ISO)
hemin  (ISO)
heparin  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
iron atom  (EXP,ISO)
iron dextran  (ISO)
iron trichloride  (EXP)
iron(0)  (EXP,ISO)
isoprenaline  (EXP,ISO)
kenpaullone  (ISO)
ketoconazole  (ISO)
lansoprazole  (ISO)
lead nitrate  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
menadione  (ISO)
mercaptopurine  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
metacetamol  (EXP)
metformin  (EXP)
methapyrilene  (ISO)
methimazole  (ISO)
mitomycin C  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP)
niclosamide  (ISO)
nimodipine  (ISO)
nitrofen  (EXP)
nocodazole  (ISO)
omeprazole  (ISO)
ozone  (EXP,ISO)
pantoprazole  (ISO)
papaverine  (ISO)
paracetamol  (EXP,ISO)
pentacarbonyliron  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (EXP)
phenformin  (EXP)
phenylephrine  (EXP)
pirinixic acid  (ISO)
pravastatin  (EXP,ISO)
protein kinase inhibitor  (ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rabeprazole  (ISO)
rotenone  (EXP)
rottlerin  (ISO)
Rutecarpine  (ISO)
serpentine asbestos  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
sulforaphane  (EXP,ISO)
tamoxifen  (ISO)
tebuconazole  (EXP)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
verapamil  (ISO)
vincristine  (ISO)
vitamin D  (EXP)
vitamin E  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (IEP)
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
cell surface receptor signaling pathway via JAK-STAT  (ISO)
cellular response to bile acid  (IEP)
cellular response to interleukin-6  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to tumor necrosis factor  (IEP)
cellular response to X-ray  (IEP)
defense response to bacterium  (IBA,ISO)
defense response to fungus  (ISO)
establishment of localization in cell  (ISO)
inflammatory response  (ISO)
intracellular iron ion homeostasis  (IBA,IDA,IEA,ISO)
iron ion transmembrane transport  (ISO)
liver regeneration  (IEP)
macrophage activation  (ISO)
multicellular organismal-level iron ion homeostasis  (IEA,ISO)
myeloid cell homeostasis  (ISO)
negative regulation of bone resorption  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of intestinal absorption  (IEA,ISO)
negative regulation of iron export across plasma membrane  (IEA,ISO)
negative regulation of iron ion transmembrane transport  (IBA,ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (IMP)
positive regulation of macrophage activation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
positive regulation of protein catabolic process  (ISO)
positive regulation of protein polyubiquitination  (ISO)
positive regulation of receptor catabolic process  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein catabolic process  (ISO)
response to erythropoietin  (IEP)
response to ethanol  (IEP)
response to iron ion  (IEA,ISO)
response to iron ion starvation  (IEP)
response to vitamin A  (IEP)
response to zinc ion  (IEP)
signal transduction  (IEA)
transcription by RNA polymerase II  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Association of hepcidin promoter c.-582 A>G variant and iron overload in thalassemia major. Andreani M, etal., Haematologica. 2009 Sep;94(9):1293-6. doi: 10.3324/haematol.2009.006270.
2. Vitamin A deficiency increases hepcidin expression and oxidative stress in rat. Arruda SF, etal., Nutrition. 2009 Apr;25(4):472-8. doi: 10.1016/j.nut.2008.11.030. Epub 2009 Feb 12.
3. Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease. Ashby DR, etal., Kidney Int. 2009 May;75(9):976-81. doi: 10.1038/ki.2009.21. Epub 2009 Feb 11.
4. Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice. Bartnikas TB, etal., Blood. 2011 Jan 13;117(2):630-7. doi: 10.1182/blood-2010-05-287359. Epub 2010 Oct 18.
5. Changes in serum hepcidin levels in acute iron intoxication in a rat model. Ben-Assa E, etal., Toxicol Lett. 2009 Sep 28;189(3):242-7. doi: 10.1016/j.toxlet.2009.06.848. Epub 2009 Jun 12.
6. Suppressed hepcidin expression correlates with hypotransferrinemia in copper-deficient rat pups but not dams. Broderius M, etal., Genes Nutr. 2012 Jul;7(3):405-14. doi: 10.1007/s12263-012-0293-7. Epub 2012 Mar 29.
7. Hepcidin demonstrates a biphasic association with anemia in acute Plasmodium falciparum malaria. Casals-Pascual C, etal., Haematologica. 2012 Nov;97(11):1695-8. doi: 10.3324/haematol.2012.065854. Epub 2012 Jun 11.
8. x-Irradiation in rat liver: consequent upregulation of hepcidin and downregulation of hemojuvelin and ferroportin-1 gene expression. Christiansen H, etal., Radiology. 2007 Jan;242(1):189-97. Epub 2006 Nov 7.
9. C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism. Courselaud B, etal., J Biol Chem 2002 Oct 25;277(43):41163-70.
10. Vitamin A deficiency modulates iron metabolism via ineffective erythropoiesis. da Cunha MS, etal., J Nutr Biochem. 2014 Oct;25(10):1035-44. doi: 10.1016/j.jnutbio.2014.05.005. Epub 2014 Jun 5.
11. Hepcidin is involved in iron regulation in the ischemic brain. Ding H, etal., PLoS One. 2011;6(9):e25324. doi: 10.1371/journal.pone.0025324. Epub 2011 Sep 21.
12. Hepcidin in anemia of chronic heart failure. Divakaran V, etal., Am J Hematol. 2011 Jan;86(1):107-9. doi: 10.1002/ajh.21902.
13. Ironing out Ferroportin. Drakesmith H, etal., Cell Metab. 2015 Nov 3;22(5):777-87. doi: 10.1016/j.cmet.2015.09.006. Epub 2015 Oct 1.
14. Iron as the key modulator of hepcidin expression in erythroid antibody-mediated hypoplasia. Fernandes JC, etal., Biomed Res Int. 2014;2014:421304. doi: 10.1155/2014/421304. Epub 2014 Dec 18.
15. Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin. Gardenghi S, etal., Blood. 2007 Jun 1;109(11):5027-35. Epub 2007 Feb 13.
16. Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus. Gardenghi S, etal., Blood. 2014 Feb 20;123(8):1137-45. doi: 10.1182/blood-2013-08-521625. Epub 2013 Dec 19.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Hepcidin expression in colon during trinitrobenzene sulfonic acid-induced colitis in rats. Gotardo EM, etal., World J Gastroenterol. 2014 Apr 21;20(15):4345-52. doi: 10.3748/wjg.v20.i15.4345.
20.  Differences in hepatic expression of iron, inflammation and stress-related genes in patients with nonalcoholic steatohepatitis. Handa P, etal., Ann Hepatol. 2017 Jan-Feb 2017;16(1):77-85. doi: 10.5604/16652681.1226818.
21. Regulation of liver hepcidin expression by alcohol in vivo does not involve Kupffer cell activation or TNF-alpha signaling. Harrison-Findik DD, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Jan;296(1):G112-8. doi: 10.1152/ajpgi.90550.2008. Epub 2008 Nov 13.
22. Maternal iron and zinc supplementation during pregnancy affects body weight and iron status in rat pups at weaning. Hossain MB, etal., J Nutr. 2011 May;141(5):798-804. doi: 10.3945/jn.110.135681. Epub 2011 Mar 23.
23. Cholestasis downregulate hepcidin expression through inhibiting IL-6-induced phosphorylation of signal transducer and activator of transcription 3 signaling. Huang YH, etal., Lab Invest. 2009 Oct;89(10):1128-39. doi: 10.1038/labinvest.2009.82. Epub 2009 Aug 3.
24. Expression of the peptide hormone hepcidin increases in cardiomyocytes under myocarditis and myocardial infarction. Isoda M, etal., J Nutr Biochem. 2010 Aug;21(8):749-56. doi: 10.1016/j.jnutbio.2009.04.009. Epub 2009 Jul 16.
25. Inflammatory regulation of iron metabolism during thioacetamide-induced acute liver injury in rats. Izawa T, etal., Exp Toxicol Pathol. 2014 Mar;66(2-3):155-62. doi: 10.1016/j.etp.2013.12.002. Epub 2013 Dec 25.
26. Age-dependent expression of duodenal cytochrome b, divalent metal transporter 1, ferroportin 1, and hephaestin in the duodenum of rats. Kong WN, etal., J Gastroenterol Hepatol. 2015 Mar;30(3):513-20. doi: 10.1111/jgh.12830.
27. Effect of erythropoietin on hepcidin, DMT1 with IRE, and hephaestin gene expression in duodenum of rats. Kong WN, etal., J Gastroenterol. 2008;43(2):136-43. doi: 10.1007/s00535-007-2138-5. Epub 2008 Feb 29.
28. The iron-regulatory peptide hormone hepcidin: expression and cellular localization in the mammalian kidney. Kulaksiz H, etal., J Endocrinol. 2005 Feb;184(2):361-70.
29. Study of iron metabolism disturbances in an animal model of insulin resistance. Le Guenno G, etal., Diabetes Res Clin Pract. 2007 Mar 8;.
30. Does hepatic hepcidin play an important role in exercise-associated anemia in rats? Liu YQ, etal., Int J Sport Nutr Exerc Metab. 2011 Feb;21(1):19-26.
31. Hepcidin levels correlate to liver iron content, but not steatohepatitis, in non-alcoholic fatty liver disease. Marmur J, etal., BMC Gastroenterol. 2018 Jun 5;18(1):78. doi: 10.1186/s12876-018-0804-0.
32. Hepcidin and GDF15 in anemia of multiple myeloma. Mei S, etal., Int J Hematol. 2014 Sep;100(3):266-73. doi: 10.1007/s12185-014-1626-7. Epub 2014 Jul 23.
33. The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation. Merle U, etal., Endocrinology. 2007 Jun;148(6):2663-8. Epub 2007 Mar 15.
34. Gene Data Set MGD Curation, June 12, 2002
35. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
36. Iron-regulatory gene expression during liver regeneration. Mollbrink A, etal., Scand J Gastroenterol. 2012 May;47(5):591-600. doi: 10.3109/00365521.2012.661761. Epub 2012 Feb 27.
37. Hepcidin is increased in the hypertrophied heart of Dahl salt-sensitive rats. Naito Y, etal., Int J Cardiol. 2014 Mar 1;172(1):e45-7. doi: 10.1016/j.ijcard.2013.12.067. Epub 2013 Dec 28.
38. Ferroportin-1 is a 'nuclear'-negative acute-phase protein in rat liver: a comparison with other iron-transport proteins. Naz N, etal., Lab Invest. 2012 Jun;92(6):842-56. doi: 10.1038/labinvest.2012.52.
39. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
40. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
41. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
42. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. Pigeon C, etal., J Biol Chem 2001 Mar 16;276(11):7811-9.
43. Hepcidin expression from monocyte of splenectomized and non-splenectomized patients with HbE-beta-thalassemia. Pratummo K, etal., Hematology. 2014 Apr;19(3):175-80. doi: 10.1179/1607845413Y.0000000110. Epub 2013 Nov 25.
44. GOA pipeline RGD automated data pipeline
45. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
46. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
47. Comprehensive gene review and curation RGD comprehensive gene curation
48. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Roetto A, etal., Nat Genet. 2003 Jan;33(1):21-2. Epub 2002 Dec 9.
49. Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation. Roy CN, etal., Blood. 2007 May 1;109(9):4038-44. Epub 2007 Jan 11.
50. Hepcidin is localised in gastric parietal cells, regulates acid secretion and is induced by Helicobacter pylori infection. Schwarz P, etal., Gut. 2012 Feb;61(2):193-201. doi: 10.1136/gut.2011.241208. Epub 2011 Jul 13.
51. Erythropoietin regulates intestinal iron absorption in a rat model of chronic renal failure. Srai SK, etal., Kidney Int. 2010 Oct;78(7):660-7. doi: 10.1038/ki.2010.217. Epub 2010 Jul 14.
52. Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats. Theurl I, etal., Blood. 2011 Nov 3;118(18):4977-84. doi: 10.1182/blood-2011-03-345066. Epub 2011 Jul 5.
53. Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats. Theurl M, etal., Haematologica. 2014 Sep;99(9):1516-24. doi: 10.3324/haematol.2013.099481. Epub 2014 Jun 3.
54. Hepcidin and DNA promoter methylation in hepatocellular carcinoma. Udali S, etal., Eur J Clin Invest. 2018 Feb;48(2):e12870. doi: 10.1111/eci.12870. Epub 2017 Dec 28.
55. Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells. Urrutia P, etal., J Neurochem. 2013 Aug;126(4):541-9. doi: 10.1111/jnc.12244. Epub 2013 Apr 3.
56. Inhibiting heme oxygenase-1 attenuates rat liver fibrosis by removing iron accumulation. Wang QM, etal., World J Gastroenterol. 2013 May 21;19(19):2921-34. doi: 10.3748/wjg.v19.i19.2921.
57. [Effect of hepcidin on the development of alcoholic liver disease in rats]. Xu L, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Nov;39(6):936-9.
58. Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat. Yeh KY, etal., Am J Physiol Gastrointest Liver Physiol 2004 Mar;286(3):G385-94. Epub 2003 Oct 30.
59. Suppression of hepcidin expression and iron overload mediate Salmonella susceptibility in ankyrin 1 ENU-induced mutant. Yuki KE, etal., PLoS One. 2013;8(2):e55331. doi: 10.1371/journal.pone.0055331. Epub 2013 Feb 4.
60. Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein. Zhang AS, etal., Blood. 2011 Feb 3;117(5):1687-99. doi: 10.1182/blood-2010-06-287292. Epub 2010 Nov 29.
Additional References at PubMed
PMID:2995362   PMID:11034317   PMID:11113131   PMID:11447267   PMID:15514116   PMID:15973703   PMID:16221503   PMID:16574947   PMID:17435114   PMID:18189270   PMID:18450970   PMID:18539898  
PMID:18541141   PMID:18800028   PMID:18808386   PMID:18839536   PMID:19721414   PMID:20113314   PMID:20530874   PMID:20553779   PMID:20726229   PMID:20811044   PMID:20937842   PMID:21438013  
PMID:21700773   PMID:21736832   PMID:21785164   PMID:21859731   PMID:22128145   PMID:22326661   PMID:22383698   PMID:22560353   PMID:22682227   PMID:22985399   PMID:23376588   PMID:23439664  
PMID:23637785   PMID:24357728   PMID:24561287   PMID:24646470   PMID:24962641   PMID:25151311   PMID:25576700   PMID:25742771   PMID:25896789   PMID:25907691   PMID:26788496   PMID:26839325  
PMID:26907911   PMID:26944476   PMID:26990350   PMID:27250827   PMID:27282570   PMID:27356575   PMID:27922109   PMID:28915963   PMID:29147463   PMID:29254298   PMID:29306260   PMID:29757912  
PMID:31839527   PMID:33544508   PMID:34143808  


Genomics

Comparative Map Data
Hamp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8195,298,332 - 95,300,271 (-)NCBIGRCr8
mRatBN7.2186,170,926 - 86,172,865 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,170,901 - 86,172,891 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx191,591,061 - 91,592,997 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01100,057,225 - 100,059,161 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0193,349,359 - 93,351,295 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0189,368,021 - 89,369,960 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,368,021 - 89,369,960 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,523,506 - 90,525,473 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,978,120 - 85,980,059 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1186,056,230 - 86,058,170 (-)NCBI
Celera180,539,771 - 80,541,710 (-)NCBICelera
Cytogenetic Map1q21NCBI
HAMP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,282,528 - 35,285,143 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1935,280,716 - 35,285,143 (+)EnsemblGRCh38hg38GRCh38
GRCh371935,773,431 - 35,776,046 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361940,465,250 - 40,467,886 (+)NCBINCBI36Build 36hg18NCBI36
Build 341940,465,249 - 40,467,883NCBI
Celera1932,486,848 - 32,489,484 (+)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1932,282,038 - 32,284,542 (+)NCBIHuRef
CHM1_11935,775,030 - 35,777,667 (+)NCBICHM1_1
T2T-CHM13v2.01937,827,196 - 37,829,811 (+)NCBIT2T-CHM13v2.0
Hamp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,641,793 - 30,643,454 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl730,641,793 - 30,643,457 (-)EnsemblGRCm39 Ensembl
GRCm38730,942,368 - 30,944,029 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,942,368 - 30,944,032 (-)EnsemblGRCm38mm10GRCm38
MGSCv37731,727,387 - 31,729,036 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36730,651,128 - 30,652,777 (-)NCBIMGSCv36mm8
Celera725,508,433 - 25,510,082 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map719.27NCBI
Hamp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554684,575,510 - 4,577,649 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554684,576,080 - 4,577,591 (+)NCBIChiLan1.0ChiLan1.0
HAMP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22041,294,878 - 41,297,684 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11943,278,243 - 43,281,051 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01932,228,701 - 32,231,494 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11940,964,445 - 40,968,861 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1940,964,445 - 40,968,861 (+)Ensemblpanpan1.1panPan2
HAMP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11117,305,531 - 117,306,587 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1117,305,411 - 117,306,619 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1116,708,503 - 116,709,559 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01117,905,446 - 117,906,502 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,905,326 - 117,906,534 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11117,468,198 - 117,469,254 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01117,094,052 - 117,095,108 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01118,149,597 - 118,150,653 (-)NCBIUU_Cfam_GSD_1.0
Hamp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934910,634,907 - 10,636,644 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365701,009,312 - 1,010,686 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365701,009,344 - 1,010,654 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAMP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl644,784,160 - 44,787,305 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1644,785,863 - 44,787,303 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,205,859 - 40,207,301 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HAMP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1630,214,820 - 30,218,100 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl630,215,563 - 30,217,996 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660737,989,379 - 7,992,640 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hamp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247948,257,760 - 8,259,264 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247948,257,760 - 8,259,243 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hamp
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:105
Count of miRNA genes:80
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000028545
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat

Markers in Region
RH129420  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8195,298,348 - 95,298,633 (+)Marker Load Pipeline
mRatBN7.2186,170,942 - 86,171,227 (+)MAPPERmRatBN7.2
Rnor_6.0189,368,038 - 89,368,322NCBIRnor6.0
Rnor_5.0190,523,551 - 90,523,835UniSTSRnor5.0
RGSC_v3.4185,978,137 - 85,978,421UniSTSRGSC3.4
Celera180,539,788 - 80,540,072UniSTS
RH 3.4 Map1842.9UniSTS
Cytogenetic Map1q21UniSTS


Genetic Models
This gene Hamp is modified in the following models/strains:
SD-Hamp em1Jfcol +/-     SD-Hamp em1Jfcol -/-     SD-Hamp em2Jfcol +/-     SD-Hamp em4Jfcol -/-     SD-Hamp em3Jfcol +/-     SD-Hamp em3Jfcol -/-     SD-Hamp em4Jfcol +/-     SD-Hamp em2Jfcol -/-    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 9 49 79 85 85 58 24 58 4 200 92 61 37 55 27

Sequence


Ensembl Acc Id: ENSRNOT00000028545   ⟹   ENSRNOP00000028545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl186,170,901 - 86,172,891 (-)Ensembl
Rnor_6.0 Ensembl189,368,021 - 89,369,960 (-)Ensembl
RefSeq Acc Id: NM_053469   ⟹   NP_445921
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,298,332 - 95,300,271 (-)NCBI
mRatBN7.2186,170,926 - 86,172,865 (-)NCBI
Rnor_6.0189,368,021 - 89,369,960 (-)NCBI
Rnor_5.0190,523,506 - 90,525,473 (-)NCBI
RGSC_v3.4185,978,120 - 85,980,059 (-)RGD
Celera180,539,771 - 80,541,710 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445921 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK12966 (Get FASTA)   NCBI Sequence Viewer  
  AAO63264 (Get FASTA)   NCBI Sequence Viewer  
  EDM07698 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028545.2
GenBank Protein Q99MH3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445921   ⟸   NM_053469
- Peptide Label: precursor
- UniProtKB: Q99MH3 (UniProtKB/Swiss-Prot),   A6JA36 (UniProtKB/TrEMBL),   A0A8L2UKH6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028545   ⟸   ENSRNOT00000028545

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99MH3-F1-model_v2 AlphaFold Q99MH3 1-84 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689936
Promoter ID:EPDNEW_R460
Type:multiple initiation site
Name:Hamp_1
Description:hepcidin antimicrobial peptide
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0189,369,986 - 89,370,046EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70971 AgrOrtholog
BioCyc Gene G2FUF-60055 BioCyc
Ensembl Genes ENSRNOG00000021029 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028545.5 UniProtKB/TrEMBL
InterPro Hepcidin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84604 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 84604 ENTREZGENE
PANTHER HEPCIDIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR16877 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hepcidin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hamp PhenoGen
RatGTEx ENSRNOG00000021029 RatGTEx
UniProt A0A8L2UKH6 ENTREZGENE, UniProtKB/TrEMBL
  A6JA36 ENTREZGENE, UniProtKB/TrEMBL
  HEPC_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Hamp  hepcidin antimicrobial peptide      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference