Axin2 (axin 2) - Rat Genome Database

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Gene: Axin2 (axin 2) Rattus norvegicus
Analyze
Symbol: Axin2
Name: axin 2
RGD ID: 69259
Description: Enables beta-catenin binding activity and protein kinase binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; dorsal/ventral axis specification; and positive regulation of fat cell differentiation. Part of protein-containing complex. Used to study Parkinson's disease. Biomarker of dilated cardiomyopathy and transient cerebral ischemia. Human ortholog(s) of this gene implicated in endometrial adenocarcinoma; gastrointestinal system cancer (multiple); lung cancer (multiple); and orofacial cleft. Orthologous to human AXIN2 (axin 2); PARTICIPATES IN altered Wnt signaling, canonical pathway; colorectal cancer pathway; endometrial cancer pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: axil; axin-2; axin-like; axis inhibition protein 2; conductin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81094,393,379 - 94,426,579 (+)NCBIGRCr8
mRatBN7.21093,893,830 - 93,927,042 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1093,899,245 - 93,926,231 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1098,956,855 - 98,983,848 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01098,419,947 - 98,446,939 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01093,835,953 - 93,862,903 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01097,212,483 - 97,238,824 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1097,212,432 - 97,239,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01096,933,422 - 96,959,748 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41098,294,466 - 98,321,830 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11098,308,835 - 98,336,196 (+)NCBI
Celera1092,540,720 - 92,589,078 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-formyltetrahydrofolic acid  (EXP)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (ISO)
Aeroplysinin 1  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
caffeine  (ISO)
cannabidiol  (EXP)
carbamazepine  (ISO)
casticin  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
clozapine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
ethanol  (ISO)
fluoranthene  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
gemcitabine  (ISO)
glyphosate  (EXP)
haloperidol  (EXP)
harmine  (ISO)
inulin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
LY294002  (ISO)
manganese(II) chloride  (EXP)
methimazole  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
mifepristone  (ISO)
Muraglitazar  (EXP)
N,N-dimethylaniline  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
okadaic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phosgene  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
PX-866  (ISO)
pyrvinium  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
temozolomide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vitamin K  (EXP)
vorinostat  (ISO)
warfarin  (EXP)
XAV939  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve morphogenesis  (IEA,ISO)
bone mineralization  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cell development  (IBA,IEA)
cell population proliferation  (ISO)
cellular response to dexamethasone stimulus  (IEP)
cellular response to organic cyclic compound  (IEP)
chondrocyte differentiation involved in endochondral bone morphogenesis  (IEA,ISO)
dorsal/ventral axis specification  (IDA)
intramembranous ossification  (IEA,ISO)
maintenance of DNA repeat elements  (IEA,ISO)
mitral valve morphogenesis  (IEA,ISO)
mRNA stabilization  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IBA,IEA,ISO)
negative regulation of cell population proliferation  (IDA)
negative regulation of osteoblast differentiation  (IEA,ISO)
negative regulation of osteoblast proliferation  (IEA,ISO)
negative regulation of Wnt signaling pathway  (IDA)
odontogenesis  (IEA,ISO)
osteoblast differentiation  (IEA,ISO)
osteoblast proliferation  (IEA,ISO)
positive regulation of cellular process  (IMP)
positive regulation of epithelial to mesenchymal transition  (IEA,ISO)
positive regulation of fat cell differentiation  (IMP)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IBA,IEA)
positive regulation of protein kinase activity  (IDA)
positive regulation of protein phosphorylation  (IEA,ISO)
protein localization  (IEA,ISO)
regulation of centromeric sister chromatid cohesion  (IBA,IEA,ISO)
regulation of chondrocyte development  (IEA,ISO)
regulation of extracellular matrix organization  (IEA,ISO)
regulation of mismatch repair  (IEA,ISO)
regulation of Wnt signaling pathway  (ISO)
response to steroid hormone  (IEP)
secondary heart field specification  (IEA,ISO)
somitogenesis  (IEA,ISO)
stem cell proliferation  (IEA,ISO)
Wnt signaling pathway  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The Axin2-snail axis promotes bone invasion by activating cancer-associated fibroblasts in oral squamous cell carcinoma. An YZ, etal., BMC Cancer. 2020 Oct 12;20(1):987. doi: 10.1186/s12885-020-07495-9.
2. Insights from studies with oral cleft genes suggest associations between WNT-pathway genes and risk of oral cancer. Andrade Filho PA, etal., J Dent Res. 2011 Jun;90(6):740-6. doi: 10.1177/0022034511401622. Epub 2011 Mar 10.
3. Genetic Variants in the Wingless Antagonist Genes (sFRP, DKK, and Axin2) Predict the Overall Survival and Prognosis of North Indian Lung Cancer Patients Treated with Platinum-Based Doublet Chemotherapy. Bahl C, etal., Cancer Biother Radiopharm. 2018 Dec;33(10):466-477. doi: 10.1089/cbr.2018.2491. Epub 2018 Oct 20.
4. Association study between genetic variations in Axin2 gene and lung cancer risk in North Indian population: A multiple interaction analysis. Bahl C, etal., Tumour Biol. 2017 Apr;39(4):1010428317695533. doi: 10.1177/1010428317695533.
5. Dominant-stable beta-catenin expression causes cell fate alterations and Wnt signaling antagonist expression in a murine granulosa cell tumor model. Boerboom D, etal., Cancer Res. 2006 Feb 15;66(4):1964-73.
6. Inhibitory effect of 2-(piperidinoethoxyphenyl)-3-(4-hydroxyphenyl)-2H-benzo(b)pyran (K-1) on human primary endometrial hyperplasial cells mediated via combined suppression of Wnt/ß-catenin signaling and PI3K/Akt survival pathway. Chandra V, etal., Cell Death Dis. 2014 Aug 21;5:e1380. doi: 10.1038/cddis.2014.334.
7. Gone with the Wnt: the canonical Wnt signaling axis is present and androgen dependent in the rodent gubernaculum. Chen N, etal., J Pediatr Surg. 2011 Dec;46(12):2363-9. doi: 10.1016/j.jpedsurg.2011.09.032.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Cross-talk between pRb/E2F and Wnt/beta-catenin pathways: E2F1 induces axin2 leading to repression of Wnt signalling and to increased cell death. Hughes TA and Brady HJ, Exp Cell Res. 2005 Feb 1;303(1):32-46.
10. Single nucleotide polymorphism of the AXIN2 gene is preferentially associated with human lung cancer risk in a Japanese population. Kanzaki H, etal., Int J Mol Med. 2006 Aug;18(2):279-84.
11. Esculetin suppresses tumor growth and metastasis by targeting Axin2/E-cadherin axis in colorectal cancer. Kim WK, etal., Biochem Pharmacol. 2018 Jun;152:71-83. doi: 10.1016/j.bcp.2018.03.009. Epub 2018 Mar 10.
12. Wnt signalling and its impact on development and cancer. Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98.
13. Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling. Leung JY, etal., J Biol Chem. 2002 Jun 14;277(24):21657-65. Epub 2002 Apr 8.
14. The Axin2 rs2240308 polymorphism and susceptibility to lung cancer in a Chinese population. Liu D, etal., Tumour Biol. 2014 Nov;35(11):10987-91. doi: 10.1007/s13277-014-2399-6. Epub 2014 Aug 5.
15. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Lustig B, etal., Mol Cell Biol. 2002 Feb;22(4):1184-93. doi: 10.1128/MCB.22.4.1184-1193.2002.
16. AXIS inhibition protein 2, orofacial clefts and a family history of cancer. Menezes R, etal., J Am Dent Assoc. 2009 Jan;140(1):80-4. doi: 10.14219/jada.archive.2009.0022.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Dopamine receptor activation mitigates mitochondrial dysfunction and oxidative stress to enhance dopaminergic neurogenesis in 6-OHDA lesioned rats: A role of Wnt signalling. Mishra A, etal., Neurochem Int. 2019 Oct;129:104463. doi: 10.1016/j.neuint.2019.104463. Epub 2019 May 10.
19. Up-regulation of Axin2 by dexamethasone promotes adipocyte differentiation in ROB-C26 mesenchymal progenitor cells. Naito M, etal., Cell Tissue Res. 2013 Dec;354(3):761-70. doi: 10.1007/s00441-013-1696-5. Epub 2013 Aug 31.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. MicroRNA-221-3p promotes pulmonary artery smooth muscle cells proliferation by targeting AXIN2 during pulmonary arterial hypertension. Nie X, etal., Vascul Pharmacol. 2019 May;116:24-35. doi: 10.1016/j.vph.2017.07.002. Epub 2017 Jul 8.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
24. Variations in AXIN2 predict risk and prognosis of colorectal cancer. Otero L, etal., BDJ Open. 2019 Oct 16;5:13. doi: 10.1038/s41405-019-0022-z. eCollection 2019.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. LncRNA AC061961.2 overexpression inhibited endoplasmic reticulum stress induced apoptosis in dilated cardiomyopathy rats and cardiomyocytes via activating wnt/β-catenin pathway. Qiu Z, etal., J Recept Signal Transduct Res. 2021 Oct;41(5):494-503. doi: 10.1080/10799893.2020.1828915. Epub 2020 Oct 22.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Comprehensive gene review and curation RGD comprehensive gene curation
31. Expression and localization of axin 2 in colorectal carcinoma and its clinical implication. Schaal U, etal., Int J Colorectal Dis. 2013 Nov;28(11):1469-78. doi: 10.1007/s00384-013-1709-6. Epub 2013 May 24.
32. 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells. Simeckova P, etal., Toxicology. 2009 Jun 16;260(1-3):104-11. Epub 2009 Mar 28.
33. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
34. Activation of the Wnt/beta-catenin signaling pathway by mechanical ventilation is associated with ventilator-induced pulmonary fibrosis in healthy lungs. Villar J, etal., PLoS One. 2011;6(9):e23914. doi: 10.1371/journal.pone.0023914. Epub 2011 Sep 15.
35. Downregulation of microRNA-103a reduces microvascular endothelial cell injury in a rat model of cerebral ischemia by targeting AXIN2. Wu Z, etal., J Cell Physiol. 2020 May;235(5):4720-4733. doi: 10.1002/jcp.29350. Epub 2019 Oct 24.
36. Association of Wnt signaling pathway genetic variants in gallbladder cancer susceptibility and survival. Yadav A, etal., Tumour Biol. 2016 Jun;37(6):8083-95. doi: 10.1007/s13277-015-4728-9. Epub 2015 Dec 29.
37. Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos. Yamamoto H, etal., Mol Cell Biol 1998 May;18(5):2867-75.
38. Snail and Axin2 expression predict the malignant transformation of oral leukoplakia. Zhang X, etal., Oral Oncol. 2017 Oct;73:48-55. doi: 10.1016/j.oraloncology.2017.08.004. Epub 2017 Aug 12.
Additional References at PubMed
PMID:9554852   PMID:11017067   PMID:12072559   PMID:12636920   PMID:15042511   PMID:15790973   PMID:16247484   PMID:16432638   PMID:16601693   PMID:17072303   PMID:18755497   PMID:19623616  
PMID:19759537   PMID:20300119   PMID:20569694   PMID:21383061   PMID:21478859   PMID:21991325   PMID:22711842   PMID:30176346  


Genomics

Comparative Map Data
Axin2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81094,393,379 - 94,426,579 (+)NCBIGRCr8
mRatBN7.21093,893,830 - 93,927,042 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1093,899,245 - 93,926,231 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1098,956,855 - 98,983,848 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01098,419,947 - 98,446,939 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01093,835,953 - 93,862,903 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01097,212,483 - 97,238,824 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1097,212,432 - 97,239,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01096,933,422 - 96,959,748 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41098,294,466 - 98,321,830 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11098,308,835 - 98,336,196 (+)NCBI
Celera1092,540,720 - 92,589,078 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
AXIN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381765,528,563 - 65,561,648 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1765,528,563 - 65,561,648 (-)EnsemblGRCh38hg38GRCh38
GRCh371763,524,681 - 63,557,766 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361760,955,143 - 60,988,227 (-)NCBINCBI36Build 36hg18NCBI36
Build 341760,956,105 - 60,985,289NCBI
Celera1760,094,914 - 60,128,039 (-)NCBICelera
Cytogenetic Map17q24.1NCBI
HuRef1758,916,746 - 58,949,692 (-)NCBIHuRef
CHM1_11763,588,742 - 63,621,757 (-)NCBICHM1_1
T2T-CHM13v2.01766,399,210 - 66,432,347 (-)NCBIT2T-CHM13v2.0
Axin2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911108,808,687 - 108,841,609 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11108,811,175 - 108,841,609 (+)EnsemblGRCm39 Ensembl
GRCm3811108,917,828 - 108,950,783 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11108,920,349 - 108,950,783 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711108,781,663 - 108,812,097 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611108,736,456 - 108,766,873 (+)NCBIMGSCv36mm8
Celera11120,655,477 - 120,686,142 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1171.83NCBI
Axin2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554784,952,488 - 4,982,225 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554784,952,551 - 4,982,223 (-)NCBIChiLan1.0ChiLan1.0
AXIN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21981,569,068 - 81,602,088 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11786,388,368 - 86,421,386 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01759,476,336 - 59,509,358 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11764,688,416 - 64,720,086 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1764,688,416 - 64,720,086 (-)Ensemblpanpan1.1panPan2
AXIN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1914,559,476 - 14,588,950 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl914,559,388 - 14,588,530 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha915,451,561 - 15,482,654 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0916,221,743 - 16,252,811 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl916,221,593 - 16,252,389 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1915,167,377 - 15,198,389 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0912,335,210 - 12,366,239 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0912,336,357 - 12,367,417 (-)NCBIUU_Cfam_GSD_1.0
Axin2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560211,952,128 - 11,986,668 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365417,211,985 - 7,242,470 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365417,155,963 - 7,242,466 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AXIN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1212,311,298 - 12,343,200 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11212,311,293 - 12,343,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21212,654,639 - 12,662,408 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AXIN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11655,874,043 - 55,906,739 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1655,874,072 - 55,907,281 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607726,473,341 - 26,506,608 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Axin2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248702,800,873 - 2,832,626 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248702,803,743 - 2,832,489 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Axin2
147 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:53
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000004898
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1092238497101012337Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat

Markers in Region
D10Got218  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21093,879,144 - 93,879,389 (+)MAPPERmRatBN7.2
Rnor_6.01097,192,042 - 97,192,286NCBIRnor6.0
Rnor_5.01096,913,637 - 96,913,881UniSTSRnor5.0
RGSC_v3.41098,266,340 - 98,266,584UniSTSRGSC3.4
Celera1092,542,420 - 92,542,660UniSTS
Cytogenetic Map10q32.1UniSTS
Axin2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21093,899,346 - 93,899,451 (+)MAPPERmRatBN7.2
Rnor_6.01097,212,497 - 97,212,601NCBIRnor6.0
Rnor_5.01096,933,436 - 96,933,540UniSTSRnor5.0
RGSC_v3.41098,294,568 - 98,294,672UniSTSRGSC3.4
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 11 2 8 2 65 20 29 11
Low 1 43 46 39 11 39 8 11 9 15 12 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000088599   ⟹   ENSRNOP00000073088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1093,899,245 - 93,926,231 (+)Ensembl
Rnor_6.0 Ensembl1097,212,432 - 97,239,642 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099900   ⟹   ENSRNOP00000080393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1093,899,245 - 93,926,231 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108496   ⟹   ENSRNOP00000091222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1093,899,245 - 93,926,231 (+)Ensembl
RefSeq Acc Id: NM_024355   ⟹   NP_077331
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81094,398,785 - 94,425,774 (+)NCBI
mRatBN7.21093,899,245 - 93,926,237 (+)NCBI
Rnor_6.01097,212,483 - 97,238,824 (+)NCBI
Rnor_5.01096,933,422 - 96,959,748 (+)NCBI
RGSC_v3.41098,294,466 - 98,321,830 (+)RGD
Celera1092,540,720 - 92,589,078 (+)RGD
Sequence:
RefSeq Acc Id: XM_039085700   ⟹   XP_038941628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81094,396,006 - 94,426,579 (+)NCBI
mRatBN7.21093,896,465 - 93,927,042 (+)NCBI
RefSeq Acc Id: XM_039085701   ⟹   XP_038941629
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81094,396,364 - 94,426,579 (+)NCBI
mRatBN7.21093,896,850 - 93,927,042 (+)NCBI
RefSeq Acc Id: XM_039085702   ⟹   XP_038941630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81094,395,431 - 94,426,579 (+)NCBI
mRatBN7.21093,895,928 - 93,927,042 (+)NCBI
RefSeq Acc Id: XM_039085703   ⟹   XP_038941631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81094,397,234 - 94,426,579 (+)NCBI
mRatBN7.21093,897,683 - 93,927,042 (+)NCBI
RefSeq Acc Id: XM_039085704   ⟹   XP_038941632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81094,396,821 - 94,426,579 (+)NCBI
mRatBN7.21093,897,323 - 93,927,042 (+)NCBI
RefSeq Acc Id: XM_039085705   ⟹   XP_038941633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81094,393,379 - 94,426,579 (+)NCBI
mRatBN7.21093,893,830 - 93,927,042 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_077331   ⟸   NM_024355
- UniProtKB: O70240 (UniProtKB/Swiss-Prot),   A0A8I6AE31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073088   ⟸   ENSRNOT00000088599
RefSeq Acc Id: XP_038941633   ⟸   XM_039085705
- Peptide Label: isoform X1
- UniProtKB: O70240 (UniProtKB/Swiss-Prot),   A0A8I6AE31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941630   ⟸   XM_039085702
- Peptide Label: isoform X1
- UniProtKB: O70240 (UniProtKB/Swiss-Prot),   A0A8I6AE31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941628   ⟸   XM_039085700
- Peptide Label: isoform X1
- UniProtKB: O70240 (UniProtKB/Swiss-Prot),   A0A8I6AE31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941629   ⟸   XM_039085701
- Peptide Label: isoform X1
- UniProtKB: O70240 (UniProtKB/Swiss-Prot),   A0A8I6AE31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941632   ⟸   XM_039085704
- Peptide Label: isoform X1
- UniProtKB: O70240 (UniProtKB/Swiss-Prot),   A0A8I6AE31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941631   ⟸   XM_039085703
- Peptide Label: isoform X1
- UniProtKB: O70240 (UniProtKB/Swiss-Prot),   A0A8I6AE31 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000080393   ⟸   ENSRNOT00000099900
RefSeq Acc Id: ENSRNOP00000091222   ⟸   ENSRNOT00000108496
Protein Domains
DIX   RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70240-F1-model_v2 AlphaFold O70240 1-838 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69259 AgrOrtholog
BioCyc Gene G2FUF-22872 BioCyc
Ensembl Genes ENSRNOG00000055010 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055030636 UniProtKB/Swiss-Prot
  ENSRNOG00060014006 UniProtKB/Swiss-Prot
  ENSRNOG00065019121 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000088599 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000088599.2 UniProtKB/Swiss-Prot
  ENSRNOT00000099900.1 UniProtKB/TrEMBL
  ENSRNOT00000108496.1 UniProtKB/TrEMBL
  ENSRNOT00055053177 UniProtKB/Swiss-Prot
  ENSRNOT00060023980 UniProtKB/Swiss-Prot
  ENSRNOT00065032163 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.196.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.240.130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Axin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Axin_b-cat-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Axin_TNKS-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DIX_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdom1/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29134 UniProtKB/Swiss-Prot
NCBI Gene 29134 ENTREZGENE
PANTHER AXIN-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46102 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AXIN1_TNKS_BD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Axin_b-cat_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Axin2 PhenoGen
PRINTS RGSPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055010 RatGTEx
  ENSRNOG00055030636 RatGTEx
  ENSRNOG00060014006 RatGTEx
  ENSRNOG00065019121 RatGTEx
SMART DAX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC230314
UniProt A0A0G2K4L4_RAT UniProtKB/TrEMBL
  A0A8I5ZPY7_RAT UniProtKB/TrEMBL
  A0A8I6AE31 ENTREZGENE, UniProtKB/TrEMBL
  A6HK96_RAT UniProtKB/TrEMBL
  AXIN2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Axin2  axin 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds glycogen synthase kinase 3beta and beta catenin 68736