Stk3 (serine/threonine kinase 3) - Rat Genome Database

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Pathways
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Gene: Stk3 (serine/threonine kinase 3) Rattus norvegicus
Analyze
Symbol: Stk3
Name: serine/threonine kinase 3
RGD ID: 68412
Description: Predicted to enable identical protein binding activity; ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in hippo signaling; protein localization to organelle; and regulation of MAPK cascade. Predicted to act upstream of or within several processes, including chordate embryonic development; hepatocyte apoptotic process; and regulation of signal transduction. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Predicted to be active in centrosome and cytoplasm. Orthologous to human STK3 (serine/threonine kinase 3); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: mammalian STE20-like protein kinase 2; MST-2; MST2; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20 yeast homolog) STK3; serine/threonine kinase 3 (Ste20, yeast homolog) STK3; serine/threonine-protein kinase 3; STE20-like kinase MST2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8767,938,341 - 68,208,472 (-)NCBIGRCr8
mRatBN7.2766,053,209 - 66,323,292 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl766,052,345 - 66,323,233 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx767,942,463 - 68,211,608 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0770,144,143 - 70,414,225 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0770,017,776 - 70,274,776 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0773,617,926 - 73,883,896 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl773,618,644 - 73,883,812 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0773,793,705 - 74,055,204 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4770,308,195 - 70,597,445 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1770,447,334 - 70,618,175 (-)NCBI
Celera763,152,608 - 63,416,831 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cell differentiation involved in embryonic placenta development  (IEA,ISO)
cell population proliferation  (ISO)
central nervous system development  (IEA,ISO)
endocardium development  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
hepatocyte apoptotic process  (IEA,ISO)
hippo signaling  (IEA,ISO,ISS)
intracellular signal transduction  (IBA,IEA,ISO)
JNK cascade  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of organ growth  (IEA,ISO)
neural tube formation  (IEA,ISO)
organ growth  (IEA,ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
positive regulation of fat cell differentiation  (IEA,ISO)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
primitive hemopoiesis  (IEA,ISO)
protein import into nucleus  (IEA,ISO)
protein localization to centrosome  (IEA,ISO)
protein stabilization  (IEA,ISO)
protein tetramerization  (IEA)
regulation of cell differentiation involved in embryonic placenta development  (IEA,ISO)
regulation of MAPK cascade  (IBA,IEA)

Cellular Component
centrosome  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO,ISS)
nucleus  (IEA,ISO,ISS)
protein-containing complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of the thyroid transcription factor-1 as a target for rat MST2 kinase. Aurisicchio L, etal., J Biol Chem 1998 Jan 16;273(3):1477-82.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8566796   PMID:11278283   PMID:11805089   PMID:12477932   PMID:12554736   PMID:15109305   PMID:15688006   PMID:16930133   PMID:18328708   PMID:18362890   PMID:19525978   PMID:19786569  
PMID:19962960   PMID:20080598   PMID:20080689   PMID:20086174   PMID:20412773   PMID:20562859   PMID:22292086   PMID:23972470   PMID:24595170   PMID:28087714   PMID:31847471  


Genomics

Comparative Map Data
Stk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8767,938,341 - 68,208,472 (-)NCBIGRCr8
mRatBN7.2766,053,209 - 66,323,292 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl766,052,345 - 66,323,233 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx767,942,463 - 68,211,608 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0770,144,143 - 70,414,225 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0770,017,776 - 70,274,776 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0773,617,926 - 73,883,896 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl773,618,644 - 73,883,812 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0773,793,705 - 74,055,204 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4770,308,195 - 70,597,445 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1770,447,334 - 70,618,175 (-)NCBI
Celera763,152,608 - 63,416,831 (-)NCBICelera
Cytogenetic Map7q22NCBI
STK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38898,343,975 - 98,942,610 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl898,371,228 - 98,942,827 (-)EnsemblGRCh38hg38GRCh38
GRCh37899,466,861 - 99,954,838 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36899,536,037 - 99,907,085 (-)NCBINCBI36Build 36hg18NCBI36
Build 34899,536,042 - 99,907,085NCBI
Celera895,652,680 - 96,023,711 (-)NCBICelera
Cytogenetic Map8q22.2NCBI
HuRef894,670,086 - 95,157,575 (-)NCBIHuRef
CHM1_1899,507,181 - 99,995,466 (-)NCBICHM1_1
T2T-CHM13v2.0899,469,462 - 100,069,002 (-)NCBIT2T-CHM13v2.0
Stk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391534,875,645 - 35,155,990 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1534,875,642 - 35,179,067 (-)EnsemblGRCm39 Ensembl
GRCm381534,875,499 - 35,155,882 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1534,875,496 - 35,178,921 (-)EnsemblGRCm38mm10GRCm38
MGSCv371534,805,254 - 35,085,561 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361534,821,196 - 35,100,274 (-)NCBIMGSCv36mm8
Celera1535,503,253 - 35,772,245 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1514.34NCBI
Stk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541714,095,694 - 14,381,607 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541714,098,851 - 14,381,553 (-)NCBIChiLan1.0ChiLan1.0
STK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27115,664,689 - 116,170,207 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1891,344,435 - 91,711,597 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0895,098,185 - 95,465,324 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1897,278,139 - 97,592,727 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl897,355,173 - 97,708,437 (-)Ensemblpanpan1.1panPan2
STK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.113647,363 - 920,887 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl13648,216 - 920,847 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha13640,435 - 1,015,875 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.013796,957 - 1,172,656 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl13796,966 - 1,070,759 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.113639,257 - 1,015,142 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.013747,613 - 1,123,107 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.013753,947 - 1,129,925 (-)NCBIUU_Cfam_GSD_1.0
Stk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530336,733,336 - 37,010,196 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647044,159,419 - 44,436,330 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647044,159,449 - 44,436,295 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl438,011,814 - 38,306,773 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1438,011,802 - 38,306,777 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2441,016,047 - 41,330,062 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1893,374,528 - 93,698,143 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl893,374,517 - 93,697,758 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603947,027,424 - 47,360,853 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247635,564,835 - 5,886,769 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247635,568,079 - 5,886,722 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stk3
1138 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:382
Count of miRNA genes:208
Interacting mature miRNAs:249
Transcripts:ENSRNOT00000065722
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat

Markers in Region
WI-20184  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2766,053,212 - 66,053,464 (+)MAPPERmRatBN7.2
Rnor_6.0773,618,646 - 73,618,897NCBIRnor6.0
Rnor_5.0773,793,709 - 73,793,960UniSTSRnor5.0
RGSC_v3.4770,308,162 - 70,308,413UniSTSRGSC3.4
Celera763,152,575 - 63,152,826UniSTS
Cytogenetic Map7q22UniSTS
BF403719  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2766,117,012 - 66,117,228 (+)MAPPERmRatBN7.2
Rnor_6.0773,682,433 - 73,682,648NCBIRnor6.0
Rnor_5.0773,856,506 - 73,856,721UniSTSRnor5.0
RGSC_v3.4770,375,409 - 70,375,624UniSTSRGSC3.4
Celera763,215,616 - 63,215,831UniSTS
RH 3.4 Map7643.78UniSTS
Cytogenetic Map7q22UniSTS
RH140000  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2766,053,291 - 66,053,473 (+)MAPPERmRatBN7.2
Rnor_6.0773,618,725 - 73,618,906NCBIRnor6.0
Rnor_5.0773,793,788 - 73,793,969UniSTSRnor5.0
RGSC_v3.4770,308,241 - 70,308,422UniSTSRGSC3.4
Celera763,152,654 - 63,152,835UniSTS
Cytogenetic Map7q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 30 25 9 18 9 2 2 28 35 35 11 2
Low 13 32 32 1 32 6 9 46 6 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC134134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC136386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ001529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC161844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000065722   ⟹   ENSRNOP00000062778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl766,052,345 - 66,323,233 (-)Ensembl
Rnor_6.0 Ensembl773,618,644 - 73,883,812 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115086   ⟹   ENSRNOP00000080505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl766,053,212 - 66,323,188 (-)Ensembl
RefSeq Acc Id: NM_031735   ⟹   NP_113923
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8767,938,378 - 68,208,287 (-)NCBI
mRatBN7.2766,053,246 - 66,323,127 (-)NCBI
Rnor_6.0773,618,679 - 73,883,701 (-)NCBI
Rnor_5.0773,793,705 - 74,055,204 (-)NCBI
RGSC_v3.4770,308,195 - 70,597,445 (-)RGD
Celera763,152,608 - 63,416,831 (-)RGD
Sequence:
RefSeq Acc Id: XM_008765459   ⟹   XP_008763681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8767,987,591 - 68,208,472 (-)NCBI
mRatBN7.2766,102,466 - 66,323,292 (-)NCBI
Rnor_6.0773,665,931 - 73,883,896 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765462   ⟹   XP_008763684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8767,938,341 - 68,208,472 (-)NCBI
mRatBN7.2766,053,209 - 66,323,292 (-)NCBI
Rnor_6.0773,617,926 - 73,883,896 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079865   ⟹   XP_038935793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8767,938,341 - 68,208,472 (-)NCBI
mRatBN7.2766,053,209 - 66,323,292 (-)NCBI
RefSeq Acc Id: XM_039079866   ⟹   XP_038935794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8767,938,341 - 68,208,472 (-)NCBI
mRatBN7.2766,053,209 - 66,323,292 (-)NCBI
RefSeq Acc Id: XM_039079867   ⟹   XP_038935795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8767,938,341 - 68,112,594 (-)NCBI
mRatBN7.2766,053,209 - 66,227,491 (-)NCBI
RefSeq Acc Id: XM_063264222   ⟹   XP_063120292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8767,938,341 - 68,173,457 (-)NCBI
RefSeq Acc Id: XM_063264223   ⟹   XP_063120293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8767,950,609 - 68,208,472 (-)NCBI
RefSeq Acc Id: XM_063264224   ⟹   XP_063120294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8768,100,986 - 68,208,472 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_113923   ⟸   NM_031735
- UniProtKB: O54748 (UniProtKB/Swiss-Prot),   B1WBQ5 (UniProtKB/TrEMBL),   F7ER57 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763684   ⟸   XM_008765462
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_008763681   ⟸   XM_008765459
- Peptide Label: isoform X2
- UniProtKB: O54748 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000062778   ⟸   ENSRNOT00000065722
RefSeq Acc Id: XP_038935794   ⟸   XM_039079866
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038935793   ⟸   XM_039079865
- Peptide Label: isoform X1
- UniProtKB: O54748 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038935795   ⟸   XM_039079867
- Peptide Label: isoform X7
RefSeq Acc Id: ENSRNOP00000080505   ⟸   ENSRNOT00000115086
RefSeq Acc Id: XP_063120292   ⟸   XM_063264222
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063120293   ⟸   XM_063264223
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063120294   ⟸   XM_063264224
- Peptide Label: isoform X8
Protein Domains
Protein kinase   SARAH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54748-F1-model_v2 AlphaFold O54748 1-491 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695286
Promoter ID:EPDNEW_R5811
Type:initiation region
Name:Stk3_1
Description:serine/threonine kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0773,883,786 - 73,883,846EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68412 AgrOrtholog
BioCyc Gene G2FUF-33667 BioCyc
Ensembl Genes ENSRNOG00000011278 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065722 ENTREZGENE
  ENSRNOT00000065722.4 UniProtKB/TrEMBL
  ENSRNOT00000115086.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.4270 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9027884 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mst1_SARAH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mst2_SARAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  p53_tetramer_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SARAH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65189 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:187362 IMAGE-MGC_LOAD
NCBI Gene 65189 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE TAO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Mst1_SARAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Stk3 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SARAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011278 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC209812
UniProt A0A8I6G6P5_RAT UniProtKB/TrEMBL
  B1WBQ5 ENTREZGENE, UniProtKB/TrEMBL
  F7ER57 ENTREZGENE, UniProtKB/TrEMBL
  O54748 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Stk3  serine/threonine kinase 3  Stk3  serine/threonine kinase 3 (STE20 homolog, yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Stk3  serine/threonine kinase 3 (STE20 homolog, yeast)    serine/threonine kinase 3  Name updated 1299863 APPROVED
2002-06-10 Stk3  serine/threonine kinase 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference