Hmox2 (heme oxygenase 2) - Rat Genome Database

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Gene: Hmox2 (heme oxygenase 2) Rattus norvegicus
Analyze
Symbol: Hmox2
Name: heme oxygenase 2
RGD ID: 67402
Description: Enables heme oxygenase (decyclizing) activity. Involved in response to oxidative stress. Predicted to be located in plasma membrane. Orthologous to human HMOX2 (heme oxygenase 2); PARTICIPATES IN porphyrin and chlorophyll metabolic pathway; INTERACTS WITH ammonium chloride; bacitracin; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: heme oxygenase (decycling) 2; heme oxygenase-2 non-reducing isoform; Ho-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Hmox2-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81011,303,512 - 11,337,640 (-)NCBIGRCr8
mRatBN7.21010,797,076 - 10,831,178 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1010,797,055 - 10,831,148 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1015,505,604 - 15,539,849 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01014,994,426 - 15,028,671 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01010,663,877 - 10,698,152 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01010,990,034 - 11,035,493 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1010,990,034 - 11,035,484 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0109,756,647 - 9,800,842 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41010,914,157 - 10,929,448 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11010,914,156 - 10,929,448 (-)NCBI
Celera109,760,483 - 9,793,519 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(-)-quinic acid  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-bromohexadecanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic GMP  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
abexinostat  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
bacitracin  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon monoxide  (EXP)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
fenthion  (ISO)
folic acid  (ISO)
gallic acid  (ISO)
gentamycin  (EXP)
hemin  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoniazide  (EXP)
ivermectin  (ISO)
ketamine  (EXP)
kojic acid  (EXP)
levetiracetam  (EXP)
lipopolysaccharide  (ISO)
melatonin  (EXP)
methapyrilene  (ISO)
miconazole  (EXP)
morphine  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodiethylamine  (EXP)
O-acetyl-L-carnitine  (EXP)
ochratoxin A  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pinosylvin  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (EXP)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
streptozocin  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trans-pinosylvin  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
uranium atom  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc protoporphyrin  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Role of heme oxygenases in sepsis-induced diaphragmatic contractile dysfunction and oxidative stress. Barreiro E, etal., Am J Physiol Lung Cell Mol Physiol 2002 Aug;283(2):L476-84.
2. Heme oxygenase-2 is activated by calcium-calmodulin. Boehning D, etal., J Biol Chem. 2004 Jul 23;279(30):30927-30. Epub 2004 Jun 2.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
6. cDNA microarray analysis of gene expression in rat alveolar macrophages in response to organic extract of diesel exhaust particles. Koike E, etal., Toxicol Sci 2002 Jun;67(2):241-6.
7. The heme oxygenase system and cellular defense mechanisms. Do HO-1 and HO-2 have different functions? Maines MD and Panahian N, Adv Exp Med Biol 2001;502:249-72.
8. Human heme oxygenase-2: characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal. McCoubrey WK, etal., Arch Biochem Biophys. 1992 May 15;295(1):13-20. doi: 10.1016/0003-9861(92)90481-b.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps. Remmers EF, etal., Transplant Proc 1999 May;31(3):1549-54.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Isolation, characterization, and expression in Escherichia coli of a cDNA encoding rat heme oxygenase-2. Rotenberg MO and Maines MD, J Biol Chem 1990 May 5;265(13):7501-6.
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:3343248   PMID:8112599   PMID:12736392   PMID:12890663   PMID:14514669   PMID:14654370   PMID:14753474   PMID:15486027   PMID:15489334   PMID:15528406   PMID:16115734   PMID:16181109  
PMID:16524721   PMID:17614955   PMID:18375546   PMID:18626777   PMID:18633193   PMID:18971354   PMID:19323368   PMID:19648213   PMID:19682508   PMID:19821077   PMID:19946888   PMID:20876213  
PMID:21239629   PMID:22100509   PMID:23659033   PMID:24163720   PMID:28088559   PMID:30132448   PMID:34223768   PMID:34984919  


Genomics

Comparative Map Data
Hmox2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81011,303,512 - 11,337,640 (-)NCBIGRCr8
mRatBN7.21010,797,076 - 10,831,178 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1010,797,055 - 10,831,148 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1015,505,604 - 15,539,849 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01014,994,426 - 15,028,671 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01010,663,877 - 10,698,152 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01010,990,034 - 11,035,493 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1010,990,034 - 11,035,484 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0109,756,647 - 9,800,842 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41010,914,157 - 10,929,448 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11010,914,156 - 10,929,448 (-)NCBI
Celera109,760,483 - 9,793,519 (-)NCBICelera
Cytogenetic Map10q12NCBI
HMOX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38164,474,736 - 4,510,347 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl164,474,690 - 4,510,347 (+)EnsemblGRCh38hg38GRCh38
GRCh37164,524,737 - 4,560,348 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36164,466,447 - 4,500,349 (+)NCBINCBI36Build 36hg18NCBI36
Build 34164,466,446 - 4,500,348NCBI
Celera164,733,625 - 4,769,241 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef164,492,031 - 4,527,516 (+)NCBIHuRef
CHM1_1164,524,657 - 4,560,277 (+)NCBICHM1_1
T2T-CHM13v2.0164,504,257 - 4,539,822 (+)NCBIT2T-CHM13v2.0
Hmox2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39164,544,225 - 4,584,606 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl164,544,225 - 4,584,606 (+)EnsemblGRCm39 Ensembl
GRCm38164,726,361 - 4,766,742 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl164,726,361 - 4,766,742 (+)EnsemblGRCm38mm10GRCm38
MGSCv37164,726,361 - 4,766,249 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36164,656,841 - 4,681,476 (+)NCBIMGSCv36mm8
Celera165,357,042 - 5,398,127 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map162.46NCBI
Hmox2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544212,913,983 - 12,920,152 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544212,913,983 - 12,947,412 (-)NCBIChiLan1.0ChiLan1.0
HMOX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2185,004,553 - 5,040,043 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1168,794,278 - 8,830,538 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0163,399,715 - 3,436,018 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1164,567,825 - 4,604,596 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl164,567,828 - 4,604,596 (+)Ensemblpanpan1.1panPan2
HMOX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1636,881,073 - 36,898,062 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl636,881,506 - 36,898,042 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha638,209,606 - 38,240,992 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0637,085,031 - 37,117,118 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl637,085,038 - 37,117,547 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1636,879,455 - 36,911,205 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0636,772,360 - 36,804,385 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0637,174,250 - 37,205,632 (-)NCBIUU_Cfam_GSD_1.0
Hmox2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344106,695,873 - 106,712,812 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365304,556,706 - 4,557,663 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365304,556,617 - 4,558,250 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMOX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl337,831,439 - 37,868,128 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1337,829,044 - 37,868,163 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2338,887,097 - 38,923,044 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HMOX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.154,157,402 - 4,201,223 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606826,486,456 - 26,522,635 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hmox2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248242,272,515 - 2,317,115 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hmox2
193 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:108
Count of miRNA genes:84
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000005031
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129497586Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat

Markers in Region
D10Wox36  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.41010,927,455 - 10,927,638UniSTSRGSC3.4
Celera109,773,770 - 9,773,953UniSTS
Cytogenetic Map10 RGD
RH133204  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21010,797,160 - 10,797,354 (+)MAPPERmRatBN7.2
Rnor_6.01010,990,119 - 10,990,312NCBIRnor6.0
Rnor_5.0109,756,732 - 9,756,925UniSTSRnor5.0
RGSC_v3.41010,914,228 - 10,914,421UniSTSRGSC3.4
Celera109,760,568 - 9,760,761UniSTS
Cytogenetic Map10q12UniSTS
AU047167  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21010,812,082 - 10,812,230 (+)MAPPERmRatBN7.2
Rnor_6.01011,005,670 - 11,005,817NCBIRnor6.0
Rnor_5.0109,772,136 - 9,772,283UniSTSRnor5.0
RGSC_v3.41010,929,175 - 10,929,322UniSTSRGSC3.4
Celera109,775,490 - 9,775,636UniSTS
Cytogenetic Map10q12UniSTS
D10Wox36  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.41010,927,455 - 10,927,638UniSTSRGSC3.4
Celera109,773,770 - 9,773,953UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000005031   ⟹   ENSRNOP00000005031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1010,797,081 - 10,831,137 (-)Ensembl
Rnor_6.0 Ensembl1010,990,034 - 11,005,952 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077164   ⟹   ENSRNOP00000075102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1010,797,055 - 10,831,148 (-)Ensembl
Rnor_6.0 Ensembl1010,990,034 - 11,035,484 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114400   ⟹   ENSRNOP00000084166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1010,797,076 - 10,801,608 (-)Ensembl
RefSeq Acc Id: NM_001277073   ⟹   NP_001264002
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81011,303,512 - 11,337,612 (-)NCBI
mRatBN7.21010,797,076 - 10,831,178 (-)NCBI
Rnor_6.01010,990,034 - 11,035,484 (-)NCBI
Rnor_5.0109,756,647 - 9,800,842 (-)NCBI
Celera109,760,483 - 9,793,519 (-)NCBI
Sequence:
RefSeq Acc Id: NM_024387   ⟹   NP_077363
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81011,303,512 - 11,318,800 (-)NCBI
mRatBN7.21010,797,076 - 10,812,365 (-)NCBI
Rnor_6.01010,990,034 - 11,005,952 (-)NCBI
Rnor_5.0109,756,647 - 9,800,842 (-)NCBI
RGSC_v3.41010,914,157 - 10,929,448 (-)RGD
Celera109,760,483 - 9,775,771 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245827   ⟹   XP_006245889
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81011,304,073 - 11,337,640 (-)NCBI
mRatBN7.21010,797,077 - 10,831,148 (-)NCBI
Rnor_6.01010,990,595 - 11,035,493 (-)NCBI
Rnor_5.0109,756,647 - 9,800,842 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063269916   ⟹   XP_063125986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81011,304,073 - 11,337,617 (-)NCBI
RefSeq Acc Id: NP_077363   ⟸   NM_024387
- UniProtKB: P23711 (UniProtKB/Swiss-Prot),   A6K4R4 (UniProtKB/TrEMBL),   A0A8L2URJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264002   ⟸   NM_001277073
- UniProtKB: P23711 (UniProtKB/Swiss-Prot),   A6K4R4 (UniProtKB/TrEMBL),   A0A8L2URJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245889   ⟸   XM_006245827
- Peptide Label: isoform X1
- UniProtKB: P23711 (UniProtKB/Swiss-Prot),   A6K4R4 (UniProtKB/TrEMBL),   A0A8L2URJ2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075102   ⟸   ENSRNOT00000077164
Ensembl Acc Id: ENSRNOP00000005031   ⟸   ENSRNOT00000005031
Ensembl Acc Id: ENSRNOP00000084166   ⟸   ENSRNOT00000114400
RefSeq Acc Id: XP_063125986   ⟸   XM_063269916
- Peptide Label: isoform X1
- UniProtKB: P23711 (UniProtKB/Swiss-Prot),   A6K4R4 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23711-F1-model_v2 AlphaFold P23711 1-315 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696972
Promoter ID:EPDNEW_R7497
Type:initiation region
Name:Hmox2_2
Description:heme oxygenase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7498  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01011,005,961 - 11,006,021EPDNEW
RGD ID:13696973
Promoter ID:EPDNEW_R7498
Type:initiation region
Name:Hmox2_1
Description:heme oxygenase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7497  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01011,035,484 - 11,035,544EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:67402 AgrOrtholog
BioCyc Gene G2FUF-26040 BioCyc
Ensembl Genes ENSRNOG00000003773 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055028051 UniProtKB/Swiss-Prot
  ENSRNOG00060007820 UniProtKB/Swiss-Prot
  ENSRNOG00065010283 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005031.6 UniProtKB/Swiss-Prot
  ENSRNOT00000077164.2 UniProtKB/TrEMBL
  ENSRNOT00000114400.1 UniProtKB/TrEMBL
  ENSRNOT00055048553 UniProtKB/Swiss-Prot
  ENSRNOT00060012904 UniProtKB/Swiss-Prot
  ENSRNOT00065016608 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.910.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599345 IMAGE-MGC_LOAD
InterPro Haem_Oase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_Oase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_Oase-like_multi-hlx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_oxygenase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72426 IMAGE-MGC_LOAD
NCBI Gene 79239 ENTREZGENE
PANTHER HEME OXYGENASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Heme_oxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hmox2 PhenoGen
PRINTS HAEMOXYGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HEME_OXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003773 RatGTEx
  ENSRNOG00055028051 RatGTEx
  ENSRNOG00060007820 RatGTEx
  ENSRNOG00065010283 RatGTEx
Superfamily-SCOP SSF48613 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZX80_RAT UniProtKB/TrEMBL
  A0A8L2URJ2 ENTREZGENE, UniProtKB/TrEMBL
  A6K4R4 ENTREZGENE, UniProtKB/TrEMBL
  HMOX2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-26 Hmox2  heme oxygenase 2  Hmox2  heme oxygenase (decycling) 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Hmox2  heme oxygenase (decycling) 2    heme oxygenase 2  Name updated 1299863 APPROVED
2002-06-10 Hmox2  heme oxygenase 2      Symbol and Name status set to approved 70586 APPROVED
2001-10-23 Hmox2  heme oxygenase 2      Name updated 68916 RESERVED

RGD Curation Notes
Note Type Note Reference
gene_disease amyloid beta induced expression is observed in Alzheimers disease which could be a result of defective heme oxygenase 2 and carbon monoxide signaling 734540
gene_drugs activated by hemin a heme containing molecule 734540
gene_expression expression is decreased 2.6 fold in SHR compared with WKY rats 1357414
gene_expression localized to neurons in autonomic ganglia, including the petrosal, superior cervical, and nodose ganglia, as well as ganglia in the myenteric plexus of the intestine 61515
gene_expression expressed in endothelial cells and adventitial nerves of blood vessels 61515
gene_function cleaves heme to form biliverdin, which is subsequently converted to bilirubin, a putative neurotransmitter  
gene_process functions in heme catabolism to yield carbon monoxide 734540