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Gene: Ehd4 (EH-domain containing 4) Rattus norvegicus

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Symbol:

Ehd4

Name:

EH-domain containing 4

RGD ID:

628883

Description:

Predicted to enable protein-macromolecule adaptor activity. Involved in cellular response to growth factor stimulus; pinocytosis; and regulation of endocytosis. Predicted to be located in endoplasmic reticulum; endosome; and membrane. Predicted to be active in several cellular components, including adherens junction; cytoplasmic vesicle; and perinuclear region of cytoplasm. Orthologous to human EHD4 (EH domain containing 4); PARTICIPATES IN endocytosis pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

EH domain-containing protein 4; MGC91469; Past2; pincher; pinocytic chaperone

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EHD4 (EH domain containing 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ehd4 (EH-domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ehd4 (EH domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EHD4 (EH domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EHD4 (EH domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ehd4 (EH domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EHD4 (EH domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EHD4 (EH domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ehd4 (EH domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Ehd4 (EH domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	EHD4 (EH domain containing 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ehd4 (EH-domain containing 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ehd4 (EH-domain containing 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Past1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rme-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	IRS4	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	SLA1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	ehd4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	127,511,973 - 127,575,856 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	127,511,954 - 127,576,072 (-)	Ensembl				GRCr8
mRatBN7.2	3	107,058,191 - 107,121,985 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	107,058,958 - 107,122,002 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	110,733,330 - 110,797,125 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	119,328,884 - 119,392,677 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	116,989,277 - 117,053,073 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	111,877,853 - 111,941,841 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	111,877,853 - 111,941,841 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	118,425,620 - 118,489,608 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	106,594,931 - 106,658,722 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	105,967,084 - 106,030,732 (-)	NCBI		Celera
RGSC_v3.1	3	106,491,358 - 106,555,150 (-)	NCBI
Cytogenetic Map	3	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-demecolcine (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dimethoxyphenol (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

beta-naphthoflavone (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bleomycin A5 (ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

calcitriol (ISO)

cantharidin (ISO)

carbon nanotube (ISO)

chrysene (ISO)

cisplatin (ISO)

clofibrate (ISO)

cobalt dichloride (EXP,ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

cyclosporin A (ISO)

dextran sulfate (ISO)

dibutyl phthalate (EXP,ISO)

diethylstilbestrol (EXP)

dioxygen (ISO)

diquat (ISO)

dorsomorphin (ISO)

entinostat (ISO)

ethanol (ISO)

fenamidone (ISO)

folic acid (ISO)

FR900359 (ISO)

fulvestrant (ISO)

furan (EXP)

furfural (ISO)

gentamycin (EXP)

glycidyl methacrylate (ISO)

ivermectin (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

methimazole (EXP)

methotrexate (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

N-nitrosodiethylamine (EXP)

naphthalene (ISO)

nickel atom (ISO)

nitrates (ISO)

ochratoxin A (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

propiconazole (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

Soman (EXP)

sulfadimethoxine (EXP)

temozolomide (ISO)

tetrachloromethane (EXP,ISO)

tetraphene (ISO)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

urethane (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell migration involved in sprouting angiogenesis (IEA,ISO)

cellular response to growth factor stimulus (IDA)

cilium assembly (IBA)

endocytic recycling (IBA,IEA,ISO)

endocytosis (IBA)

pinocytosis (IMP)

positive regulation of peptidyl-tyrosine phosphorylation (IMP)

protein homooligomerization (IEA,ISO)

protein localization to plasma membrane (IBA)

regulation of endocytosis (IMP)

Cellular Component

adherens junction (IEA,ISO)

cytoplasm (IBA,IEA)

early endosome (IBA)

endocytic vesicle (IBA)

endoplasmic reticulum (IEA,ISO)

perinuclear region of cytoplasm (IBA,IEA,ISO)

plasma membrane (IBA,IEA)

recycling endosome membrane (IBA,IEA,ISO)

Molecular Function

ATP binding (IEA)

calcium ion binding (IEA)

GTP binding (IEA)

metal ion binding (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein-macromolecule adaptor activity (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

endocytosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Pincher, a pinocytic chaperone for nerve growth factor/TrkA signaling endosomes.	Shao Y, etal., J Cell Biol 2002 May 13;157(4):679-91.

Additional References at PubMed

PMID:11423532	PMID:12477932	PMID:17233914	PMID:19056867	PMID:19946888	PMID:20083601	PMID:20458337	PMID:20463227	PMID:20489164	PMID:21187387	PMID:22871113	PMID:23376485
PMID:23533145	PMID:25468996	PMID:26945066

Genomics

Comparative Map Data

Ehd4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	127,511,973 - 127,575,856 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	127,511,954 - 127,576,072 (-)	Ensembl				GRCr8
mRatBN7.2	3	107,058,191 - 107,121,985 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	107,058,958 - 107,122,002 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	110,733,330 - 110,797,125 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	119,328,884 - 119,392,677 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	116,989,277 - 117,053,073 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	111,877,853 - 111,941,841 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	111,877,853 - 111,941,841 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	118,425,620 - 118,489,608 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	106,594,931 - 106,658,722 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	105,967,084 - 106,030,732 (-)	NCBI		Celera
RGSC_v3.1	3	106,491,358 - 106,555,150 (-)	NCBI
Cytogenetic Map	3	q35	NCBI

EHD4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	41,895,933 - 41,972,557 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	41,895,933 - 41,972,593 (-)	Ensembl			hg38	GRCh38
GRCh37	15	42,188,131 - 42,264,755 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	39,978,930 - 40,052,034 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	15	39,978,932 - 40,052,034	NCBI
Celera	15	18,959,279 - 19,032,401 (-)	NCBI		Celera
Cytogenetic Map	15	q15.1	NCBI
HuRef	15	19,040,062 - 19,112,734 (-)	NCBI		HuRef
CHM1_1	15	42,310,118 - 42,383,225 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	39,701,891 - 39,778,529 (-)	NCBI		T2T-CHM13v2.0

Ehd4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	119,919,958 - 119,985,028 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	119,919,656 - 119,985,087 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	120,089,487 - 120,154,575 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	120,089,175 - 120,154,606 (-)	Ensembl			mm10	GRCm38
MGSCv37	2	119,915,223 - 119,980,311 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	119,780,928 - 119,846,017 (-)	NCBI		MGSCv36	mm8
Celera	2	121,247,550 - 121,315,043 (-)	NCBI		Celera
Cytogenetic Map	2	E5	NCBI
cM Map	2	60.16	NCBI

Ehd4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	8,686,709 - 8,739,400 (-)	Ensembl
ChiLan1.0	NW_004955416	8,686,709 - 8,758,096 (-)	NCBI	ChiLan1.0	ChiLan1.0

EHD4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	31,137,520 - 31,216,467 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	35,292,150 - 35,369,007 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	20,840,517 - 20,926,900 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	39,010,302 - 39,086,713 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	39,010,302 - 39,086,713 (-)	Ensembl			panPan2	panpan1.1

EHD4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	8,926,119 - 9,007,207 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	8,929,411 - 9,007,094 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	8,985,219 - 9,066,118 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	9,061,348 - 9,142,314 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	9,062,300 - 9,142,399 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	8,982,300 - 9,063,077 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	9,086,292 - 9,167,405 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	9,221,076 - 9,302,003 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ehd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	87,357,122 - 87,446,445 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	5,205,183 - 5,294,557 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	5,205,185 - 5,294,507 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EHD4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	129,374,613 - 129,458,686 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	129,374,515 - 129,460,206 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	144,621,574 - 144,641,532 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EHD4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	41,012,296 - 41,085,738 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	41,012,991 - 41,089,182 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666048	99,916,538 - 99,989,971 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ehd4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624804	9,053,321 - 9,128,281 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624804	9,052,857 - 9,128,141 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ehd4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	98,241,856 - 98,306,061 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ehd4
312 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	479
Count of miRNA genes:	251
Interacting mature miRNAs:	298
Transcripts:	ENSRNOT00000010701
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	96509147	141509147	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	73592512	136118980	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	73592512	136118980	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	67641776	167835660	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	58601291	153936591	Rat
1582216	Bw65	Body weight QTL 65	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	122654702	136118980	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	49872657	138829559	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	73592512	136118980	Rat
1582219	Bw63	Body weight QTL 63	3.8	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	3	116582412	136118980	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	85062224	136118980	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	85062224	136118980	Rat
7387306	Bw124	Body weight QTL 124	3.2	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	3	104545086	149545086	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	81425008	141509147	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	70845569	136091483	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	3	93829559	138829559	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	112250810	157250810	Rat
2302273	Gluco35	Glucose level QTL 35	5.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	101255536	134750886	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	79649560	177741895	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	67641995	130815812	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	96509147	141509147	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	117537367	162537367	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	125116475	170116475	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	110225882	155225882	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	90755164	141509147	Rat
5686842	Rf59	Renal function QTL 59			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	3	122395989	167395989	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	1	141509147	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	98651826	167012663	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	125814931	139636791	Rat
1331758	Bp207	Blood pressure QTL 207	2.848		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	110634702	155634702	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	5675975	141509147	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	67641995	130815812	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	116188400	161188400	Rat

Markers in Region

BI284307

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	107,058,419 - 107,058,593 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	111,878,082 - 111,878,255	NCBI	Rnor6.0
Rnor_5.0	3	118,425,849 - 118,426,022	UniSTS	Rnor5.0
RGSC_v3.4	3	106,595,160 - 106,595,333	UniSTS	RGSC3.4
Celera	3	105,967,313 - 105,967,486	UniSTS
RH 3.4 Map	3	935.49	UniSTS
Cytogenetic Map	3	q35	UniSTS

BI278840

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	107,058,186 - 107,058,338 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	111,877,849 - 111,878,000	NCBI	Rnor6.0
Rnor_5.0	3	118,425,616 - 118,425,767	UniSTS	Rnor5.0
RGSC_v3.4	3	106,594,927 - 106,595,078	UniSTS	RGSC3.4
Celera	3	105,967,080 - 105,967,231	UniSTS
RH 3.4 Map	3	935.49	UniSTS
Cytogenetic Map	3	q35	UniSTS

RH134817

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	107,059,143 - 107,059,326 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	111,878,806 - 111,878,988	NCBI	Rnor6.0
Rnor_5.0	3	118,426,573 - 118,426,755	UniSTS	Rnor5.0
RGSC_v3.4	3	106,595,884 - 106,596,066	UniSTS	RGSC3.4
Celera	3	105,968,037 - 105,968,219	UniSTS
RH 3.4 Map	3	921.9	UniSTS
Cytogenetic Map	3	q35	UniSTS

RH139179

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	107,059,866 - 107,059,988 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	111,879,529 - 111,879,650	NCBI	Rnor6.0
Rnor_5.0	3	118,427,296 - 118,427,417	UniSTS	Rnor5.0
RGSC_v3.4	3	106,596,607 - 106,596,728	UniSTS	RGSC3.4
Celera	3	105,968,760 - 105,968,881	UniSTS
RH 3.4 Map	3	934.8	UniSTS
Cytogenetic Map	3	q35	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_139324	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063283055	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY094093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC083175	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ227831	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232475	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000010701 ⟹ ENSRNOP00000010701

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	127,511,954 - 127,576,072 (-)	Ensembl
mRatBN7.2 Ensembl	3	107,058,958 - 107,122,002 (-)	Ensembl
Rnor_6.0 Ensembl	3	111,877,853 - 111,941,841 (-)	Ensembl

RefSeq Acc Id:

NM_139324 ⟹ NP_647540

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	127,511,973 - 127,575,763 (-)	NCBI
mRatBN7.2	3	107,058,191 - 107,121,985 (-)	NCBI
Rnor_6.0	3	111,877,853 - 111,941,841 (-)	NCBI
Rnor_5.0	3	118,425,620 - 118,489,608 (-)	NCBI
RGSC_v3.4	3	106,594,931 - 106,658,722 (-)	RGD
Celera	3	105,967,084 - 106,030,732 (-)	RGD

Sequence:

show sequence

GGCAAGTTGTCGGGCGGCGGCATGTTCAGCTGGATGGGGCGGCAGGCGGGCGGGCGCGAGCGCT
CGGGCGGTATGGACGCGGTGCAGACGGTGACGGGAGGCCTGCGCTCACTCTACCAACGCAAGGT
GCTGCCGCTGGAAGAGGCGTACCGCTTCCACGAGTTCCACTCGCCAGCGCTGGAGGACGCCGAC
TTCGAAAACAAGCCCATGATCCTGCTGGTGGGCCAGTACAGCACGGGCAAGACCACTTTCATCA
GATACTTACTGGAGCAAGATTTCCCAGGCATGAGAATTGGTCCAGAGCCAACCACAGATTCCTT
CATTGCTGTGATGTATGGGGAGACCGAGGGAAGTACCCCTGGGAATGCTTTAGTTGTGGATCCC
AAAAAGCCATTCCGAAAGCTCAGTCGCTTTGGAAATGCTTTCCTGAACAGATTCATGTGCTCAC
AGCTGCCCAACCAGGTTCTGAAGAGCATCAGCATCATCGACAGTCCTGGCATCCTGTCTGGGGA
AAAGCAGCGCATTAGCCGAGGGTATGACTTCTGCCAGGTCTTACAGTGGTTTGCCGAGAGGGTT
GACAGGATCATCCTGCTCTTTGATGCTCACAAATTGGACATCTCAGATGAGTTCTCAGAGGCGA
TCAAAGCCTTCCGGGGCCAGGATGACAAAATCCGAGTGGTACTGAACAAGGCTGACCAAGTGGA
CACACAGCAGCTGATGCGAGTCTATGGGGCCCTCATGTGGTCTCTGGGTAAGGTCATCAACACA
CCCGAAGTACTTCGAGTCTACATTGGCTCCTTTTGGGCACAGCCTCTGCAGAATACAGACAACC
GCCGGCTCTTTGAGGCTGAAGCACAGGACCTCTTCAGAGACATCCAGAGCCTGCCCCAGAAGGC
TGCAGTGCGCAAACTCAATGACCTCATCAAGCGAGCAAGGTTGGCCAAAGTCCACGCCTACATC
ATCAGCTACCTGAAGAAGGAAATGCCCAGTATGTTTGGAAAAGAAAATAAGAAGCGAGAACTTA
TCTTCAGACTTCCAGAAATCTATGTTCAGCTGCAGCGAGAATACCAGATTTCTGCAGGGGACTT
CCCTGAGGTCAAGGCCATGCAGGAGCAGCTTGAGAACTATGACTTCACCAAGTTCCACTCACTG
AAGCCCAAGCTGATCGAGGCTGTGGACAACATGCTGACCAACAAGATCTCATCCCTGATGAGCC
TCATTAGCCAGGAGGAGATGAACATGCCCACGCAAATGGTGCAGGGTGGTGCCTTCGATGGCAC
CACAGAGGGGCCCTTCAACCAGGGCTATGGGGAGGGAGCCAAGGAGGGTGCTGATGAGGAAGAG
TGGGTCGTGGCTAAAGACAAGCCTGTGTATGATGAACTCTTTTATACACTGTCACCCATCAATG
GCAAGATATCAGGTGTCAATGCCAAGAAGGAAATGGTGACCTCCAAGCTGCCCAACAGTGTCCT
GGGCAAGATCTGGAAGCTGGCCGACTGTGACTGCGATGGCATGCTGGACGAAGAGGAGTTTGCA
CTGGCCAAGCACCTCATCAAGATCAAGTTGGATGGCTATGAGCTCCCAAACAGCCTGCCCCCTC
ACCTTGTGCCCCCCTCGCACAGGAAGTCCCTGCCAAAGGCTGACTGAGAGTACAGAGCTGGGAT
GGGAGGGGTGGTGCCTGGGCCTGAAGTCTGCTCTGCCACTGACTTGCTGAATGTCCTTGGCCAA
GATTCTGTCCTCTCCGTGGCTCAGTTTCCTCATATGTAGGGCAGGGAGGGCAGATTCTGGACAC
TAGATAATGTCCTTATACCTCTAAAGTCCCTAAGTTTCTATCAAAATATTAAGAAGACAAAAAA
TAAAAAAAAATTAAGAAGAGCAATATATAGATATGAAGATAAAGGTCTAAGAAGAAAAAGAAAT
TATCCAAAGAATATAGGTGTGACACAGGCTGGCGAACTCTGGGGACTCAGGGAGTGAGGAAGCT
CATTGGAGTCTTCAGGGCTGTGCTGGACAGTTCATTACCATGAACCTCTGTCCTTCACAGGCAC
TGAGAGGCGGCAAATGACCTAATTTATTTTTCTTACTGTGTTTCCTGCTCTAGCTAGAGAGGGA
ACAGAGCAGAGAGCTTCTGCTCTCCACAGACTGACACCAAAGAGAAGACTAATCCCCAGGTTTG
AAAGAGGATGTGCCATGTCTGTGGGCCATCTGCAGCCCCCAGCAGAGTAGGCAGCCAGGCCAGG
AGAGCCAGTGTTGTCCCAGCACCTGCTGCCTGATCCTGCCAAGCCTCCCGCTCAGCAAAGTCGG
AATTCACAAACTGTGGCCCCCTGGAAGACCTTTAGACCTCAAATCACGCTGAAGCCCGGGCACT
GCCTCCTTGCATTTCATCCATAGGTTACAGCAGAGCTAATTTATCAGACGTAAGGAAAGAGACA
GTTCCTGTCTGTCACTAAGTGTGCCCTTTGACCACTGAATGTCCCAAGGCTTTTGGGTAGGTGG
TAGAATTTAAATTCAATAGAGCCATGTCTTGATTTGTGTGGAGTCCCAGAGCCTTTGGACCCAA
GTAAAGAGACCAGCCCCATCCTGAGCCATCAATGGAAGAGATCAGTGTCTTGGTATTGATGCTT
TGGTTTGATTTTTAAAGAAAAAAATGCATTTTATTGTGTCCAGTTGTGTTTTTCTCACACAATG
AAGCCTGTGCAGAAATCTCTCTTGTAACACCTTTTCTTCCAAGCTTATACACTTCACATCAGGA
GTGCCCATCTGGGGCCAGGATCAGGCTGCTTCTGACTGCTCAGTGTTCTCTCCCAAGCCCTTGA
ATTTCTCTGCCCCACTTATTCAGGCACAGGGGCTGCTTCTACTGTACCCTGCTCTGGGCACAGC
TGAGGAGCACTGTCACCATCACTTGACAAAGCAGGAGTCACAGCACAGCAGTGACCACATGGCC
CAGCCCCAACAGCACCAGAAATGAATGAATGTGAACCTTCACAAAAACACTCCAACCCCTAATT
GTTTGCCTCTGGCAACCTCAGGGTCAGAACCAGTGACAAGAGAAAATGCTAGAAGCTCACCCCT
GTTATCCCAGCACTTGAGAGGCAAATGGAGGGGGATTACCATGAGTTCGAAGCCAGCCTGAGCT
ACATCCTTAGTGTTATGGTAGTCTGTGTAAAACAAGAGTACTTACGTCATCACTCACGGTTCCC
TATCTTACTGTCTAAATAATTGCTCTAAGAGAAACATGGTGCCCTTTACTCTGAAAGCATGTCT
TACTAATTGGACACACACAGGTGAACATTTGATCCTGGGGCTGTAACTGAATGTGGGCATTTTT
GTGGTGTGAAGACCCTGGTGTCCACAGAGTGGTGATGCCTTGGGGCTGCCTTTCCTCCCAAGTG
TCTTCTGCTTTCTCTGCACAGTTGGCATATATCTACCCTCGTGCCG

hide sequence

RefSeq Acc Id:

XM_063283055 ⟹ XP_063139125

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	127,522,448 - 127,575,856 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_647540	(Get FASTA)	NCBI Sequence Viewer
	XP_063139125	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH83175	(Get FASTA)	NCBI Sequence Viewer
	AAM09109	(Get FASTA)	NCBI Sequence Viewer
	EDL79933	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000010701
	ENSRNOP00000010701.4

RefSeq Acc Id:

NP_647540 ⟸ NM_139324

- UniProtKB:

Q8R3Z7 (UniProtKB/TrEMBL), F7F1H3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFSWMGRQAGGRERSGGMDAVQTVTGGLRSLYQRKVLPLEEAYRFHEFHSPALEDADFENKPMI
LLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMYGETEGSTPGNALVVDPKKPFRKL
SRFGNAFLNRFMCSQLPNQVLKSISIIDSPGILSGEKQRISRGYDFCQVLQWFAERVDRIILLF
DAHKLDISDEFSEAIKAFRGQDDKIRVVLNKADQVDTQQLMRVYGALMWSLGKVINTPEVLRVY
IGSFWAQPLQNTDNRRLFEAEAQDLFRDIQSLPQKAAVRKLNDLIKRARLAKVHAYIISYLKKE
MPSMFGKENKKRELIFRLPEIYVQLQREYQISAGDFPEVKAMQEQLENYDFTKFHSLKPKLIEA
VDNMLTNKISSLMSLISQEEMNMPTQMVQGGAFDGTTEGPFNQGYGEGAKEGADEEEWVVAKDK
PVYDELFYTLSPINGKISGVNAKKEMVTSKLPNSVLGKIWKLADCDCDGMLDEEEFALAKHLIK
IKLDGYELPNSLPPHLVPPSHRKSLPKAD

hide sequence

Ensembl Acc Id:

ENSRNOP00000010701 ⟸ ENSRNOT00000010701

RefSeq Acc Id:	XP_063139125 ⟸ XM_063283055
- Peptide Label:	isoform X1

Protein Domains

Dynamin-type G EF-hand EH

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8R3Z7-F1-model_v2	AlphaFold	Q8R3Z7	1-541	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692338

Promoter ID:

EPDNEW_R2862

Type:

initiation region

Name:

Ehd4_1

Description:

EH-domain containing 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	111,941,871 - 111,941,931	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628883	AgrOrtholog
BioCyc Gene	G2FUF-48182	BioCyc
Ensembl Genes	ENSRNOG00000007584	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000010701	ENTREZGENE
	ENSRNOT00000010701.6	UniProtKB/TrEMBL
Gene3D-CATH	1.10.268.20	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
	EF-hand	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7105816	IMAGE-MGC_LOAD
InterPro	DUF5600	UniProtKB/TrEMBL
	Dynamin_N	UniProtKB/TrEMBL
	EF-hand-like_dom	UniProtKB/TrEMBL
	EF_Hand_1_Ca_BS	UniProtKB/TrEMBL
	EF_hand_Ca-bd	UniProtKB/TrEMBL
	EHD_N	UniProtKB/TrEMBL
	EPS15_homology	UniProtKB/TrEMBL
	G_DYNAMIN_dom	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
KEGG Report	rno:192204	UniProtKB/TrEMBL
MGC_CLONE	MGC:91469	IMAGE-MGC_LOAD
NCBI Gene	192204	ENTREZGENE
PANTHER	DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D	UniProtKB/TrEMBL
	EH DOMAIN	UniProtKB/TrEMBL
Pfam	DUF5600	UniProtKB/TrEMBL
	Dynamin_N	UniProtKB/TrEMBL
	EF-hand_4	UniProtKB/TrEMBL
	EHD_N	UniProtKB/TrEMBL
PhenoGen	Ehd4	PhenoGen
PROSITE	EF_HAND_1	UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/TrEMBL
	G_DYNAMIN_2	UniProtKB/TrEMBL
	PS50031	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000007584	RatGTEx
SMART	SM00027	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47473	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	F7F1H3	ENTREZGENE, UniProtKB/TrEMBL
	Q5XJW5_RAT	UniProtKB/TrEMBL
	Q8R3Z7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Ehd4	EH-domain containing 4		pincher	Name updated	1299863	APPROVED
2003-02-27	Ehd4	pincher			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_mutations_overexpression	overexpression ultimately leads to mediated TrkA-erk5 mitogen-activated protein kinase signaling	632501
gene_regulation	NGF-induced	632501

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)