Oas1a (2'-5' oligoadenylate synthetase 1A)

Gene: Oas1a (2'-5' oligoadenylate synthetase 1A) Rattus norvegicus

Analyze

Symbol:

Oas1a

Name:

2'-5' oligoadenylate synthetase 1A

RGD ID:

621760

Description:

Enables 2'-5'-oligoadenylate synthetase activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; regulation of cytokine production; and regulation of innate immune response. Located in nucleus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human OAS1 (2'-5'-oligoadenylate synthetase 1); PARTICIPATES IN hepatitis C pathway; influenza A pathway; measles pathway; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; Actein; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

(2-5')oligo(A) synthase 1; (2-5')oligo(A) synthase 1A; (2-5')oligo(A) synthetase 1; 2',5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5' oligoadenylate synthetase 1G; 2'-5'-oligoadenylate synthase 1; 2'-5'-oligoadenylate synthase 1A; 2'-5'-oligoadenylate synthetase 1; 2-5A synthase 1; 2-5A synthase 1A; 2-5A synthetase 1; 25 oligoadenylate synthetase; MGC93097; Oas1; Oas1g

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	41,330,423 - 41,341,130 (+)	NCBI		GRCr8
mRatBN7.2	12	35,669,798 - 35,680,505 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	35,669,801 - 35,680,517 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	36,848,682 - 36,859,311 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	37,459,883 - 37,470,514 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	36,512,331 - 36,522,962 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	41,200,680 - 41,211,393 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	41,200,718 - 41,211,909 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	43,064,691 - 43,075,400 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	36,806,061 - 36,816,722 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	36,669,448 - 36,680,110 (+)	NCBI
Celera	12	37,333,307 - 37,343,967 (+)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

genetic disease (ISO)

Human Influenza (ISO)

IMMUNODEFICIENCY 100 WITH PULMONARY ALVEOLAR PROTEINOSIS AND HYPOGAMMAGLOBULINEMIA (ISO)

viral infectious disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-alpha-phellandrene (ISO)

(-)-epigallocatechin 3-gallate (ISO)

(S)-nicotine (ISO)

1,2-dichloroethane (ISO)

1-nitropyrene (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-Nitrobenzanthrone (ISO)

4,4'-sulfonyldiphenol (ISO)

6alpha-methylprednisolone (ISO)

acetylsalicylic acid (ISO)

Actein (EXP)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

alpha-phellandrene (ISO)

aluminium atom (ISO)

aluminium(0) (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

ATP (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

carnosic acid (ISO)

ciglitazone (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

D-glucose (ISO)

dexamethasone (ISO)

diclofenac (ISO)

dimethylarsinous acid (ISO)

dioxygen (EXP)

doxorubicin (ISO)

epoxiconazole (ISO)

formaldehyde (ISO)

fructose (ISO)

glucose (ISO)

hydroquinone (ISO)

isotretinoin (ISO)

leflunomide (ISO)

lipopolysaccharide (ISO)

methotrexate (ISO)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

niclosamide (ISO)

nicotine (ISO)

ozone (EXP)

paracetamol (EXP,ISO)

pentanal (ISO)

perfluorooctanoic acid (ISO)

poly(I:C) (ISO)

potassium chromate (ISO)

prednisolone (ISO)

progesterone (ISO)

propanal (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

ribavirin (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

serpentine asbestos (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium aurothiomalate (ISO)

sodium fluoride (EXP)

sotorasib (ISO)

succimer (ISO)

tamibarotene (ISO)

tamoxifen (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

thalidomide (ISO)

tofacitinib (ISO)

trametinib (ISO)

trichloroethene (EXP)

triptonide (ISO)

valproic acid (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to interferon-alpha (ISO)

cellular response to interferon-beta (ISO)

defense response to virus (IBA,IEA)

glucose homeostasis (ISO)

glucose metabolic process (ISO)

innate immune response (IEA)

interleukin-27-mediated signaling pathway (ISO)

negative regulation of chemokine (C-X-C motif) ligand 2 production (ISO)

negative regulation of IP-10 production (ISO)

negative regulation of type I interferon-mediated signaling pathway (ISO)

negative regulation of viral genome replication (IBA,IEA,ISO)

positive regulation of cellular respiration (ISO)

positive regulation of interferon-beta production (ISO)

positive regulation of monocyte chemotactic protein-1 production (ISO)

positive regulation of tumor necrosis factor production (ISO)

protein complex oligomerization (ISO)

purine nucleotide biosynthetic process (ISS)

response to virus (ISO,TAS)

surfactant homeostasis (ISO)

toll-like receptor 3 signaling pathway (ISO)

toll-like receptor 4 signaling pathway (ISO)

type I interferon-mediated signaling pathway (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (IBA,IEA,ISO)

endoplasmic reticulum (IEA)

membrane (IBA,IEA)

mitochondrion (IEA,ISO)

nucleoplasm (IBA,IEA,ISO)

nucleus (IDA,ISO)

ribosome (ISO)

Molecular Function

2'-5'-oligoadenylate synthetase activity (IBA,IDA,IEA,ISO)

ATP binding (IEA)

double-stranded RNA binding (IBA,IEA,ISO,ISS)

metal ion binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

hepatitis C pathway (IEA)

influenza A pathway (IEA)

measles pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Characterization of oligoadenylate synthetase-1 expression in rat mammary gland and prostate: effects of 17beta-estradiol on the regulation of OAS1g in both tissues.	Maia CJ, etal., Mol Cell Biochem. 2008 Jul;314(1-2):113-21. doi: 10.1007/s11010-008-9771-z. Epub 2008 Apr 18.
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla.	Perelygin AA, etal., J Mol Evol. 2006 Oct;63(4):562-76. Epub 2006 Oct 5.
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Transgenic potato plants expressing mammalian 2'-5' oligoadenylate synthetase are protected from potato virus X infection under field conditions.	Truve E, etal., Biotechnology (N Y) 1993 Sep;11(9):1048-52.

Additional References at PubMed

PMID:3753689	PMID:3754863	PMID:6654863	PMID:11682059	PMID:12477932	PMID:12799444	PMID:12892903	PMID:18931074	PMID:19923450	PMID:20844035	PMID:21245038	PMID:23319625
PMID:23575436	PMID:25930096	PMID:28146100	PMID:30822544

Genomics

Comparative Map Data

Oas1a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	41,330,423 - 41,341,130 (+)	NCBI		GRCr8
mRatBN7.2	12	35,669,798 - 35,680,505 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	35,669,801 - 35,680,517 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	36,848,682 - 36,859,311 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	37,459,883 - 37,470,514 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	36,512,331 - 36,522,962 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	41,200,680 - 41,211,393 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	41,200,718 - 41,211,909 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	43,064,691 - 43,075,400 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	36,806,061 - 36,816,722 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	36,669,448 - 36,680,110 (+)	NCBI
Celera	12	37,333,307 - 37,343,967 (+)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

OAS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	112,906,962 - 112,933,219 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	112,905,856 - 112,933,219 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	113,344,767 - 113,371,024 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	111,829,122 - 111,842,095 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	111,807,531 - 111,820,427	NCBI
Celera	12	112,971,828 - 112,984,801 (+)	NCBI		Celera
Cytogenetic Map	12	q24.13	NCBI
HuRef	12	110,357,341 - 110,370,314 (+)	NCBI		HuRef
CHM1_1	12	113,313,139 - 113,326,112 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	112,883,649 - 112,909,905 (+)	NCBI		T2T-CHM13v2.0

Oas1g
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	121,014,205 - 121,025,676 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	121,014,205 - 121,025,676 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	120,876,142 - 120,887,613 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	120,876,142 - 120,887,613 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	121,326,151 - 121,337,607 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	121,136,759 - 121,148,215 (-)	NCBI		MGSCv36	mm8
Celera	5	117,962,394 - 117,973,852 (-)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	60.65	NCBI

OAS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	120,996,177 - 121,009,992 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	120,992,579 - 121,006,388 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	110,511,984 - 110,525,343 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	113,896,687 - 113,922,082 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	113,896,760 - 113,921,814 (+)	Ensembl	panpan1.1		panPan2

OAS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	10,385,393 - 10,396,734 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	10,385,447 - 10,396,733 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	10,503,053 - 10,513,130 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	10,624,806 - 10,636,143 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	10,624,845 - 10,638,025 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	10,598,606 - 10,608,681 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	10,661,801 - 10,671,881 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	10,710,236 - 10,720,322 (+)	NCBI		UU_Cfam_GSD_1.0

OAS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	38,851,918 - 38,859,409 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	38,851,083 - 38,867,427 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	41,260,747 - 41,268,627 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

OAS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	108,163,203 - 108,176,191 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	108,163,299 - 108,176,193 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	136,898,457 - 136,923,042 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Oas1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	19,428,833 - 19,434,550 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	19,428,994 - 19,434,512 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Oas1a
187 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	363
Count of miRNA genes:	168
Interacting mature miRNAs:	181
Transcripts:	ENSRNOT00000038426, ENSRNOT00000048450, ENSRNOT00000057279, ENSRNOT00000067176
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411660	Foco28	Food consumption QTL 28	10.9	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
9590086	Insglur6	Insulin/glucose ratio QTL 6	18.97	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	12	1	42110980	Rat
8694179	Bw150	Body weight QTL 150	2.9	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
7411586	Foco5	Food consumption QTL 5	5.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411595	Foco9	Food consumption QTL 9	4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411545	Bw128	Body weight QTL 128	5.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
9590147	Scort7	Serum corticosterone level QTL 7	13.61	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	12	1	42110980	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	1	42450532	Rat
737979	Pia22	Pristane induced arthritis QTL 22	53.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	1	44465750	Rat
634351	Apr5	Acute phase response QTL 5	6.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	12	1	44503507	Rat
2302042	Pia38	Pristane induced arthritis QTL 38	3.5	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	1	44503507	Rat
634350	Apr4	Acute phase response QTL 4	6		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	1172005	46172005	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	5564495	46669029	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564498	46669029	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	6107579	46669029	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	7196730	46669029	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	9603277	46669029	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	10474137	46669029	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	10474137	46669029	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	11073825	45055165	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	12351619	46669029	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	12812385	46669029	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	12812385	46669029	Rat
1549902	Bp269	Blood pressure QTL 269			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	13182736	46669029	Rat
1549912	Bp268	Blood pressure QTL 268			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	13182736	46669029	Rat
2302060	Pia37	Pristane induced arthritis QTL 37	6.1	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	13198157	46669029	Rat
61421	Cia12	Collagen induced arthritis QTL 12	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	13635523	35682913	Rat
631543	Bp83	Blood pressure QTL 83	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	15550826	38478808	Rat
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	19144362	46669029	Rat
737822	Alc10	Alcohol consumption QTL 10	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	19610870	40218516	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	19610870	42828880	Rat
61324	Eae5	Experimental allergic encephalomyelitis QTL 5	14		nervous system integrity trait (VT:0010566)	percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)	12	19610870	46669029	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	19610889	35682913	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	19835789	38193007	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	20328819	46669029	Rat
70169	Eae13	Experimental allergic encephalomyelitis QTL 13		0.032	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	12	24139202	36638073	Rat
1556747	Calcic1	Intracellular calcium level QTL 1		3.6	platelet calcium amount (VT:0010500)	platelet intracellular calcium level (CMO:0000922)	12	28064433	40130419	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	28064433	45899022	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	28064433	46669029	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	28064557	40218380	Rat
631829	Alc6	Alcohol consumption QTL 6	4.7		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	28607526	37691617	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	32103174	45899022	Rat

Markers in Region

RH129983

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	35,680,351 - 35,680,501 (+)	MAPPER	mRatBN7.2
mRatBN7.2	12	35,680,351 - 35,680,501 (-)	MAPPER	mRatBN7.2
Rnor_6.0	12	41,293,807 - 41,293,956	NCBI	Rnor6.0
Rnor_6.0	12	41,211,240 - 41,211,389	NCBI	Rnor6.0
Rnor_5.0	12	43,152,978 - 43,153,127	UniSTS	Rnor5.0
Rnor_5.0	12	43,075,247 - 43,075,396	UniSTS	Rnor5.0
RGSC_v3.4	12	36,896,820 - 36,896,969	UniSTS	RGSC3.4
RGSC_v3.4	12	36,816,573 - 36,816,722	UniSTS	RGSC3.4
Celera	12	37,343,818 - 37,343,967	UniSTS
Celera	12	37,425,280 - 37,425,429	UniSTS
RH 3.4 Map	12	621.5	UniSTS
Cytogenetic Map	12	q16	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			5	5	8	5					13	9
Low	3	21	42	26	11	26	6	8	41	15	26	2	6
Below cutoff		20	10	10		10	2	3	31	20	2		2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_138913	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006249382	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC098508	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY221507	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC086979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231421	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231433	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232784	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	Z18877	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000038426 ⟹ ENSRNOP00000036734

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	35,669,801 - 35,680,501 (+)	Ensembl
Rnor_6.0 Ensembl	12	41,200,718 - 41,211,909 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000041741 ⟹ ENSRNOP00000048411

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	35,669,801 - 35,680,517 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000048450 ⟹ ENSRNOP00000040841

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	35,669,835 - 35,680,501 (+)	Ensembl
Rnor_6.0 Ensembl	12	41,200,729 - 41,211,389 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000067176 ⟹ ENSRNOP00000059183

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	35,669,801 - 35,679,657 (+)	Ensembl
Rnor_6.0 Ensembl	12	41,200,776 - 41,210,449 (+)	Ensembl

RefSeq Acc Id:

NM_138913 ⟹ NP_620268

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	41,330,466 - 41,341,126 (+)	NCBI
mRatBN7.2	12	35,669,835 - 35,680,501 (+)	NCBI
Rnor_6.0	12	41,200,729 - 41,211,389 (+)	NCBI
Rnor_5.0	12	43,064,691 - 43,075,400 (+)	NCBI
RGSC_v3.4	12	36,806,061 - 36,816,722 (+)	RGD
Celera	12	37,333,307 - 37,343,967 (+)	RGD

Sequence:

show sequence

CCGCGCGAGACACAGGACCTGCAGGCTGCAGAGGCAAAAGCTCCGGAGGTCATGGAGCAGGAAC
TCAGGAGCACCCCGTCCTGGAAGCTGGACAAGTTCATAGAGGTTTACCTCCTTCCAAACACCAG
CTTCCGTGATGATGTCAAATCAGCTATCAATGTCCTGTGTGATTTCCTGAAGGAGAGATGCTTC
CGAGATACTGTCCACCCAGTGAGGGTCTCCAAGGTGGTGAAGGGTGGCTCCTCAGGCAAAGGCA
CCACACTCAAGGGCAAGTCAGACGCTGACCTGGTGGTGTTCCTTAACAATTTCACCAGCTTTGA
GGATCAGTTAAACAGACGGGGAGAGTTCATCAAGGAAATTAAGAAACAGCTGTATGAGGTTCAG
CGTGAAAAACATTTTAGAGTGAAGTTTGAGGTCCAGAGTTCATGGTGGCCCAACCCCCGGGCTC
TGAGCTTCAAGCTGAGTGCACCACACCTCCAACAGGAGGTGGAGTTTGATGTGCTTCCAGCCTA
TGATGTCCTAGGTCATGTTAGCCTCTACAGCAATCCTGATCCCAAGATCTACACCATCCTCATC
TCCGAATGTATCTCCCTGGGGAAGGATGGCGAGTTCTCTACCTGCTTCACGGAGCTCCAGAGGA
ACTTCCTGAAGCAGCGCCCAACCAAGCTGAAGAGTCTCATCCGCCTGGTCAAGCACTGGTACCA
ACTGTGTAAGGAGAAGCTGGGGAAGCCGCTGCCCCCACAGTACGCCCTGGAGCTGCTCACGGTC
TATGCCTGGGAACGTGGAAATGGAATTACTGAGTTCAACACAGCTCAGGGCTTCCGGACAATCT
TGGAACTGGTCACAAAGTACCAGCAGCTTCGAATCTACTGGACAAAGTATTATGACTTTCAACA
CCCAGATGTCTCCAAATACCTACACAGACAGCTCAGAAAATCCAGGCCTGTGATCCTGGACCCT
GCTGACCCAACAGGGAACGTGGCTGGTGGGAACCAAGAAGGCTGGCGGCGGTTGGCCTCAGAGG
CGAGGCTGTGGCTGCAGTACCCATGTTTTATGAACAGGGGTGGTTCCCCAGTGAGTTCCTGGGA
AGTGCCGGTGGATGAGGCCTGGTCATGCATCCTGCTGTGAACCCAGCAGCACCAGCCCAGGAGG
CTCCGGAGTCAGGGGCACGTGCTGCTCTGCTGCAGGACCTTGACACAGTGAGGGAGGCCCCACT
CGGGATCACAGTCCATGCTTCTGATGCCCGCCCGCCATGTTTGAATACTGTCCAATCACAGACA
GCCTTCCTCAACAGATTCAGAAGGGGCGGAAAGAACTCAAGCTTGACTTCCATCTGACCGTCCA
CCTGTTGGGAGGTTCTGTCCAACCATGTCTGTCAACAACAATAAAGTACAGCAGGTGCC

hide sequence

RefSeq Acc Id:

XM_006249382 ⟹ XP_006249444

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	41,330,423 - 41,341,130 (+)	NCBI
mRatBN7.2	12	35,669,798 - 35,680,505 (+)	NCBI
Rnor_6.0	12	41,200,680 - 41,211,393 (+)	NCBI
Rnor_5.0	12	43,064,691 - 43,075,400 (+)	NCBI

Sequence:

show sequence

CCTCTCGGGAAATGGAAACTGAAAATCTTGTTCCAAGTTCAACCAGGCTGCGAGACACAGGACC
TGCAGGCTGCAGAGGCAAAAGCTCCGGAGGTCATGGAGCAGGAACTCAGGAGCACCCCGTCCTG
GAAGCTGGACAAGTTCATAGAGGTTTACCTCCTTCCAAACACCAGCTTCCGTGATGATGTCAAA
TCAGCTATCAATGTCCTGTGTGATTTCCTGAAGGAGAGATGCTTCCGAGATACTGTCCACCCAG
TGAGGGTCTCCAAGGTGGTGAAGGGCGGCTCCTCAGGCAAAGGCACCACACTCAAGGGCAAGTC
AGACGCTGACCTGGTGGTGTTCCTTAACAATTTCACCAGCTTTGAGGATCAGTTAAACAGACGG
GGAGAGTTCATCAAGGAAATTAAGAAACAGCTGTATGAGGTTCAGCGTGAAAAACATTTTAGAG
TGAAGTTTGAGGTCCAGAGTTCATGGTGGCCCAACCCCCGGGCTCTGAGCTTCAAGCTGAGTGC
ACCACACCTCCAACAGGAGGTGGAGTTTGATGTGCTTCCAGCCTATGATGTCCTAGGTCATGTT
AGCCTCTACAGCAATCCTGATCCCAAGATCTACACCATCCTCATCTCCGAATGTATCTCCCTGG
GGAAGGAGGGCGAGTTCTCTACCTGCTTCACGGAGCTCCAGAGGAACTTCCTGAAGCAGCGCCC
AACCAAGCTTAAGAGTCTCATCCGCCTGGTCAAGCACTGGTACCAACTGTGTAAGGAGAAGCTG
GGGAAGCCGCTGCCCCCACAGTACGCCCTGGAGCTGCTCACGGTCTATGCCTGGGAACGTGGAA
ATGGAATTACTGAGTTCAACACAGCTCAGGGCTTCCGGACAATCTTGGAACTGGTCACAAAGTA
CCAGCAGCTTCGAATCTACTGGACAAAGTATTATGACTTTCAACACCCAGATGTCTCCAAATAC
CTACACAGACAGCTCAGAAAATCCAGGCCTGTGATCCTGGACCCTGCTGACCCAACAGGGAACG
TGGCTGGTGGGAACCAAGAAGGCTGGCGGCGGTTGGCCTCAGAGGCGAGGCTGTGGCTGCAGTA
CCCATGTTTTATGAACAGGGGTGGTTCCCCAGTGAGCTCCTGGGAAGTGCCGACAGAGGTTCCT
GTGCCTTCAGAGCAGGTGGATGAGGCCTGGTCATGCATCCTGCTGTGAACCCAGCAGCACCAGC
CCAGGAGGCTCCGGAGTCAGGGGCACGTGCTGCTCTGCTGCAGGACCTTGACACAGTGAGGGAG
GGCCCCACTCGGGATCACAGTCCATGCTTCTGATGCCCGCCCGCCATGTTTGAATACTGTCCAA
TCACAGACAGCCTTCCTCAACAGATTCAGAAGGGGCGGAAAGAACTCAAGCTTGACTTCCATCT
GACCGTCCACCTGTTGGGAGGTTCTGTCCAACCATGTCTGTCAACAACAATAAAGTACAGCAGG
TGCCATAA

hide sequence

RefSeq Acc Id:

XM_063271037 ⟹ XP_063127107

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	41,330,461 - 41,341,130 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_620268	(Get FASTA)	NCBI Sequence Viewer
	XP_006249444	(Get FASTA)	NCBI Sequence Viewer
	XP_063127107	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH86979	(Get FASTA)	NCBI Sequence Viewer
	AAP50499	(Get FASTA)	NCBI Sequence Viewer
	CAA79317	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000036734
	ENSRNOP00000036734.5
	ENSRNOP00000040841
	ENSRNOP00000040841.2
	ENSRNOP00000048411.4
	ENSRNOP00000059183.4
GenBank Protein	Q05961	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_620268 ⟸ NM_138913

- UniProtKB:

Q05961 (UniProtKB/Swiss-Prot), G3V9A4 (UniProtKB/TrEMBL), A6J1H0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEQELRSTPSWKLDKFIEVYLLPNTSFRDDVKSAINVLCDFLKERCFRDTVHPVRVSKVVKGGS
SGKGTTLKGKSDADLVVFLNNFTSFEDQLNRRGEFIKEIKKQLYEVQREKHFRVKFEVQSSWWP
NPRALSFKLSAPHLQQEVEFDVLPAYDVLGHVSLYSNPDPKIYTILISECISLGKDGEFSTCFT
ELQRNFLKQRPTKLKSLIRLVKHWYQLCKEKLGKPLPPQYALELLTVYAWERGNGITEFNTAQG
FRTILELVTKYQQLRIYWTKYYDFQHPDVSKYLHRQLRKSRPVILDPADPTGNVAGGNQEGWRR
LASEARLWLQYPCFMNRGGSPVSSWEVPVDEAWSCILL

hide sequence

RefSeq Acc Id:	XP_006249444 ⟸ XM_006249382
- Peptide Label:	isoform X1
- UniProtKB:	Q05961 (UniProtKB/Swiss-Prot), Q5MYW5 (UniProtKB/TrEMBL), F7EEP6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEQELRSTPSWKLDKFIEVYLLPNTSFRDDVKSAINVLCDFLKERCFRDTVHPVRVSKVVKGGS SGKGTTLKGKSDADLVVFLNNFTSFEDQLNRRGEFIKEIKKQLYEVQREKHFRVKFEVQSSWWP NPRALSFKLSAPHLQQEVEFDVLPAYDVLGHVSLYSNPDPKIYTILISECISLGKEGEFSTCFT ELQRNFLKQRPTKLKSLIRLVKHWYQLCKEKLGKPLPPQYALELLTVYAWERGNGITEFNTAQG FRTILELVTKYQQLRIYWTKYYDFQHPDVSKYLHRQLRKSRPVILDPADPTGNVAGGNQEGWRR LASEARLWLQYPCFMNRGGSPVSSWEVPTEVPVPSEQVDEAWSCILL hide sequence

RefSeq Acc Id:

ENSRNOP00000059183 ⟸ ENSRNOT00000067176

RefSeq Acc Id:

ENSRNOP00000040841 ⟸ ENSRNOT00000048450

RefSeq Acc Id:

ENSRNOP00000036734 ⟸ ENSRNOT00000038426

RefSeq Acc Id:

ENSRNOP00000048411 ⟸ ENSRNOT00000041741

RefSeq Acc Id:	XP_063127107 ⟸ XM_063271037
- Peptide Label:	isoform X2

Protein Domains

2'-5'-oligoadenylate synthetase Polymerase nucleotidyl transferase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q05961-F1-model_v2	AlphaFold	Q05961	1-358	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698663

Promoter ID:

EPDNEW_R9186

Type:

initiation region

Name:

Oas1a_1

Description:

2'-5' oligoadenylate synthetase 1A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	41,200,720 - 41,200,780	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621760	AgrOrtholog
BioCyc Gene	G2FUF-19196	BioCyc
Ensembl Genes	ENSRNOG00000001369	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000038426.7	UniProtKB/TrEMBL
	ENSRNOT00000041741.5	UniProtKB/TrEMBL
	ENSRNOT00000048450	ENTREZGENE
	ENSRNOT00000048450.5	UniProtKB/TrEMBL
	ENSRNOT00000067176.5	UniProtKB/TrEMBL
Gene3D-CATH	2'-5'-oligoadenylate synthetase 1, domain 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.460.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7191865	IMAGE-MGC_LOAD
InterPro	2-5-oligoadenylate_synth_CS	UniProtKB/Swiss-Prot
	2-5-oligoadenylate_synth_N	UniProtKB/Swiss-Prot
	2-5-oligoAdlate_synth_1_dom2/C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2-5OAS_C_CS	UniProtKB/TrEMBL
	2-5OAS_N_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NT_2-5OAS_ClassI-CCAase	UniProtKB/TrEMBL
	NT_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Polymerase_NTP_transf_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:192281	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93097	IMAGE-MGC_LOAD
NCBI Gene	192281	ENTREZGENE
PANTHER	2'-5'-OLIGOADENYLATE SYNTHASE 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11258	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	NTP_transf_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	OAS1_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Oas1a	PhenoGen
PROSITE	25A_SYNTH_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	25A_SYNTH_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	25A_SYNTH_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001369	RatGTEx
Superfamily-SCOP	PAP/OAS1 substrate-binding domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF81301	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8J8XSI7_RAT	UniProtKB/TrEMBL
	A6J1H0	ENTREZGENE, UniProtKB/TrEMBL
	D4A5A2_RAT	UniProtKB/TrEMBL
	F7EEP6	ENTREZGENE
	G3V9A4	ENTREZGENE, UniProtKB/TrEMBL
	OAS1A_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q5MYW5	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F7EEP6	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-25	Oas1a	2'-5' oligoadenylate synthetase 1A	Oas1	2',5'-oligoadenylate synthetase 1, 40/46kDa	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Oas1	2',5'-oligoadenylate synthetase 1, 40/46kDa		25 oligoadenylate synthetase	Name updated	1299863	APPROVED
2002-08-07	Oas1	25 oligoadenylate synthetase			Symbol and Name status set to provisional	70820	PROVISIONAL

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Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)