Arc (activity-regulated cytoskeleton-associated protein) - Rat Genome Database

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Gene: Arc (activity-regulated cytoskeleton-associated protein) Rattus norvegicus
Analyze
Symbol: Arc
Name: activity-regulated cytoskeleton-associated protein
RGD ID: 62037
Description: Enables mRNA binding activity. Involved in several processes, including learning or memory; regulation of synaptic plasticity; and vesicle-mediated intercellular transport. Located in actin cytoskeleton and extracellular vesicle. Is active in glutamatergic synapse; postsynaptic density membrane; and postsynaptic endosome. Used to study anxiety disorder and morphine dependence. Biomarker of anxiety disorder; middle cerebral artery infarction; visual epilepsy; and withdrawal disorder. Orthologous to human ARC (activity regulated cytoskeleton associated protein); INTERACTS WITH (25R)-cholest-5-ene-3beta,26-diol; (S)-amphetamine; 1,2,4-trimethylbenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: activity regulated cytoskeletal-associated protein; activity-regulated gene 3.1 protein; ARC/ARG3.1; arg3.1; rg3.1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Bp335
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87108,444,959 - 108,448,413 (-)NCBIGRCr8
mRatBN7.27106,555,968 - 106,559,697 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7106,555,785 - 106,559,378 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7108,314,166 - 108,317,612 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07110,537,836 - 110,541,282 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07110,483,777 - 110,487,223 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07115,907,097 - 115,911,059 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7115,907,097 - 115,910,541 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07115,812,499 - 115,815,958 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47112,771,937 - 112,775,381 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17112,806,166 - 112,809,611 (-)NCBI
Celera7102,957,256 - 102,960,700 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (EXP)
(S)-amphetamine  (EXP)
(S)-nicotine  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',3,3',6,6'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
26-hydroxycholesterol  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
6-propyl-2-thiouracil  (EXP)
8-OH-DPAT  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
aristolochic acid A  (ISO)
arsenous acid  (EXP)
asarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bicuculline  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bisphenol F  (EXP)
butanal  (ISO)
cerium trichloride  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (ISO)
Citreoviridin  (ISO)
clozapine  (EXP)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
desipramine  (EXP)
Diacetoxyscirpenol  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (EXP,ISO)
dieldrin  (ISO)
disulfiram  (ISO)
dizocilpine maleate  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
fluoxetine  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
furan  (EXP)
furosemide  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glufosinate  (ISO)
glycidol  (EXP)
graphite  (EXP)
haloperidol  (EXP)
iron dichloride  (ISO)
isoflurane  (EXP)
kainic acid  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
maneb  (ISO)
memantine  (ISO)
mercury dichloride  (EXP)
methamphetamine  (EXP)
methapyrilene  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (EXP)
monosodium L-glutamate  (ISO)
morphine  (EXP,IEP)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
naloxone  (EXP)
naphthalenes  (EXP)
nicotine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
paroxetine  (EXP)
pentanal  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
poly(I:C)  (EXP)
progesterone  (EXP)
propanal  (ISO)
propofol  (EXP)
reserpine  (EXP)
resveratrol  (EXP,ISO)
SCH 23390  (EXP)
scopolamine  (EXP,ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
SKF 38393  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sterigmatocystin  (EXP)
sulfur dioxide  (EXP)
temozolomide  (ISO)
tetradecane  (EXP)
tetrodotoxin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP)
tranylcypromine  (EXP)
triazolam  (ISO)
trichloroethene  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Stress and cocaine interact to modulate Arc/Arg3.1 expression in rat brain. Caffino L, etal., Psychopharmacology (Berl). 2011 Nov;218(1):241-8. doi: 10.1007/s00213-011-2331-3. Epub 2011 May 18.
2. Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. Chowdhury S, etal., Neuron. 2006 Nov 9;52(3):445-59.
3. Prenatal stress leads to chromatin and synaptic remodeling and excessive alcohol intake comorbid with anxiety-like behaviors in adult offspring. Dong E, etal., Neuropharmacology. 2018 Sep 15;140:76-85. doi: 10.1016/j.neuropharm.2018.07.010. Epub 2018 Aug 4.
4. Differential regulation by stimulants of neocortical expression of mrt1, arc, and homer1a mRNA in the rats treated with repeated methamphetamine. Fujiyama K, etal., Synapse 2003 Sep 1;49(3):143-9.
5. Distinct regulation pattern of Egr-1, BDNF and Arc during morphine-withdrawal conditioned place aversion paradigm: Role of glucocorticoids. García-Pérez D, etal., Behav Brain Res. 2019 Mar 15;360:244-254. doi: 10.1016/j.bbr.2018.12.026. Epub 2018 Dec 11.
6. Glucocorticoid Homeostasis in the Dentate Gyrus Is Essential for Opiate Withdrawal-Associated Memories. García-Pérez D, etal., Mol Neurobiol. 2017 Oct;54(8):6523-6541. doi: 10.1007/s12035-016-0186-7. Epub 2016 Oct 11.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Involvement of hippocampal Arc in amnesia and its recovery by alcoholic extract of Ashwagandha leaves. Gautam A, etal., Neurobiol Learn Mem. 2013 Nov;106:177-84. doi: 10.1016/j.nlm.2013.08.009. Epub 2013 Sep 3.
9. Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. Guzowski JF, etal., J Neurosci. 2000 Jun 1;20(11):3993-4001.
10. Exposure to lead elevates induction of zif268 and Arc mRNA in rats after electroconvulsive shock: the involvement of protein kinase C. Kim KA, etal., J Neurosci Res 2002 Jul 15;69(2):268-77.
11. Synaptic targeting by Alzheimer's-related amyloid beta oligomers. Lacor PN, etal., J Neurosci. 2004 Nov 10;24(45):10191-200.
12. Expression pattern of neural synaptic plasticity marker-Arc in different brain regions induced by conditioned drug withdrawal from acute morphine-dependent rats. Li M, etal., Acta Pharmacol Sin. 2009 Mar;30(3):282-90. doi: 10.1038/aps.2009.10.
13. Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC. Li PF, etal., Mol Cell 2002 Aug;10(2):247-58.
14. Somatodendritic expression of an immediate early gene is regulated by synaptic activity. Link W, etal., Proc Natl Acad Sci U S A 1995 Jun 6;92(12):5734-8.
15. Expression of activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) in the nucleus accumbens is critical for the acquisition, expression and reinstatement of morphine-induced conditioned place preference. Lv XF, etal., Behav Brain Res. 2011 Sep 30;223(1):182-91. doi: 10.1016/j.bbr.2011.04.029. Epub 2011 Apr 27.
16. NAc Shell Arc/Arg3.1 Protein Mediates Reconsolidation of Morphine CPP by Increased GluR1 Cell Surface Expression: Activation of ERK-Coupled CREB is Required. Lv XF, etal., Int J Neuropsychopharmacol. 2015 Mar 6;18(9). pii: pyv030. doi: 10.1093/ijnp/pyv030.
17. Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. Lyford GL, etal., Neuron 1995 Feb;14(2):433-45.
18. Mating behavior induces differential Arc expression in the main and accessory olfactory bulbs of adult rats. Matsuoka M, etal., Neurosci Lett 2002 Dec 25;335(2):111-4.
19. Erythropoietin-induced changes in brain gene expression reveal induction of synaptic plasticity genes in experimental stroke. Mengozzi M, etal., Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9617-22. doi: 10.1073/pnas.1200554109. Epub 2012 May 29.
20. Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo. Messaoudi E, etal., J Neurosci. 2007 Sep 26;27(39):10445-55.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. The role of amygdaloid brain-derived neurotrophic factor, activity-regulated cytoskeleton-associated protein and dendritic spines in anxiety and alcoholism. Moonat S, etal., Addict Biol. 2011 Apr;16(2):238-50. doi: 10.1111/j.1369-1600.2010.00275.x. Epub 2010 Dec 23.
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Localized brain differences in Arc expression between mice showing low vs. high propensity to ethanol sensitization. Nona CN, etal., Pharmacol Biochem Behav. 2016 Mar;142:15-22. doi: 10.1016/j.pbb.2015.12.006. Epub 2015 Dec 18.
25. Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIbeta. Okuno H, etal., Cell. 2012 May 11;149(4):886-98. doi: 10.1016/j.cell.2012.02.062.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. Effector immediate-early gene arc in the amygdala plays a critical role in alcoholism. Pandey SC, etal., J Neurosci. 2008 Mar 5;28(10):2589-600. doi: 10.1523/JNEUROSCI.4752-07.2008.
28. Potential role of adolescent alcohol exposure-induced amygdaloid histone modifications in anxiety and alcohol intake during adulthood. Pandey SC, etal., Neurobiol Dis. 2015 Oct;82:607-619. doi: 10.1016/j.nbd.2015.03.019. Epub 2015 Mar 24.
29. Midazolam reverses salicylate-induced changes in brain-derived neurotrophic factor and arg3.1 expression: implications for tinnitus perception and auditory plasticity. Panford-Walsh R, etal., Mol Pharmacol. 2008 Sep;74(3):595-604. doi: 10.1124/mol.108.046375. Epub 2008 Jun 4.
30. The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer. Pastuzyn ED, etal., Cell. 2018 Jan 11;172(1-2):275-288.e18. doi: 10.1016/j.cell.2017.12.024.
31. Amphetamine sensitization in mice is sufficient to produce both manic- and depressive-related behaviors as well as changes in the functional connectivity of corticolimbic structures. Pathak G, etal., Neuropharmacology. 2015 Aug;95:434-47. doi: 10.1016/j.neuropharm.2015.04.026. Epub 2015 May 7.
32. Plasticity in the rat prefrontal cortex: linking gene expression and an operant learning with a computational theory. Rapanelli M, etal., PLoS One. 2010 Jan 11;5(1):e8656.
33. GOA pipeline RGD automated data pipeline
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Activity-Regulated Cytoskeleton-Associated Protein Accumulates in the Nucleus in Response to Cocaine and Acts as a Brake on Chromatin Remodeling and Long-Term Behavioral Alterations. Salery M, etal., Biol Psychiatry. 2017 Apr 1;81(7):573-584. doi: 10.1016/j.biopsych.2016.05.025. Epub 2016 Jun 16.
36. Delayed electrical stimulation and BDNF application following induced deafness in rats. Song BN, etal., Acta Otolaryngol. 2009 Feb;129(2):142-54. doi: 10.1080/00016480802043949.
37. Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c. Stoss O, etal., J Biol Chem 1999 Apr 16;274(16):10951-62.
38. Changes in the Egr1 and Arc expression in brain structures of pentylenetetrazole-kindled rats. Szyndler J, etal., Pharmacol Rep. 2013;65(2):368-78.
39. Tinnitus behavior and hearing function correlate with the reciprocal expression patterns of BDNF and Arg3.1/arc in auditory neurons following acoustic trauma. Tan J, etal., Neuroscience. 2007 Mar 16;145(2):715-26. Epub 2007 Feb 1.
40. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
41. Experience-dependent coincident expression of the effector immediate-early genes arc and Homer 1a in hippocampal and neocortical neuronal networks. Vazdarjanova A, etal., J Neurosci 2002 Dec 1;22(23):10067-71.
42. Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent beta-amyloid generation. Wu J, etal., Cell. 2011 Oct 28;147(3):615-28. doi: 10.1016/j.cell.2011.09.036.
43. Reversal of deficits in dendritic spines, BDNF and Arc expression in the amygdala during alcohol dependence by HDAC inhibitor treatment. You C, etal., Int J Neuropsychopharmacol. 2014 Feb;17(2):313-22. doi: 10.1017/S1461145713001144. Epub 2013 Oct 9.
Additional References at PubMed
PMID:10644725   PMID:10727859   PMID:12787067   PMID:12878684   PMID:14580947   PMID:14969744   PMID:15048929   PMID:15087240   PMID:15147503   PMID:15248288   PMID:15336574   PMID:15659610  
PMID:15716412   PMID:15932597   PMID:16221847   PMID:16367764   PMID:16415163   PMID:16553613   PMID:16871537   PMID:17026535   PMID:17088212   PMID:17088213   PMID:17286278   PMID:17611082  
PMID:17614950   PMID:18062938   PMID:18305102   PMID:18419604   PMID:18501523   PMID:18555615   PMID:18798281   PMID:19159662   PMID:19222557   PMID:19290048   PMID:19544747   PMID:19576731  
PMID:20189687   PMID:20452974   PMID:20592749   PMID:20599428   PMID:20653942   PMID:20654701   PMID:20675582   PMID:20824728   PMID:20850902   PMID:20865740   PMID:20942997   PMID:21162918  
PMID:21315825   PMID:21319893   PMID:21420441   PMID:21515256   PMID:21562269   PMID:21737703   PMID:21834987   PMID:21921210   PMID:22071872   PMID:22179607   PMID:22350812   PMID:22535445  
PMID:22573703   PMID:22584581   PMID:22613772   PMID:22617701   PMID:22683463   PMID:22844515   PMID:22871113   PMID:22933785   PMID:22945419   PMID:22982514   PMID:23079472   PMID:23154938  
PMID:23345235   PMID:23426670   PMID:23708554   PMID:23791196   PMID:23843540   PMID:23872190   PMID:23876329   PMID:24671994   PMID:24704997   PMID:24810662   PMID:25239865   PMID:25249385  
PMID:25623071   PMID:25646592   PMID:25682931   PMID:26219984   PMID:26238574   PMID:26774022   PMID:26888068   PMID:26895748   PMID:26976088   PMID:27397520   PMID:27474832   PMID:27702572  
PMID:28185871   PMID:28472857   PMID:28553222   PMID:28585865   PMID:28630256   PMID:28716957   PMID:28856239   PMID:29232477   PMID:29264923   PMID:29326059   PMID:29588465   PMID:29723575  
PMID:30244496   PMID:30458282   PMID:31151856   PMID:31919348   PMID:32333254   PMID:32861833   PMID:33843051   PMID:34648950   PMID:37820952  


Genomics

Comparative Map Data
Arc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87108,444,959 - 108,448,413 (-)NCBIGRCr8
mRatBN7.27106,555,968 - 106,559,697 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7106,555,785 - 106,559,378 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7108,314,166 - 108,317,612 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07110,537,836 - 110,541,282 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07110,483,777 - 110,487,223 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07115,907,097 - 115,911,059 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7115,907,097 - 115,910,541 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07115,812,499 - 115,815,958 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47112,771,937 - 112,775,381 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17112,806,166 - 112,809,611 (-)NCBI
Celera7102,957,256 - 102,960,700 (-)NCBICelera
Cytogenetic Map7q34NCBI
ARC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388142,611,049 - 142,614,479 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8142,611,049 - 142,614,479 (-)EnsemblGRCh38hg38GRCh38
GRCh378143,692,410 - 143,695,840 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368143,689,412 - 143,692,835 (-)NCBINCBI36Build 36hg18NCBI36
Build 348143,689,411 - 143,692,835NCBI
Celera8140,003,980 - 140,007,899 (-)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8138,948,085 - 138,951,389 (-)NCBIHuRef
CHM1_18143,732,641 - 143,736,069 (-)NCBICHM1_1
T2T-CHM13v2.08143,754,593 - 143,758,023 (-)NCBIT2T-CHM13v2.0
Arc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391574,540,930 - 74,544,419 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1574,540,932 - 74,544,419 (-)EnsemblGRCm39 Ensembl
GRCm381574,669,081 - 74,672,570 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1574,669,083 - 74,672,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv371574,499,513 - 74,503,000 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361574,496,338 - 74,499,825 (-)NCBIMGSCv36mm8
Celera1576,173,822 - 76,177,304 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1534.25NCBI
Arc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554541,379,998 - 1,383,414 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554541,379,998 - 1,383,414 (-)NCBIChiLan1.0ChiLan1.0
ARC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27160,047,111 - 160,050,549 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18135,570,636 - 135,574,069 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08139,320,366 - 139,323,802 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18142,365,962 - 142,369,309 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8142,367,995 - 142,369,185 (-)Ensemblpanpan1.1panPan2
ARC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11336,743,027 - 36,744,266 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1336,609,093 - 36,612,592 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01337,136,507 - 37,140,000 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1337,138,390 - 37,140,028 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11336,855,275 - 36,858,753 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01336,944,976 - 36,948,432 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01337,366,985 - 37,370,448 (-)NCBIUU_Cfam_GSD_1.0
Arc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053031,759,046 - 1,762,161 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364709,185,145 - 9,186,320 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364709,185,145 - 9,188,260 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl41,518,180 - 1,519,370 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.141,517,986 - 1,521,403 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ARC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18136,857,402 - 136,860,933 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8136,859,438 - 136,860,628 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660393,095,686 - 3,099,176 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473513,968,654 - 13,972,026 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473513,968,628 - 13,972,026 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arc
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:570
Count of miRNA genes:250
Interacting mature miRNAs:299
Transcripts:ENSRNOT00000067442
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)793595647106839474Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat

Markers in Region
C86064  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27106,556,107 - 106,556,196 (+)MAPPERmRatBN7.2
Rnor_6.07115,907,232 - 115,907,320NCBIRnor6.0
Rnor_5.07115,812,634 - 115,812,722UniSTSRnor5.0
RGSC_v3.47112,772,072 - 112,772,160UniSTSRGSC3.4
Celera7102,957,391 - 102,957,479UniSTS
Cytogenetic Map7q34UniSTS
RH137921  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27106,556,035 - 106,556,176 (+)MAPPERmRatBN7.2
Rnor_6.07115,907,160 - 115,907,300NCBIRnor6.0
Rnor_5.07115,812,562 - 115,812,702UniSTSRnor5.0
RGSC_v3.47112,772,000 - 112,772,140UniSTSRGSC3.4
Celera7102,957,319 - 102,957,459UniSTS
RH 3.4 Map7764.5UniSTS
Cytogenetic Map7q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 19
Low 2 36 22 6 13 6 7 10 55 35 38 7
Below cutoff 1 7 29 29 6 29 1 1 3 11 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000067442   ⟹   ENSRNOP00000063719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7115,907,097 - 115,910,541 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076998   ⟹   ENSRNOP00000068090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7106,555,785 - 106,559,378 (-)Ensembl
Rnor_6.0 Ensembl7115,907,097 - 115,910,522 (-)Ensembl
RefSeq Acc Id: NM_019361   ⟹   NP_062234
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87108,444,959 - 108,448,403 (-)NCBI
mRatBN7.27106,555,973 - 106,559,417 (-)NCBI
Rnor_6.07115,907,097 - 115,910,541 (-)NCBI
Rnor_5.07115,812,499 - 115,815,958 (-)NCBI
RGSC_v3.47112,771,937 - 112,775,381 (-)RGD
Celera7102,957,256 - 102,960,700 (-)RGD
Sequence:
RefSeq Acc Id: XM_017595064   ⟹   XP_017450553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87108,444,959 - 108,448,413 (-)NCBI
mRatBN7.27106,555,968 - 106,559,697 (-)NCBI
Rnor_6.07115,907,097 - 115,911,059 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_062234   ⟸   NM_019361
- UniProtKB: Q63053 (UniProtKB/Swiss-Prot),   Q62743 (UniProtKB/Swiss-Prot),   A6HRX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450553   ⟸   XM_017595064
- Peptide Label: isoform X1
- UniProtKB: Q62743 (UniProtKB/Swiss-Prot),   Q63053 (UniProtKB/Swiss-Prot),   A6HRX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000063719   ⟸   ENSRNOT00000067442
RefSeq Acc Id: ENSRNOP00000068090   ⟸   ENSRNOT00000076998
Protein Domains
Activity-regulated cytoskeleton-associated protein

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63053-F1-model_v2 AlphaFold Q63053 1-396 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695376
Promoter ID:EPDNEW_R5896
Type:single initiation site
Name:Arc_1
Description:activity-regulated cytoskeleton-associated protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07115,910,541 - 115,910,601EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62037 AgrOrtholog
BioCyc Gene G2FUF-33024 BioCyc
Ensembl Genes ENSRNOG00000043465 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055025242 UniProtKB/Swiss-Prot
  ENSRNOG00060023163 UniProtKB/Swiss-Prot
  ENSRNOG00065009634 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000076998 ENTREZGENE
  ENSRNOT00000076998.3 UniProtKB/Swiss-Prot
  ENSRNOT00055043515 UniProtKB/Swiss-Prot
  ENSRNOT00060040062 UniProtKB/Swiss-Prot
  ENSRNOT00065015439 UniProtKB/Swiss-Prot
InterPro Activity-reg_cytoskelet-assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arc_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arc_capsid_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arc_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54323 UniProtKB/Swiss-Prot
NCBI Gene 54323 ENTREZGENE
PANTHER ACTIVITY-REGULATED CYTOSKELETON-ASSOCIATED PROTEIN UniProtKB/Swiss-Prot
  ACTIVITY-REGULATED CYTOSKELETON-ASSOCIATED PROTEIN UniProtKB/TrEMBL
  ACTIVITY-REGULATED CYTOSKELETON-ASSOCIATED PROTEIN UniProtKB/TrEMBL
  PTHR15962 UniProtKB/Swiss-Prot
Pfam Arc_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arc_capsid_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arc_MA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arc PhenoGen
PRINTS ARCARG31 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000043465 RatGTEx
  ENSRNOG00055025242 RatGTEx
  ENSRNOG00060023163 RatGTEx
  ENSRNOG00065009634 RatGTEx
TIGR TC207326
UniProt A6HRX2 ENTREZGENE, UniProtKB/TrEMBL
  ARC_RAT UniProtKB/Swiss-Prot
  Q62743 ENTREZGENE
  Q63053 ENTREZGENE
UniProt Secondary Q62743 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Arc  activity-regulated cytoskeleton-associated protein  Arc  activity regulated cytoskeletal-associated protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Arc  activity regulated cytoskeletal-associated protein      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in hippocampal and neocortical neurons 628408
gene_function immediate-early gene (IEG) encoding an effector protein 628408
gene_process involved as a dynamic response to synaptic activity 628408
gene_process mouse homolog is essential for maintenance of long-term potentiation (LTP) and consolidation of memory for spatial experience; may modify structure and functions of dendrites affecting synaptic efficacy 628408
gene_process capable of modifying synaptic function 628408