Eif5 (eukaryotic translation initiation factor 5) - Rat Genome Database

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Gene: Eif5 (eukaryotic translation initiation factor 5) Rattus norvegicus
Analyze
Symbol: Eif5
Name: eukaryotic translation initiation factor 5
RGD ID: 619861
Description: Enables eukaryotic initiation factor eIF2 binding activity and translation initiation factor activity. Involved in activation of GTPase activity and formation of translation preinitiation complex. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol and synapse. Orthologous to human EIF5 (eukaryotic translation initiation factor 5); PARTICIPATES IN translation initiation pathway; RNA transport pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: eIF-5; eukaryotic initiation factor 5; eukaryotic initiation factor 5 (eIF-5); NEWGENE_619861
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Eif5-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86136,410,333 - 136,418,827 (+)NCBIGRCr8
mRatBN7.26130,589,162 - 130,597,656 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6130,589,143 - 130,597,656 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6130,756,452 - 130,764,934 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06131,052,437 - 131,060,919 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06130,419,289 - 130,427,783 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06136,002,962 - 136,011,409 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6136,004,214 - 136,011,406 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06144,405,130 - 144,413,556 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46136,311,381 - 136,318,586 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16136,317,567 - 136,324,773 (+)NCBI
Celera6128,144,864 - 128,153,363 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-phellandrene  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (EXP)
diclofenac  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
glyphosate  (EXP,ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
iron dichloride  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nefazodone  (EXP)
nicotine  (ISO)
nimesulide  (EXP)
orotic acid  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (EXP)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
theophylline  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
cytosol  (IBA,ISO)
nucleus  (ISO)
plasma membrane  (ISO)
synapse  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and expression of cDNA for mammalian translation initiation factor 5. Das K, etal., Proc Natl Acad Sci U S A 1993 Apr 1;90(7):3058-62.
2. Mutational analysis of mammalian translation initiation factor 5 (eIF5): role of interaction between the beta subunit of eIF2 and eIF5 in eIF5 function in vitro and in vivo. Das S and Maitra U, Mol Cell Biol. 2000 Jun;20(11):3942-50.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. The scanning mechanism of eukaryotic translation initiation. Hinnebusch AG Annu Rev Biochem. 2014;83:779-812. doi: 10.1146/annurev-biochem-060713-035802. Epub 2014 Jan 29.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:9395514   PMID:11861906   PMID:12426392   PMID:15489334   PMID:15632090   PMID:22156057   PMID:22681889   PMID:25468996   PMID:25943107   PMID:35352799  


Genomics

Comparative Map Data
Eif5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86136,410,333 - 136,418,827 (+)NCBIGRCr8
mRatBN7.26130,589,162 - 130,597,656 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6130,589,143 - 130,597,656 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6130,756,452 - 130,764,934 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06131,052,437 - 131,060,919 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06130,419,289 - 130,427,783 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06136,002,962 - 136,011,409 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6136,004,214 - 136,011,406 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06144,405,130 - 144,413,556 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46136,311,381 - 136,318,586 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16136,317,567 - 136,324,773 (+)NCBI
Celera6128,144,864 - 128,153,363 (+)NCBICelera
Cytogenetic Map6q32NCBI
EIF5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814103,334,237 - 103,345,025 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14103,333,544 - 103,345,025 (+)EnsemblGRCh38hg38GRCh38
GRCh3714103,800,574 - 103,811,362 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614102,870,246 - 102,881,115 (+)NCBINCBI36Build 36hg18NCBI36
Build 3414102,870,988 - 102,881,112NCBI
Celera1483,854,670 - 83,865,542 (+)NCBICelera
Cytogenetic Map14q32.32NCBI
HuRef1483,978,717 - 83,989,557 (+)NCBIHuRef
CHM1_114103,738,116 - 103,749,143 (+)NCBICHM1_1
T2T-CHM13v2.01497,570,092 - 97,580,884 (+)NCBIT2T-CHM13v2.0
Eif5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912111,504,535 - 111,513,187 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12111,504,450 - 111,513,186 (+)EnsemblGRCm39 Ensembl
GRCm3812111,538,101 - 111,546,753 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12111,538,016 - 111,546,752 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712112,776,312 - 112,784,964 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612111,987,328 - 111,994,247 (+)NCBIMGSCv36mm8
Celera12112,732,164 - 112,740,796 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.03NCBI
Eif5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555382,226,443 - 2,233,403 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555382,226,493 - 2,233,275 (+)NCBIChiLan1.0ChiLan1.0
EIF5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215104,493,199 - 104,500,545 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114103,710,151 - 103,717,045 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01483,960,299 - 83,969,352 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114103,772,370 - 103,783,403 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14103,773,309 - 103,783,403 (+)Ensemblpanpan1.1panPan2
EIF5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1871,102,628 - 71,111,971 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl871,102,690 - 71,270,399 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha870,614,368 - 70,623,740 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0871,378,362 - 71,387,734 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl871,378,488 - 71,387,734 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1871,067,872 - 71,077,243 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0871,106,898 - 71,116,259 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0871,506,710 - 71,516,119 (+)NCBIUU_Cfam_GSD_1.0
Eif5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086402,943,160 - 2,950,723 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366211,769,952 - 1,779,709 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366211,772,116 - 1,779,669 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF5
(Sus scrofa - pig)		 No map positions available.
EIF5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12481,303,713 - 81,313,254 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2481,303,911 - 81,313,807 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605368,570,883 - 68,580,155 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247341,501,684 - 1,509,686 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eif5
33 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:660
Count of miRNA genes:293
Interacting mature miRNAs:397
Transcripts:ENSRNOT00000013695
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat

Markers in Region
RH128669  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21772,175,412 - 72,175,575 (-)MAPPERmRatBN7.2
mRatBN7.2X113,219,370 - 113,219,533 (+)MAPPERmRatBN7.2
mRatBN7.26130,597,408 - 130,597,571 (+)MAPPERmRatBN7.2
Rnor_6.0X120,316,701 - 120,316,863NCBIRnor6.0
Rnor_6.06136,011,162 - 136,011,324NCBIRnor6.0
Rnor_5.06144,405,215 - 144,405,377UniSTSRnor5.0
Rnor_5.0X120,464,025 - 120,464,187UniSTSRnor5.0
Cytogenetic Map6q32UniSTS
RH138444  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26130,592,617 - 130,592,770 (+)MAPPERmRatBN7.2
Rnor_6.06136,006,455 - 136,006,607NCBIRnor6.0
Rnor_5.06144,409,932 - 144,410,084UniSTSRnor5.0
RGSC_v3.46136,313,551 - 136,313,703UniSTSRGSC3.4
Celera6128,148,378 - 128,148,530UniSTS
Cytogenetic Map6q32UniSTS
RH140805  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 11 43 82 57 60 41 19 41 160 73 74 35 41 19

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001329879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC062398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L11651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000013695   ⟹   ENSRNOP00000013695
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6130,589,143 - 130,597,656 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102717   ⟹   ENSRNOP00000085445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6130,589,870 - 130,595,962 (+)Ensembl
RefSeq Acc Id: NM_001329879   ⟹   NP_001316808
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,410,333 - 136,418,827 (+)NCBI
mRatBN7.26130,589,162 - 130,597,656 (+)NCBI
RefSeq Acc Id: XM_006240609   ⟹   XP_006240671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,410,950 - 136,418,827 (+)NCBI
mRatBN7.26130,589,986 - 130,597,656 (+)NCBI
RefSeq Acc Id: XM_039111602   ⟹   XP_038967530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,410,937 - 136,418,827 (+)NCBI
mRatBN7.26130,589,788 - 130,597,656 (+)NCBI
RefSeq Acc Id: NP_001316808   ⟸   NM_001329879
- UniProtKB: Q07205 (UniProtKB/Swiss-Prot),   A0A8I6A040 (UniProtKB/TrEMBL),   A6KBR3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967530   ⟸   XM_039111602
- Peptide Label: isoform X1
- UniProtKB: Q07205 (UniProtKB/Swiss-Prot),   A0A8I6A040 (UniProtKB/TrEMBL),   A6KBR3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_006240671   ⟸   XM_006240609
- Peptide Label: isoform X1
- UniProtKB: Q07205 (UniProtKB/Swiss-Prot),   A0A8I6A040 (UniProtKB/TrEMBL),   A6KBR3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013695   ⟸   ENSRNOT00000013695
Ensembl Acc Id: ENSRNOP00000085445   ⟸   ENSRNOT00000102717
Protein Domains
W2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q07205-F1-model_v2 AlphaFold Q07205 1-429 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619861 AgrOrtholog
BioCyc Gene G2FUF-35842 BioCyc
Ensembl Genes ENSRNOG00000010218 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055028084 UniProtKB/Swiss-Prot
  ENSRNOG00060027016 UniProtKB/Swiss-Prot
  ENSRNOG00065025212 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013695.8 UniProtKB/Swiss-Prot
  ENSRNOT00000102717.1 UniProtKB/TrEMBL
  ENSRNOT00055048637 UniProtKB/Swiss-Prot
  ENSRNOT00060046908 UniProtKB/Swiss-Prot
  ENSRNOT00065043439 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.20.25.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.30.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623373 IMAGE-MGC_LOAD
InterPro ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF2/IF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transl_init_fac_IF2/IF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transl_init_fac_IF2/IF5_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transl_init_fac_IF2/IF5_Zn-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  W2_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:108348073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72473 IMAGE-MGC_LOAD
NCBI Gene Eif5 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam eIF-5_eIF-2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF02020 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eif5 PhenoGen
PROSITE PS51363 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010218 RatGTEx
  ENSRNOG00055028084 RatGTEx
  ENSRNOG00060027016 RatGTEx
  ENSRNOG00065025212 RatGTEx
SMART eIF2B_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  eIF5C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100966 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF75689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A040 ENTREZGENE, UniProtKB/TrEMBL
  A6KBR3 ENTREZGENE, UniProtKB/TrEMBL
  IF5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-03-21 Eif5  eukaryotic translation initiation factor 5  NEWGENE_619861  eukaryotic translation initiation factor 5  Data merged from RGD:11471634 737654 PROVISIONAL
2016-08-02 NEWGENE_619861  eukaryotic translation initiation factor 5      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Eif5  eukaryotic translation initiation factor 5    eukaryotic initiation factor 5 (eIF-5)  Name updated 1299863 APPROVED
2002-08-07 Eif5  eukaryotic initiation factor 5 (eIF-5)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product putative member of the GTPase superfamily 728212
gene_protein 3.55 kB cDNA encodes a 429 aa protein of approximately 49 kDa 728212