Fgf7 (fibroblast growth factor 7) - Rat Genome Database

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Gene: Fgf7 (fibroblast growth factor 7) Rattus norvegicus
Analyze
Symbol: Fgf7
Name: fibroblast growth factor 7
RGD ID: 61805
Description: Enables growth factor activity; heparin binding activity; and type 2 fibroblast growth factor receptor binding activity. Involved in several processes, including ovarian follicle development; phosphatidylcholine biosynthetic process; and surfactant homeostasis. Located in extracellular space. Orthologous to human FGF7 (fibroblast growth factor 7); PARTICIPATES IN glypican signaling pathway; melanoma pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2-amino-2-deoxy-D-glucopyranose; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: FGF-7; Fgf5b; fibroblast growth factor 5b; HBGF-7; heparin-binding growth factor 7; keratinocyte growth factor; Keratinocyte Growth Factor Fgf-7; Kgf; KGF/FGF7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83133,734,557 - 133,786,678 (+)NCBIGRCr8
mRatBN7.23113,280,448 - 113,333,279 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3113,281,283 - 113,332,929 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3117,157,853 - 117,207,039 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03125,753,368 - 125,802,554 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03123,413,729 - 123,462,917 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03118,315,859 - 118,368,464 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3118,317,761 - 118,366,872 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03124,840,157 - 124,892,611 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43113,468,427 - 113,517,538 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13113,373,999 - 113,423,111 (+)NCBI
Celera3112,134,799 - 112,183,941 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (EXP)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
ANTU  (EXP)
arabinoxylan  (ISO)
Aroclor 1254  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CHIR 99021  (ISO)
cholesterol  (EXP,ISO)
cisplatin  (ISO)
cortisol  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dermatan sulfate  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diiodine  (ISO)
doxorubicin  (EXP)
fluoranthene  (ISO)
geldanamycin  (ISO)
glucose  (ISO)
graphite  (EXP)
heparan sulfate  (ISO)
heparin  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (ISO)
indometacin  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
loliolide  (ISO)
LY294002  (ISO)
medroxyprogesterone acetate  (ISO)
methotrexate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
nifedipine  (ISO)
nitrofen  (EXP)
oxaliplatin  (EXP)
paclitaxel  (ISO)
PCB138  (ISO)
pentanal  (ISO)
phenethyl caffeate  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
prostaglandin E2  (EXP)
quartz  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
shikimic acid  (ISO)
sirolimus  (ISO)
sodium atom  (ISO)
sodium aurothiomalate  (ISO)
sunitinib  (ISO)
suramin  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA,ISO)
animal organ morphogenesis  (IBA)
branching involved in salivary gland morphogenesis  (IEA,ISO)
cell differentiation  (IBA,IEA)
endothelial cell proliferation  (IEA,ISO)
epithelial cell proliferation  (ISO)
fibroblast growth factor receptor signaling pathway  (IBA,IEA,ISO)
hair follicle morphogenesis  (IEA,ISO)
lung development  (IBA,IMP)
mesenchymal cell proliferation  (IEA,ISO)
myoblast proliferation  (IEA,ISO)
ovarian follicle development  (IMP)
phosphatidylcholine biosynthetic process  (IMP)
phospholipid biosynthetic process  (IMP)
positive chemotaxis  (IBA,IEA,ISO)
positive regulation of cell division  (IEA)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (IBA,IEA,ISO)
positive regulation of endothelial cell proliferation  (IEA,ISO)
positive regulation of epithelial cell proliferation  (IBA,IDA,IMP,ISO)
positive regulation of epithelial cell proliferation involved in lung morphogenesis  (IEA,ISO)
positive regulation of gene expression  (IBA,IEA)
positive regulation of keratinocyte migration  (IEA,ISO)
positive regulation of keratinocyte proliferation  (IEA,ISO)
positive regulation of myoblast proliferation  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IBA,IEA,ISO)
protein localization to cell surface  (IEA,ISO)
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  (IEA,ISO)
regulation of cell migration  (IBA)
regulation of synapse maturation  (ISO)
secretion by lung epithelial cell involved in lung growth  (IEA,ISO)
surfactant homeostasis  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KGF and HGF are growth factors for mesothelial cells in pleural lavage fluid after intratracheal asbestos. Adamson IY and Bakowska J, Exp Lung Res. 2001 Oct-Nov;27(7):605-16.
2. Keratinocyte growth factor in inflammatory bowel disease. Increased mRNA transcripts in ulcerative colitis compared with Crohn's disease in biopsies and isolated mucosal myofibroblasts. Bajaj-Elliott M, etal., Am J Pathol. 1997 Nov;151(5):1469-76.
3. Basic fibroblast growth factor and keratinocyte growth factor over-expression in benign prostatic hyperplasia. Boget S, etal., Farmaco. 2001 May-Jul;56(5-7):467-9.
4. Role of keratinocyte growth factor in the control of surfactant synthesis by fetal lung mesenchyme. Chelly N, etal., Endocrinology 2001 May;142(5):1814-9.
5. Keratinocyte growth factor ameliorates dextran sodium sulfate colitis in mice. Egger B, etal., Dig Dis Sci. 1999 Apr;44(4):836-44. doi: 10.1023/a:1026642715764.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Citrobacter rodentium infection in mice elicits a mucosal Th1 cytokine response and lesions similar to those in murine inflammatory bowel disease. Higgins LM, etal., Infect Immun. 1999 Jun;67(6):3031-9. doi: 10.1128/IAI.67.6.3031-3039.1999.
9. Differential distribution of fibroblast growth factor (FGF)-7 and FGF-10 in L-arginine-induced acute pancreatitis. Ishiwata T, etal., Exp Mol Pathol 2002 Dec;73(3):181-90.
10. Keratinocyte growth factor acts as a mesenchymal factor that promotes ovarian primordial to primary follicle transition. Kezele P, etal., Biol Reprod. 2005 Nov;73(5):967-73. Epub 2005 Jul 6.
11. Keratinocyte growth factor induces mammary and prostatic hyperplasia and mammary adenocarcinoma in transgenic mice. Kitsberg DI and Leder P, Oncogene. 1996 Dec 19;13(12):2507-15.
12. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
13. Keratinocyte growth factor expression in hormone insensitive prostate cancer. Leung HY, etal., Oncogene. 1997 Aug 28;15(9):1115-20.
14. Microarray study of gene expression in uterine leiomyoma. Litovkin KV, etal., Exp Oncol. 2008 Jun;30(2):106-11.
15. The glycine box: a determinant of specificity for fibroblast growth factor. Luo Y, etal., Biochemistry. 1998 Nov 24;37(47):16506-15.
16. Gene profiling in Pap-cell smears of high-risk human papillomavirus-positive squamous cervical carcinoma. Manavi M, etal., Gynecol Oncol. 2007 May;105(2):418-26. Epub 2007 Feb 15.
17. Keratinocyte growth factor and the transcription factors C/EBP alpha, C/EBP delta, and SREBP-1c regulate fatty acid synthesis in alveolar type II cells. Mason RJ, etal., J Clin Invest 2003 Jul;112(2):244-55.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Angiogenesis and capillary maturation phenotypes associated with the Edpm3 locus on rat chromosome 3. Pandey J and Wendell DL, Mamm Genome. 2006 Jan;17(1):49-57. Epub 2006 Jan 13.
21. Expression and action of keratinocyte growth factor (KGF) in normal ovarian surface epithelium and ovarian cancer. Parrott JA, etal., Mol Cell Endocrinol. 2000 Sep 25;167(1-2):77-87.
22. Liposomal gene transfer of keratinocyte growth factor improves wound healing by altering growth factor and collagen expression. Pereira CT, etal., J Surg Res. 2007 May 15;139(2):222-8. Epub 2007 Feb 9.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Distinct patterns of expression of keratinocyte growth factor and its receptor in endometrial carcinoma. Siegfried S, etal., Cancer. 1997 Mar 15;79(6):1166-71.
29. Keratinocyte growth factor protects against Pseudomonas aeruginosa-induced lung injury. Viget NB, etal., Am J Physiol Lung Cell Mol Physiol. 2000 Dec;279(6):L1199-209. doi: 10.1152/ajplung.2000.279.6.L1199.
30. Heparin-binding keratinocyte growth factor is a candidate stromal-to-epithelial-cell andromedin. Yan G, etal., Mol Endocrinol. 1992 Dec;6(12):2123-8.
31. Effects of aging on growth factors gene and protein expression in the dorsal and ventral lobes of rat prostate. Zhao H, etal., Biochem Biophys Res Commun 2002 Mar 29;292(2):482-91.
Additional References at PubMed
PMID:1869483   PMID:8663044   PMID:9740653   PMID:10541313   PMID:11023837   PMID:11098134   PMID:11493558   PMID:12581741   PMID:12837279   PMID:12861530   PMID:14506240   PMID:14697353  
PMID:15690149   PMID:15806171   PMID:17187775   PMID:17392324   PMID:17394208   PMID:17449030   PMID:17872496   PMID:18091341   PMID:18559345   PMID:19266047   PMID:20069574   PMID:21136143  
PMID:21436609   PMID:26894526   PMID:27035760   PMID:30816491   PMID:30858037   PMID:30894415   PMID:31017714   PMID:32586178   PMID:34898359  


Genomics

Comparative Map Data
Fgf7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83133,734,557 - 133,786,678 (+)NCBIGRCr8
mRatBN7.23113,280,448 - 113,333,279 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3113,281,283 - 113,332,929 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3117,157,853 - 117,207,039 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03125,753,368 - 125,802,554 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03123,413,729 - 123,462,917 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03118,315,859 - 118,368,464 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3118,317,761 - 118,366,872 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03124,840,157 - 124,892,611 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43113,468,427 - 113,517,538 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13113,373,999 - 113,423,111 (+)NCBI
Celera3112,134,799 - 112,183,941 (+)NCBICelera
Cytogenetic Map3q36NCBI
FGF7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381549,423,242 - 49,488,775 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1549,423,237 - 49,488,775 (+)EnsemblGRCh38hg38GRCh38
GRCh371549,715,439 - 49,780,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361547,502,751 - 47,566,815 (+)NCBINCBI36Build 36hg18NCBI36
Build 341547,502,750 - 47,566,815NCBI
Celera1526,608,551 - 26,672,713 (+)NCBICelera
Cytogenetic Map15q21.2NCBI
HuRef1526,547,279 - 26,611,441 (+)NCBIHuRef
CHM1_11549,833,504 - 49,897,659 (+)NCBICHM1_1
T2T-CHM13v2.01547,231,591 - 47,297,131 (+)NCBIT2T-CHM13v2.0
Fgf7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392125,876,578 - 125,933,105 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2125,876,578 - 125,933,105 (+)EnsemblGRCm39 Ensembl
GRCm382126,034,658 - 126,091,185 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2126,034,658 - 126,091,185 (+)EnsemblGRCm38mm10GRCm38
MGSCv372125,860,394 - 125,916,921 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362125,726,225 - 125,781,966 (+)NCBIMGSCv36mm8
Celera2127,270,998 - 127,337,627 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.76NCBI
Fgf7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554094,632,858 - 4,686,860 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554094,633,542 - 4,686,768 (-)NCBIChiLan1.0ChiLan1.0
FGF7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21638,669,957 - 38,734,413 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11542,853,936 - 42,921,604 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01528,378,339 - 28,442,800 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1 Ensembl1546,702,119 - 46,770,163 (+)Ensemblpanpan1.1panPan2
FGF7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13015,555,016 - 15,608,230 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3015,555,266 - 15,606,521 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3015,481,488 - 15,531,854 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03015,698,949 - 15,751,444 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3015,501,581 - 15,752,197 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13015,623,415 - 15,673,818 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03015,739,231 - 15,789,330 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03015,843,740 - 15,894,109 (+)NCBIUU_Cfam_GSD_1.0
Fgf7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864093,787,837 - 93,847,287 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647111,635,876 - 11,693,821 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647111,636,733 - 11,692,782 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1122,215,882 - 122,277,750 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11122,215,878 - 122,278,705 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21135,926,619 - 135,928,879 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGF7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12633,802,349 - 33,867,743 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2633,802,328 - 33,867,333 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048107,261,064 - 107,330,391 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473110,413,645 - 10,468,690 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473110,413,715 - 10,468,660 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fgf7
188 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:73
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000012700
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat

Markers in Region
D3Mco11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23113,299,924 - 113,300,170 (+)MAPPERmRatBN7.2
Rnor_6.03118,335,462 - 118,335,705NCBIRnor6.0
Rnor_5.03124,859,156 - 124,859,399UniSTSRnor5.0
RGSC_v3.43113,486,127 - 113,486,371RGDRGSC3.4
RGSC_v3.43113,486,128 - 113,486,371UniSTSRGSC3.4
RGSC_v3.13113,391,700 - 113,391,944RGD
Celera3112,152,539 - 112,152,780UniSTS
Cytogenetic Map3q36UniSTS
FGF7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23113,330,075 - 113,331,264 (+)MAPPERmRatBN7.2
Rnor_6.03118,365,609 - 118,366,797NCBIRnor6.0
Rnor_5.03124,889,756 - 124,890,944UniSTSRnor5.0
RGSC_v3.43113,516,275 - 113,517,463UniSTSRGSC3.4
Celera3112,182,678 - 112,183,866UniSTS
Cytogenetic Map3q36UniSTS
FGF7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23113,330,079 - 113,331,336 (+)MAPPERmRatBN7.2
Rnor_6.03118,365,613 - 118,366,869NCBIRnor6.0
Rnor_5.03124,889,760 - 124,891,016UniSTSRnor5.0
RGSC_v3.43113,516,279 - 113,517,535UniSTSRGSC3.4
Celera3112,182,682 - 112,183,938UniSTS
Cytogenetic Map3q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 5 11 3 3 6 11 3
Low 2 33 19 8 8 8 5 8 25 31 28 5
Below cutoff 6 11 11 11 35 4 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012700   ⟹   ENSRNOP00000012700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3113,281,283 - 113,332,929 (+)Ensembl
Rnor_6.0 Ensembl3118,317,761 - 118,366,872 (+)Ensembl
RefSeq Acc Id: NM_022182   ⟹   NP_071518
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83133,735,627 - 133,784,738 (+)NCBI
mRatBN7.23113,282,222 - 113,331,339 (+)NCBI
Rnor_6.03118,317,761 - 118,366,872 (+)NCBI
Rnor_5.03124,840,157 - 124,892,611 (+)NCBI
RGSC_v3.43113,468,427 - 113,517,538 (+)RGD
Celera3112,134,799 - 112,183,941 (+)RGD
Sequence:
RefSeq Acc Id: XM_006234903   ⟹   XP_006234965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83133,734,557 - 133,786,678 (+)NCBI
mRatBN7.23113,280,448 - 113,333,279 (+)NCBI
Rnor_6.03118,315,859 - 118,368,464 (+)NCBI
Rnor_5.03124,840,157 - 124,892,611 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104434   ⟹   XP_038960362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83133,734,565 - 133,786,678 (+)NCBI
mRatBN7.23113,280,566 - 113,333,279 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_071518   ⟸   NM_022182
- Peptide Label: precursor
- UniProtKB: Q02195 (UniProtKB/Swiss-Prot),   Q9ERN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234965   ⟸   XM_006234903
- Peptide Label: isoform X1
- UniProtKB: G3V775 (UniProtKB/TrEMBL),   A6HPY1 (UniProtKB/TrEMBL),   Q9ERN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012700   ⟸   ENSRNOT00000012700
RefSeq Acc Id: XP_038960362   ⟸   XM_039104434
- Peptide Label: isoform X1
- UniProtKB: G3V775 (UniProtKB/TrEMBL),   A6HPY1 (UniProtKB/TrEMBL),   Q9ERN5 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q02195-F1-model_v2 AlphaFold Q02195 1-194 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692385
Promoter ID:EPDNEW_R2910
Type:initiation region
Name:Fgf7_1
Description:fibroblast growth factor 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03118,317,831 - 118,317,891EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61805 AgrOrtholog
BioCyc Gene G2FUF-48028 BioCyc
Ensembl Genes ENSRNOG00000009425 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012700.5 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fibroblast_GF_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29348 UniProtKB/Swiss-Prot
NCBI Gene 29348 ENTREZGENE
PANTHER PTHR11486 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11486:SF20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fgf7 PhenoGen
PRINTS HBGFFGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1HBGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HBGF_FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009425 RatGTEx
SMART FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HPY1 ENTREZGENE, UniProtKB/TrEMBL
  FGF7_RAT UniProtKB/Swiss-Prot
  G3V775 ENTREZGENE, UniProtKB/TrEMBL
  Q02195 ENTREZGENE
  Q9ERN5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Fgf7  fibroblast growth factor 7      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed at higher levels in prostates of older animals than in younger animals 68696
gene_expression expressed at higher levels in prostates of older animals than in younger animals 70812
gene_expression expressed in embryonic lungs 68696
gene_expression expressed in embryonic lungs 70812
gene_expression produced by stromal mesenchyme-derived cells 68696
gene_expression produced by stromal mesenchyme-derived cells 70812
gene_process enhances glucocorticoid stimulation of fetal alveolar epithelial type II cell maturation 68696
gene_process enhances glucocorticoid stimulation of fetal alveolar epithelial type II cell maturation 70812
gene_process stimulates surfactant component synthesis 68696
gene_process stimulates surfactant component synthesis 70812
gene_regulation regulated by androgen 68696
gene_regulation regulated by androgen 70812