Thrsp (thyroid hormone responsive) - Rat Genome Database

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Gene: Thrsp (thyroid hormone responsive) Rattus norvegicus
Analyze
Symbol: Thrsp
Name: thyroid hormone responsive
RGD ID: 3859
Description: Predicted to enable molecular function inhibitor activity and protein homodimerization activity. Involved in regulation of lipid biosynthetic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Orthologous to human THRSP (thyroid hormone responsive); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,4,7,8-Pentachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: lipogenic protein S14; Lpgp; S14; spot 14 protein; SPOT14; thyroid hormone responsive protein; Thyroid hormone responsive protein (spot14); thyroid hormone responsive SPOT14 homolog; thyroid hormone responsive SPOT14 homolog (Rattus); thyroid hormone-inducible hepatic protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81161,134,640 - 161,138,964 (-)NCBIGRCr8
mRatBN7.21151,723,415 - 151,727,740 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1151,723,086 - 151,728,075 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1159,711,451 - 159,715,792 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01166,891,619 - 166,895,960 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01159,765,126 - 159,769,467 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01162,381,251 - 162,385,575 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1162,381,253 - 162,385,575 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01168,587,724 - 168,592,048 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41154,647,339 - 154,651,663 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11154,725,746 - 154,730,069 (-)NCBI
Celera1149,823,345 - 149,827,669 (-)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+/-)-Aegeline  (ISO)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
1,2-dichloroethane  (ISO)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
Bardoxolone methyl  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cantharidin  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroform  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
clemizole  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clopidogrel  (ISO)
clothianidin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
daidzein  (EXP)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
diethyl maleate  (EXP)
diquat  (ISO)
doxorubicin  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
Ethylenethiourea  (ISO)
fenofibrate  (ISO)
finasteride  (EXP)
fipronil  (ISO)
flurbiprofen  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (EXP)
glycidol  (EXP,ISO)
graphite  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
inulin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lipopolysaccharide  (ISO)
metformin  (EXP)
methapyrilene  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
microcystin-LR  (ISO)
Mitotane  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naloxone  (EXP)
naphthalene  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
O-methyleugenol  (ISO)
oleic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorobutyric acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
pioglitazone  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (EXP,ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
resveratrol  (EXP)
ritodrine  (ISO)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
streptozocin  (EXP,ISO)
sulconazole  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (EXP,ISO)
sulindac  (EXP)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
theophylline  (EXP)
thiacloprid  (ISO)
thioacetamide  (EXP)
thiophanate-methyl  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
triticonazole  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP)
ursodeoxycholic acid  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
XL147  (ISO)
yohimbine  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Overlapping roles of the glucose-responsive genes, S14 and S14R, in hepatic lipogenesis. Aipoalani DL, etal., Endocrinology. 2010 May;151(5):2071-7. doi: 10.1210/en.2009-1058. Epub 2010 Mar 16.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Thyroid hormone and dietary carbohydrate interact to regulate rat liver S14 gene transcription and chromatin structure. Jump DB, etal., J Biol Chem 1990 Feb 25;265(6):3474-8.
5. Identification of genes enhanced by protein-calorie malnutrition by differential display polymerase chain reaction (expression of fibrinogen B beta chain, B cell translocation gene 1 and thyroid hormone responsive protein genes). Lee AK, etal., Mol Cell Biochem 2002 Feb;231(1-2):163-71.
6. Characterization of a thyroid hormone-responsive gene from rat. Liaw CW and Towle HC, J Biol Chem 1984 Jun 10;259(11):7253-60.
7. Identification of functional cis-acting elements within the rat liver S14 promoter. MacDougald OA and Jump DB, Biochem J 1991 Dec 15;280 ( Pt 3):761-7.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12477932   PMID:12960053   PMID:15490139   PMID:15890771   PMID:18219437   PMID:20952656   PMID:23012479   PMID:25416956  


Genomics

Comparative Map Data
Thrsp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81161,134,640 - 161,138,964 (-)NCBIGRCr8
mRatBN7.21151,723,415 - 151,727,740 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1151,723,086 - 151,728,075 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1159,711,451 - 159,715,792 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01166,891,619 - 166,895,960 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01159,765,126 - 159,769,467 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01162,381,251 - 162,385,575 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1162,381,253 - 162,385,575 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01168,587,724 - 168,592,048 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41154,647,339 - 154,651,663 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11154,725,746 - 154,730,069 (-)NCBI
Celera1149,823,345 - 149,827,669 (-)NCBICelera
Cytogenetic Map1q32NCBI
THRSP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381178,063,861 - 78,068,351 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1178,063,861 - 78,068,351 (+)EnsemblGRCh38hg38GRCh38
GRCh371177,774,907 - 77,779,397 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361177,452,555 - 77,457,045 (+)NCBINCBI36Build 36hg18NCBI36
Build 341177,452,554 - 77,457,044NCBI
Celera1175,083,371 - 75,087,862 (+)NCBICelera
Cytogenetic Map11q14.1NCBI
HuRef1174,073,273 - 74,077,767 (+)NCBIHuRef
CHM1_11177,658,098 - 77,662,594 (+)NCBICHM1_1
T2T-CHM13v2.01177,997,088 - 78,001,580 (+)NCBIT2T-CHM13v2.0
Thrsp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39797,062,140 - 97,066,757 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl797,062,145 - 97,066,937 (-)EnsemblGRCm39 Ensembl
GRCm38797,412,933 - 97,417,550 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl797,412,938 - 97,417,730 (-)EnsemblGRCm38mm10GRCm38
MGSCv377104,561,467 - 104,566,020 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36797,288,149 - 97,292,702 (-)NCBIMGSCv36mm8
Celera797,723,964 - 97,728,458 (-)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.49NCBI
Thrsp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541413,879,095 - 13,883,378 (-)NCBIChiLan1.0ChiLan1.0
THRSP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2978,996,033 - 78,997,431 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11180,039,905 - 80,041,303 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01173,123,030 - 73,128,461 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11176,747,532 - 76,751,718 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1176,747,547 - 76,747,987 (+)Ensemblpanpan1.1panPan2
THRSP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12120,759,291 - 20,761,740 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2120,761,109 - 20,761,558 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2120,653,623 - 20,656,058 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02120,962,317 - 20,964,752 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2120,964,135 - 20,964,584 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12120,737,129 - 20,739,564 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02120,953,229 - 20,955,664 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02120,878,006 - 20,880,441 (-)NCBIUU_Cfam_GSD_1.0
Thrsp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494765,013,973 - 65,025,358 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364986,622,004 - 6,624,961 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364986,622,007 - 6,624,961 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THRSP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl912,479,907 - 12,488,557 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1912,479,913 - 12,484,323 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2913,814,645 - 13,819,062 (+)NCBISscrofa10.2Sscrofa10.2susScr3
THRSP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1169,269,174 - 69,274,270 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl169,269,746 - 69,270,198 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604356,472,709 - 56,477,534 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thrsp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248631,062,047 - 1,069,959 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248631,062,047 - 1,069,969 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Thrsp
38 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:132
Interacting mature miRNAs:145
Transcripts:ENSRNOT00000016540
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1117917486196963478Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1150452391168228760Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1123556856196963478Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat

Markers in Region
D1Arb38  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01162,387,857 - 162,388,769NCBIRnor6.0
Cytogenetic Map1q32UniSTS
RH135409  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21151,723,626 - 151,723,838 (+)MAPPERmRatBN7.2
Rnor_6.01162,381,463 - 162,381,674NCBIRnor6.0
Rnor_5.01168,587,936 - 168,588,147UniSTSRnor5.0
RGSC_v3.41154,647,551 - 154,647,762UniSTSRGSC3.4
Celera1149,823,557 - 149,823,768UniSTS
RH 3.4 Map11166.0UniSTS
Cytogenetic Map1q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 25 99 71 70 39 25 39 6 170 73 79 41 40 31

Sequence


Ensembl Acc Id: ENSRNOT00000016540   ⟹   ENSRNOP00000016540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1151,723,086 - 151,728,075 (-)Ensembl
Rnor_6.0 Ensembl1162,381,253 - 162,385,575 (-)Ensembl
RefSeq Acc Id: NM_012703   ⟹   NP_036835
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,134,640 - 161,138,964 (-)NCBI
mRatBN7.21151,723,415 - 151,727,740 (-)NCBI
Rnor_6.01162,381,251 - 162,385,575 (-)NCBI
Rnor_5.01168,587,724 - 168,592,048 (-)NCBI
RGSC_v3.41154,647,339 - 154,651,663 (-)RGD
Celera1149,823,345 - 149,827,669 (-)RGD
Sequence:
RefSeq Acc Id: NP_036835   ⟸   NM_012703
- UniProtKB: Q63536 (UniProtKB/Swiss-Prot),   P04143 (UniProtKB/Swiss-Prot),   Q5HZE3 (UniProtKB/TrEMBL),   A6I696 (UniProtKB/TrEMBL),   F7FEP1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016540   ⟸   ENSRNOT00000016540

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04143-F1-model_v2 AlphaFold P04143 1-150 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690205
Promoter ID:EPDNEW_R730
Type:multiple initiation site
Name:Thrsp_1
Description:thyroid hormone responsive
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01162,385,586 - 162,385,646EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3859 AgrOrtholog
BioCyc Gene G2FUF-58447 BioCyc
Ensembl Genes ENSRNOG00000012404 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016540.7 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.1610 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7308757 IMAGE-MGC_LOAD
InterPro Lipogen_MT_Stabilize_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spot_14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25357 UniProtKB/TrEMBL
MGC_CLONE MGC:105418 IMAGE-MGC_LOAD
NCBI Gene 25357 ENTREZGENE
PANTHER PTHR14315 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROID HORMONE-INDUCIBLE HEPATIC PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Spot_14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Thrsp PhenoGen
RatGTEx ENSRNOG00000012404 RatGTEx
TIGR TC204408
UniProt A6I693_RAT UniProtKB/TrEMBL
  A6I694_RAT UniProtKB/TrEMBL
  A6I695_RAT UniProtKB/TrEMBL
  A6I696 ENTREZGENE, UniProtKB/TrEMBL
  F7FEP1 ENTREZGENE, UniProtKB/TrEMBL
  P04143 ENTREZGENE
  Q5HZE3 ENTREZGENE
  Q63536 ENTREZGENE
  THRSP_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q5HZE3 UniProtKB/TrEMBL
  Q63536 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-07-28 Thrsp  thyroid hormone responsive  Thrsp  thyroid hormone responsive protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Thrsp  thyroid hormone responsive SPOT14 homolog (Rattus)      Symbol and Name updated 629477 APPROVED
2003-03-07 Thrsp  thyroid hormone responsive SPOT14 homolog (Rattus)  Lpgp  Lipogenic protein S14  Data merged from RGD:3016 628472 PROVISIONAL
2002-06-10 Thrsp  Thyroid hormone responsive protein (spot14)      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Lpgp  Lipogenic protein S14      Symbol and Name status set to approved 70586 APPROVED