(+)-catechin multiple interactions EXP 6480464 Catechin inhibits the reaction [Rotenone results in decreased activity of TH protein] CTD PMID:35337893 (+)-sesamin multiple interactions EXP 6480464 sesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] CTD PMID:19794909 (+)-taxifolin multiple interactions EXP 6480464 taxifolin inhibits the reaction [Rotenone results in decreased activity of TH protein] CTD PMID:35187747 (-)-epigallocatechin 3-gallate decreases expression EXP 6480464 epigallocatechin gallate results in decreased expression of TH protein CTD PMID:27659729 (-)-selegiline multiple interactions EXP 6480464 Selegiline inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:16490285 (-)-selegiline decreases expression EXP 6480464 Selegiline results in decreased expression of TH mRNA CTD PMID:11862330 (R)-adrenaline increases chemical synthesis ISO Th (Mus musculus) 6480464 TH protein results in increased chemical synthesis of Epinephrine CTD PMID:9822156 (R)-adrenaline multiple interactions EXP 6480464 [Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine CTD PMID:19067675 (R)-noradrenaline multiple interactions EXP 6480464 [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Norepinephrine and [Clonidine results in increased expression of TH protein] which results in increased abundance of Norepinephrine CTD PMID:19067675 (R)-noradrenaline increases chemical synthesis ISO Th (Mus musculus) 6480464 TH protein results in increased chemical synthesis of Norepinephrine CTD PMID:9822156 (R,R,R)-alpha-tocopherol multiple interactions EXP 6480464 [Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in decreased expression of TH protein and alpha-Tocopherol inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:15790535 and PMID:25891525 (S)-AMPA decreases expression EXP 6480464 alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in decreased expression of TH protein CTD PMID:36775207 (S)-AMPA multiple interactions EXP 6480464 1-naphthylacetylspermine inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in decreased expression of TH protein] and aminophenyl fluorescein inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in decreased expression of TH protein] CTD PMID:36775207 (S)-amphetamine increases expression ISO Th (Mus musculus) 6480464 Dextroamphetamine results in increased expression of TH mRNA CTD PMID:18681898 (S)-naringenin multiple interactions EXP 6480464 naringenin inhibits the reaction [Paraquat results in decreased expression of TH protein] CTD PMID:34655599 (S)-naringenin decreases expression EXP 6480464 naringenin results in decreased expression of TH protein CTD PMID:34655599 (S)-nicotine multiple interactions EXP 6480464 [conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]] more ... CTD PMID:29246838 (S)-nicotine multiple interactions ISO Th (Mus musculus) 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:19594327 more ... (S)-nicotine multiple interactions ISO TH (Homo sapiens) 6480464 [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA] CTD PMID:17498763 (S)-nicotine increases expression ISO TH (Homo sapiens) 6480464 Nicotine results in increased expression of TH mRNA and Nicotine results in increased expression of TH protein CTD PMID:17498763 (S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of TH mRNA and Nicotine results in increased expression of TH protein CTD PMID:29246838 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO Th (Mus musculus) 6480464 (3R)-((2 more ... CTD PMID:16402076 more ... 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expression ISO Th (Mus musculus) 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:30195017 and PMID:38016618 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO TH (Homo sapiens) 6480464 PRKN protein inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:24140863 and PMID:25447324 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression ISO Th (Mus musculus) 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:15329391 more ... 1-Naphthylacetylspermine multiple interactions EXP 6480464 1-naphthylacetylspermine inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in decreased expression of TH protein] CTD PMID:36775207 15-deoxy-Delta(12,14)-prostaglandin J2 increases expression EXP 6480464 15-deoxy-delta(12 and 14)-prostaglandin J2 results in increased expression of TH protein CTD PMID:15212945 17beta-estradiol affects expression EXP 6480464 Estradiol affects the expression of TH protein CTD PMID:16427766 17beta-estradiol multiple interactions ISO Th (Mus musculus) 6480464 Estradiol inhibits the reaction [manganese chloride results in decreased expression of TH mRNA] and Estradiol inhibits the reaction [manganese chloride results in decreased expression of TH protein] CTD PMID:29183790 17beta-estradiol increases expression ISO TH (Homo sapiens) 6480464 Estradiol results in increased expression of TH mRNA CTD PMID:27271280 and PMID:31614463 17beta-estradiol multiple interactions ISO TH (Homo sapiens) 6480464 Estradiol promotes the reaction [ESR2 protein affects the expression of TH mRNA] and Estradiol results in increased expression of and results in increased secretion of TH protein CTD PMID:20404318 and PMID:27271280 17beta-estradiol affects expression ISO TH (Homo sapiens) 6480464 Estradiol affects the expression of TH mRNA CTD PMID:14699072 2',5'-Dideoxyadenosine multiple interactions EXP 6480464 2' and 5'-dideoxyadenosine inhibits the reaction [epibatidine results in increased expression of TH mRNA] CTD PMID:15588622 2,2',4,4',5,5'-hexachlorobiphenyl increases expression EXP 6480464 2 more ... CTD PMID:29233657 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Th (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TH protein] more ... CTD PMID:19481886 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of TH mRNA CTD PMID:22808131 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Th (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of TH protein CTD PMID:19481886 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Th (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of TH mRNA and Tetrachlorodibenzodioxin results in increased expression of TH protein CTD PMID:19500377 more ... 2,3,7,8-tetrachlorodibenzodioxine increases activity ISO Th (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased activity of TH protein CTD PMID:19500377 2,3,7,8-tetrachlorodibenzodioxine decreases methylation ISO Th (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased methylation of TH gene CTD PMID:21212295 2,4-D increases expression EXP 6480464 2 and 4-Dichlorophenoxyacetic Acid results in increased expression of TH protein CTD PMID:16931444 2-methyl-6-(phenylethynyl)pyridine multiple interactions EXP 6480464 6-methyl-2-(phenylethynyl)pyridine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the expression of TH protein] CTD PMID:33571554 3,4-dihydroxyphenylacetaldehyde affects binding EXP 6480464 3 and 4-dihydroxyphenylacetaldehyde binds to TH protein CTD PMID:21238438 3,4-dihydroxyphenylacetaldehyde decreases activity EXP 6480464 3 and 4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein CTD PMID:21514317 3,4-dihydroxyphenylacetaldehyde multiple interactions EXP 6480464 [3 and 4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein] which results in decreased chemical synthesis of Levodopa CTD PMID:21514317 3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide multiple interactions ISO Th (Mus musculus) 6480464 Raclopride inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:16088948 3,7-dihydropurine-6-thione multiple interactions EXP 6480464 [GW 1929 co-treated with Mercaptopurine] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] and Mercaptopurine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] CTD PMID:27435855 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione multiple interactions EXP 6480464 bisindolylmaleimide I inhibits the reaction [3-(2-hydroxy-4-(1 more ... CTD PMID:18992715 3-Amino-1-methyl-5H-pyrido[4,3-b]indole decreases activity EXP 6480464 3-amino-1-methyl-5H-pyrido(4 and 3-b)indole results in decreased activity of TH protein CTD PMID:2904812 3-hydroxybutyric acid multiple interactions ISO Th (Mus musculus) 6480464 3-Hydroxybutyric Acid affects the reaction [ZFP36 protein affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]] more ... CTD PMID:36435477 3-methyladenine multiple interactions EXP 6480464 3-methyladenine inhibits the reaction [fenvalerate results in decreased expression of TH protein] and 3-methyladenine inhibits the reaction [Oxidopamine results in decreased expression of TH protein] CTD PMID:28802652 and PMID:31734597 3-phenylprop-2-enal multiple interactions ISO Th (Mus musculus) 6480464 cinnamaldehyde inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] CTD PMID:31187328 4,4'-sulfonyldiphenol increases expression EXP 6480464 bisphenol S results in increased expression of TH mRNA CTD PMID:26186136 4,4'-sulfonyldiphenol affects methylation ISO Th (Mus musculus) 6480464 bisphenol S affects the methylation of TH exon CTD PMID:33297965 4,4'-sulfonyldiphenol increases expression ISO Th (Mus musculus) 6480464 bisphenol S results in increased expression of TH mRNA CTD PMID:30951980 4-phenylbutyric acid increases expression ISO Th (Mus musculus) 6480464 4-phenylbutyric acid results in increased expression of TH protein CTD PMID:21372141 5-(2-chloroethyl)-4-methylthiazole multiple interactions ISO Th (Mus musculus) 6480464 Chlormethiazole inhibits the reaction [Methamphetamine results in decreased activity of TH protein] CTD PMID:1381816 5-aza-2'-deoxycytidine increases expression ISO TH (Homo sapiens) 6480464 Decitabine results in increased expression of TH mRNA CTD PMID:23441691 5-fluorouracil affects expression ISO Th (Mus musculus) 6480464 Fluorouracil affects the expression of TH protein CTD PMID:21296659 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of TH mRNA CTD PMID:25825206 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of TH mRNA CTD PMID:33150595 6-propyl-2-thiouracil increases methylation EXP 6480464 Propylthiouracil results in increased methylation of TH promoter CTD PMID:33150595 7-NITROINDAZOLE multiple interactions ISO Th (Mus musculus) 6480464 7-nitroindazole affects the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:8931477 8-bromo-3',5'-cyclic GMP multiple interactions EXP 6480464 8-bromocyclic GMP inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein] and 8-bromocyclic GMP inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein] CTD PMID:16023617 9-cis-retinoic acid decreases expression ISO TH (Homo sapiens) 6480464 Alitretinoin results in decreased expression of TH protein CTD PMID:36805303 acetic acid decreases expression ISO Th (Mus musculus) 6480464 Acetic Acid results in decreased expression of TH protein CTD PMID:21296659 acetylcholine multiple interactions EXP 6480464 conotoxin AuIB inhibits the reaction [Acetylcholine results in increased expression of TH mRNA] more ... CTD PMID:29246838 acetylcholine increases expression EXP 6480464 Acetylcholine results in increased expression of TH mRNA CTD PMID:29246838 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of TH mRNA and Acrylamide results in increased expression of TH protein CTD PMID:25943760 acrylonitrile multiple interactions EXP 6480464 Acrylonitrile inhibits the reaction [3 and 3'-iminodipropionitrile results in increased expression of TH protein] CTD PMID:19244277 aflatoxin B1 increases methylation ISO TH (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of TH intron CTD PMID:30157460 Aflatoxin B2 alpha decreases methylation ISO TH (Homo sapiens) 6480464 aflatoxin B2 results in decreased methylation of TH polyA tail CTD PMID:30157460 agmatine multiple interactions EXP 6480464 Agmatine inhibits the reaction [Morphine results in increased expression of TH protein] CTD PMID:15541421 albiflorin affects expression EXP 6480464 albiflorin affects the expression of TH CTD PMID:26475043 all-trans-retinoic acid multiple interactions ISO TH (Homo sapiens) 6480464 [Tretinoin co-treated with CNTF protein] results in increased expression of TH more ... CTD PMID:17017122 more ... all-trans-retinoic acid increases expression ISO Th (Mus musculus) 6480464 Tretinoin results in increased expression of TH mRNA CTD PMID:34627992 all-trans-retinoic acid decreases expression ISO TH (Homo sapiens) 6480464 Tretinoin results in decreased expression of TH protein CTD PMID:36805303 all-trans-retinoic acid multiple interactions ISO Th (Mus musculus) 6480464 [bisphenol A co-treated with Tretinoin] results in decreased expression of TH mRNA and [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of TH mRNA CTD PMID:30951980 and PMID:36189433 all-trans-retinoic acid increases expression ISO TH (Homo sapiens) 6480464 Tretinoin results in increased expression of TH mRNA and Tretinoin results in increased expression of TH protein CTD PMID:15464216 more ... AM-251 multiple interactions EXP 6480464 AM 251 affects the reaction [(3R)-((2 more ... CTD PMID:29113897 amentoflavone multiple interactions ISO Th (Mus musculus) 6480464 amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:28185818 aminoguanidine multiple interactions ISO Th (Mus musculus) 6480464 pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein] CTD PMID:20455021 amitraz increases expression EXP 6480464 amitraz results in increased expression of TH mRNA and amitraz results in increased expression of TH protein CTD PMID:28463726 amitraz multiple interactions EXP 6480464 Tamoxifen inhibits the reaction [amitraz results in increased expression of TH mRNA] and Tamoxifen inhibits the reaction [amitraz results in increased expression of TH protein] CTD PMID:28463726 amitrole multiple interactions EXP 6480464 Amitrole promotes the reaction [Sodium Chloride and Dietary results in increased expression of TH protein] CTD PMID:25891026 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of TH mRNA CTD PMID:16483693 ammonium chloride decreases expression EXP 6480464 Ammonium Chloride results in decreased expression of TH protein CTD PMID:16483693 amphetamine decreases expression ISO Th (Mus musculus) 6480464 Amphetamine results in decreased expression of TH protein CTD PMID:20620199 amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of TH mRNA CTD PMID:16126238 amphetamine multiple interactions ISO Th (Mus musculus) 6480464 PTN protein inhibits the reaction [Amphetamine results in decreased expression of TH protein] CTD PMID:20620199 amphetamine increases expression ISO Th (Mus musculus) 6480464 Amphetamine results in increased expression of TH mRNA and Amphetamine results in increased expression of TH protein CTD PMID:16916582 and PMID:19059431 amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of TH protein CTD PMID:12468030 more ... apigenin multiple interactions EXP 6480464 Apigenin inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:28389404 apocynin decreases expression EXP 6480464 acetovanillone results in decreased expression of TH mRNA CTD PMID:25217652 apocynin multiple interactions EXP 6480464 acetovanillone analog inhibits the reaction [Chlorpyrifos results in decreased expression of TH protein] CTD PMID:29859868 aprepitant multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Aprepitant inhibits the reaction [Rotenone results in decreased expression of TH protein]] and Aprepitant inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:37224993 Aroclor 1254 multiple interactions EXP 6480464 [aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of TH protein and [Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1242 co-treated with aroclor 1248] results in decreased expression of TH mRNA CTD PMID:17324953 and PMID:29879404 Aroclor 1254 decreases expression ISO Th (Mus musculus) 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of TH protein CTD PMID:22094459 arsane multiple interactions EXP 6480464 [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TH protein] CTD PMID:22704994 arsane increases expression ISO Th (Mus musculus) 6480464 Arsenic results in increased expression of TH protein CTD PMID:27413109 arsane decreases expression EXP 6480464 Arsenic results in decreased expression of TH protein CTD PMID:22704994 arsenic atom decreases expression EXP 6480464 Arsenic results in decreased expression of TH protein CTD PMID:22704994 arsenic atom increases expression ISO Th (Mus musculus) 6480464 Arsenic results in increased expression of TH protein CTD PMID:27413109 arsenic atom multiple interactions EXP 6480464 [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TH protein] CTD PMID:22704994 arsenite(3-) increases expression ISO Th (Mus musculus) 6480464 arsenite results in increased expression of TH mRNA CTD PMID:33053406 arsenite(3-) decreases expression EXP 6480464 arsenite results in decreased expression of TH protein CTD PMID:29982692 arsenite(3-) decreases expression ISO Th (Mus musculus) 6480464 arsenite results in decreased expression of TH mRNA and arsenite results in decreased expression of TH protein CTD PMID:29982692 and PMID:33053406 arsenous acid decreases expression ISO Th (Mus musculus) 6480464 Arsenic Trioxide results in decreased expression of TH mRNA CTD PMID:23392890 and PMID:23518225 arsenous acid multiple interactions ISO Th (Mus musculus) 6480464 Taurine inhibits the reaction [Arsenic Trioxide results in decreased expression of TH mRNA] CTD PMID:23392890 arsenous acid decreases expression ISO TH (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of TH protein CTD PMID:11027660 Asiaticoside multiple interactions EXP 6480464 [asiaticoside co-treated with Rotenone] results in decreased expression of TH protein CTD PMID:28238857 atrazine decreases expression EXP 6480464 Atrazine results in decreased expression of TH mRNA and Atrazine results in decreased expression of TH protein CTD PMID:14550852 more ... atrazine decreases expression ISO TH (Homo sapiens) 6480464 Atrazine results in decreased expression of TH mRNA CTD PMID:34146662 baicalein multiple interactions ISO Th (Mus musculus) 6480464 baicalein inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:27425033 baicalin multiple interactions ISO Th (Mus musculus) 6480464 baicalin inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:38016618 Bardoxolone methyl multiple interactions ISO Th (Mus musculus) 6480464 bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased phosphorylation of TH protein] CTD PMID:25637688 benzo[a]pyrene multiple interactions ISO Th (Mus musculus) 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to TH promoter] CTD PMID:19654925 benzo[a]pyrene increases expression ISO TH (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of TH mRNA CTD PMID:35870112 benzo[a]pyrene affects methylation ISO TH (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of TH promoter CTD PMID:27901495 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of TH protein CTD PMID:28049045 bicuculline multiple interactions EXP 6480464 Bicuculline promotes the reaction [Reserpine affects the activity of TH protein] and Bicuculline promotes the reaction [Reserpine results in increased expression of TH mRNA] CTD PMID:1981253 bis(2-chloroethyl) sulfide increases expression ISO Th (Mus musculus) 6480464 Mustard Gas results in increased expression of TH mRNA CTD PMID:15674843 bis(2-ethylhexyl) phthalate decreases expression ISO Th (Mus musculus) 6480464 Diethylhexyl Phthalate results in decreased expression of TH protein CTD PMID:19481886 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of TH mRNA CTD PMID:29982774 bis(2-ethylhexyl) phthalate multiple interactions ISO Th (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TH protein] more ... CTD PMID:19481886 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of TH protein CTD PMID:16427766 bisphenol A increases expression ISO Th (Mus musculus) 6480464 bisphenol A results in increased expression of TH mRNA CTD PMID:30951980 bisphenol A multiple interactions ISO TH (Homo sapiens) 6480464 IGF1 protein inhibits the reaction [bisphenol A results in decreased expression of TH mRNA] and IGF1 protein inhibits the reaction [bisphenol A results in decreased expression of TH protein] CTD PMID:27271280 bisphenol A decreases expression ISO TH (Homo sapiens) 6480464 bisphenol A results in decreased expression of TH mRNA and bisphenol A results in decreased expression of TH protein CTD PMID:27271280 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of TH mRNA CTD PMID:26141625 bisphenol A decreases expression ISO Th (Mus musculus) 6480464 bisphenol A results in decreased expression of TH protein CTD PMID:19481886 bisphenol A multiple interactions ISO Th (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TH protein] more ... CTD PMID:19481886 and PMID:30951980 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of TH mRNA and bisphenol A results in decreased expression of TH protein CTD PMID:16909604 more ... bisphenol F decreases expression EXP 6480464 4 and 4'-bisphenol F results in decreased expression of TH mRNA CTD PMID:26186136 bisphenol F increases expression ISO Th (Mus musculus) 6480464 bisphenol F results in increased expression of TH mRNA CTD PMID:30951980 BQ 123 multiple interactions EXP 6480464 cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased activity of TH protein] and cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased expression of TH mRNA] CTD PMID:11911850 bromochloroacetic acid affects expression ISO Th (Mus musculus) 6480464 bromochloroacetic acid affects the expression of TH protein CTD PMID:21296659 bucladesine increases expression EXP 6480464 Bucladesine results in increased expression of TH mRNA CTD PMID:19912776 butanal increases expression ISO TH (Homo sapiens) 6480464 butyraldehyde results in increased expression of TH mRNA CTD PMID:26079696 Butylparaben multiple interactions EXP 6480464 [Plasticizers co-treated with Fungicides and Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of TH mRNA CTD PMID:34383603 cadmium atom increases expression ISO TH (Homo sapiens) 6480464 Cadmium results in increased expression of TH mRNA CTD PMID:21694771 cadmium dichloride decreases methylation EXP 6480464 Cadmium Chloride results in decreased methylation of TH promoter CTD PMID:22457795 caffeine multiple interactions ISO Th (Mus musculus) 6480464 [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 and PMID:7996441 calcitriol multiple interactions ISO TH (Homo sapiens) 6480464 [Calcitriol co-treated with VDR protein] results in increased expression of TH mRNA and [Calcitriol co-treated with VDR protein] results in increased expression of TH protein CTD PMID:26210580 calcitriol decreases expression EXP 6480464 Calcitriol results in decreased expression of TH protein CTD PMID:32147540 cannabidiol multiple interactions ISO Th (Mus musculus) 6480464 [Cannabidiol co-treated with Naltrexone] results in decreased expression of TH mRNA more ... CTD PMID:29624642 and PMID:29859012 carmustine increases activity EXP 6480464 Carmustine results in increased activity of TH protein CTD PMID:14670008 carmustine increases expression EXP 6480464 Carmustine results in increased expression of TH mRNA and Carmustine results in increased expression of TH protein CTD PMID:14670008 carnosic acid multiple interactions EXP 6480464 salvin inhibits the reaction [Oxidopamine results in decreased expression of TH protein] CTD PMID:25446857 Carnosol increases expression ISO Th (Mus musculus) 6480464 carnosol results in increased expression of TH protein CTD PMID:17047462 Carnosol multiple interactions ISO Th (Mus musculus) 6480464 5-iodo-3-((3 more ... CTD PMID:17047462 carvedilol multiple interactions EXP 6480464 carvedilol inhibits the reaction [Ethanol results in increased expression of TH protein] CTD PMID:22413959 carvedilol decreases expression EXP 6480464 carvedilol results in decreased expression of TH mRNA and carvedilol results in decreased expression of TH protein CTD PMID:20359859 chelerythrine multiple interactions EXP 6480464 chelerythrine inhibits the reaction [3-(2-hydroxy-4-(1 more ... CTD PMID:18992715 chitosan multiple interactions EXP 6480464 [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TH protein] CTD PMID:22704994 Chloralose multiple interactions EXP 6480464 [Nitroprusside co-treated with Urethane co-treated with Chloralose] results in increased expression of TH protein CTD PMID:12088752 chlorisondamine multiple interactions EXP 6480464 Chlorisondamine inhibits the reaction [Reserpine results in increased expression of TH mRNA] and Chlorisondamine promotes the reaction [Reserpine results in increased expression of TH mRNA] CTD PMID:1714554 chlorisondamine increases expression EXP 6480464 Chlorisondamine results in increased expression of TH mRNA CTD PMID:1714554 chlorpyrifos increases expression EXP 6480464 Chlorpyrifos results in increased expression of TH mRNA CTD PMID:18812211 chlorpyrifos increases expression ISO TH (Homo sapiens) 6480464 Chlorpyrifos results in increased expression of TH mRNA and Chlorpyrifos results in increased expression of TH protein CTD PMID:34259569 chlorpyrifos multiple interactions ISO TH (Homo sapiens) 6480464 CDH8 protein affects the reaction [Chlorpyrifos results in increased expression of TH protein] CTD PMID:34259569 chlorpyrifos decreases expression ISO TH (Homo sapiens) 6480464 Chlorpyrifos results in decreased expression of TH protein CTD PMID:24793810 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of TH protein CTD PMID:22714038 and PMID:29859868 chlorpyrifos multiple interactions EXP 6480464 acetovanillone analog inhibits the reaction [Chlorpyrifos results in decreased expression of TH protein] and Acetylcysteine inhibits the reaction [Chlorpyrifos results in decreased expression of TH protein] CTD PMID:22714038 and PMID:29859868 cisplatin increases expression ISO Th (Mus musculus) 6480464 Cisplatin results in increased expression of TH mRNA CTD PMID:15464296 and PMID:15471895 clonidine multiple interactions EXP 6480464 [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine more ... CTD PMID:19067675 clonidine (amino form) multiple interactions EXP 6480464 [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine more ... CTD PMID:19067675 clonidine (imino form) multiple interactions EXP 6480464 [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine more ... CTD PMID:19067675 clozapine decreases activity EXP 6480464 Clozapine results in decreased activity of TH protein CTD PMID:15983997 clozapine multiple interactions EXP 6480464 Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein] CTD PMID:15983997 clozapine increases expression EXP 6480464 Clozapine results in increased expression of TH protein CTD PMID:17028028 clozapine decreases expression EXP 6480464 Clozapine results in decreased expression of TH mRNA and Clozapine results in decreased expression of TH protein CTD PMID:12645084 and PMID:15983997 clozapine increases activity ISO Th (Mus musculus) 6480464 Clozapine results in increased activity of TH protein CTD PMID:16415089 clozapine multiple interactions ISO Th (Mus musculus) 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:16402076 and PMID:16415089 cobalt dichloride multiple interactions ISO Th (Mus musculus) 6480464 [cobaltous chloride co-treated with Y 27632] results in increased expression of TH protein CTD PMID:16772336 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of TH mRNA CTD PMID:9458725 cocaine affects expression EXP 6480464 Cocaine affects the expression of TH protein CTD PMID:12787079 cocaine multiple interactions ISO Th (Mus musculus) 6480464 resveratrol promotes the reaction [Cocaine results in decreased phosphorylation of TH protein] CTD PMID:23499958 cocaine decreases phosphorylation ISO Th (Mus musculus) 6480464 Cocaine results in decreased phosphorylation of TH protein CTD PMID:23499958 cocaine increases expression EXP 6480464 Cocaine results in increased expression of TH protein CTD PMID:18992788 cocaine multiple interactions EXP 6480464 Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine] and Spiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]] CTD PMID:20729865 cocaine decreases expression EXP 6480464 Cocaine results in decreased expression of TH protein CTD PMID:11391778 colforsin daropate hydrochloride multiple interactions EXP 6480464 3-(2-hydroxy-4-(1 more ... CTD PMID:18992715 colforsin daropate hydrochloride increases expression ISO TH (Homo sapiens) 6480464 Colforsin results in increased expression of TH protein CTD PMID:34897981 colforsin daropate hydrochloride increases activity EXP 6480464 Colforsin results in increased activity of TH protein CTD PMID:9288946 colforsin daropate hydrochloride increases expression EXP 6480464 Colforsin results in increased expression of TH mRNA and Colforsin results in increased expression of TH protein CTD PMID:14550852 and PMID:18992715 copper atom multiple interactions ISO Th (Mus musculus) 6480464 [Copper Sulfate results in increased abundance of Copper] which results in decreased expression of TH protein CTD PMID:36775208 copper(0) multiple interactions ISO Th (Mus musculus) 6480464 [Copper Sulfate results in increased abundance of Copper] which results in decreased expression of TH protein CTD PMID:36775208 copper(II) sulfate multiple interactions ISO Th (Mus musculus) 6480464 [Copper Sulfate results in increased abundance of Copper] which results in decreased expression of TH protein and Copper Sulfate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of TH protein] CTD PMID:20184101 and PMID:36775208 copper(II) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of TH mRNA CTD PMID:18369385 corticosterone increases expression ISO Th (Mus musculus) 6480464 Corticosterone results in increased expression of TH protein CTD PMID:28186389 Cuprizon decreases expression EXP 6480464 Cuprizone results in decreased expression of TH mRNA CTD PMID:27523638 curcumin multiple interactions EXP 6480464 [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TH protein] and Curcumin inhibits the reaction [sodium arsenite results in decreased expression of TH protein] CTD PMID:19631675 more ... curcumin multiple interactions ISO Th (Mus musculus) 6480464 Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] CTD PMID:31187328 curcumin multiple interactions ISO TH (Homo sapiens) 6480464 Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] CTD PMID:30463061 cyanazine increases expression EXP 6480464 cyanazine results in increased expression of TH protein CTD PMID:14550852 cyanocob(III)alamin multiple interactions EXP 6480464 Vitamin B 12 inhibits the reaction [Streptozocin results in decreased expression of TH protein] CTD PMID:38049026 cyclosporin A decreases methylation ISO TH (Homo sapiens) 6480464 Cyclosporine results in decreased methylation of TH promoter CTD PMID:27989131 cyhalothrin decreases expression EXP 6480464 cyhalothrin results in decreased expression of TH mRNA and cyhalothrin results in decreased expression of TH protein CTD PMID:22366556 more ... cypermethrin decreases expression EXP 6480464 cypermethrin results in decreased expression of TH mRNA and cypermethrin results in decreased expression of TH protein CTD PMID:26115703 cytarabine decreases expression ISO TH (Homo sapiens) 6480464 Cytarabine results in decreased expression of TH protein CTD PMID:21198554 dabigatran multiple interactions EXP 6480464 Dabigatran inhibits the reaction [Rotenone results in decreased expression of TH mRNA] CTD PMID:28585189 DDE multiple interactions EXP 6480464 [Plasticizers co-treated with Fungicides and Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of TH mRNA CTD PMID:34383603 desferrioxamine B increases expression EXP 6480464 Deferoxamine results in increased expression of TH mRNA CTD PMID:9458725 desipramine multiple interactions EXP 6480464 Desipramine inhibits the reaction [Reserpine results in increased expression of TH mRNA] CTD PMID:1717808 dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of TH protein CTD PMID:14550852 dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of TH mRNA CTD PMID:11072875 diarsenic trioxide decreases expression ISO Th (Mus musculus) 6480464 Arsenic Trioxide results in decreased expression of TH mRNA CTD PMID:23392890 and PMID:23518225 diarsenic trioxide multiple interactions ISO Th (Mus musculus) 6480464 Taurine inhibits the reaction [Arsenic Trioxide results in decreased expression of TH mRNA] CTD PMID:23392890 diarsenic trioxide decreases expression ISO TH (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of TH protein CTD PMID:11027660 diazinon increases expression EXP 6480464 Diazinon results in increased expression of TH mRNA CTD PMID:17452286 and PMID:18812211 dichlorvos increases activity EXP 6480464 Dichlorvos results in increased activity of TH protein CTD PMID:12186780 dichlorvos multiple interactions EXP 6480464 Nimodipine inhibits the reaction [Dichlorvos results in increased activity of TH protein] CTD PMID:12186780 dieldrin increases expression EXP 6480464 Dieldrin results in increased expression of TH mRNA CTD PMID:18812211 diethyldithiocarbamic acid multiple interactions EXP 6480464 Ditiocarb results in decreased expression of and results in increased phosphorylation of TH protein CTD PMID:22874009 dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of TH mRNA CTD PMID:10486562 more ... dipyridamole decreases expression EXP 6480464 Dipyridamole results in decreased expression of TH protein CTD PMID:17568153 dopamine increases chemical synthesis ISO TH (Homo sapiens) 6480464 TH protein results in increased chemical synthesis of Dopamine CTD PMID:19815691 dopamine affects abundance ISO Th (Mus musculus) 6480464 TH protein affects the abundance of Dopamine CTD PMID:10984662 and PMID:8707341 dopamine increases chemical synthesis EXP 6480464 TH protein results in increased chemical synthesis of Dopamine CTD PMID:10661506 dopamine affects abundance EXP 6480464 TH affects the abundance of Dopamine CTD PMID:20615977 dopamine decreases activity EXP 6480464 Dopamine results in decreased activity of TH protein CTD PMID:2884129 dopamine multiple interactions EXP 6480464 1-phenyl-3-dimethylamino-1 more ... CTD PMID:10661506 more ... dopamine affects chemical synthesis ISO Th (Mus musculus) 6480464 TH protein affects the chemical synthesis of Dopamine CTD PMID:9822156 dopamine multiple interactions ISO Th (Mus musculus) 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:10984662 more ... dopaminechrome (enol form) decreases expression EXP 6480464 aminochrome 1 results in decreased expression of TH protein CTD PMID:29588162 edaravone multiple interactions EXP 6480464 Edaravone inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:27108097 elemental selenium increases activity EXP 6480464 Selenium deficiency results in increased activity of TH protein CTD PMID:11113527 elemental selenium increases expression EXP 6480464 Selenium deficiency results in increased expression of TH mRNA CTD PMID:11113527 elemental selenium multiple interactions EXP 6480464 [Selenium deficiency results in increased activity of TH protein] which results in increased chemical synthesis of Dopamine CTD PMID:11113527 enzacamene multiple interactions EXP 6480464 [Plasticizers co-treated with Fungicides and Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of TH mRNA CTD PMID:34383603 epibatidine multiple interactions EXP 6480464 1 more ... CTD PMID:15588622 epibatidine increases expression EXP 6480464 epibatidine results in increased expression of TH mRNA CTD PMID:15588622 ethanol multiple interactions EXP 6480464 carvedilol inhibits the reaction [Ethanol results in increased expression of TH protein] CTD PMID:22413959 ethanol decreases expression ISO Th (Mus musculus) 6480464 Ethanol results in decreased expression of TH protein CTD PMID:26747301 and PMID:34808223 ethanol multiple interactions ISO Th (Mus musculus) 6480464 Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein] and Ethanol promotes the reaction [mephedrone results in decreased expression of TH protein] CTD PMID:26747301 and PMID:34590183 ethanol increases expression EXP 6480464 Ethanol results in increased expression of TH protein CTD PMID:22413959 fasudil multiple interactions EXP 6480464 [[propionic acid co-treated with fasudil] affects the susceptibility to Rotenone] which results in increased expression of TH mRNA CTD PMID:32481507 fenvalerate decreases expression EXP 6480464 fenvalerate results in decreased expression of TH protein CTD PMID:31734597 fenvalerate multiple interactions EXP 6480464 3-methyladenine inhibits the reaction [fenvalerate results in decreased expression of TH protein] and SB 203580 inhibits the reaction [fenvalerate results in decreased expression of TH protein] CTD PMID:31734597 ferrostatin-1 multiple interactions ISO Th (Mus musculus) 6480464 ferrostatin-1 inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:36435477 fipronil decreases expression ISO TH (Homo sapiens) 6480464 fipronil results in decreased expression of TH protein CTD PMID:21296133 flavonoids increases expression EXP 6480464 Flavonoids results in increased expression of TH mRNA CTD PMID:18035473 fluoxetine decreases expression ISO Th (Mus musculus) 6480464 Fluoxetine results in decreased expression of TH mRNA CTD PMID:20857517 fluoxetine affects expression EXP 6480464 Fluoxetine affects the expression of TH CTD PMID:26475043 fluoxetine increases expression EXP 6480464 Fluoxetine results in increased expression of TH mRNA CTD PMID:1351783 and PMID:20626387 fluoxetine decreases expression EXP 6480464 Fluoxetine results in decreased expression of TH mRNA CTD PMID:15936043 fluoxetine increases expression ISO Th (Mus musculus) 6480464 Fluoxetine results in increased expression of TH mRNA CTD PMID:20374287 formaldehyde increases expression ISO Th (Mus musculus) 6480464 Formaldehyde results in increased expression of TH protein CTD PMID:15064152 fructose increases expression ISO Th (Mus musculus) 6480464 Fructose results in increased expression of TH mRNA CTD PMID:16843071 ganglioside GM1 increases activity EXP 6480464 G(M1) Ganglioside results in increased activity of TH protein CTD PMID:14552908 genistein affects expression EXP 6480464 Genistein affects the expression of TH protein CTD PMID:16427766 genistein multiple interactions ISO Th (Mus musculus) 6480464 Genistein inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein] CTD PMID:20455021 geraniol multiple interactions ISO Th (Mus musculus) 6480464 geraniol inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:23943375 ginkgetin multiple interactions ISO Th (Mus musculus) 6480464 ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:25968939 ginsenoside Re multiple interactions ISO TH (Homo sapiens) 6480464 ginsenoside Re inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased activity of TH protein] CTD PMID:25523949 ginsenoside Re multiple interactions ISO Th (Mus musculus) 6480464 3-((3 more ... CTD PMID:29467000 glyburide multiple interactions ISO Th (Mus musculus) 6480464 Glyburide promotes the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:16725203 glycidol decreases expression EXP 6480464 glycidol results in decreased expression of TH mRNA CTD PMID:33150645 glycidol increases methylation EXP 6480464 glycidol results in increased methylation of TH promoter CTD PMID:33150595 guanethidine decreases expression EXP 6480464 Guanethidine results in decreased expression of TH protein CTD PMID:9460767 GW 1929 multiple interactions EXP 6480464 [GW 1929 co-treated with Mercaptopurine] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] and GW 1929 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] CTD PMID:27435855 haloperidol increases expression EXP 6480464 Haloperidol results in increased expression of TH protein CTD PMID:17028028 heptachlor increases expression ISO Th (Mus musculus) 6480464 Heptachlor results in increased expression of TH protein CTD PMID:16112329 herbicide decreases expression EXP 6480464 Herbicides results in decreased expression of TH mRNA CTD PMID:23123945 hydrogen peroxide multiple interactions ISO TH (Homo sapiens) 6480464 TH protein inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein] CTD PMID:19815691 hydrogen peroxide affects expression EXP 6480464 Hydrogen Peroxide affects the expression of TH mRNA CTD PMID:9458725 hydrogen peroxide affects abundance EXP 6480464 TH protein affects the abundance of Hydrogen Peroxide CTD PMID:9458725 hydrogen peroxide affects response to substance ISO TH (Homo sapiens) 6480464 TH protein affects the susceptibility to Hydrogen Peroxide CTD PMID:19815691 icariin multiple interactions EXP 6480464 icariin inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:31251943 idazoxan increases expression EXP 6480464 Idazoxan results in increased expression of TH mRNA CTD PMID:1351783 imidacloprid multiple interactions EXP 6480464 [conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]] more ... CTD PMID:29246838 imidacloprid increases expression EXP 6480464 imidacloprid results in increased expression of TH mRNA and imidacloprid results in increased expression of TH protein CTD PMID:29246838 juglone multiple interactions ISO Th (Mus musculus) 6480464 juglone inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:23754278 ketoconazole multiple interactions ISO Th (Mus musculus) 6480464 Ketoconazole inhibits the reaction [Maneb results in decreased expression of TH protein] more ... CTD PMID:19594327 and PMID:22334051 KT 5720 decreases expression EXP 6480464 KT 5720 results in decreased expression of TH mRNA CTD PMID:18992715 KT 5720 multiple interactions EXP 6480464 KT 5720 inhibits the reaction [Colforsin results in increased expression of TH mRNA] and KT 5720 inhibits the reaction [HU 211 results in decreased expression of TH mRNA] CTD PMID:18992715 L-ascorbic acid increases expression EXP 6480464 Ascorbic Acid results in increased expression of TH mRNA CTD PMID:15372504 L-ascorbic acid multiple interactions EXP 6480464 [Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in decreased expression of TH protein CTD PMID:25891525 L-ascorbic acid decreases expression EXP 6480464 Ascorbic Acid results in decreased expression of TH protein CTD PMID:25891525 L-ascorbic acid decreases expression ISO Th (Mus musculus) 6480464 Ascorbic Acid results in decreased expression of TH protein CTD PMID:22285708 lead(0) decreases expression ISO Th (Mus musculus) 6480464 Lead results in decreased expression of TH protein CTD PMID:21703292 linalool decreases expression EXP 6480464 linalool results in decreased expression of TH mRNA CTD PMID:20536181 linuron multiple interactions EXP 6480464 [Plasticizers co-treated with Fungicides and Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of TH mRNA CTD PMID:34383603 lipopolysaccharide decreases methylation ISO Th (Mus musculus) 6480464 Lipopolysaccharides results in decreased methylation of TH gene CTD PMID:21212295 lipopolysaccharide decreases expression ISO Th (Mus musculus) 6480464 Lipopolysaccharides results in decreased expression of TH protein CTD PMID:29338785 lipopolysaccharide multiple interactions EXP 6480464 Lipopolysaccharides results in increased phosphorylation of and results in increased activity of TH protein CTD PMID:23483921 lipopolysaccharide multiple interactions ISO Th (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of TH gene and VCE-003 analog inhibits the reaction [Lipopolysaccharides results in decreased expression of TH protein] CTD PMID:21212295 and PMID:29338785 lithium atom multiple interactions EXP 6480464 Lithium inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:19149911 lithium hydride multiple interactions EXP 6480464 Lithium inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:19149911 lovastatin increases expression ISO TH (Homo sapiens) 6480464 Lovastatin results in increased expression of TH protein CTD PMID:20694854 lovastatin multiple interactions ISO Th (Mus musculus) 6480464 Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of TH protein] CTD PMID:20694854 lovastatin increases expression ISO Th (Mus musculus) 6480464 Lovastatin results in increased expression of TH protein CTD PMID:20694854 lovastatin multiple interactions ISO TH (Homo sapiens) 6480464 Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of TH protein] CTD PMID:20694854 LY294002 multiple interactions ISO Th (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [HU 211 results in decreased expression of TH mRNA] CTD PMID:18950629 maneb decreases expression ISO Th (Mus musculus) 6480464 Maneb results in decreased expression of TH protein CTD PMID:22334051 maneb multiple interactions EXP 6480464 [Paraquat co-treated with Maneb] results in decreased expression of TH more ... CTD PMID:24376148 and PMID:29152652 maneb multiple interactions ISO Th (Mus musculus) 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein] more ... CTD PMID:11124998 more ... manganese atom decreases expression EXP 6480464 Manganese results in decreased expression of TH mRNA and Manganese results in decreased expression of TH protein CTD PMID:16943606 more ... manganese atom multiple interactions ISO Th (Mus musculus) 6480464 [manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein and Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein] CTD PMID:34590183 manganese(0) decreases expression EXP 6480464 Manganese results in decreased expression of TH mRNA and Manganese results in decreased expression of TH protein CTD PMID:16943606 more ... manganese(0) multiple interactions ISO Th (Mus musculus) 6480464 [manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein and Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein] CTD PMID:34590183 manganese(II) chloride multiple interactions EXP 6480464 [wortmannin co-treated with manganese chloride] results in decreased expression of TH protein more ... CTD PMID:21310168 and PMID:23604964 manganese(II) chloride increases methylation ISO TH (Homo sapiens) 6480464 manganese chloride results in increased methylation of TH gene CTD PMID:27913844 manganese(II) chloride decreases expression ISO TH (Homo sapiens) 6480464 manganese chloride results in decreased expression of TH mRNA CTD PMID:27913844 manganese(II) chloride decreases expression EXP 6480464 manganese chloride results in decreased expression of TH protein CTD PMID:20798247 more ... manganese(II) chloride multiple interactions ISO Th (Mus musculus) 6480464 [manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein more ... CTD PMID:24969583 more ... manganese(II) chloride decreases expression ISO Th (Mus musculus) 6480464 manganese chloride results in decreased expression of TH mRNA and manganese chloride results in decreased expression of TH protein CTD PMID:24969583 more ... manganese(II) chloride increases expression EXP 6480464 manganese chloride results in increased expression of TH mRNA and manganese chloride results in increased expression of TH protein CTD PMID:12106697 manganese(II) chloride decreases activity EXP 6480464 manganese chloride results in decreased activity of TH protein CTD PMID:21310168 manganese(II) sulfate decreases expression EXP 6480464 manganese sulfate results in decreased expression of TH mRNA CTD PMID:16943606 melatonin multiple interactions EXP 6480464 Melatonin inhibits the reaction [Methamphetamine results in decreased expression of TH protein] and Melatonin inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:18289173 and PMID:19409439 melatonin multiple interactions ISO Th (Mus musculus) 6480464 Melatonin inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:20964710 more ... mephedrone multiple interactions ISO Th (Mus musculus) 6480464 Ethanol promotes the reaction [mephedrone results in decreased expression of TH protein] CTD PMID:26747301 mephedrone decreases expression EXP 6480464 mephedrone results in decreased expression of TH protein CTD PMID:25817894 mephedrone decreases expression ISO Th (Mus musculus) 6480464 mephedrone results in decreased expression of TH protein CTD PMID:26747301 mercaptopurine multiple interactions EXP 6480464 [GW 1929 co-treated with Mercaptopurine] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] and Mercaptopurine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] CTD PMID:27435855 metformin multiple interactions EXP 6480464 Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TH protein] CTD PMID:35085591 methamphetamine decreases expression ISO TH (Homo sapiens) 6480464 Methamphetamine results in decreased expression of TH protein CTD PMID:16622715 methamphetamine multiple interactions ISO TH (Homo sapiens) 6480464 ginsenoside Re inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased activity of TH protein] more ... CTD PMID:25523949 methamphetamine decreases expression ISO Th (Mus musculus) 6480464 Methamphetamine results in decreased expression of TH mRNA and Methamphetamine results in decreased expression of TH protein CTD PMID:12871582 more ... methamphetamine decreases activity ISO Th (Mus musculus) 6480464 Methamphetamine results in decreased activity of TH protein CTD PMID:1381816 more ... methamphetamine affects expression EXP 6480464 Methamphetamine affects the expression of TH mRNA CTD PMID:24042092 methamphetamine decreases expression EXP 6480464 Methamphetamine results in decreased expression of TH protein CTD PMID:10773198 more ... methamphetamine decreases activity EXP 6480464 Methamphetamine results in decreased activity of TH protein CTD PMID:2579200 methamphetamine multiple interactions EXP 6480464 diadenosine tetraphosphate inhibits the reaction [Methamphetamine results in decreased expression of TH protein] more ... CTD PMID:15276877 more ... methamphetamine affects response to substance ISO Th (Mus musculus) 6480464 TH protein affects the susceptibility to Methamphetamine CTD PMID:9822156 methamphetamine multiple interactions ISO Th (Mus musculus) 6480464 3-((3 more ... CTD PMID:10984662 more ... methoxychlor increases methylation EXP 6480464 Methoxychlor results in increased methylation of TH gene CTD PMID:23303685 methyllycaconitine multiple interactions ISO TH (Homo sapiens) 6480464 [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA] CTD PMID:17498763 methylmercury chloride decreases expression ISO Th (Mus musculus) 6480464 methylmercuric chloride results in decreased expression of TH mRNA CTD PMID:21385734 methylmercury chloride multiple interactions ISO Th (Mus musculus) 6480464 3 and 9-bis((ethylthio)methyl)-K-252a inhibits the reaction [methylmercuric chloride results in decreased expression of TH mRNA] CTD PMID:21385734 methylphenidate decreases expression ISO Th (Mus musculus) 6480464 Methylphenidate results in decreased expression of TH mRNA CTD PMID:22470460 mevalonic acid multiple interactions ISO Th (Mus musculus) 6480464 Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of TH protein] CTD PMID:20694854 mevalonic acid multiple interactions ISO TH (Homo sapiens) 6480464 Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of TH protein] CTD PMID:20694854 mifepristone decreases expression ISO TH (Homo sapiens) 6480464 Mifepristone results in decreased expression of TH mRNA CTD PMID:17584828 mifepristone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Monocrotophos results in increased activity of TH protein] CTD PMID:22305719 mono(2-ethylhexyl) phthalate decreases expression EXP 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of TH mRNA CTD PMID:21145954 mono(2-ethylhexyl) phthalate multiple interactions ISO Th (Mus musculus) 6480464 [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of TH mRNA CTD PMID:36189433 mono(2-ethylhexyl) phthalate increases expression ISO Th (Mus musculus) 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of TH mRNA CTD PMID:22401849 monocrotophos multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Monocrotophos results in increased activity of TH protein] CTD PMID:22305719 monocrotophos increases activity EXP 6480464 Monocrotophos results in increased activity of TH protein CTD PMID:22305719 monosodium L-glutamate decreases expression EXP 6480464 Sodium Glutamate results in decreased expression of TH mRNA CTD PMID:1980722 monosodium L-glutamate decreases activity EXP 6480464 Sodium Glutamate results in decreased activity of TH protein CTD PMID:1980722 montelukast multiple interactions EXP 6480464 montelukast inhibits the reaction [Rotenone results in increased expression of TH protein] CTD PMID:30222980 morphine multiple interactions EXP 6480464 [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of TH protein] more ... CTD PMID:15541421 more ... morphine decreases expression EXP 6480464 Morphine results in decreased expression of TH protein CTD PMID:26386147 morphine multiple interactions ISO Th (Mus musculus) 6480464 [Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein and CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein] CTD PMID:25582704 morphine increases phosphorylation EXP 6480464 Morphine deficiency results in increased phosphorylation of TH protein CTD PMID:24398105 morphine increases expression EXP 6480464 Morphine results in increased expression of TH protein CTD PMID:15541421 N(gamma)-nitro-L-arginine methyl ester decreases expression ISO Th (Mus musculus) 6480464 NG-Nitroarginine Methyl Ester results in decreased expression of TH protein CTD PMID:31187328 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions EXP 6480464 [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with exoenzyme C3 more ... CTD PMID:18992715 and PMID:29246838 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide decreases expression EXP 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of TH mRNA CTD PMID:18992715 N-acetyl-L-cysteine multiple interactions EXP 6480464 [Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in decreased expression of TH protein and Acetylcysteine inhibits the reaction [Chlorpyrifos results in decreased expression of TH protein] CTD PMID:22714038 and PMID:25891525 N-acetyl-L-cysteine decreases expression EXP 6480464 Acetylcysteine results in decreased expression of TH protein CTD PMID:25891525 N-ethyl-N-nitrosourea increases mutagenesis EXP 6480464 Ethylnitrosourea results in increased mutagenesis of TH gene CTD PMID:16495775 N-ethylmaleimide multiple interactions EXP 6480464 Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein] CTD PMID:15983997 N-methyl-4-phenylpyridinium multiple interactions ISO Th (Mus musculus) 6480464 3-Hydroxybutyric Acid affects the reaction [ZFP36 protein affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]] more ... CTD PMID:20184101 more ... N-methyl-4-phenylpyridinium increases expression ISO TH (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in increased expression of TH mRNA CTD PMID:24810058 N-methyl-4-phenylpyridinium decreases expression ISO TH (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of TH mRNA and 1-Methyl-4-phenylpyridinium results in decreased expression of TH protein CTD PMID:26364587 and PMID:30463061 N-methyl-4-phenylpyridinium multiple interactions ISO TH (Homo sapiens) 6480464 BMP2 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] more ... CTD PMID:20007850 more ... N-methyl-4-phenylpyridinium decreases expression ISO Th (Mus musculus) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of TH mRNA and 1-Methyl-4-phenylpyridinium results in decreased expression of TH protein CTD PMID:20007850 more ... N-methyl-4-phenylpyridinium decreases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of TH mRNA and 1-Methyl-4-phenylpyridinium results in decreased expression of TH protein CTD PMID:19794909 more ... N-methyl-4-phenylpyridinium multiple interactions EXP 6480464 [GW 1929 co-treated with Mercaptopurine] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] more ... CTD PMID:19794909 more ... N-methyl-4-phenylpyridinium decreases activity ISO Th (Mus musculus) 6480464 1-Methyl-4-phenylpyridinium results in decreased activity of TH protein CTD PMID:20184101 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of TH mRNA CTD PMID:20360939 N-nitrosodiethylamine multiple interactions ISO Th (Mus musculus) 6480464 [Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of TH gene CTD PMID:23968726 naloxone multiple interactions EXP 6480464 [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased phosphorylation of TH protein] and [Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein CTD PMID:24398105 and PMID:25308750 naloxone multiple interactions ISO Th (Mus musculus) 6480464 [Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein and CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein] CTD PMID:25582704 naloxone increases phosphorylation EXP 6480464 Naloxone results in increased phosphorylation of TH protein CTD PMID:24398105 naltrexone multiple interactions ISO Th (Mus musculus) 6480464 [Cannabidiol co-treated with Naltrexone] results in decreased expression of TH mRNA CTD PMID:29859012 nickel atom increases expression EXP 6480464 Nickel results in increased expression of TH mRNA CTD PMID:18812211 nickel dichloride multiple interactions ISO TH (Homo sapiens) 6480464 nickel chloride inhibits the reaction [Tretinoin results in increased expression of TH protein] CTD PMID:25614230 nicotine increases expression EXP 6480464 Nicotine results in increased expression of TH mRNA and Nicotine results in increased expression of TH protein CTD PMID:29246838 nicotine multiple interactions EXP 6480464 [conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]] more ... CTD PMID:29246838 nicotine multiple interactions ISO Th (Mus musculus) 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:19594327 more ... nicotine multiple interactions ISO TH (Homo sapiens) 6480464 [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA] CTD PMID:17498763 nicotine increases expression ISO TH (Homo sapiens) 6480464 Nicotine results in increased expression of TH mRNA and Nicotine results in increased expression of TH protein CTD PMID:17498763 nimodipine multiple interactions EXP 6480464 Nimodipine inhibits the reaction [Dichlorvos results in increased activity of TH protein] CTD PMID:12186780 nitroprusside multiple interactions EXP 6480464 [Nitroprusside co-treated with Urethane co-treated with Chloralose] results in increased expression of TH protein more ... CTD PMID:12088752 and PMID:16023617 nitroprusside increases expression EXP 6480464 Nitroprusside results in increased expression of TH protein CTD PMID:12088752 Nookatone multiple interactions EXP 6480464 nootkatone inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:35833337 Norbinaltorphimine multiple interactions ISO Th (Mus musculus) 6480464 3-((3 more ... CTD PMID:29467000 olanzapine multiple interactions EXP 6480464 olanzapine inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:15276877 oleuropein multiple interactions ISO Th (Mus musculus) 6480464 oleuropein inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:36774383 oridonin multiple interactions EXP 6480464 oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH mRNA] CTD PMID:31430510 oxidopamine decreases expression EXP 6480464 Oxidopamine results in decreased expression of TH mRNA and Oxidopamine results in decreased expression of TH protein CTD PMID:11730701 more ... oxidopamine affects response to substance ISO TH (Homo sapiens) 6480464 TH protein affects the susceptibility to Oxidopamine CTD PMID:19815691 oxidopamine multiple interactions ISO TH (Homo sapiens) 6480464 TH protein inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein] CTD PMID:19815691 oxidopamine multiple interactions ISO Th (Mus musculus) 6480464 LY 344864 inhibits the reaction [Oxidopamine results in decreased expression of TH protein] more ... CTD PMID:16914382 more ... oxidopamine decreases expression ISO Th (Mus musculus) 6480464 Oxidopamine results in decreased expression of TH mRNA and Oxidopamine results in decreased expression of TH protein CTD PMID:15899244 more ... oxidopamine multiple interactions EXP 6480464 2-chloro-5-hydroxyphenylglycine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the expression of TH protein] more ... CTD PMID:12585172 more ... P(1),P(4)-bis(5'-adenosyl) tetraphosphate multiple interactions EXP 6480464 diadenosine tetraphosphate inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:19442829 paracetamol multiple interactions EXP 6480464 [Plasticizers co-treated with Fungicides and Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of TH mRNA CTD PMID:34383603 paraquat decreases expression ISO Th (Mus musculus) 6480464 Paraquat results in decreased expression of TH protein CTD PMID:22334051 more ... paraquat multiple interactions ISO TH (Homo sapiens) 6480464 MT2A protein inhibits the reaction [Paraquat results in increased expression of TH mRNA] CTD PMID:34623211 paraquat affects expression ISO Th (Mus musculus) 6480464 Paraquat affects the expression of TH protein CTD PMID:28428137 paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of TH mRNA and Paraquat results in decreased expression of TH protein CTD PMID:16190885 more ... paraquat increases expression ISO TH (Homo sapiens) 6480464 Paraquat results in increased expression of TH protein CTD PMID:26498265 paraquat increases activity EXP 6480464 Paraquat results in increased activity of TH protein CTD PMID:24743698 paraquat multiple interactions EXP 6480464 [Paraquat co-treated with Maneb] results in decreased expression of TH more ... CTD PMID:20553223 more ... paraquat multiple interactions ISO Th (Mus musculus) 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein] more ... CTD PMID:11124998 more ... pentanal decreases expression ISO TH (Homo sapiens) 6480464 pentanal results in decreased expression of TH mRNA CTD PMID:26079696 perfluorodecanoic acid multiple interactions ISO Th (Mus musculus) 6480464 [perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA CTD PMID:34371090 perfluorododecanoic acid multiple interactions ISO Th (Mus musculus) 6480464 [perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA CTD PMID:34371090 perfluorononanoic acid multiple interactions ISO Th (Mus musculus) 6480464 [perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA CTD PMID:34371090 perfluorooctane-1-sulfonic acid decreases expression ISO Th (Mus musculus) 6480464 perfluorooctane sulfonic acid results in decreased expression of TH mRNA CTD PMID:26686188 perfluorooctane-1-sulfonic acid multiple interactions ISO Th (Mus musculus) 6480464 [perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA CTD PMID:34371090 perfluorooctanoic acid multiple interactions ISO Th (Mus musculus) 6480464 [perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA CTD PMID:34371090 perfluoroundecanoic acid multiple interactions ISO Th (Mus musculus) 6480464 [perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA CTD PMID:34371090 permethrin multiple interactions EXP 6480464 Permethrin results in decreased expression of and results in decreased activity of TH protein CTD PMID:15461254 permethrin increases expression EXP 6480464 Permethrin results in increased expression of TH mRNA CTD PMID:31175960 permethrin decreases expression EXP 6480464 Permethrin results in decreased expression of TH mRNA CTD PMID:15461254 phencyclidine multiple interactions ISO Th (Mus musculus) 6480464 Phencyclidine inhibits the reaction [Methamphetamine results in decreased activity of TH protein] CTD PMID:1381816 phencyclidine increases expression ISO Th (Mus musculus) 6480464 Phencyclidine results in increased expression of TH mRNA CTD PMID:12105081 Phenelzine increases expression EXP 6480464 Phenelzine results in increased expression of TH mRNA CTD PMID:1351783 phenethyl caffeate multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of TH mRNA CTD PMID:20360939 phorbol 13-acetate 12-myristate increases expression EXP 6480464 Tetradecanoylphorbol Acetate results in increased expression of TH mRNA CTD PMID:18992715 phorbol 13-acetate 12-myristate multiple interactions ISO TH (Homo sapiens) 6480464 [Tretinoin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TH protein CTD PMID:24101030 piperazine decreases expression ISO TH (Homo sapiens) 6480464 Piperazine analog results in decreased expression of TH protein CTD PMID:28874085 piperonyl butoxide multiple interactions ISO Th (Mus musculus) 6480464 [Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of TH gene CTD PMID:23968726 pirinixic acid multiple interactions ISO TH (Homo sapiens) 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TH mRNA CTD PMID:19710929 pregabalin affects expression ISO Th (Mus musculus) 6480464 Pregabalin affects the expression of TH mRNA CTD PMID:22017514 pregabalin increases expression ISO Th (Mus musculus) 6480464 Pregabalin results in increased expression of TH mRNA CTD PMID:22489711 probenecid multiple interactions ISO Th (Mus musculus) 6480464 1 more ... CTD PMID:19653878 and PMID:25406165 progesterone decreases phosphorylation EXP 6480464 Progesterone results in decreased phosphorylation of TH protein CTD PMID:18096660 progesterone decreases activity EXP 6480464 Progesterone results in decreased activity of TH protein CTD PMID:18096660 propanal decreases expression ISO TH (Homo sapiens) 6480464 propionaldehyde results in decreased expression of TH mRNA CTD PMID:26079696 propionic acid multiple interactions EXP 6480464 [[propionic acid co-treated with fasudil] affects the susceptibility to Rotenone] which results in increased expression of TH mRNA CTD PMID:32481507 propionic acid increases expression EXP 6480464 propionic acid results in increased expression of TH mRNA CTD PMID:32481507 propofol decreases expression ISO Th (Mus musculus) 6480464 Propofol results in decreased expression of TH protein CTD PMID:32612007 prothioconazole increases expression ISO TH (Homo sapiens) 6480464 prothioconazole results in increased expression of TH mRNA CTD PMID:35048155 purine-6-thiol multiple interactions EXP 6480464 [GW 1929 co-treated with Mercaptopurine] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] and Mercaptopurine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] CTD PMID:27435855 pyrrolidine dithiocarbamate multiple interactions ISO Th (Mus musculus) 6480464 pyrrolidine dithiocarbamic acid affects the reaction [GPX1 protein affects the reaction [Methamphetamine results in decreased expression of and results in decreased activity of TH protein]] and pyrrolidine dithiocarbamic acid inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased activity of TH protein] CTD PMID:34082047 pyrroloquinoline quinone multiple interactions EXP 6480464 PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:26276080 and PMID:27108097 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Rotenone results in decreased activity of TH protein] and Quercetin inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:23357119 and PMID:35337893 quercetin 3-O-beta-D-glucofuranoside multiple interactions EXP 6480464 isoquercitrin promotes the reaction [Oxidopamine results in decreased expression of TH mRNA] CTD PMID:25129099 quercetin 3-O-beta-D-glucopyranoside multiple interactions EXP 6480464 isoquercitrin promotes the reaction [Oxidopamine results in decreased expression of TH mRNA] CTD PMID:25129099 reserpine increases expression ISO Th (Mus musculus) 6480464 Reserpine results in increased expression of TH mRNA CTD PMID:8666980 reserpine increases activity EXP 6480464 Reserpine results in increased activity of TH protein CTD PMID:1978789 more ... reserpine increases expression EXP 6480464 Reserpine results in increased expression of TH mRNA and Reserpine results in increased expression of TH protein CTD PMID:11438978 more ... reserpine decreases expression EXP 6480464 Reserpine results in decreased expression of TH mRNA CTD PMID:20504635 reserpine affects activity EXP 6480464 Reserpine affects the activity of TH protein CTD PMID:1981253 reserpine increases stability EXP 6480464 Reserpine results in increased stability of TH mRNA CTD PMID:11161478 reserpine multiple interactions EXP 6480464 Bicuculline promotes the reaction [Reserpine affects the activity of TH protein] more ... CTD PMID:11438978 more ... resveratrol multiple interactions ISO Th (Mus musculus) 6480464 resveratrol promotes the reaction [Cocaine results in decreased phosphorylation of TH protein] CTD PMID:23499958 resveratrol multiple interactions EXP 6480464 Resveratrol inhibits the reaction [Oxidopamine results in decreased expression of TH protein] CTD PMID:34302886 resveratrol multiple interactions ISO TH (Homo sapiens) 6480464 [Plant Extracts co-treated with Resveratrol] results in decreased expression of TH mRNA CTD PMID:23557933 rimonabant increases activity EXP 6480464 Rimonabant results in increased activity of TH protein CTD PMID:15882845 rimonabant multiple interactions EXP 6480464 Rimonabant affects the reaction [PRKN mutant form affects the activity of TH protein] and Rimonabant inhibits the reaction [Dronabinol results in increased activity of TH protein] CTD PMID:10700552 more ... risperidone increases expression EXP 6480464 Risperidone results in increased expression of TH protein CTD PMID:17028028 rotenone multiple interactions ISO Th (Mus musculus) 6480464 baicalein inhibits the reaction [Rotenone results in decreased expression of TH protein] more ... CTD PMID:17047462 more ... rotenone decreases activity EXP 6480464 Rotenone results in decreased activity of TH protein CTD PMID:35187747 and PMID:35337893 rotenone increases expression EXP 6480464 Rotenone results in increased expression of TH protein CTD PMID:30222980 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of TH mRNA and Rotenone results in decreased expression of TH protein CTD PMID:12385818 more ... rotenone multiple interactions EXP 6480464 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Docosahexaenoic Acids inhibits the reaction [Rotenone results in decreased expression of TH protein]] more ... CTD PMID:15790535 more ... rotenone increases response to substance EXP 6480464 TH protein results in increased susceptibility to Rotenone CTD PMID:14622122 rotenone decreases expression ISO Th (Mus musculus) 6480464 Rotenone results in decreased expression of TH protein CTD PMID:17047462 more ... rottlerin multiple interactions EXP 6480464 rottlerin inhibits the reaction [manganese chloride results in decreased activity of TH protein] CTD PMID:21310168 rottlerin multiple interactions ISO Th (Mus musculus) 6480464 [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased activity of TH protein] and [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:22512859 rutin multiple interactions EXP 6480464 Rutin inhibits the reaction [Oxidopamine results in decreased expression of TH mRNA] CTD PMID:25129099 salubrinal multiple interactions EXP 6480464 salubrinal inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:26446018 saxagliptin multiple interactions EXP 6480464 saxagliptin inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:25446674 SB 203580 multiple interactions EXP 6480464 SB 203580 inhibits the reaction [fenvalerate results in decreased expression of TH protein] and SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of TH protein] CTD PMID:31734597 and PMID:9288946 SCH 23390 multiple interactions ISO Th (Mus musculus) 6480464 SCH 23390 inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of TH protein] and SCH 23390 inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:16088948 and PMID:30922767 selenium atom increases activity EXP 6480464 Selenium deficiency results in increased activity of TH protein CTD PMID:11113527 selenium atom increases expression EXP 6480464 Selenium deficiency results in increased expression of TH mRNA CTD PMID:11113527 selenium atom multiple interactions EXP 6480464 [Selenium deficiency results in increased activity of TH protein] which results in increased chemical synthesis of Dopamine CTD PMID:11113527 simazine decreases expression EXP 6480464 Simazine results in decreased expression of TH protein CTD PMID:14550852 simazine decreases expression ISO Th (Mus musculus) 6480464 Simazine results in decreased expression of TH mRNA and Simazine results in decreased expression of TH protein CTD PMID:34936186 simazine affects expression ISO Th (Mus musculus) 6480464 Simazine affects the expression of TH mRNA and Simazine affects the expression of TH protein CTD PMID:29137186 simazine increases expression ISO Th (Mus musculus) 6480464 Simazine results in increased expression of TH mRNA and Simazine results in increased expression of TH protein CTD PMID:27513680 and PMID:32822773 simazine multiple interactions ISO Th (Mus musculus) 6480464 LMX1A protein promotes the reaction [Simazine results in increased expression of TH protein] CTD PMID:32822773 sodium arsenite multiple interactions ISO Th (Mus musculus) 6480464 [sodium arsenite affects the localization of NR4A2 protein] inhibits the reaction [NR4A2 protein results in increased expression of TH mRNA] CTD PMID:23283970 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of TH protein CTD PMID:25179238 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of TH protein CTD PMID:19631675 more ... sodium arsenite multiple interactions EXP 6480464 Curcumin inhibits the reaction [sodium arsenite results in decreased expression of TH protein] more ... CTD PMID:19631675 more ... sodium arsenite increases expression ISO Th (Mus musculus) 6480464 sodium arsenite results in increased expression of TH protein CTD PMID:27413109 sodium arsenite decreases expression ISO Th (Mus musculus) 6480464 sodium arsenite results in decreased expression of TH mRNA CTD PMID:19121333 more ... sodium chloride increases expression EXP 6480464 Sodium Chloride results in increased expression of TH mRNA CTD PMID:10613505 Sophoricoside multiple interactions ISO Th (Mus musculus) 6480464 sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:37741537 spiperone multiple interactions EXP 6480464 Spiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]] CTD PMID:20729865 streptozocin multiple interactions EXP 6480464 [Streptozocin co-treated with Dietary Fats] results in increased expression of TH protein more ... CTD PMID:35085591 and PMID:38049026 streptozocin decreases expression EXP 6480464 Streptozocin results in decreased expression of TH protein CTD PMID:38049026 sulforaphane multiple interactions ISO Th (Mus musculus) 6480464 sulforaphane inhibits the reaction [Oxidopamine results in decreased expression of TH protein] CTD PMID:23518299 sulpiride multiple interactions EXP 6480464 Sulpiride inhibits the reaction [Dopamine results in decreased activity of TH protein] and Sulpiride inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:18289173 and PMID:2884129 sulpiride multiple interactions ISO Th (Mus musculus) 6480464 Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of TH protein] CTD PMID:30922767 sulpiride increases activity EXP 6480464 Sulpiride results in increased activity of TH protein CTD PMID:2884129 Talipexole dihydrochloride multiple interactions ISO Th (Mus musculus) 6480464 talipexole inhibits the reaction [Methamphetamine results in decreased activity of TH protein] CTD PMID:9655613 tamoxifen multiple interactions ISO Th (Mus musculus) 6480464 Tamoxifen inhibits the reaction [manganese chloride results in decreased expression of TH mRNA] and Tamoxifen inhibits the reaction [manganese chloride results in decreased expression of TH protein] CTD PMID:29183790 tamoxifen decreases expression EXP 6480464 Tamoxifen results in decreased expression of TH mRNA and Tamoxifen results in decreased expression of TH protein CTD PMID:28463726 tamoxifen multiple interactions EXP 6480464 Tamoxifen inhibits the reaction [amitraz results in increased expression of TH mRNA] and Tamoxifen inhibits the reaction [amitraz results in increased expression of TH protein] CTD PMID:28463726 taurine multiple interactions ISO Th (Mus musculus) 6480464 Taurine inhibits the reaction [arsenic trioxide results in decreased expression of TH mRNA] CTD PMID:23392890 telmisartan multiple interactions ISO Th (Mus musculus) 6480464 telmisartan inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:23747572 testosterone decreases expression EXP 6480464 Testosterone results in decreased expression of TH protein CTD PMID:11883789 topiramate affects expression ISO Th (Mus musculus) 6480464 topiramate affects the expression of TH mRNA CTD PMID:22017514 topiramate increases expression ISO Th (Mus musculus) 6480464 topiramate results in increased expression of TH mRNA CTD PMID:22489711 trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of TH protein CTD PMID:33636387 trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of TH mRNA CTD PMID:33387578 triprolidine multiple interactions EXP 6480464 Triprolidine inhibits the reaction [1-phenyl-3-dimethylamino-1 more ... CTD PMID:10661506 tris(2-butoxyethyl) phosphate affects expression ISO TH (Homo sapiens) 6480464 tris(2-butoxyethyl) phosphate affects the expression of TH mRNA CTD PMID:29024780 urethane multiple interactions EXP 6480464 [Nitroprusside co-treated with Urethane co-treated with Chloralose] results in increased expression of TH protein CTD PMID:12088752 valproic acid affects expression ISO Th (Mus musculus) 6480464 Valproic Acid affects the expression of TH mRNA CTD PMID:17963808 valproic acid increases methylation EXP 6480464 Valproic Acid results in increased methylation of TH promoter CTD PMID:33150595 valproic acid multiple interactions ISO Th (Mus musculus) 6480464 Valproic Acid inhibits the reaction [manganese chloride results in decreased expression of TH mRNA] and Valproic Acid inhibits the reaction [manganese chloride results in decreased expression of TH protein] CTD PMID:29778792 valproic acid affects expression ISO TH (Homo sapiens) 6480464 Valproic Acid affects the expression of TH mRNA CTD PMID:25979313 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of TH mRNA and Valproic Acid results in increased expression of TH protein CTD PMID:18976638 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of TH mRNA and Valproic Acid results in decreased expression of TH protein CTD PMID:18976638 and PMID:33150595 valproic acid multiple interactions EXP 6480464 CREB1 protein affects the reaction [Valproic Acid results in increased expression of TH mRNA] and Valproic Acid inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:18976638 and PMID:19149911 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of TH protein CTD PMID:19460635 vitamin D decreases expression EXP 6480464 Vitamin D deficiency results in decreased expression of TH mRNA and Vitamin D deficiency results in decreased expression of TH protein CTD PMID:28365874 vorinostat decreases expression ISO TH (Homo sapiens) 6480464 vorinostat results in decreased expression of TH mRNA CTD PMID:27188386 WIN 55212-2 affects expression EXP 6480464 (3R)-((2 more ... CTD PMID:29113897 WIN 55212-2 multiple interactions EXP 6480464 AM 251 affects the reaction [(3R)-((2 more ... CTD PMID:29113897 WIN 55212-2 multiple interactions ISO Th (Mus musculus) 6480464 (3R)-((2 more ... CTD PMID:28092019 wortmannin multiple interactions ISO Th (Mus musculus) 6480464 wortmannin affects the reaction [HU 211 results in decreased expression of TH mRNA] CTD PMID:18950629 wortmannin multiple interactions EXP 6480464 [wortmannin co-treated with manganese chloride] results in decreased expression of TH protein CTD PMID:23604964 Y-27632 multiple interactions ISO Th (Mus musculus) 6480464 [cobaltous chloride co-treated with Y 27632] results in increased expression of TH protein CTD PMID:16772336 zearalenone decreases expression ISO TH (Homo sapiens) 6480464 Zearalenone results in decreased expression of TH mRNA CTD PMID:24412706 zinc atom increases expression EXP 6480464 Zinc results in increased expression of TH protein CTD PMID:11165868 zinc atom decreases expression EXP 6480464 Zinc results in decreased expression of TH protein CTD PMID:32060784 zinc atom multiple interactions EXP 6480464 Paraquat promotes the reaction [Zinc results in decreased expression of TH protein] and Zinc promotes the reaction [Paraquat results in decreased expression of TH protein] CTD PMID:32060784 zinc sulfate multiple interactions EXP 6480464 Paraquat promotes the reaction [Zinc Sulfate results in decreased expression of TH protein] and Zinc Sulfate promotes the reaction [Paraquat results in decreased expression of TH protein] CTD PMID:20553223 zinc sulfate decreases expression EXP 6480464 Zinc Sulfate results in decreased expression of TH protein CTD PMID:20553223 zinc(0) increases expression EXP 6480464 Zinc results in increased expression of TH protein CTD PMID:11165868 zinc(0) multiple interactions EXP 6480464 Paraquat promotes the reaction [Zinc results in decreased expression of TH protein] and Zinc promotes the reaction [Paraquat results in decreased expression of TH protein] CTD PMID:32060784 zinc(0) decreases expression EXP 6480464 Zinc results in decreased expression of TH protein CTD PMID:32060784 zonisamide increases expression ISO TH (Homo sapiens) 6480464 Zonisamide results in increased expression of TH mRNA and Zonisamide results in increased expression of TH protein CTD PMID:20196486 zonisamide multiple interactions ISO Th (Mus musculus) 6480464 [zonisamide co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:19199078 and PMID:19948168 zonisamide increases expression ISO Th (Mus musculus) 6480464 zonisamide results in increased expression of TH protein CTD PMID:19199078
