Sox10 (SRY-box transcription factor 10) - Rat Genome Database

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Gene: Sox10 (SRY-box transcription factor 10) Rattus norvegicus
Analyze
Symbol: Sox10
Name: SRY-box transcription factor 10
RGD ID: 3735
Description: Enables several functions, including DNA-binding transcription activator activity; promoter-specific chromatin binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to progesterone stimulus; regulation of gene expression; and regulation of nervous system development. Located in chromatin. Human ortholog(s) of this gene implicated in Kallmann syndrome; PCWH syndrome; Waardenburg syndrome type 2E; and Waardenburg syndrome type 4C. Orthologous to human SOX10 (SRY-box transcription factor 10); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2-trans,6-trans,10-trans-geranylgeranyl diphosphate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: SRY (sex determining region Y)-box 10; SRY box 10; SRY-box containing gene 10; transcription factor SOX-10
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau6
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87112,605,721 - 112,615,097 (-)NCBIGRCr8
mRatBN7.27110,725,274 - 110,734,651 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7110,725,274 - 110,735,544 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7112,473,920 - 112,483,178 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07114,697,448 - 114,706,706 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07114,666,769 - 114,676,030 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07120,393,238 - 120,403,523 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,393,254 - 120,403,523 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07120,387,071 - 120,397,340 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47117,138,694 - 117,149,939 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17117,172,923 - 117,184,169 (-)NCBI
Celera7107,059,767 - 107,070,023 (-)NCBICelera
RH 3.4 Map7839.3RGD
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell development  (NAS)
cell differentiation  (ISO)
cell maturation  (ISO)
cellular response to progesterone stimulus  (IEP)
cellular response to xenobiotic stimulus  (IEP)
central nervous system myelination  (ISO,ISS)
developmental growth  (ISO)
digestive tract morphogenesis  (ISO)
enteric nervous system development  (IBA,ISO)
in utero embryonic development  (ISO)
lacrimal gland development  (ISO)
melanocyte differentiation  (ISO)
morphogenesis of a branching epithelium  (ISO)
morphogenesis of an epithelium  (IBA)
negative regulation of apoptotic process  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of DNA-templated transcription  (IDA)
negative regulation of Schwann cell proliferation  (IMP)
negative regulation of transcription by RNA polymerase II  (IBA)
neural crest cell migration  (IBA,ISO)
neuroblast proliferation  (ISO)
oligodendrocyte development  (ISO,ISS)
oligodendrocyte differentiation  (ISO,ISS)
peripheral nervous system development  (IBA,ISO)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of gene expression  (IMP)
positive regulation of gliogenesis  (ISO)
positive regulation of myelination  (IMP)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of DNA-templated transcription  (IDA)
stem cell differentiation  (IEP)
transcription by RNA polymerase II  (ISO)
transcription elongation by RNA polymerase II  (IDA)

Cellular Component
chromatin  (IDA)
cytoplasm  (ISO)
mitochondrial outer membrane  (ISO)
nucleoplasm  (ISO,TAS)
nucleus  (IBA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Transcription factors Sox10 and Sox2 functionally interact with positive transcription elongation factor b in Schwann cells. Arter J and Wegner M, J Neurochem. 2015 Feb;132(4):384-93. doi: 10.1111/jnc.13013. Epub 2015 Jan 22.
2. Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes. Baroti T, etal., J Neurochem. 2016 Jan;136(2):316-28. doi: 10.1111/jnc.13414. Epub 2015 Nov 25.
3. Genetic counseling for a three-generation Chinese family with Waardenburg syndrome type II associated with a rare SOX10 mutation. Chen K, etal., Int J Pediatr Otorhinolaryngol. 2015 May;79(5):745-8. doi: 10.1016/j.ijporl.2015.03.006. Epub 2015 Mar 17.
4. SOX10 regulates an alternative promoter at the Charcot-Marie-Tooth disease locus MTMR2. Fogarty EA, etal., Hum Mol Genet. 2016 Sep 15;25(18):3925-3936. doi: 10.1093/hmg/ddw233. Epub 2016 Jul 27.
5. SOX10 transactivates S100B to suppress Schwann cell proliferation and to promote myelination. Fujiwara S, etal., PLoS One. 2014 Dec 23;9(12):e115400. doi: 10.1371/journal.pone.0115400. eCollection 2014.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease. Herbarth B, etal., Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5161-5.
9. SOX10 regulates expression of the SH3-domain kinase binding protein 1 (Sh3kbp1) locus in Schwann cells via an alternative promoter. Hodonsky CJ, etal., Mol Cell Neurosci. 2012 Feb;49(2):85-96. doi: 10.1016/j.mcn.2011.10.004. Epub 2011 Oct 19.
10. Additive dominant effect of a SOX10 mutation underlies a complex phenotype of PCWH. Ito Y, etal., Neurobiol Dis. 2015 Aug;80:1-14. doi: 10.1016/j.nbd.2015.04.013. Epub 2015 May 7.
11. SOX10 maintains multipotency and inhibits neuronal differentiation of neural crest stem cells. Kim J, etal., Neuron. 2003 Apr 10;38(1):17-31.
12. Sox10, a novel transcriptional modulator in glial cells. Kuhlbrodt K, etal., J Neurosci 1998 Jan 1;18(1):237-50.
13. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
14. Cell type-specific activation of neuronal nicotinic acetylcholine receptor subunit genes by Sox10. Liu Q, etal., J Neurosci. 1999 Nov 15;19(22):9747-55.
15. Progesterone derivatives increase expression of Krox-20 and Sox-10 in rat Schwann cells. Magnaghi V, etal., J Mol Neurosci. 2007;31(2):149-57.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Loss-of-function mutations in SOX10 cause Kallmann syndrome with deafness. Pingault V, etal., Am J Hum Genet. 2013 May 2;92(5):707-24. doi: 10.1016/j.ajhg.2013.03.024.
20. SOX10 mutations in patients with Waardenburg-Hirschsprung disease. Pingault V, etal., Nat Genet. 1998 Feb;18(2):171-3.
21. Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation. Rehberg S, etal., Mol Cell Biol. 2002 Aug;22(16):5826-34.
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Comprehensive gene review and curation RGD comprehensive gene curation
26. The high-mobility group transcription factor Sox10 interacts with the N-myc-interacting protein Nmi. Schlierf B, etal., J Mol Biol. 2005 Nov 11;353(5):1033-42. Epub 2005 Sep 23.
27. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
28. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
29. M2 muscarinic receptor activation regulates Schwann cell differentiation and myelin organization. Uggenti C, etal., Dev Neurobiol. 2014 Jul;74(7):676-91. doi: 10.1002/dneu.22161. Epub 2014 Jan 9.
30. The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Wissmuller S, etal., Nucleic Acids Res. 2006 Mar 31;34(6):1735-44. Print 2006.
31. Functional analysis of Waardenburg syndrome-associated PAX3 and SOX10 mutations: report of a dominant-negative SOX10 mutation in Waardenburg syndrome type II. Zhang H, etal., Hum Genet. 2012 Mar;131(3):491-503. doi: 10.1007/s00439-011-1098-2. Epub 2011 Oct 1.
Additional References at PubMed
PMID:6512238   PMID:11029584   PMID:11799060   PMID:15102707   PMID:15489334   PMID:15572147   PMID:15713637   PMID:15729346   PMID:15843399   PMID:16684879   PMID:16790476   PMID:16857183  
PMID:17084361   PMID:17177851   PMID:17325040   PMID:17875931   PMID:18512230   PMID:19179536   PMID:19304657   PMID:21610032   PMID:21653862   PMID:22082260   PMID:23575864   PMID:24204311  
PMID:24924191   PMID:25433207   PMID:26253417   PMID:27532821   PMID:28071739   PMID:29130118   PMID:32362205   PMID:32428246   PMID:32908618   PMID:38791273  


Genomics

Comparative Map Data
Sox10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87112,605,721 - 112,615,097 (-)NCBIGRCr8
mRatBN7.27110,725,274 - 110,734,651 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7110,725,274 - 110,735,544 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7112,473,920 - 112,483,178 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07114,697,448 - 114,706,706 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07114,666,769 - 114,676,030 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07120,393,238 - 120,403,523 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,393,254 - 120,403,523 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07120,387,071 - 120,397,340 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47117,138,694 - 117,149,939 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17117,172,923 - 117,184,169 (-)NCBI
Celera7107,059,767 - 107,070,023 (-)NCBICelera
RH 3.4 Map7839.3RGD
Cytogenetic Map7q34NCBI
SOX10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382237,972,312 - 37,984,555 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2237,970,686 - 37,987,422 (-)EnsemblGRCh38hg38GRCh38
GRCh372238,368,319 - 38,380,562 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362236,698,265 - 36,710,485 (-)NCBINCBI36Build 36hg18NCBI36
Build 342236,692,819 - 36,705,039NCBI
Celera2222,170,048 - 22,182,268 (-)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2221,334,376 - 21,346,534 (-)NCBIHuRef
CHM1_12238,327,060 - 38,339,280 (-)NCBICHM1_1
T2T-CHM13v2.02238,433,934 - 38,446,177 (-)NCBIT2T-CHM13v2.0
Sox10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391579,039,113 - 79,048,690 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1579,039,108 - 79,049,440 (-)EnsemblGRCm39 Ensembl
GRCm381579,154,913 - 79,164,490 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1579,154,908 - 79,165,240 (-)EnsemblGRCm38mm10GRCm38
MGSCv371578,985,343 - 78,994,920 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361578,982,168 - 78,992,495 (-)NCBIMGSCv36mm8
Celera1581,267,600 - 81,277,195 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.7NCBI
Sox10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541324,311,783 - 24,323,315 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541324,313,311 - 24,323,112 (-)NCBIChiLan1.0ChiLan1.0
SOX10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22347,828,983 - 47,841,204 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12250,517,348 - 50,529,603 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02218,885,679 - 18,897,927 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12236,712,128 - 36,724,192 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2236,713,310 - 36,723,439 (-)Ensemblpanpan1.1panPan2
SOX10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11026,680,441 - 26,690,530 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1026,681,122 - 26,689,882 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1026,635,515 - 26,646,171 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01027,472,272 - 27,482,931 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1027,472,118 - 27,482,924 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11027,192,256 - 27,202,906 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01027,503,817 - 27,514,467 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01027,681,016 - 27,691,677 (+)NCBIUU_Cfam_GSD_1.0
Sox10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494510,163,344 - 10,174,369 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364923,173,741 - 3,185,024 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364923,173,770 - 3,183,423 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOX10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl59,891,525 - 9,901,743 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.159,890,439 - 9,901,746 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.257,289,992 - 7,299,054 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOX10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11920,673,053 - 20,685,506 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045105,090,681 - 105,103,173 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sox10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247529,965,756 - 9,973,777 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247529,965,015 - 9,976,244 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sox10
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:491
Count of miRNA genes:220
Interacting mature miRNAs:258
Transcripts:ENSRNOT00000015283
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
RH132696  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27110,725,302 - 110,725,492 (+)MAPPERmRatBN7.2
Rnor_6.07120,393,283 - 120,393,472NCBIRnor6.0
Rnor_5.07120,387,100 - 120,387,289UniSTSRnor5.0
RGSC_v3.47117,138,723 - 117,138,912UniSTSRGSC3.4
Celera7107,059,796 - 107,059,985UniSTS
RH 3.4 Map7839.2UniSTS
Cytogenetic Map7q34UniSTS
RH142225  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27110,725,690 - 110,725,840 (+)MAPPERmRatBN7.2
Rnor_6.07120,393,671 - 120,393,820NCBIRnor6.0
Rnor_5.07120,387,488 - 120,387,637UniSTSRnor5.0
RGSC_v3.47117,139,111 - 117,139,260UniSTSRGSC3.4
Celera7107,060,184 - 107,060,333UniSTS
RH 3.4 Map7839.3UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 59 58 27 25 27 6 181 97 93 40 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000015283   ⟹   ENSRNOP00000015283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7110,725,274 - 110,735,544 (-)Ensembl
Rnor_6.0 Ensembl7120,393,254 - 120,403,523 (-)Ensembl
RefSeq Acc Id: NM_019193   ⟹   NP_062066
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,605,721 - 112,615,097 (-)NCBI
mRatBN7.27110,725,274 - 110,734,651 (-)NCBI
Rnor_6.07120,393,254 - 120,403,523 (-)NCBI
Rnor_5.07120,387,071 - 120,397,340 (-)NCBI
RGSC_v3.47117,138,694 - 117,149,939 (-)RGD
Celera7107,059,767 - 107,070,023 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062066 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH62067 (Get FASTA)   NCBI Sequence Viewer  
  CAA04485 (Get FASTA)   NCBI Sequence Viewer  
  EDM15819 (Get FASTA)   NCBI Sequence Viewer  
  EDM15820 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015283.3
  ENSRNOP00055044884
  ENSRNOP00060026908
  ENSRNOP00065046871
GenBank Protein O55170 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062066   ⟸   NM_019193
- UniProtKB: O55170 (UniProtKB/Swiss-Prot),   A6HSQ2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015283   ⟸   ENSRNOT00000015283
Protein Domains
HMG box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O55170-F1-model_v2 AlphaFold O55170 1-466 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3735 AgrOrtholog
BioCyc Gene G2FUF-32778 BioCyc
Ensembl Genes ENSRNOG00000011305 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055031334 UniProtKB/Swiss-Prot
  ENSRNOG00060019038 UniProtKB/Swiss-Prot
  ENSRNOG00065033091 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015283.4 UniProtKB/Swiss-Prot
  ENSRNOT00055054279 UniProtKB/Swiss-Prot
  ENSRNOT00060032911 UniProtKB/Swiss-Prot
  ENSRNOT00065056930 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.30.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599259 IMAGE-MGC_LOAD
InterPro HMG_box_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sox_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOX_TF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29361 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72475 IMAGE-MGC_LOAD
NCBI Gene 29361 ENTREZGENE
PANTHER SOX100B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR SOX-10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HMG_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sox_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sox10 PhenoGen
PROSITE HMG_BOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011305 RatGTEx
  ENSRNOG00055031334 RatGTEx
  ENSRNOG00060019038 RatGTEx
  ENSRNOG00065033091 RatGTEx
SMART HMG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP HMG-box UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC208619
UniProt A6HSQ2 ENTREZGENE, UniProtKB/TrEMBL
  O55170 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-05 Sox10  SRY-box transcription factor 10  Sox10  SRY box 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-13 Sox10  SRY box 10  Sox10  SRY (sex determining region Y)-box 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Sox10  SRY (sex determining region Y)-box 10  Sox10  SRY-box containing gene 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Sox10  SRY-box containing gene 10      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed predominantly in glial cells in the nervous system of adults 70017
gene_expression mRNA expressed in embryonic glial precursor cells in the neural crest and in adult oligodendrocytes 70017
gene_physical_interaction binds to and functions synergistically with POU homeodomain protein Tst1/Oct6/Scip 70017
gene_process may confer cell specificity to transcription factor function in glial cell development 70017