Muc1 (mucin 1, cell surface associated) - Rat Genome Database

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Gene: Muc1 (mucin 1, cell surface associated) Rattus norvegicus
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Symbol: Muc1
Name: mucin 1, cell surface associated
RGD ID: 3122
Description: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; p53 binding activity; and transcription coregulator activity. Involved in several processes, including cellular response to retinoic acid; female pregnancy; and response to hypoxia. Located in apical plasma membrane. Used to study allergic rhinitis. Biomarker of allergic rhinitis; cholangiocarcinoma; and otitis media. Human ortholog(s) of this gene implicated in several diseases, including biliary tract benign neoplasm; dry eye syndrome; familial juvenile hyperuricemic nephropathy; mucinous adenocarcinoma; and pancreatic cancer (multiple). Orthologous to human MUC1 (mucin 1, cell surface associated); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC188069; mucin 1; mucin 1, transmembrane; mucin-1; Mucin1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Muc1em1Mcwi   Muc1em1Cgen  
Genetic Models: SD-Muc1em1Cgen FHH-Muc1em1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,933,312 - 176,938,497 (+)NCBIGRCr8
mRatBN7.22174,635,989 - 174,640,738 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,635,995 - 174,640,733 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,781,854 - 181,786,592 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,804,226 - 179,808,966 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,404,055 - 174,408,741 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,543,137 - 188,547,874 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,543,137 - 188,547,874 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,957,206 - 207,962,396 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,399,482 - 181,403,640 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12181,352,002 - 181,353,687 (+)NCBI
Celera2168,578,421 - 168,583,038 (+)NCBICelera
RH 3.4 Map21155.0RGD
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adult respiratory distress syndrome  (ISO)
allergic conjunctivitis  (ISO)
allergic rhinitis  (IEP,IMP,ISO)
asthma  (ISO)
Autosomal Dominant Tubulointerstitial Kidney Disease 2  (ISO)
bacterial conjunctivitis  (ISO)
biliary tract benign neoplasm  (ISO)
bird fancier's lung  (ISO)
blepharitis  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
bronchiolitis obliterans  (ISO)
bronchopulmonary dysplasia  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
cholangiocarcinoma  (IEP,ISO)
chronic obstructive pulmonary disease  (ISO)
common bile duct neoplasm  (ISO)
COVID-19  (ISO)
cystic fibrosis  (ISO)
Diabetes Complications  (IEP)
dry eye syndrome  (ISO)
Experimental Mammary Neoplasms  (ISO)
Fetal Growth Retardation  (IEP)
Gallbladder Neoplasms  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
heart disease  (ISO)
Hematologic Neoplasms  (ISO)
idiopathic pulmonary fibrosis  (ISO)
immunodeficiency 42  (ISO)
interstitial lung disease  (ISO)
Kidney Reperfusion Injury  (IDA)
Liver Reperfusion Injury  (IEP)
lung adenocarcinoma  (ISO)
lung disease  (ISO)
Lymphatic Metastasis  (ISO)
malignant mesothelioma  (ISO)
measles  (ISO)
Mesothelioma  (ISO)
MHC class II deficiency  (ISO)
mucinous adenocarcinoma  (ISO)
multiple myeloma  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
obstructive sleep apnea  (ISO)
otitis media  (IEP)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
parathyroid carcinoma  (ISO)
Peritoneal Neoplasms  (ISO)
pneumocystosis  (ISO)
pneumonia  (ISO)
pre-malignant neoplasm  (ISO)
prostate cancer  (ISO)
pulmonary sarcoidosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IEP)
severe congenital neutropenia 3  (ISO)
severe congenital neutropenia 5  (ISO)
Stomach Neoplasms  (ISO)
systemic scleroderma  (ISO)
Tubulointerstitial Nephritis and Uveitis  (ISO)
urinary bladder cancer  (ISO)
Viral Bronchiolitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-dichloroaniline  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boric acids  (ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
ceric oxide  (ISO)
CHIR 99021  (ISO)
chitin  (ISO)
chloramine T  (ISO)
chloroquine  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper(II) chloride  (ISO)
cyanuric chloride  (ISO)
cyclosporin A  (EXP,ISO)
DDE  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dibenzo[a,l]pyrene  (ISO)
diethylstilbestrol  (EXP,ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
favipiravir  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glutaraldehyde  (ISO)
hydralazine  (ISO)
indole-3-methanol  (EXP,ISO)
isoniazide  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
mancozeb  (ISO)
medroxyprogesterone acetate  (ISO)
methimazole  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
naphthalene  (EXP)
Neoisoliquiritin  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
ochratoxin A  (ISO)
Octicizer  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
piperazine  (ISO)
pirinixic acid  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
procymidone  (ISO)
progesterone  (ISO)
prostaglandin E2  (ISO)
prothioconazole  (ISO)
Prothioconazole-desthio  (ISO)
pyrimidifen  (ISO)
quercetin  (EXP)
raloxifene  (EXP,ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vandetanib  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Serum KL-6 and surfactant proteins A and D in pediatric interstitial lung disease. Al-Salmi QA, etal., Chest. 2005 Jan;127(1):403-7.
2. MUC1, a new hypoxia inducible factor target gene, is an actor in clear renal cell carcinoma tumor progression. Aubert S, etal., Cancer Res. 2009 Jul 15;69(14):5707-15. Epub 2009 Jun 23.
3. Transcriptional regulation by p53. Beckerman R and Prives C, Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000935. doi: 10.1101/cshperspect.a000935. Epub 2010 Apr 28.
4. Circulating levels of KL-6 in acute respiratory distress syndrome sepsis or traumatic brain injury in critically ill children. Briassoulis G, etal., Pediatr Pulmonol. 2006 Aug;41(8):790-5.
5. Phenotypic alterations of mucins and cytokeratins during gallbladder carcinogenesis. Chang HJ, etal., Pathol Int. 2004 Aug;54(8):576-84.
6. MUC1 and MUC2 expression in pancreatic ductal carcinoma obtained by fine-needle aspiration. Chhieng DC, etal., Cancer. 2003 Dec 25;99(6):365-71.
7. MUC1, MUC2, MUC4, MUC5AC and MUC6 expression in the progression of prostate cancer. Cozzi PJ, etal., Clin Exp Metastasis. 2005;22(7):565-73. Epub 2006 Feb 11.
8. Lymph node involvement and not the histophatologic subtype is correlated with outcome after resection of adenocarcinoma of the ampulla of vater. de Paiva Haddad LB, etal., J Gastrointest Surg. 2010 Apr;14(4):719-28. Epub 2010 Jan 27.
9. Reduction of mucin-1 expression during the receptive phase in the rat uterus. DeSouza MM, etal., Biol Reprod 1998 Jun;58(6):1503-7.
10. Alterations of the ocular surface epithelial mucins 1, 2, 4 and the tear functions in patients with atopic keratoconjunctivitis. Dogru M, etal., Clin Exp Allergy. 2006 Dec;36(12):1556-65.
11. Amelioration of renal ischemia-reperfusion injury with a novel protective cocktail. Dorai T, etal., J Urol. 2011 Dec;186(6):2448-54. doi: 10.1016/j.juro.2011.08.010. Epub 2011 Oct 21.
12. Intrauterine growth restriction alters postnatal colonic barrier maturation in rats. Fanca-Berthon P, etal., Pediatr Res. 2009 Jul;66(1):47-52. doi: 10.1203/PDR.0b013e3181a2047e.
13. Proteomic analysis of human bile from malignant biliary stenosis induced by pancreatic cancer. Farina A, etal., J Proteome Res. 2009 Jan;8(1):159-69.
14. Expression of MUC1 mucins inversely correlated with post-surgical survival of renal cell carcinoma patients. Fujita K, etal., Br J Cancer. 1999 Apr;80(1-2):301-8.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Targeted imaging of breast tumor progression and therapeutic response in a human uMUC-1 expressing transgenic mouse model. Ghosh SK, etal., Int J Cancer. 2013 Apr 15;132(8):1860-7. doi: 10.1002/ijc.27872. Epub 2012 Oct 25.
17. Comparison of mucin levels at the ocular surface of postmenopausal women with and without a history of dry eye. Gipson IK, etal., Cornea. 2011 Dec;30(12):1346-52. doi: 10.1097/ICO.0b013e31820d852a.
18. Regulation of MUC5 and MUC1 gene expression: correlation with airway mucous differentiation. Guzman K, etal., Am J Physiol 1996 May;270(5 Pt 1):L846-53.
19. KL-6 as a serologic indicator of Pneumocystis carinii pneumonia in immunocompromised hosts. Hamada H, etal., Intern Med. 1998 Mar;37(3):307-10.
20. Surfactant protein D and KL-6 as serum biomarkers of interstitial lung disease in patients with scleroderma. Hant FN, etal., J Rheumatol. 2009 Apr;36(4):773-80. Epub 2009 Mar 13.
21. Heterogeneity of mucin gene expression in normal and neoplastic tissues. Ho SB, etal., Cancer Res. 1993 Feb 1;53(3):641-51.
22. Serum KL-6 levels in pediatric patients: reference values for children and levels in pneumonia, asthma, and measles patients. Imai T, etal., Pediatr Pulmonol. 2002 Feb;33(2):135-41.
23. MUC1 and estrogen receptor alpha gene polymorphisms in dry eye patients. Imbert Y, etal., Exp Eye Res. 2009 Mar;88(3):334-8. doi: 10.1016/j.exer.2008.05.019. Epub 2008 Jun 20.
24. Ultrastructural localisation of Muc-1 on the plasma membrane of uterine epithelial cells. Isaacs J and Murphy CR, Acta Histochem. 2003;105(3):239-43.
25. Levels of Surfactant Proteins A and D and KL-6 Are Elevated in the Induced Sputum of Chronic Obstructive Pulmonary Disease Patients: A Sequential Sputum Analysis. Ishikawa N, etal., Respiration. 2011 Apr 7.
26. Expression of epidermal growth factor receptor, apomucins, matrix metalloproteinases, and p53 in rat and human cholangiocarcinoma: appraisal of an animal model of cholangiocarcinoma. Jan YY, etal., Ann Surg. 2004 Jul;240(1):89-94.
27. Study of Clara cell 16, KL-6, and surfactant protein-D in serum as disease markers in pulmonary sarcoidosis. Janssen R, etal., Chest. 2003 Dec;124(6):2119-25.
28. Analysis of KL-6 and SP-D as disease markers in bird fancier's lung. Janssen R, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2005 Mar;22(1):51-7.
29. Bacterial conjunctivitis in Muc1 null mice. Kardon R, etal., Invest Ophthalmol Vis Sci. 1999 Jun;40(7):1328-35.
30. Elevation of serum Krebs von den Lunge-6 levels in patients with tubulointerstitial nephritis and uveitis syndrome. Kase S, etal., Am J Kidney Dis. 2006 Dec;48(6):935-41.
31. MUC1 and MUC2 expression in human gallbladder carcinoma: a clinicopathological study and relationship with prognosis. Kashiwagi H, etal., Oncol Rep. 2001 May-Jun;8(3):485-9.
32. Poxvirus-based vaccine therapy for patients with advanced pancreatic cancer. Kaufman HL, etal., J Transl Med. 2007 Nov 26;5:60.
33. Expression of MUC1 recognized by a monoclonal antibody MY.1E12 is a useful biomarker for tumor aggressiveness of carcinoma of the gallbladder. Kawamoto T, etal., Clin Exp Metastasis. 2004;21(4):353-62.
34. Adoptive immunotherapy for pancreatic cancer: cytotoxic T lymphocytes stimulated by the MUC1-expressing human pancreatic cancer cell line YPK-1. Kawaoka T, etal., Oncol Rep. 2008 Jul;20(1):155-63.
35. Serum KL-6 levels as a biomarker of lung injury in respiratory syncytial virus bronchiolitis. Kawasaki Y, etal., J Med Virol. 2009 Dec;81(12):2104-8.
36. Cord blood KL-6, a specific lung injury marker, correlates with the subsequent development and severity of atypical bronchopulmonary dysplasia. Kim DH, etal., Neonatology. 2008;93(4):223-9. Epub 2007 Nov 16.
37. Role of KL-6 in evaluating the disease severity of rheumatoid lung disease: comparison with HRCT. Kinoshita F, etal., Respir Med. 2004 Nov;98(11):1131-7.
38. Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing. Kirby A, etal., Nat Genet. 2013 Mar;45(3):299-303. doi: 10.1038/ng.2543. Epub 2013 Feb 10.
39. Expression of mucin carbohydrates and core proteins in carcinomas of the ampulla of Vater: their relationship to prognosis. Kitamura H, etal., Jpn J Cancer Res. 1996 Jun;87(6):631-40.
40. Contribution of the MUC1 tandem repeat and cytoplasmic tail to invasive and metastatic properties of a pancreatic cancer cell line. Kohlgraf KG, etal., Cancer Res. 2003 Aug 15;63(16):5011-20.
41. Adoptive immunotherapy for pancreatic cancer using MUC1 peptide-pulsed dendritic cells and activated T lymphocytes. Kondo H, etal., Anticancer Res. 2008 Jan-Feb;28(1B):379-87.
42. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
43. Immunohistochemical evidence of Muc1 expression during rat embryonic development. Lacunza E, etal., Eur J Histochem. 2010 Nov 26;54(4):e49.
44. Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response. Laes JF, etal., Cytogenet Cell Genet 2001;92(1-2):130-3.
45. Circulating KL-6, a biomarker of lung injury, in obstructive sleep apnoea. Lederer DJ, etal., Eur Respir J. 2009 Apr;33(4):793-6.
46. A phase I/II study of a MUC1 peptide pulsed autologous dendritic cell vaccine as adjuvant therapy in patients with resected pancreatic and biliary tumors. Lepisto AJ, etal., Cancer Ther. 2008;6(B):955-964.
47. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
48. Progression of pancreatic adenocarcinoma is significantly impeded with a combination of vaccine and COX-2 inhibition. Mukherjee P, etal., J Immunol. 2009 Jan 1;182(1):216-24.
49. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
50. Novel biomarkers of arterial and venous ischemia in microvascular flaps. Nguyen GK, etal., PLoS One. 2013 Aug 14;8(8):e71628. doi: 10.1371/journal.pone.0071628.
51. KL-6, a mucinous glycoprotein, as an indicator of chronic lung disease of the newborn. Ogihara T, etal., J Pediatr. 2000 Aug;137(2):280-2.
52. Serum KL-6 as a novel disease marker in adolescent and adult cystic fibrosis. Ohshimo S, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2009 Jul;26(1):47-53.
53. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
54. Expression of MUC1, MUC2, MUC5AC and MUC6 in cholangiocarcinoma: prognostic impact. Park SY, etal., Oncol Rep. 2009 Sep;22(3):649-57.
55. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
56. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
57. Comprehensive gene review and curation RGD comprehensive gene curation
58. The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D. Samukawa T, etal., BMC Pulm Med. 2012 Sep 11;12:55. doi: 10.1186/1471-2466-12-55.
59. Pattern of mucin gene expression in normal and neoplastic lung tissues. Seregni E, etal., Anticancer Res. 1996 Jul-Aug;16(4B):2209-13.
60. MUC1 Is a Useful Molecular Marker for Malignant Intraductal Papillary Mucinous Neoplasms in Pancreatic Juice Obtained From Endoscopic Retrograde Pancreatography. Shimamoto T, etal., Pancreas. 2010 Mar 30.
61. MUC1 mucin as a tumour marker in bladder cancer. Simms MS, etal., BJU Int. 1999 Aug;84(3):350-2.
62. A novel "patient-like" model of cholangiocarcinoma progression based on bile duct inoculation of tumorigenic rat cholangiocyte cell lines. Sirica AE, etal., Hepatology. 2008 Apr;47(4):1178-90.
63. Elevation of serum KL-6 levels in patients with hematological malignancies associated with cytomegalovirus or Pneumocystis carinii pneumonia. Tanaka M, etal., Hematology. 2002 Apr;7(2):105-8.
64. KL-6 mucin expression in carcinoma of the ampulla of Vater: association with cancer progression. Tang W, etal., World J Gastroenterol. 2005 Sep 21;11(35):5450-4.
65. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
66. Downregulation of mucins in graft bile ducts after liver transplantation in rats. Tian F, etal., Transplantation. 2011 Sep 15;92(5):529-35. doi: 10.1097/TP.0b013e318229f785.
67. MUC1 enhances tumor progression and contributes toward immunosuppression in a mouse model of spontaneous pancreatic adenocarcinoma. Tinder TL, etal., J Immunol. 2008 Sep 1;181(5):3116-25.
68. Pattern changes of mucin gene expression with pneumococcal otitis media. Tsuboi Y, etal., Int J Pediatr Otorhinolaryngol. 2001 Oct 19;61(1):23-30.
69. RNA interference suppression of MUC1 reduces the growth rate and metastatic phenotype of human pancreatic cancer cells. Tsutsumida H, etal., Clin Cancer Res. 2006 May 15;12(10):2976-87.
70. Serum level of KL-6 as a marker of interstitial lung disease in patients with juvenile systemic sclerosis. Vesely R, etal., J Rheumatol. 2004 Apr;31(4):795-800.
71. Humoral immune response to polymorphic epithelial mucin (MUC-1) in patients with benign and malignant breast tumours. von Mensdorff-Pouilly S, etal., Eur J Cancer. 1996 Jul;32A(8):1325-31.
72. Serum KL-6 as a marker for bronchiolitis obliterans syndrome after lung transplantation. Walter JN, etal., Transplantation. 2006 Sep 15;82(5):709-11.
73. Elevation of serum KL-6 mucin levels in patients with cholangiocarcinoma. Xu H, etal., Hepatogastroenterology. 2008 Nov-Dec;55(88):2000-4.
74. Expression and localization of MUC1, MUC2, MUC5AC and small intestinal mucin antigen in pancreatic tumors. Yamasaki H, etal., Int J Oncol. 2004 Jan;24(1):107-13.
75. Expression of MUC1 and MUC2 mucin core proteins and their messenger RNA in gall bladder carcinoma: an immunohistochemical and in situ hybridization study. Yamato T, etal., J Pathol. 1999 May;188(1):30-7.
76. MUC1 induces metastasis in esophageal squamous cell carcinoma by upregulating matrix metalloproteinase 13. Ye Q, etal., Lab Invest. 2011 May;91(5):778-87. doi: 10.1038/labinvest.2011.12. Epub 2011 Feb 21.
77. MUC1 deficiency promotes nasal epithelial barrier dysfunction in subjects with allergic rhinitis. Zhou LB, etal., J Allergy Clin Immunol. 2019 Dec;144(6):1716-1719.e5. doi: 10.1016/j.jaci.2019.07.042. Epub 2019 Aug 16.
Additional References at PubMed
PMID:1569123   PMID:7698991   PMID:12477932   PMID:14999001   PMID:15326289   PMID:15710329   PMID:16240224   PMID:16472605   PMID:16502470   PMID:17187413   PMID:17545040   PMID:19056867  
PMID:19190083   PMID:19199708   PMID:23376485   PMID:23533145   PMID:24298937   PMID:29847197  


Genomics

Comparative Map Data
Muc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,933,312 - 176,938,497 (+)NCBIGRCr8
mRatBN7.22174,635,989 - 174,640,738 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,635,995 - 174,640,733 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,781,854 - 181,786,592 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,804,226 - 179,808,966 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,404,055 - 174,408,741 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,543,137 - 188,547,874 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,543,137 - 188,547,874 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,957,206 - 207,962,396 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,399,482 - 181,403,640 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12181,352,002 - 181,353,687 (+)NCBI
Celera2168,578,421 - 168,583,038 (+)NCBICelera
RH 3.4 Map21155.0RGD
Cytogenetic Map2q34NCBI
MUC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381155,185,824 - 155,192,915 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1155,185,824 - 155,192,916 (-)EnsemblGRCh38hg38GRCh38
GRCh371155,158,300 - 155,162,706 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361153,424,924 - 153,429,324 (-)NCBINCBI36Build 36hg18NCBI36
Build 341151,971,671 - 151,975,732NCBI
Celera1128,229,565 - 128,235,983 (-)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1126,521,570 - 126,525,810 (-)NCBIHuRef
CHM1_11156,554,155 - 156,558,213 (-)NCBICHM1_1
T2T-CHM13v2.01154,325,440 - 154,331,478 (-)NCBIT2T-CHM13v2.0
Muc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,136,363 - 89,140,688 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl389,136,364 - 89,140,688 (+)EnsemblGRCm39 Ensembl
GRCm38389,229,056 - 89,233,381 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,229,057 - 89,233,381 (+)EnsemblGRCm38mm10GRCm38
MGSCv37389,032,974 - 89,037,291 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36389,314,979 - 89,319,296 (+)NCBIMGSCv36mm8
Celera389,262,943 - 89,267,242 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.02NCBI
Muc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555451,657,728 - 1,662,112 (-)NCBIChiLan1.0ChiLan1.0
MUC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2194,649,069 - 94,655,513 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,381,477 - 94,386,968 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01130,533,508 - 130,537,866 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11134,141,969 - 134,146,791 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1134,141,969 - 134,145,850 (-)Ensemblpanpan1.1panPan2
MUC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,338,939 - 42,344,690 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,340,375 - 42,344,690 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,831,252 - 41,835,267 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0742,208,174 - 42,213,894 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl742,209,579 - 42,213,894 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,989,397 - 41,993,712 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0742,043,322 - 42,047,575 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0742,326,882 - 42,331,197 (+)NCBIUU_Cfam_GSD_1.0
Muc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505825,661,448 - 25,667,022 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365804,691,870 - 4,694,092 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MUC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1494,626,317 - 94,631,194 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24103,409,143 - 103,413,841 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MUC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1208,641,701 - 8,646,739 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl208,642,842 - 8,646,962 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660387,970,061 - 7,974,280 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Muc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248852,339,281 - 2,343,351 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Muc1
105 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:57
Count of miRNA genes:48
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000027850
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
61457Niddm8Non-insulin dependent diabetes mellitus QTL 84.10.01blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2174543008175950118Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921175950118Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2172982062175950118Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat

Markers in Region
RH94427  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map21155.0UniSTS
Cytogenetic Map2q34UniSTS
AU047994  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,639,799 - 174,639,956 (+)MAPPERmRatBN7.2
Rnor_6.02188,546,942 - 188,547,096NCBIRnor6.0
Rnor_5.02207,961,460 - 207,961,614UniSTSRnor5.0
RGSC_v3.42181,402,708 - 181,402,862UniSTSRGSC3.4
Celera2168,582,106 - 168,582,260UniSTS
Cytogenetic Map2q34UniSTS
Muc1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,637,758 - 174,638,821 (+)MAPPERmRatBN7.2
mRatBN7.22174,637,932 - 174,638,821 (+)MAPPERmRatBN7.2
Rnor_6.02188,545,075 - 188,545,963NCBIRnor6.0
Rnor_6.02188,544,901 - 188,545,963NCBIRnor6.0
Rnor_5.02207,959,419 - 207,960,481UniSTSRnor5.0
Rnor_5.02207,959,593 - 207,960,481UniSTSRnor5.0
RGSC_v3.42181,400,365 - 181,401,729UniSTSRGSC3.4
Celera2168,580,239 - 168,581,127UniSTS
Celera2168,580,065 - 168,581,127UniSTS
Cytogenetic Map2q34UniSTS
Muc1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,639,085 - 174,640,651 (+)MAPPERmRatBN7.2
Rnor_6.02188,546,228 - 188,547,791NCBIRnor6.0
Rnor_5.02207,960,746 - 207,962,309UniSTSRnor5.0
RGSC_v3.42181,401,994 - 181,403,557UniSTSRGSC3.4
Celera2168,581,392 - 168,582,955UniSTS
Cytogenetic Map2q34UniSTS


Genetic Models
This gene Muc1 is modified in the following models/strains:
SD-Muc1em1Cgen     FHH-Muc1em1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 8 41 108 86 90 59 25 59 6 202 82 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000027850   ⟹   ENSRNOP00000027850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,635,995 - 174,640,733 (+)Ensembl
Rnor_6.0 Ensembl2188,543,137 - 188,547,874 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103512   ⟹   ENSRNOP00000096371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,636,309 - 174,640,733 (+)Ensembl
RefSeq Acc Id: NM_001398538   ⟹   NP_001385467
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,933,750 - 176,938,497 (+)NCBI
mRatBN7.22174,635,989 - 174,640,738 (+)NCBI
RefSeq Acc Id: XM_063281292   ⟹   XP_063137362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,933,312 - 176,938,121 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001385467 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137362 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB62948 (Get FASTA)   NCBI Sequence Viewer  
  AAI66505 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027850.5
  ENSRNOP00000096371.1
Ensembl Acc Id: ENSRNOP00000027850   ⟸   ENSRNOT00000027850
Ensembl Acc Id: ENSRNOP00000096371   ⟸   ENSRNOT00000103512
RefSeq Acc Id: NP_001385467   ⟸   NM_001398538
- Peptide Label: precursor
- UniProtKB: F1LMZ5 (UniProtKB/TrEMBL),   B2GV31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137362   ⟸   XM_063281292
- Peptide Label: isoform X1
Protein Domains
SEA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GV31-F1-model_v2 AlphaFold B2GV31 1-655 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691464
Promoter ID:EPDNEW_R1989
Type:single initiation site
Name:Muc1_1
Description:mucin 1, cell surface associated
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02188,543,130 - 188,543,190EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3122 AgrOrtholog
BioCyc Gene G2FUF-52432 BioCyc
Ensembl Genes ENSRNOG00000020539 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027850.8 UniProtKB/TrEMBL
  ENSRNOT00000103512.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.600 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7122817 IMAGE-MGC_LOAD
InterPro SEA UniProtKB/TrEMBL
  SEA_dom_sf UniProtKB/TrEMBL
MGC_CLONE MGC:188069 IMAGE-MGC_LOAD
NCBI Gene 24571 ENTREZGENE
PANTHER MUCIN-1 UniProtKB/TrEMBL
  MUCIN-1-RELATED UniProtKB/TrEMBL
Pfam SEA UniProtKB/TrEMBL
PhenoGen Muc1 PhenoGen
PROSITE SEA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020539 RatGTEx
SMART SEA UniProtKB/TrEMBL
Superfamily-SCOP SSF82671 UniProtKB/TrEMBL
TIGR TC219475
UniProt A0A8I6GM17_RAT UniProtKB/TrEMBL
  B2GV31 ENTREZGENE, UniProtKB/TrEMBL
  F1LMZ5 ENTREZGENE
  O35770_RAT UniProtKB/TrEMBL
UniProt Secondary F1LMZ5 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-08-29 Muc1  mucin 1, cell surface associated  Muc1  mucin 1, transmembrane  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Muc1  mucin 1, transmembrane    mucin 1  Name updated 1299863 APPROVED
2002-06-10 Muc1  Mucin1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression is decreased at Day 5 of pregnancy in the uterine epithelium 633409