Enables insulin receptor binding activity. Involved in several processes, including cellular response to glucose stimulus; response to cAMP; and response to dimethyl sulfoxide. Located in extracellular space. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to several human genes including INS (insulin); PARTICIPATES IN insulin signaling pathway; aldosterone signaling pathway; autophagy pathway; INTERACTS WITH (+)-catechin; (R)-adrenaline; (R)-carnitine.
[Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of INS1 protein
[Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of INS1 protein
[Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of INS1 protein more ...
[GPD2 mutant form co-treated with Aminooxyacetic Acid] inhibits the reaction [Glucose results in increased secretion of INS1 protein] and [Potassium Chloride co-treated with Diazoxide] inhibits the reaction [[GPD2 mutant form co-treated with Aminooxyacetic Acid] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]
[acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of CIDEA mRNA more ...
Colchicine inhibits the reaction [apigenin-6-C-(2''-O-rhamnopyranosyl)-fucopyranoside promotes the reaction [Glucose results in increased secretion of INS1 protein]]
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of CS mRNA more ...
Dithiothreitol affects the reaction [oxophenylarsine results in decreased activity of INS1 protein] and Dithiothreitol inhibits the reaction [INS1 protein results in increased uptake of Glucose]
ESR1 gene mutant form inhibits the reaction [Ethinyl Estradiol results in decreased expression of and results in decreased secretion of INS1 protein] more ...
Estradiol inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein] and INS1 protein promotes the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA]
[Dietary Sucrose co-treated with Dietary Fats co-treated with bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2 more ...
dioxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA] more ...
[Dietary Sucrose co-treated with Dietary Fats co-treated with bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2 more ...
glyceryl 2-arachidonate promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose] and N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [glyceryl 2-arachidonate promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]]
[Oleic Acid co-treated with Palmitic Acid] inhibits the reaction [INS1 protein inhibits the reaction [[Cyclic AMP co-treated with Dexamethasone] results in increased expression of G6PC1 protein]] more ...
[tetrabromobisphenol A co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA more ...
(+)-JQ1 compound inhibits the reaction [[Triiodothyronine co-treated with Rosiglitazone co-treated with INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of UCP1 mRNA] more ...
(+)-JQ1 compound inhibits the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Troglitazone] results in increased expression of CEBPA protein] more ...
[acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of CIDEA mRNA more ...
[bisphenol S co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] affects the expression of CEBPA protein more ...
4-phenylbutyric acid inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1 and 3-diazol-4-yl)amino)-2-deoxyglucose]]
cobaltiprotoporphyrin inhibits the reaction [Methylprednisolone inhibits the reaction [Glucose results in increased secretion of INS1 protein]] and Methylprednisolone inhibits the reaction [Glucose results in increased secretion of INS1 protein]
9-phenanthrol inhibits the reaction [[GCG protein co-treated with Glucose] results in increased secretion of INS1 protein] and 9-phenanthrol inhibits the reaction [Glucose results in increased secretion of INS1 protein]
[Acrylamide co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CDKN1A protein more ...
Dactinomycin inhibits the reaction [bisphenol A results in increased secretion of INS1 protein] and Dactinomycin inhibits the reaction [nonylphenol results in increased secretion of INS1 protein]
AICA ribonucleotide inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D1 protein] and AICA ribonucleotide inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D4 protein]
[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA more ...
Allopurinol inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of INS1 protein] and Allopurinol inhibits the reaction [Fructose results in increased expression of INS1 protein]
allyl isothiocyanate inhibits the reaction [Dietary Fats results in increased expression of INS1 protein] and allyl isothiocyanate inhibits the reaction [Streptozocin promotes the reaction [Dietary Fats results in increased expression of INS1 protein]]
[Zeranol co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in decreased expression of TRPC6 protein and [Zeranol co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in decreased expression of TRPV1 protein
[Glucose co-treated with Amino Acids] results in increased secretion of INS1 protein and GNAI2 gene mutant form inhibits the reaction [[Glucose co-treated with Amino Acids] results in increased secretion of INS1 protein]
andrographolide affects the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] affects the expression of CEBPA mRNA] more ...
Apigenin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] and Apigenin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]
INS1 protein inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of LIMK1 protein] and INS1 protein inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased phosphorylation of CFL1 protein]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] and asiatic acid inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of INS1 protein]
[[Glucose co-treated with INS1 protein] results in increased abundance of Adenosine Triphosphate] which results in increased secretion of LEP protein more ...
avobenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA] more ...
bafilomycin A1 promotes the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1 and 3-diazol-4-yl)amino)-2-deoxyglucose]]
benazepril inhibits the reaction [Glucose results in increased secretion of INS1 protein] and benazepril promotes the reaction [INS1 protein results in increased metabolism of Glucose]
[acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of CIDEA mRNA more ...
Diethylhexyl Phthalate promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]
[Dietary Sucrose co-treated with Dietary Fats co-treated with bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2 more ...
[bisphenol A co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] affects the expression of IFNG mRNA more ...
2 and 2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [chrysin inhibits the reaction [Fructose results in increased expression of INS1 protein]]
6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [BL 11282 promotes the reaction [Glucose results in increased secretion of INS1 protein]]
Budesonide inhibits the reaction [Colforsin promotes the reaction [Glucose results in increased secretion of INS1 protein]] and Budesonide inhibits the reaction [Glucose results in increased secretion of INS1 protein]
butylbenzyl phthalate promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]
[[valyl-histidyl-threonyl-aspartamide binds to Zinc] results in increased activity of [INS1 protein binds to INS1 protein binds to INS1 protein binds to INS1 protein binds to INS1 protein binds to INS1 protein]] which results in decreased abundance of C-Peptide
[Cadmium Chloride results in increased abundance of Cadmium] which affects the expression of INS1 protein and Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased secretion of INS1 protein]
[Cadmium Chloride co-treated with methylmercuric chloride] results in increased expression of INS1 protein and [Cadmium Chloride results in increased abundance of Cadmium] inhibits the reaction [Glucose results in increased secretion of INS1 protein]
[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of INS1 protein
[Carnosine co-treated with asiatic acid] inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] and Carnosine inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]
Celecoxib inhibits the reaction [Dietary Fats results in increased expression of INS1 protein] and Celecoxib inhibits the reaction [Dietary Fats results in increased expression of INS1]
chicoric acid inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein] and chicoric acid inhibits the reaction [INS1 protein results in increased phosphorylation of MTOR protein]
[Methionine deficiency co-treated with Choline deficiency co-treated with aroclor 1260] results in decreased expression of and results in decreased secretion of INS1 protein and [Methionine deficiency co-treated with Choline deficiency] results in decreased expression of and results in decreased secretion of INS1 protein
Chromium affects the reaction [INS1 protein affects the reaction [[AVP protein results in increased uptake of Calcium] which results in increased secretion of Calcium]] more ...
chromic chloride promotes the reaction [INS1 protein results in decreased expression of UBC mRNA] and chromic chloride promotes the reaction [INS1 protein results in increased expression of IGF1 mRNA]
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL2 mRNA more ...
[Cobalt co-treated with INS1 protein] results in increased phosphorylation of INSR protein and [Cobalt co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein
coumarin inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased expression of INS1 protein] and coumarin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of INS1 protein]
Curcumin inhibits the reaction [Lamotrigine results in increased expression of INS1 protein] and Curcumin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]
Cycloheximide inhibits the reaction [apigenin-6-C-(2''-O-rhamnopyranosyl)-fucopyranoside promotes the reaction [Glucose results in increased secretion of INS1 protein]]
Cytochalasin B inhibits the reaction [INS1 protein results in increased uptake of Glucose] and Cytochalasin B inhibits the reaction [mono-(2-ethylhexyl)phthalate promotes the reaction [INS1 protein results in increased uptake of Glucose]]
Cytochalasin B inhibits the reaction [INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids and Nonesterified]]
[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA more ...
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of INS1 protein] more ...
Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of INS1 protein] and Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of INS1 protein]
[acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of CIDEA mRNA more ...
17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [Dexamethasone inhibits the reaction [Glucose results in increased secretion of INS1 protein]] more ...
(+)-JQ1 compound inhibits the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Troglitazone] results in increased expression of CEBPA protein] more ...
Diazinon inhibits the reaction [Dietary Fats results in increased expression of INS1 protein] and Resveratrol inhibits the reaction [Diazinon results in increased expression of INS1 protein]
Diazoxide inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] and Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of INS1 mRNA]
[Potassium Chloride co-treated with Diazoxide] inhibits the reaction [[GPD2 mutant form co-treated with Aminooxyacetic Acid] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]
Diosgenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of INS1 protein] and Diosgenin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]
Sodium Selenite inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]] and Sodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of INS1 protein]
mitoquinone inhibits the reaction [Sodium Selenite inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]] and Sodium Selenite inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]
[dorsomorphin co-treated with Quercetin] inhibits the reaction [[TNF protein co-treated with INS1 protein] results in decreased expression of AKT1 protein] more ...
[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of and results in decreased secretion of INS1 protein]
[Selenium co-treated with Vitamin E co-treated with Vanadium co-treated with Chromium] results in increased expression of INS1 mRNA and [Selenium co-treated with Vitamin E co-treated with Vanadium co-treated with Chromium] results in increased expression of INS1 protein
[Ethanol results in decreased susceptibility to INS1 protein] which results in decreased expression of and results in decreased activity of IRS1 protein more ...
ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1 more ...
fisetin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] and fisetin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]
Fluticasone inhibits the reaction [Colforsin promotes the reaction [Glucose results in increased secretion of INS1 protein]] and Fluticasone inhibits the reaction [Glucose results in increased secretion of INS1 protein]
Ethanol inhibits the reaction [Fructose results in increased expression of INS1 protein] and Fructose inhibits the reaction [Ethanol results in increased expression of INS1 protein]
[Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of INS1 protein
ginsenoside Rh4 inhibits the reaction [Alloxan inhibits the reaction [Glucose results in increased secretion of INS1 protein]] and NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan inhibits the reaction [Glucose results in increased secretion of INS1 protein]]]
ginsenoside Rh4 inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 mRNA] and ginsenoside Rh4 inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 protein]
Gliclazide inhibits the reaction [Streptozocin results in decreased expression of and results in decreased secretion of INS1 protein] and Gliclazide inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]
[Plant Extracts co-treated with glimepiride] inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] and glimepiride inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]
Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of INS1 protein] and Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of INS1 protein]
[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA more ...
Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 protein] more ...
[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with Firemaster 550] results in decreased expression of SP7 mRNA more ...
Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA mRNA] more ...
4-phenylbutyric acid inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1 more ...
[Oleic Acid co-treated with Palmitic Acid] inhibits the reaction [INS1 protein inhibits the reaction [[Cyclic AMP co-treated with Dexamethasone] results in increased expression of G6PC1 protein]] more ...
[Alloxan co-treated with Homocysteine] inhibits the reaction [Glucose results in increased secretion of INS1 protein] and Homocysteine inhibits the reaction [Glucose results in increased secretion of INS1 protein]
hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester inhibits the reaction [INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids and Nonesterified]]
Dietary Fats promotes the reaction [imidacloprid results in increased secretion of INS1 protein] and imidacloprid promotes the reaction [Dietary Fats results in increased secretion of INS1 protein]
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of CS mRNA more ...
Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ACACA protein] more ...
Dithiothreitol affects the reaction [oxophenylarsine results in decreased activity of INS1 protein] and Dithiothreitol inhibits the reaction [INS1 protein results in increased uptake of Glucose]
[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with Firemaster 550] results in decreased expression of SP7 mRNA more ...
[Methionine deficiency co-treated with Choline deficiency co-treated with aroclor 1260] results in decreased expression of and results in decreased secretion of INS1 protein and [Methionine deficiency co-treated with Choline deficiency] results in decreased expression of and results in decreased secretion of INS1 protein
Lenalidomide inhibits the reaction [Arsenic Trioxide inhibits the reaction [[Glucose co-treated with Lipopolysaccharides] results in increased secretion of INS1 protein]]
[Lutein co-treated with alpha-Tocopherol] results in decreased expression of INS1 protein and [Lutein co-treated with Ascorbic Acid] results in decreased expression of INS1 protein
Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased secretion of INS1 protein] and Luteolin inhibits the reaction [Fructose results in increased expression of INS1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Anthraquinones co-treated with INS1 protein] affects the localization of SLC2A4 protein] more ...
[mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ADRB3 protein more ...
[mangiferin co-treated with Sitagliptin Phosphate] results in increased expression of INS1 protein and mangiferin inhibits the reaction [Streptozocin results in increased expression of INS1 protein]
[Mercuric Chloride results in increased abundance of Mercury] inhibits the reaction [Glucose results in increased secretion of INS1 protein] and Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased secretion of INS1 protein]
Phosphocreatine inhibits the reaction [Pyruvaldehyde results in decreased secretion of INS1 protein] and Pyruvaldehyde results in decreased secretion of and results in decreased expression of INS1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [mono-(2-ethylhexyl)phthalate promotes the reaction [INS1 protein results in increased uptake of Glucose]] more ...
[INS1 protein co-treated with mono-(2-ethylhexyl)phthalate] results in decreased expression of and results in decreased phosphorylation of INSR protein more ...
[Streptozocin co-treated with Sodium Glutamate] results in decreased expression of INS1 protein and Carbenoxolone inhibits the reaction [Sodium Glutamate results in increased secretion of INS1 protein]
morin analog inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of INS1 protein] and morin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]
Phosphocreatine inhibits the reaction [Pyruvaldehyde results in decreased secretion of INS1 protein] and Phosphocreatine inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]
[TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]
[TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of INS1 protein] and Naproxen inhibits the reaction [Capsaicin results in increased expression of INS1 protein]
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL2 mRNA more ...
[Nickel co-treated with INS1 protein] results in increased phosphorylation of INSR protein and [Nickel co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of CS mRNA more ...
nimesulide inhibits the reaction [Dietary Fats results in increased expression of INS1 protein] and nimesulide inhibits the reaction [Dietary Fats results in increased expression of INS1]
Dactinomycin inhibits the reaction [nonylphenol results in increased secretion of INS1 protein] and Fulvestrant inhibits the reaction [nonylphenol results in increased secretion of INS1 protein]
[2-ethylhexyldiphenylphosphate co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of MIR155 mRNA more ...
[Oleic Acid co-treated with Palmitic Acid] inhibits the reaction [INS1 protein inhibits the reaction [[Cyclic AMP co-treated with Dexamethasone] results in increased expression of G6PC1 protein]] more ...
oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA] more ...
Paraquat inhibits the reaction [INS1 protein results in decreased expression of IGFBP1 mRNA] and Paraquat inhibits the reaction [INS1 protein results in decreased expression of PCK1 mRNA]
2-chloro-5-nitrobenzanilide inhibits the reaction [[Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with perfluorooctanoic acid] results in increased expression of CEBPA mRNA] more ...
Permethrin inhibits the reaction [INS1 protein results in increased expression of and results in increased phosphorylation of AKT1 protein] and Permethrin inhibits the reaction [INS1 protein results in increased phosphorylation of PDK1 protein]
[[NR1H4 protein co-treated with Dietary Fats] results in increased susceptibility to caffeic acid phenethyl ester] which results in decreased expression of INS1 protein
Tetradecanoylphorbol Acetate inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in increased secretion of INS1 protein]] and Tetradecanoylphorbol Acetate promotes the reaction [Glucose results in increased secretion of INS1 protein]
[Tetradecanoylphorbol Acetate co-treated with Glucose] results in increased secretion of INS1 protein and Tetradecanoylphorbol Acetate inhibits the reaction [[INS1 protein co-treated with benzamide] results in increased activity of GPD1 protein]
Pioglitazone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]
Pioglitazone inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of INS1 protein] and Pioglitazone inhibits the reaction [Streptozocin results in increased expression of INS1 protein]
[Potassium Chloride co-treated with Diazoxide] inhibits the reaction [[GPD2 mutant form co-treated with Aminooxyacetic Acid] inhibits the reaction [Glucose results in increased secretion of INS1 protein]] more ...
Dexamethasone inhibits the reaction [Potassium Chloride results in increased secretion of INS1 protein] and SLC30A8 protein affects the reaction [Potassium Chloride results in increased secretion of INS1 protein]
potassium chromate(VI) inhibits the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG protein]
[LDLR gene mutant form results in increased susceptibility to Pravastatin] inhibits the reaction [Glucose results in increased secretion of INS1 protein] and [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of INS1 protein
[INS1 protein co-treated with Pravastatin] inhibits the reaction [Streptozocin results in decreased expression of ACE2 protein] and [INS1 protein co-treated with Pravastatin] inhibits the reaction [Streptozocin results in increased expression of ACE protein]
Quercetin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]
[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein co-treated with Quercetin] results in increased phosphorylation of ACACA protein more ...
quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]
[quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein and [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA
[quinoxyfen co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CIDEC mRNA more ...
IWR-1 compound inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CTNNB1 protein]] more ...
repaglinide analog affects the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 protein] and repaglinide inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 protein]
Resveratrol inhibits the reaction [Acrolein inhibits the reaction [Glucose results in increased secretion of INS1 protein]] and Resveratrol inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]
Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CEBPA protein] more ...
Ro 31-8220 inhibits the reaction [apigenin-6-C-(2''-O-rhamnopyranosyl)-fucopyranoside promotes the reaction [Glucose results in increased secretion of INS1 protein]]
[Selenium co-treated with Vitamin E co-treated with Vanadium co-treated with Chromium] results in increased expression of INS1 mRNA and [Selenium co-treated with Vitamin E co-treated with Vanadium co-treated with Chromium] results in increased expression of INS1 protein
[Sertraline binds to 2-Hydroxypropyl-beta-cyclodextrin] inhibits the reaction [Alloxan results in decreased expression of INS1 protein] and Sertraline inhibits the reaction [Alloxan results in decreased expression of INS1 protein]
Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CDKN1B protein] more ...
Sirolimus inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1 and 3-diazol-4-yl)amino)-2-deoxyglucose]]
[sodium arsenite co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of ADIPOQ mRNA more ...
[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Zinc deficiency results in increased expression of INS1 mRNA] more ...
[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in decreased expression of INS1 protein and cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in decreased expression of INS1 protein]
Staurosporine inhibits the reaction [INS1 protein results in decreased expression of CYP2E1 mRNA] and Staurosporine promotes the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]
[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of and results in decreased secretion of INS1 protein] more ...
[Dietary Fats co-treated with Sucrose] affects the expression of INS1 protein and Quercetin affects the reaction [[Dietary Fats co-treated with Sucrose] affects the expression of INS1 protein]
sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of INS1 protein] and Sumatriptan inhibits the reaction [Capsaicin results in increased expression of INS1 protein]
[TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]
Taurine inhibits the reaction [Arsenic Trioxide inhibits the reaction [[Glucose co-treated with Lipopolysaccharides] results in increased secretion of INS1 protein]]
Thapsigargin inhibits the reaction [ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1 more ...
theaflavin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] and theaflavin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]
[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of INS1 protein
[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of INS1 protein
thymoquinone inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of INS1 protein] and thymoquinone inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased secretion of INS1 protein]
[acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of CIDEA mRNA more ...
tributyltin promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]
[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA more ...
INS1 protein inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]
[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with triphenyl phosphate] results in decreased expression of SP7 mRNA more ...
chromium tripicolinate affects the reaction [INS1 protein affects the reaction [[AVP protein results in increased uptake of Calcium] which results in increased secretion of Calcium]] more ...
(+)-JQ1 compound inhibits the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Troglitazone] results in increased expression of CEBPA protein] more ...
[Selenium co-treated with Vitamin E co-treated with Vanadium co-treated with Chromium] results in increased expression of INS1 mRNA and [Selenium co-treated with Vitamin E co-treated with Vanadium co-treated with Chromium] results in increased expression of INS1 protein
[Selenium co-treated with Vitamin E co-treated with Vanadium co-treated with Chromium] results in increased expression of INS1 mRNA and [Selenium co-treated with Vitamin E co-treated with Vanadium co-treated with Chromium] results in increased expression of INS1 protein
dapagliflozin promotes the reaction [Vildagliptin inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]] and Vildagliptin inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]
[Selenium co-treated with Vitamin E co-treated with Vanadium co-treated with Chromium] results in increased expression of INS1 mRNA and [Selenium co-treated with Vitamin E co-treated with Vanadium co-treated with Chromium] results in increased expression of INS1 protein
Wortmannin inhibits the reaction [apigenin-6-C-(2''-O-rhamnopyranosyl)-fucopyranoside promotes the reaction [Glucose results in increased secretion of INS1 protein]] more ...
YM-254890 inhibits the reaction [Glucose results in increased secretion of INS1 protein] and YM-254890 inhibits the reaction [Palmitic Acid promotes the reaction [Glucose results in increased secretion of INS1 protein]]
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL2 mRNA more ...
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL2 mRNA more ...
[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of INS1 protein
Colocalization of chaperone Cpn60, proinsulin and convertase PC1 within immature secretory granules of insulin-secreting cells suggests a role for Cpn60 in insulin processing.
Familial hyperproinsulinaemia due to a mutation substituting histidine for arginine at position 65 in proinsulin: identification of the mutation by restriction enzyme mapping.
Transient changes in four GLUT4 compartments in rat adipocytes during the transition, insulin-stimulated to basal: implications for the GLUT4 trafficking pathway.
Effects of glucagon-like peptide-1 (GLP-1) in RINm5F insulinoma cells. Stimulation of insulin secretion, insulin content, and insulin receptor binding.
Synergistic effect of dimethyl sulfoxide on glucagon-like peptide 1 (GLP-1)-stimulated insulin secretion and gene transcription in INS-1 cells: characterization and implications.
homology_group=Homology group 45; Mammalian insulin
Tissues & Cell Lines:
pancreas islet cells
Experiment Methods:
Length measurement of an RNA product; RNA Pol II in vitro system;; low-precision data; Nuclease protection; transfected or transformed cells; Primer extension; transfected or transformed cells; Nuclease protection; experiments performed with closely related; gene; Primer extension; experiments performed with closely related; gene
