Tab3 (TGF-beta activated kinase 1 (MAP3K7) binding protein 3) - Rat Genome Database

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Gene: Tab3 (TGF-beta activated kinase 1 (MAP3K7) binding protein 3) Rattus norvegicus
Analyze
Symbol: Tab3
Name: TGF-beta activated kinase 1 (MAP3K7) binding protein 3
RGD ID: 1594527
Description: Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity; molecular adaptor activity; and zinc ion binding activity. Predicted to be involved in defense response to bacterium; non-canonical NF-kappaB signal transduction; and positive regulation of canonical NF-kappaB signal transduction. Predicted to be active in endoplasmic reticulum. Orthologous to human TAB3 (TGF-beta activated kinase 1 (MAP3K7) binding protein 3); PARTICIPATES IN interleukin-1 signaling pathway; nuclear factor kappa B signaling pathway; Toll-like receptor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC317546; similar to TAK1-binding protein 3 isoform 1; TGF-beta activated kinase 1 and MAP3K7 binding protein 3; TGF-beta activated kinase 1/MAP3K7 binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X53,923,473 - 53,995,777 (+)NCBIGRCr8
mRatBN7.2X49,972,414 - 50,044,658 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX49,972,330 - 50,042,056 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X54,035,958 - 54,090,282 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX54,062,935 - 54,086,339 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X54,239,856 - 54,291,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X72,264,496 - 72,304,801 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX50,603,539 - 50,675,711 (+)NCBICelera
Cytogenetic MapXq21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. Brown J, etal., J Dent Res. 2011 Apr;90(4):417-27. Epub 2010 Oct 12.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Expanding role of ubiquitination in NF-kappaB signaling. Liu S and Chen ZJ, Cell Res. 2011 Jan;21(1):6-21. Epub 2010 Dec 7.
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Verstrepen L, etal., Cell Mol Life Sci. 2008 Oct;65(19):2964-78.
8. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Zhu S, etal., Nat Med. 2012 Jul;18(7):1077-86. doi: 10.1038/nm.2815.
Additional References at PubMed
PMID:18570454   PMID:23487264   PMID:27352012   PMID:35201648   PMID:35982795  


Genomics

Comparative Map Data
Tab3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X53,923,473 - 53,995,777 (+)NCBIGRCr8
mRatBN7.2X49,972,414 - 50,044,658 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX49,972,330 - 50,042,056 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X54,035,958 - 54,090,282 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX54,062,935 - 54,086,339 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X54,239,856 - 54,291,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X72,264,496 - 72,304,801 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX50,603,539 - 50,675,711 (+)NCBICelera
Cytogenetic MapXq21NCBI
TAB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X30,827,442 - 30,889,254 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX30,827,442 - 30,975,084 (-)EnsemblGRCh38hg38GRCh38
GRCh37X30,845,559 - 30,907,371 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X30,755,480 - 30,817,432 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX34,973,775 - 35,018,119 (-)NCBICelera
Cytogenetic MapXp21.2NCBI
HuRefX28,586,659 - 28,648,837 (-)NCBIHuRef
CHM1_1X30,877,115 - 30,938,957 (-)NCBICHM1_1
T2T-CHM13v2.0X30,425,653 - 30,487,452 (-)NCBIT2T-CHM13v2.0
Tab3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X84,617,466 - 84,678,075 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX84,617,628 - 84,678,075 (+)EnsemblGRCm39 Ensembl
GRCm38X85,573,854 - 85,634,469 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX85,574,022 - 85,634,469 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X82,819,361 - 82,879,808 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X81,826,741 - 81,887,033 (+)NCBIMGSCv36mm8
CeleraX76,769,488 - 76,829,957 (+)NCBICelera
Cytogenetic MapXC1NCBI
cM MapX39.32NCBI
Tab3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555353,585,243 - 3,612,790 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555353,547,556 - 3,612,705 (+)NCBIChiLan1.0ChiLan1.0
TAB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X32,629,664 - 32,691,003 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X32,633,201 - 32,694,372 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X23,428,343 - 23,489,688 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X30,980,841 - 31,042,142 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX30,980,841 - 31,012,994 (-)Ensemblpanpan1.1panPan2
TAB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X25,950,071 - 26,039,180 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX25,954,145 - 26,008,169 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX30,925,754 - 31,014,854 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X25,981,434 - 26,070,564 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX25,981,444 - 26,070,578 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X26,026,007 - 26,115,373 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X26,019,013 - 26,108,164 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X26,116,786 - 26,206,101 (-)NCBIUU_Cfam_GSD_1.0
Tab3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X18,767,914 - 18,825,442 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365536,860,261 - 6,885,475 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365536,860,435 - 6,917,796 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX26,632,551 - 26,729,051 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X26,632,547 - 26,729,039 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X28,950,771 - 29,007,946 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TAB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X29,256,176 - 29,318,129 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX29,256,104 - 29,288,960 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605631,321,989 - 31,383,983 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tab3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476225,107,234 - 25,177,268 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tab3
272 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:91
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000004854
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 12 12 4 12 49 10 18
Low 3 40 44 28 15 28 8 10 25 25 23 11 8
Below cutoff 1 1 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004854   ⟹   ENSRNOP00000004854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX49,972,330 - 50,042,056 (+)Ensembl
Rnor_6.0 EnsemblX54,062,935 - 54,086,339 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100917   ⟹   ENSRNOP00000089411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX49,972,366 - 50,042,056 (+)Ensembl
RefSeq Acc Id: XM_039100564   ⟹   XP_038956492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X53,971,497 - 53,995,777 (+)NCBI
mRatBN7.2X50,020,378 - 50,044,658 (+)NCBI
RefSeq Acc Id: XM_039100565   ⟹   XP_038956493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X53,923,473 - 53,995,777 (+)NCBI
mRatBN7.2X49,972,414 - 50,044,658 (+)NCBI
RefSeq Acc Id: XM_039100567   ⟹   XP_038956495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X53,923,513 - 53,995,777 (+)NCBI
mRatBN7.2X49,972,429 - 50,044,658 (+)NCBI
RefSeq Acc Id: XR_005498528
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X53,971,497 - 53,989,411 (+)NCBI
mRatBN7.2X50,020,378 - 50,038,292 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038956492 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956493 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956495 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004854
  ENSRNOP00000004854.8
  ENSRNOP00000089411
  ENSRNOP00000089411.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000004854   ⟸   ENSRNOT00000004854
RefSeq Acc Id: XP_038956493   ⟸   XM_039100565
- Peptide Label: isoform X2
- UniProtKB: F1M1D2 (UniProtKB/TrEMBL),   A6IPW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956495   ⟸   XM_039100567
- Peptide Label: isoform X2
- UniProtKB: F1M1D2 (UniProtKB/TrEMBL),   A6IPW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956492   ⟸   XM_039100564
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ABN5 (UniProtKB/TrEMBL),   A6IPW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000089411   ⟸   ENSRNOT00000100917
Protein Domains
CUE   RanBP2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M1D2-F1-model_v2 AlphaFold F1M1D2 1-715 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594527 AgrOrtholog
BioCyc Gene G2FUF-2348 BioCyc
Ensembl Genes ENSRNOG00000003643 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004854.8 UniProtKB/TrEMBL
  ENSRNOT00000100917 ENTREZGENE
  ENSRNOT00000100917.1 UniProtKB/TrEMBL
Gene3D-CATH DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
  Zn-finger domain of Sec23/24 UniProtKB/TrEMBL
InterPro CUE UniProtKB/TrEMBL
  TAB2/3_CUE UniProtKB/TrEMBL
  Znf_RanBP2 UniProtKB/TrEMBL
  Znf_RanBP2_sf UniProtKB/TrEMBL
NCBI Gene 317546 ENTREZGENE
PANTHER TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 3 UniProtKB/TrEMBL
  TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN TAB UniProtKB/TrEMBL
Pfam CUE UniProtKB/TrEMBL
PhenoGen Tab3 PhenoGen
PROSITE CUE UniProtKB/TrEMBL
  ZF_RANBP2_1 UniProtKB/TrEMBL
  ZF_RANBP2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003643 RatGTEx
SMART CUE UniProtKB/TrEMBL
  ZnF_RBZ UniProtKB/TrEMBL
Superfamily-SCOP SSF90209 UniProtKB/TrEMBL
UniProt A0A8I6ABN5 ENTREZGENE, UniProtKB/TrEMBL
  A6IPW0 ENTREZGENE, UniProtKB/TrEMBL
  F1M1D2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-02-23 Tab3  TGF-beta activated kinase 1 (MAP3K7) binding protein 3  Tab3  TGF-beta activated kinase 1 and MAP3K7 binding protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-02-01 Tab3  TGF-beta activated kinase 1 and MAP3K7 binding protein 3  Tab3  TGF-beta activated kinase 1/MAP3K7 binding protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-09 Tab3  TGF-beta activated kinase 1/MAP3K7 binding protein 3  LOC317546  similar to TAK1-binding protein 3 isoform 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC317546  similar to TAK1-binding protein 3 isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL