Gstt4 (glutathione S-transferase, theta 4) - Rat Genome Database

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Gene: Gstt4 (glutathione S-transferase, theta 4) Rattus norvegicus
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Symbol: Gstt4
Name: glutathione S-transferase, theta 4
RGD ID: 1591294
Description: Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytoplasm. Orthologous to human GSTT4 (glutathione S-transferase theta 4); INTERACTS WITH 1,2-dimethylhydrazine; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutathione S-transferase theta-4; GST class-theta-4; LOC103694880; LOC686922; similar to Glutathione S-transferase theta-1 (GST class-theta-1) (Glutathione transferase T1-1); uncharacterized LOC103694880
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,834,613 - 12,841,730 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2012,834,612 - 12,841,744 (+)EnsemblGRCr8
mRatBN7.22012,835,178 - 12,842,306 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,835,178 - 12,842,292 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2013,541,554 - 13,548,873 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,902,481 - 12,909,800 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,374,423 - 13,381,746 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,778,185 - 13,784,813 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,778,178 - 13,784,827 (+)Ensemblrn6Rnor6.0
Rnor_5.02015,968,093 - 15,975,083 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42013,238,379 - 13,239,777 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2014,326,728 - 14,333,740 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Gstt4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,834,613 - 12,841,730 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2012,834,612 - 12,841,744 (+)EnsemblGRCr8
mRatBN7.22012,835,178 - 12,842,306 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,835,178 - 12,842,292 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2013,541,554 - 13,548,873 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,902,481 - 12,909,800 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,374,423 - 13,381,746 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,778,185 - 13,784,813 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,778,178 - 13,784,827 (+)Ensemblrn6Rnor6.0
Rnor_5.02015,968,093 - 15,975,083 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42013,238,379 - 13,239,777 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2014,326,728 - 14,333,740 (+)NCBICelera
Cytogenetic Map20p12NCBI
GSTT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,989,115 - 24,005,453 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2223,998,401 - 24,005,453 (-)Ensemblhg38GRCh38
GRCh372224,340,595 - 24,347,350 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,670,595 - 22,677,258 (-)NCBIBuild 36Build 36hg18NCBI36
Celera228,141,156 - 8,147,155 (-)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef227,288,707 - 7,295,363 (-)NCBIHuRef
CHM1_12224,353,110 - 24,360,070 (-)NCBICHM1_1
T2T-CHM13v2.02224,405,779 - 24,412,527 (-)NCBIT2T-CHM13v2.0
Gstt4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,650,777 - 75,658,405 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,650,777 - 75,658,377 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381075,814,943 - 75,822,566 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,814,943 - 75,822,543 (-)Ensemblmm10GRCm38
MGSCv371075,277,688 - 75,285,288 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361075,258,662 - 75,266,236 (-)NCBIMGSCv36mm8
Celera1076,859,618 - 76,867,219 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.58NCBI
LOC486404
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12628,553,498 - 28,564,505 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2627,626,825 - 27,637,840 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02629,959,598 - 29,970,333 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2629,930,214 - 30,010,240 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12628,040,792 - 28,052,080 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,657,366 - 27,668,529 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,647,138 - 28,658,218 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
GSTT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,812,019 - 49,819,248 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11449,812,009 - 49,819,028 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,254,244 - 53,261,383 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Gstt4
86 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:84
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000058314
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804392015089182Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 10 3 39 22 23 6 8 6 5 47 27 1 27 1 56 17 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000058314   ⟹   ENSRNOP00000055115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2012,834,612 - 12,841,744 (+)Ensembl
mRatBN7.2 Ensembl2012,835,178 - 12,842,292 (+)Ensembl
Rnor_6.0 Ensembl2013,778,178 - 13,784,827 (+)Ensembl
RefSeq Acc Id: NM_001109675   ⟹   NP_001103145
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,834,613 - 12,841,730 (+)NCBI
mRatBN7.22012,835,178 - 12,842,292 (+)NCBI
Rnor_6.02013,778,185 - 13,784,813 (+)NCBI
Rnor_5.02015,968,093 - 15,975,083 (+)NCBI
RGSC_v3.42013,238,379 - 13,239,777 (+)RGD
Celera2014,326,728 - 14,333,740 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001103145 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97423 (Get FASTA)   NCBI Sequence Viewer  
  EDL97183 (Get FASTA)   NCBI Sequence Viewer  
  EDL97184 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000055115
  ENSRNOP00000055115.3
GenBank Protein Q4V8E6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001103145   ⟸   NM_001109675
- UniProtKB: Q4V8E6 (UniProtKB/Swiss-Prot),   A6JKG7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000055115   ⟸   ENSRNOT00000058314
Protein Domains
GST C-terminal   GST N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V8E6-F1-model_v2 AlphaFold Q4V8E6 1-240 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701533
Promoter ID:EPDNEW_R12057
Type:initiation region
Name:Gstt4_1
Description:glutathione S-transferase, theta 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,778,184 - 13,778,244EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1591294 AgrOrtholog
BioCyc Gene G2FUF-4160 BioCyc
Ensembl Genes ENSRNOG00000038300 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000058314 ENTREZGENE
  ENSRNOT00000058314.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7455039 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase UniProtKB/Swiss-Prot
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot
  GST_C UniProtKB/Swiss-Prot
  GST_C_Theta UniProtKB/Swiss-Prot
  GST_N_Theta UniProtKB/Swiss-Prot
  GST_Theta UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:686922 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114470 IMAGE-MGC_LOAD
NCBI Gene 686922 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE THETA-4-RELATED UniProtKB/Swiss-Prot
  PTHR43917 UniProtKB/Swiss-Prot
Pfam GST_C UniProtKB/Swiss-Prot
  GST_N_3 UniProtKB/Swiss-Prot
PhenoGen Gstt4 PhenoGen
PROSITE GST_CTER UniProtKB/Swiss-Prot
  GST_NTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000038300 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot
UniProt A6JKG7 ENTREZGENE, UniProtKB/TrEMBL
  A6JKG8_RAT UniProtKB/TrEMBL
  GSTT4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Gstt4  glutathione S-transferase, theta 4  LOC103694880  uncharacterized LOC103694880  Data merged from RGD:9452289 737654 PROVISIONAL
2014-08-25 LOC103694880  uncharacterized LOC103694880      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-11-30 Gstt4  glutathione S-transferase, theta 4  LOC686922  similar to Glutathione S-transferase theta-1 (GST class-theta-1) (Glutathione transferase T1-1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC686922  similar to Glutathione S-transferase theta-1 (GST class-theta-1) (Glutathione transferase T1-1)      Symbol and Name status set to provisional 70820 PROVISIONAL