Rflna (refilin A) - Rat Genome Database

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Gene: Rflna (refilin A) Rattus norvegicus
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Symbol: Rflna
Name: refilin A
RGD ID: 1588777
Description: Predicted to enable filamin binding activity. Predicted to be involved in several processes, including actin filament bundle organization; negative regulation of bone mineralization involved in bone maturation; and negative regulation of chondrocyte development. Predicted to be located in cytoplasm. Predicted to be active in actin filament bundle. Orthologous to human RFLNA (refilin A); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fam101a; family with sequence similarity 101, member A; filamin-interacting protein FAM101A; hypothetical protein LOC689711; LOC689711; refilin-A; uncharacterized protein LOC689711
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,294,643 - 37,323,373 (-)NCBIGRCr8
mRatBN7.21231,633,360 - 31,642,313 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,633,361 - 31,642,317 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1232,806,382 - 32,815,296 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,417,705 - 33,426,620 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01232,469,557 - 32,478,469 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01237,038,732 - 37,047,628 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1237,038,733 - 37,047,628 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01238,914,965 - 38,923,860 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41232,730,785 - 32,739,680 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1233,324,655 - 33,333,550 (-)NCBICelera
Cytogenetic Map12q15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:24436304  


Genomics

Comparative Map Data
Rflna
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,294,643 - 37,323,373 (-)NCBIGRCr8
mRatBN7.21231,633,360 - 31,642,313 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,633,361 - 31,642,317 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1232,806,382 - 32,815,296 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,417,705 - 33,426,620 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01232,469,557 - 32,478,469 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01237,038,732 - 37,047,628 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1237,038,733 - 37,047,628 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01238,914,965 - 38,923,860 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41232,730,785 - 32,739,680 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1233,324,655 - 33,333,550 (-)NCBICelera
Cytogenetic Map12q15NCBI
RFLNA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812123,973,215 - 124,316,024 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12123,973,241 - 124,316,024 (+)EnsemblGRCh38hg38GRCh38
GRCh3712124,457,762 - 124,800,570 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612123,339,663 - 123,366,521 (+)NCBINCBI36Build 36hg18NCBI36
Celera12124,374,399 - 124,401,227 (+)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12121,419,911 - 121,763,336 (+)NCBIHuRef
CHM1_112124,278,627 - 124,622,098 (+)NCBICHM1_1
T2T-CHM13v2.012123,974,731 - 124,318,372 (+)NCBIT2T-CHM13v2.0
Rflna
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395125,080,512 - 125,089,611 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5125,080,285 - 125,089,611 (+)EnsemblGRCm39 Ensembl
GRCm385125,003,448 - 125,012,547 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5125,003,221 - 125,012,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv375125,483,845 - 125,492,917 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365125,292,454 - 125,301,526 (+)NCBIMGSCv36mm8
Celera5122,021,370 - 122,030,413 (+)NCBICelera
Cytogenetic Map5G1.1NCBI
cM Map563.95NCBI
LOC102011120
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554825,033,914 - 5,042,790 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554825,034,075 - 5,044,162 (-)NCBIChiLan1.0ChiLan1.0
RFLNA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210132,050,056 - 132,396,155 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112132,046,434 - 132,392,533 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012121,737,946 - 121,903,635 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112126,027,350 - 126,191,071 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12126,164,592 - 126,191,071 (+)Ensemblpanpan1.1panPan2
LOC103239345
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111119,497,097 - 119,666,178 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11119,647,606 - 119,668,003 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037125,621,264 - 125,639,698 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rflna
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474723,766,856 - 23,774,397 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474723,766,756 - 23,775,238 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rflna
168 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:278
Count of miRNA genes:171
Interacting mature miRNAs:201
Transcripts:ENSRNOT00000001337
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134044726024Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)122806443340130419Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)122860752637691617Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134043551788Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)122423477731894213Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)122806455740218380Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 49 113 87 86 55 25 55 6 211 94 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000001337   ⟹   ENSRNOP00000001337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1237,038,733 - 37,047,628 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119390   ⟹   ENSRNOP00000089299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1231,633,361 - 31,642,317 (-)Ensembl
RefSeq Acc Id: NM_001109547   ⟹   NP_001103017
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81237,294,643 - 37,303,535 (-)NCBI
mRatBN7.21231,633,360 - 31,642,313 (-)NCBI
Rnor_6.01237,038,733 - 37,047,628 (-)NCBI
Rnor_5.01238,914,965 - 38,923,860 (-)NCBI
RGSC_v3.41232,730,785 - 32,739,680 (-)RGD
Celera1233,324,655 - 33,333,550 (-)RGD
Sequence:
RefSeq Acc Id: XM_063271671   ⟹   XP_063127741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81237,294,647 - 37,323,373 (-)NCBI
RefSeq Acc Id: XM_063271672   ⟹   XP_063127742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81237,294,647 - 37,302,293 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001103017 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127741 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127742 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM13564 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000089299.1
RefSeq Acc Id: NP_001103017   ⟸   NM_001109547
- UniProtKB: A6J0X5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001337   ⟸   ENSRNOT00000001337
Ensembl Acc Id: ENSRNOP00000089299   ⟸   ENSRNOT00000119390
RefSeq Acc Id: XP_063127741   ⟸   XM_063271671
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063127742   ⟸   XM_063271672
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZXN7-F1-model_v2 AlphaFold D3ZXN7 1-204 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588777 AgrOrtholog
BioCyc Gene G2FUF-19373 BioCyc
Ensembl Genes ENSRNOG00000001011 Ensembl
  ENSRNOG00000063517 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000119390.1 UniProtKB/TrEMBL
InterPro Refilin UniProtKB/TrEMBL
KEGG Report rno:689711 UniProtKB/TrEMBL
NCBI Gene 689711 ENTREZGENE
PANTHER PTHR31848 UniProtKB/TrEMBL
  REFILIN-A UniProtKB/TrEMBL
Pfam FAM101 UniProtKB/TrEMBL
PhenoGen Rflna PhenoGen
RatGTEx ENSRNOG00000001011 RatGTEx
  ENSRNOG00000063517 RatGTEx
UniProt A0A8I6AKN9_RAT UniProtKB/TrEMBL
  A6J0X5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 Rflna  refilin A  Fam101a  family with sequence similarity 101, member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-08 Fam101a  family with sequence similarity 101, member A  LOC687503  hypothetical protein LOC687503  Data merged from RGD:1584261 1643240 APPROVED
2008-03-06 Fam101a  family with sequence similarity 101, member A  LOC689711  hypothetical protein LOC689711  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC689711  hypothetical protein LOC689711      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687503  hypothetical protein LOC687503      Symbol and Name status set to provisional 70820 PROVISIONAL